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ATE221400T1 - Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses - Google Patents

Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses

Info

Publication number
ATE221400T1
ATE221400T1 AT98964713T AT98964713T ATE221400T1 AT E221400 T1 ATE221400 T1 AT E221400T1 AT 98964713 T AT98964713 T AT 98964713T AT 98964713 T AT98964713 T AT 98964713T AT E221400 T1 ATE221400 T1 AT E221400T1
Authority
AT
Austria
Prior art keywords
increase
active ingredients
transdermal flow
transdermal
flow
Prior art date
Application number
AT98964713T
Other languages
English (en)
Inventor
Michael G Zuck
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE221400T1 publication Critical patent/ATE221400T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
AT98964713T 1997-12-11 1998-12-09 Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses ATE221400T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6934097P 1997-12-11 1997-12-11
PCT/US1998/026158 WO1999029364A1 (en) 1997-12-11 1998-12-09 Device for enhancing transdermal agent flux

Publications (1)

Publication Number Publication Date
ATE221400T1 true ATE221400T1 (de) 2002-08-15

Family

ID=22088315

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98964713T ATE221400T1 (de) 1997-12-11 1998-12-09 Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses

Country Status (10)

Country Link
US (1) US6050988A (de)
EP (1) EP1035889B1 (de)
JP (1) JP4061022B2 (de)
KR (1) KR100572539B1 (de)
CN (1) CN1161164C (de)
AT (1) ATE221400T1 (de)
AU (1) AU739616B2 (de)
CA (1) CA2313458C (de)
DE (1) DE69806963T2 (de)
WO (1) WO1999029364A1 (de)

Families Citing this family (252)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0914178T3 (da) * 1996-06-18 2003-04-22 Alza Corp Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CA2330207C (en) * 1998-06-10 2005-08-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
PT1124607E (pt) 1998-07-14 2008-12-31 Altea Therapeutics Corp Remoção controlada de membranas biológicas por carga pirotécnica, para transporte transmembranar
WO2000012173A1 (en) * 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
CA2370349C (en) 1999-04-16 2013-01-29 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
DK1189660T3 (da) 1999-06-08 2006-08-21 Altea Therapeutics Corp Apparat til mikroperforering af biologiske membraner ved hjælp af tyndfilms-vævsgrænseflade-anordninger samt fremgangsmåde til fremstilling deraf
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
AU782610B2 (en) * 1999-12-10 2005-08-11 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
JP2003516798A (ja) * 1999-12-16 2003-05-20 アルザ・コーポレーション 抽出した薬剤の経皮流量を増進させるための装置
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6659982B2 (en) * 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6629949B1 (en) * 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
JP5507030B2 (ja) * 2000-09-08 2014-05-28 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
AU2002210881A1 (en) 2000-10-12 2002-04-22 Ink Jet Technology Ltd. Transdermal method
MXPA03003301A (es) 2000-10-13 2004-12-13 Johnson & Johnson Aplicador de un conjunto de microsalientes mediante impacto.
RU2275871C2 (ru) 2000-10-13 2006-05-10 Алза Корпорейшн Устройство и способ для прокалывания кожи микровыступами
EP1341452B1 (de) * 2000-10-13 2008-12-10 Alza Corporation Mikronadelelementhalter für schlagapplikator
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
CZ20031164A3 (cs) 2000-10-26 2004-04-14 Alza Corporation Zařízení s potaženými mikrovýčnělky pro transdermální přenos léku
EP1345646A2 (de) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Mikronadel-vorrichtungen und deren herstellung
WO2002050584A2 (en) * 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
EP1752189A3 (de) 2001-04-20 2007-02-21 Alza Corporation Mikroprojektionsanordnung mit einem Überzug, der ein vorteilhaftes Mittel enthält
US7963935B2 (en) * 2001-04-20 2011-06-21 Alza Corporation Microprojection array having a beneficial agent containing coating
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
WO2003039620A2 (en) 2001-05-17 2003-05-15 Transpharma Medical Ltd. Integrated transdermal drug delivery system
WO2003024518A2 (en) * 2001-09-14 2003-03-27 The Procter & Gamble Company Microstructures for delivering a composition cutaneously to skin using rotatable structures
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002327675A1 (en) * 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
WO2003024508A2 (en) * 2001-09-21 2003-03-27 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
EP1480712A2 (de) * 2001-09-28 2004-12-01 BioValve Technologies, Inc. Schaltbare mikronadelanordnungen und -systeme und zugehörige methoden
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
BR0213686A (pt) * 2001-10-29 2006-05-23 Becton Dickinson Co processo e dispositivo para o fornecimento de uma substáncia
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
WO2003048031A2 (en) * 2001-11-30 2003-06-12 Alza Corporation Methods and apparatuses for forming microprojection arrays
HUP0402605A2 (hu) * 2001-12-20 2005-06-28 Alza Corporation Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
ES2701884T3 (es) * 2002-03-11 2019-02-26 Nitto Denko Corp Sistema de parche de administración transdérmica de fármacos
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
EP1499255B1 (de) * 2002-04-19 2015-07-22 Syneron Medical Ltd. In der hand gehaltene transdermale arzneimittelabgabe und analytenextraktion
DK1534376T3 (en) * 2002-06-25 2016-12-05 Theraject Inc QUICK-SOLVING MICROPERFORATORS FOR PHARMACEUTICAL DELIVERY AND OTHER APPLICATIONS
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
ATE336277T1 (de) * 2002-06-28 2006-09-15 Alza Corp Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngen
KR20120087197A (ko) 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
CA2497103C (en) 2002-08-29 2011-07-19 Becton, Dickinson And Company Microabrader with controlled abrasion features
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
CA2516547A1 (en) * 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
IL152573A (en) * 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
IL152574A (en) * 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US8133505B2 (en) * 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7045069B2 (en) * 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
CN1321706C (zh) * 2003-05-29 2007-06-20 财团法人工业技术研究院 一种数组式微针软质基材结构及其制造方法
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
KR20060038407A (ko) 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
PL1638468T3 (pl) * 2003-06-30 2008-01-31 Alza Corp Sposób powlekania mikrowystępów do przekłuwania skóry
US20050025778A1 (en) * 2003-07-02 2005-02-03 Cormier Michel J.N. Microprojection array immunization patch and method
CN1863572A (zh) * 2003-08-04 2006-11-15 阿尔扎公司 提高药剂经皮流通量的方法和装置
US8961477B2 (en) * 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
EP1660172A1 (de) * 2003-08-26 2006-05-31 Alza Corporation Vorrichtung und verfahren für die intradermale zellimplantation
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US20050106226A1 (en) * 2003-10-24 2005-05-19 Cormier Michel J. Pretreatment method and system for enhancing transdermal drug delivery
BRPI0415761A (pt) * 2003-10-24 2006-12-19 Alza Corp aparelho e processo para reforçar a distribuição transdérmica de medicamento
BRPI0415986A (pt) * 2003-10-28 2007-01-23 Alza Corp método e aparelho para reduzir a incidência do uso de tabaco
KR20070001886A (ko) * 2003-10-28 2007-01-04 알자 코포레이션 치료용 펩타이드 및 단백질의 폴리머 컨쥬게이트의 피복된미세돌출부를 통한 전달
ES2377647T3 (es) 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
US20050106209A1 (en) * 2003-11-13 2005-05-19 Mahmoud Ameri Composition and apparatus for transdermal delivery
CA2546282A1 (en) * 2003-11-13 2005-06-02 Alza Corporation System and method for transdermal delivery
DE10353629A1 (de) * 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
EP1699524A4 (de) * 2003-11-18 2009-07-15 Nanopass Technologies Ltd Verbessertes penetrationssystem und verfahren zum schieben von mikronadeln
JP2007518468A (ja) * 2003-11-21 2007-07-12 アルザ・コーポレーシヨン 超音波支援経皮ワクチン送達方法およびシステム
AU2004311977A1 (en) * 2003-12-29 2005-07-21 3M Innovative Properties Company Medical devices and kits including same
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US7611481B2 (en) * 2004-03-24 2009-11-03 Corium International, Inc. Transdermal delivery device
CA2562642A1 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of multiple vaccines
MXPA06011972A (es) * 2004-04-13 2007-04-16 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes a base de fentanilo.
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
WO2005112463A2 (en) * 2004-05-19 2005-11-24 Alza Corporation Method and formulation for transdermal delivery of immunologically active agents
US20050273075A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Method for delivering drugs to the adventitia using device having microprojections
US20050273049A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Drug delivery device using microprojections
ES2650188T3 (es) * 2004-06-10 2018-01-17 3M Innovative Properties Company Dispositivo y kit de aplicación de parches
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
AR054300A1 (es) * 2004-08-10 2007-06-20 Alza Corp Aparato y sistema de microproyeccion con escaso potencial infeccioso
US20060058602A1 (en) * 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
EP1786505A1 (de) * 2004-09-08 2007-05-23 Alza Corporation Mikroprojektionsarray mit verbesserter hautadhäsion und -compliance
AU2005289471A1 (en) * 2004-09-28 2006-04-06 Alza Corporation Stabilization of alum-adjuvanted immunologically active agents
US20060093658A1 (en) * 2004-10-26 2006-05-04 Gayatri Sathyan Apparatus and method for transdermal delivery of desmopressin
WO2006055844A2 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Method of contact coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006055802A1 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Microneedle array applicator and retainer
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
EP1827564B1 (de) * 2004-11-18 2015-07-29 3M Innovative Properties Company Maskierungsverfahren zum beschichten einer mikronadelanordnung
JP2008522875A (ja) 2004-12-07 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルの成形方法
JP2008529750A (ja) * 2005-02-16 2008-08-07 アルザ コーポレイション 生体適合性が改善されたマイクロプロジェクションアレイ
JP2008530230A (ja) * 2005-02-16 2008-08-07 アルザ・コーポレーシヨン エリスロポエチンに基づく剤の経皮送達のための装置および方法
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
WO2006130869A1 (en) * 2005-06-02 2006-12-07 Alza Corporation Method for terminal sterilization of transdermal delivery devices
EP1885405A1 (de) * 2005-06-02 2008-02-13 Alza Corporation, Inc. Verfahren zur endsterilisierung von vorrichtungen zur transdermalen verabreichung
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
CN101252967A (zh) * 2005-06-21 2008-08-27 阿尔扎公司 用于涂布微凸起构件的连续条带的方法和装置
WO2007002523A2 (en) * 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
US8784363B2 (en) * 2005-06-27 2014-07-22 3M Innovative Properties Company Microneedle array applicator device and method of array application
EP1896115B2 (de) 2005-06-27 2020-01-22 3M Innovative Properties Company Mikronadelkartuschenanordnung
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
DK1940459T3 (da) * 2005-09-06 2014-05-26 Theraject Inc Fast-opløsningsperforator indeholdende aktivstofpartikel og/eller aktivstof-adsorberede partikler
CA2619452A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
DE102005043496A1 (de) * 2005-09-13 2007-03-15 Daimlerchrysler Ag Verfahren und Vorrichtung zur Erhöhung der Sicherheit eines personengeführten Fahrzeugs
EP2559381B1 (de) 2005-09-30 2014-12-31 Intuity Medical, Inc. Vorrichtung für Körperflüssigkeitsprobennahme und -analyse
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US8900180B2 (en) * 2005-11-18 2014-12-02 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
WO2007075614A1 (en) * 2005-12-21 2007-07-05 3M Innovative Properties Company Microneedle devices
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
CN101466393A (zh) * 2006-03-15 2009-06-24 阿尔扎公司 用于经皮递送甲状旁腺激素药剂以治疗骨质减少的方法
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007127815A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
WO2007127811A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with grouped microprojections for high drug loading
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
AU2008209537B2 (en) * 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
GB2448493B (en) * 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US8439861B2 (en) * 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
CA2708445C (en) 2007-12-17 2016-11-01 New World Pharmaceuticals, Llc Integrated intra-dermal delivery, diagnostic and communication system
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
ES2687258T3 (es) * 2008-05-21 2018-10-24 Theraject, Inc. Procedimiento de fabricación de conjuntos de microagujas
WO2009145920A1 (en) 2008-05-30 2009-12-03 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
JP5642066B2 (ja) 2008-06-06 2014-12-17 インテュイティ メディカル インコーポレイテッド 体液の試料内に含まれている検体の存在または濃度を決定する検定を行う方法および装置
EP3639744B1 (de) 2008-06-06 2021-11-24 Intuity Medical, Inc. Blutzucker messgerät und methode zur verwendung
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20110105952A1 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Relatively small devices applied to the skin, modular systems, and methods of use thereof
US20110105951A1 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin
US20100256524A1 (en) 2009-03-02 2010-10-07 Seventh Sense Biosystems, Inc. Techniques and devices associated with blood sampling
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
EP2429627B1 (de) * 2009-04-24 2017-06-14 Corium International, Inc. Verfahren zur herstellung von mikroprojektionsarrays
WO2011005894A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
WO2011065981A1 (en) 2009-11-30 2011-06-03 Intuity Medical, Inc. Calibration material delivery devices and methods
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
CA2803797A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
CN103370007B (zh) 2010-11-09 2018-12-18 第七感生物系统有限公司 用于采血的系统和界面
EP2699252B1 (de) * 2011-04-22 2017-10-25 Radius Health, Inc. Verfahren zur arzneimittelverabreichung für pth, pthrp und ähnliche peptide
BR112013027351B1 (pt) 2011-04-29 2022-03-03 Seventh Sense Biosystems, Inc Dispositivo para receber fluido de um indivíduo
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
ES2675773T3 (es) 2011-08-03 2018-07-12 Intuity Medical, Inc. Disposición de muestreo de fluido corporal
US9522267B2 (en) * 2012-02-08 2016-12-20 Derma Dream Group Ltd Transdermal delivery device
CN105073178B (zh) 2012-12-21 2019-07-30 考里安国际公司 用于治疗剂递送的微阵列及其使用方法
WO2014126101A1 (ja) 2013-02-13 2014-08-21 久光製薬株式会社 マイクロニードル・アレイ
WO2014164314A1 (en) 2013-03-12 2014-10-09 Corium International, Inc. Microprojection applicators
AU2014237357B2 (en) 2013-03-15 2019-11-28 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators and methods of use
WO2014151654A1 (en) 2013-03-15 2014-09-25 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968116A1 (de) 2013-03-15 2016-01-20 Corium International, Inc. Mikroarray mit polymerfreien mikrostrukturen, verfahren zur herstellung und verfahren zur verwendung
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US20160101273A1 (en) * 2013-05-06 2016-04-14 Mupharma Pty Ltd Non-invasive agent applicator
CN103263727B (zh) * 2013-05-22 2015-09-30 清华大学 金属微针阵列、经皮给药贴片、微针滚轮及微针电极阵列
EP3011544A4 (de) 2013-06-21 2017-02-22 Intuity Medical, Inc. Analytüberwachungssystem mit hörbarem feedback
GB201314902D0 (en) * 2013-08-20 2013-10-02 Chowdhury Dewan F H Microneedle device and method of preparation
WO2015027173A1 (en) 2013-08-22 2015-02-26 Zp Opco, Inc. Stable glucagon peptide formulations
US9782344B2 (en) 2013-08-22 2017-10-10 Zp Opco, Inc. Stable glucagon peptide formulations
US10086183B2 (en) 2013-11-05 2018-10-02 Hisamitsu Pharmaceutical Co., Inc. Applicator
JP6265774B2 (ja) * 2014-02-18 2018-01-24 久光製薬株式会社 貼付剤
KR102135495B1 (ko) * 2014-02-27 2020-07-17 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들·시트
CA2943611A1 (en) 2014-03-28 2015-10-01 Duke University Method of treating cancer using selective estrogen receptor modulators
AU2015255634A1 (en) 2014-05-06 2016-11-17 Mupharma Pty Ltd Non-invasive agent applicator
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016074040A2 (en) 2014-11-12 2016-05-19 Mupharma Pty Ltd Non-invasive agent applicator
AU2016256471B2 (en) 2015-04-29 2020-09-10 Radius Pharmaceuticals, Inc. Methods of treating cancer
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017079611A1 (en) 2015-11-02 2017-05-11 Zp Opco, Inc. Stable glucagon peptide formulations
SG11201805837SA (en) * 2016-01-28 2018-08-30 Ricoh Co Ltd Microneedle array, microneedle sheet
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
JP2019205484A (ja) * 2016-09-29 2019-12-05 国立大学法人東北大学 マイクロニードルアレイ及びその製造方法
KR101837449B1 (ko) 2016-10-28 2018-03-12 삼성전자주식회사 마이크로 니들 패치, 마이크로 니들을 제조하는 방법 및 장치
HUE067541T2 (hu) 2017-01-05 2024-10-28 Radius Pharmaceuticals Inc RAD1901-2HCl polimorf formái
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
WO2019040063A1 (en) 2017-08-23 2019-02-28 Zp Opco, Inc. METHOD FOR QUICKLY PREPARING THERAPEUTIC CONCENTRATIONS OF ZOLMITRIPTAN FOR THE TREATMENT OF HORTON MIGRAINS AND HEADPHONES
KR102119675B1 (ko) * 2017-12-11 2020-06-05 랩앤피플주식회사 고밀도 마이크로 니들
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
TWI826603B (zh) * 2018-12-06 2023-12-21 愛爾蘭商索塔醫療愛爾蘭有限公司 治療組織之微刀片結構及方法
EP3917413A4 (de) 2019-04-10 2022-11-30 Absolutions Med, Inc. Abdominales verschlussverfahren und vorrichtungsvarianten zum schliessen ventraler hernien und zur verringerung des wiederauftretens
US11696851B2 (en) * 2019-04-25 2023-07-11 Alcon Inc. Cannula system with retention feature
WO2021146165A1 (en) 2020-01-13 2021-07-22 Absolutions Med, Inc. Abdominal approximation device and method
AU2021281307A1 (en) * 2020-05-29 2022-12-15 Georgia Tech Research Corporation Devices, systems, and methods for facilitating tissue delivery of drug
US20230047828A1 (en) * 2021-08-16 2023-02-16 Absolutions Med, Inc. Nipple areolar grafting methods and apparatus

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US25637A (en) * 1859-10-04 Cooking-stove
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3322121A (en) * 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2250293A1 (de) * 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
FR2232331B1 (de) * 1973-06-06 1978-03-24 Guerin A Ets
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US4753651A (en) * 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4655766A (en) * 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4756314A (en) * 1985-10-28 1988-07-12 Alza Corporation Sweat collection patch
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
KR970011449B1 (ko) * 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 이온전기 영동형 비침입 검체 채취 또는 이송 장치 및 방법
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5438984A (en) * 1988-09-08 1995-08-08 Sudor Partners Apparatus and method for the collection of analytes on a dermal patch
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5077104A (en) * 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
US5108819A (en) * 1990-02-14 1992-04-28 Eli Lilly And Company Thin film electrical component
ES2082973T3 (es) * 1990-03-30 1996-04-01 Alza Corp Dispositivo para administracion iontoforetica de farmacos.
US5242406A (en) * 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
NZ240357A (en) * 1990-10-29 1993-04-28 Alza Corp Dry state iontophoresis electrodes containing non-hydrated agent and method of hydrating same
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5312456A (en) * 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5310404A (en) * 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5391250A (en) * 1994-03-15 1995-02-21 Minimed Inc. Method of fabricating thin film sensors
CA2149943C (en) * 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
CA2149836C (en) * 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
EP0796128B1 (de) * 1994-12-09 1999-03-10 Novartis AG Transdermales system
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
HK1009321A1 (en) * 1995-08-29 1999-05-28 Nitto Denko Corporation Microporation of human skin for drug delivery and monitoring applications
DK0914178T3 (da) * 1996-06-18 2003-04-22 Alza Corp Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel

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