ATE218554T1 - Hepatobillianische magnetische resonanz- kontrastmittel - Google Patents
Hepatobillianische magnetische resonanz- kontrastmittelInfo
- Publication number
- ATE218554T1 ATE218554T1 AT94926365T AT94926365T ATE218554T1 AT E218554 T1 ATE218554 T1 AT E218554T1 AT 94926365 T AT94926365 T AT 94926365T AT 94926365 T AT94926365 T AT 94926365T AT E218554 T1 ATE218554 T1 AT E218554T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- branched
- straight
- hepatobillian
- magnetic resonance
- Prior art date
Links
- 239000002405 nuclear magnetic resonance imaging agent Substances 0.000 title 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052688 Gadolinium Inorganic materials 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- LGAILEFNHXWAJP-BMEPFDOTSA-N macrocycle Chemical group N([C@H]1[C@@H](C)CC)C(=O)C(N=2)=CSC=2CNC(=O)C(=C(O2)C)N=C2[C@H]([C@@H](C)CC)NC(=O)C2=CSC1=N2 LGAILEFNHXWAJP-BMEPFDOTSA-N 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Soft Magnetic Materials (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/129,870 US5358704A (en) | 1993-09-30 | 1993-09-30 | Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents |
| PCT/IB1994/000298 WO1995009161A1 (en) | 1993-09-30 | 1994-09-29 | Hepatobiliary magnetic resonance contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218554T1 true ATE218554T1 (de) | 2002-06-15 |
Family
ID=22441998
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01127327T ATE288422T1 (de) | 1993-09-30 | 1994-09-29 | Hepatobillianische magnetische resonanz- kontrastmittel |
| AT94926365T ATE218554T1 (de) | 1993-09-30 | 1994-09-29 | Hepatobillianische magnetische resonanz- kontrastmittel |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01127327T ATE288422T1 (de) | 1993-09-30 | 1994-09-29 | Hepatobillianische magnetische resonanz- kontrastmittel |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5358704A (de) |
| EP (2) | EP0670832B1 (de) |
| JP (1) | JP3949714B2 (de) |
| KR (1) | KR960702447A (de) |
| CN (1) | CN1115180A (de) |
| AT (2) | ATE288422T1 (de) |
| AU (1) | AU7623494A (de) |
| CA (1) | CA2150452A1 (de) |
| CZ (1) | CZ136995A3 (de) |
| DE (2) | DE69434260T2 (de) |
| HK (1) | HK1046131A1 (de) |
| IL (1) | IL111083A0 (de) |
| NO (1) | NO300131B1 (de) |
| WO (1) | WO1995009161A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
| JPH0797340A (ja) * | 1993-06-03 | 1995-04-11 | Terumo Corp | Ｍｒｉ造影剤組成物 |
| IT1269839B (it) * | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| US6962686B2 (en) * | 1994-10-12 | 2005-11-08 | California Institute Of Technology | Cell-specific gene delivery vehicles |
| US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
| TW319763B (de) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US5707605A (en) * | 1995-06-02 | 1998-01-13 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| US5980862A (en) * | 1995-06-02 | 1999-11-09 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| AU6896796A (en) * | 1995-08-17 | 1997-03-12 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
| US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
| DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
| US6495118B1 (en) | 1997-09-26 | 2002-12-17 | Schering Aktiengesellschaft | Lipophilic metal complexes for necrosis and infarction imaging |
| US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
| WO1999025389A2 (en) | 1997-11-17 | 1999-05-27 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| IT1297035B1 (it) | 1997-12-30 | 1999-08-03 | Bracco Spa | Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
| US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| US6056939A (en) * | 1998-08-28 | 2000-05-02 | Desreux; Jean F. | Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals |
| AU2001276956A1 (en) | 2000-07-17 | 2002-01-30 | California Institute Of Technology | Macrocyclic mri contrast agents |
| US7029655B2 (en) | 2000-10-04 | 2006-04-18 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
| US20030135108A1 (en) * | 2001-05-02 | 2003-07-17 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
| WO2002087632A1 (en) * | 2001-05-02 | 2002-11-07 | Metaprobe, Inc. | High throughput screening methods using magnetic resonance imaging agents |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| EP1545498A4 (de) * | 2002-09-06 | 2006-09-06 | Us Gov Health & Human Serv | Gerüst-substituierte bifunktionale dota-liganden, ihre komplexe und zusammensetzungen und ihre anwendungsverfahren |
| CN1774267A (zh) * | 2003-01-22 | 2006-05-17 | 综合医院有限公司 | 与淀粉样物质结合的金属螯合剂 |
| US7012140B1 (en) * | 2003-07-14 | 2006-03-14 | Board Of Regents, The University Of Texas System | Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents |
| US20060088475A1 (en) * | 2004-05-10 | 2006-04-27 | Northwestern University | Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase |
| AU2005253962A1 (en) | 2004-06-09 | 2005-12-29 | Kereos, Inc. | Lipophilic derivatives of chelate monoamides |
| BRPI0519754A2 (pt) | 2005-01-13 | 2009-03-10 | Cinv Ag | materiais compàsitos contendo nanopartÍculas de carbono |
| BRPI0617450A2 (pt) * | 2005-10-18 | 2011-07-26 | Cinv Ag | partÍculas de termocura e mÉtodos para produÇço das mesmas |
| WO2007124131A2 (en) * | 2006-04-20 | 2007-11-01 | The University Of North Carolina At Chapel Hill | Hybrid nanomaterials as multimodal imaging contrast agents |
| AU2007329592A1 (en) * | 2006-11-21 | 2008-06-12 | Barnes-Jewish Hospital | Methods of imaging employing chelating agents |
| CN100459932C (zh) * | 2007-01-15 | 2009-02-11 | 北京大学人民医院 | 一种mri分子影像探针及其制备方法 |
| EP2104473A1 (de) * | 2007-01-19 | 2009-09-30 | Cinvention Ag | Durch pulverformung hergestelltes poröses und nicht abbaubares implantat |
| CN101646764A (zh) * | 2007-02-28 | 2010-02-10 | 金文申有限公司 | 高表面积培养系统 |
| WO2008104599A1 (en) * | 2007-02-28 | 2008-09-04 | Cinvention Ag | High surface cultivation system bag |
| EP2072060A1 (de) | 2007-12-18 | 2009-06-24 | Institut Curie | Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten |
| US8580231B2 (en) | 2008-05-23 | 2013-11-12 | Northwestern University | Compositions and methods comprising magnetic resonance contrast agents |
| US20100029909A1 (en) * | 2008-05-23 | 2010-02-04 | Northwestern University | Compositions and methods comprising magnetic resonance contrast agents |
| CA2726050A1 (en) | 2008-05-30 | 2009-12-10 | Siemens Medical Solutions Usa, Inc. | Achievement of high therapeutic index through molecular imaging guided targeted drug treatment |
| WO2010116209A1 (en) | 2009-04-10 | 2010-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fucoidans as ligands for the diagnosis of degenerative pathologies |
| US9272054B2 (en) | 2010-12-03 | 2016-03-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Agents for the molecular imaging of serine-protease in human pathologies |
| EP2658869B1 (de) | 2010-12-30 | 2019-06-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenbindende formate zur verwendung in therapeutischen behandlungen oder diagnosetests |
| US20150337308A1 (en) | 2012-04-11 | 2015-11-26 | Chu De Bordeaux | Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof |
| EP2733153A1 (de) | 2012-11-15 | 2014-05-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon |
| KR20170054429A (ko) | 2014-09-03 | 2017-05-17 | 제네세규스 인코포레이티드 | 치료용 나노입자 및 관련 조성물, 방법, 및 시스템 |
| JP7053590B2 (ja) | 2016-09-27 | 2022-04-12 | バイエル・ファルマ・アクティエンゲゼルシャフト | カルコブトロールの変態ａの結晶形態を製造する方法 |
| CN117603148A (zh) | 2017-05-05 | 2024-02-27 | 探针技术开发及商业化中心 | 双官能螯合物的药代动力学增强及其用途 |
| EP3638320A4 (de) | 2017-05-05 | 2021-01-20 | Centre for Probe Development and Commercialization | Monoklonale igf-1r-antikörper und verwendungen davon |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| US11607462B2 (en) | 2017-05-16 | 2023-03-21 | Northwestern University | Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3267697D1 (en) * | 1981-08-24 | 1986-01-09 | Asahi Chemical Ind | Tetraazaannulene cobalt complex compounds and method for preparation thereof |
| EP0108181B1 (de) * | 1982-11-03 | 1987-04-29 | Ciba-Geigy Ag | Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenkobalt(III)jodid |
| EP0162804B1 (de) * | 1984-04-18 | 1988-05-25 | Ciba-Geigy Ag | Substituierte Dibenzotetraaza-[14]-annulenmetallkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| US4899755A (en) * | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
| DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
| DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| CA2072080A1 (en) * | 1990-01-19 | 1991-07-20 | Jo Klaveness | Chelating compounds |
-
1993
- 1993-09-30 US US08/129,870 patent/US5358704A/en not_active Expired - Lifetime
-
1994
- 1994-09-29 CN CN94190738A patent/CN1115180A/zh active Pending
- 1994-09-29 AU AU76234/94A patent/AU7623494A/en not_active Abandoned
- 1994-09-29 JP JP51019495A patent/JP3949714B2/ja not_active Expired - Fee Related
- 1994-09-29 AT AT01127327T patent/ATE288422T1/de not_active IP Right Cessation
- 1994-09-29 CA CA002150452A patent/CA2150452A1/en not_active Abandoned
- 1994-09-29 EP EP94926365A patent/EP0670832B1/de not_active Expired - Lifetime
- 1994-09-29 DE DE69434260T patent/DE69434260T2/de not_active Expired - Fee Related
- 1994-09-29 WO PCT/IB1994/000298 patent/WO1995009161A1/en active IP Right Grant
- 1994-09-29 DE DE69430730T patent/DE69430730T2/de not_active Expired - Fee Related
- 1994-09-29 CZ CZ951369A patent/CZ136995A3/cs unknown
- 1994-09-29 EP EP01127327A patent/EP1184377B1/de not_active Expired - Lifetime
- 1994-09-29 KR KR1019950702155A patent/KR960702447A/ko not_active Withdrawn
- 1994-09-29 IL IL11108394A patent/IL111083A0/xx unknown
- 1994-09-29 AT AT94926365T patent/ATE218554T1/de not_active IP Right Cessation
-
1995
- 1995-05-29 NO NO952111A patent/NO300131B1/no unknown
-
2002
- 2002-09-06 HK HK02106580.1A patent/HK1046131A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995009161A1 (en) | 1995-04-06 |
| US5358704A (en) | 1994-10-25 |
| EP0670832A1 (de) | 1995-09-13 |
| CN1115180A (zh) | 1996-01-17 |
| IL111083A0 (en) | 1994-11-28 |
| JPH08503967A (ja) | 1996-04-30 |
| NO300131B1 (no) | 1997-04-14 |
| HK1046131A1 (en) | 2002-12-27 |
| KR960702447A (ko) | 1996-04-27 |
| CA2150452A1 (en) | 1995-04-06 |
| DE69430730D1 (de) | 2002-07-11 |
| AU7623494A (en) | 1995-04-18 |
| DE69434260D1 (de) | 2005-03-10 |
| NO952111L (no) | 1995-05-29 |
| DE69434260T2 (de) | 2006-01-19 |
| JP3949714B2 (ja) | 2007-07-25 |
| EP0670832B1 (de) | 2002-06-05 |
| EP1184377B1 (de) | 2005-02-02 |
| NO952111D0 (no) | 1995-05-29 |
| DE69430730T2 (de) | 2003-02-06 |
| ATE288422T1 (de) | 2005-02-15 |
| CZ136995A3 (en) | 1995-12-13 |
| EP1184377A1 (de) | 2002-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE288422T1 (de) | Hepatobillianische magnetische resonanz- kontrastmittel | |
| PH30934A (en) | Alkyl phosphonate polyazamacrocyclic chelates for mri. | |
| ATE137228T1 (de) | Aminocarbonsäure und derivate | |
| GR77523B (de) | ||
| NZ227421A (en) | 1,4,7,10-tetraazacyclododecane derivatives and diagnosis using nmr | |
| FI915916A0 (fi) | Tetra-azamakrocykler, foerfaranden foer deras framstaellning och deras anvaendning vid magnetresonans- bildformning. | |
| PT89082A (pt) | Processo para a preparacao de novos derivados n-(23-vinblastinoilicos)do acido 1-amino-metilfosfonico | |
| ES2181372T3 (es) | Derivados de dihidro- o tetrahidronaftaleno que tienen actividad (anti)-estrogena. | |
| ATE160566T1 (de) | Amphotere tricyclische verbindungen als antihistaminische und antiallergische mittel | |
| ATE161844T1 (de) | Acyl-(2'-hydroxybiphenyl-2-yl)- phosphinsäuresalze, ihre herstellung und verwendung | |
| ES8300116A1 (es) | Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina | |
| WO1999032068A3 (de) | Neue entwicklerkombinationen für oxidationsfärbemittel | |
| IL76936A0 (en) | 3-amino-2,3-dihydro-1-benzoxepine compounds,their preparation and pharmaceutical compositions containing them | |
| ES2018407A6 (es) | Procedimiento para la obtencion de 1-ariloxi-3-nitroamino-2-propanoles. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |