ATE313068T1 - Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben - Google Patents

Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben

Info

Publication number: ATE313068T1
Authority: AT; Austria
Prior art keywords: thromboplastin; reagents; solution; clotting factors; membrane
Prior art date: 1998-10-07

Application number

AT99956522T

Other languages

English (en)

Inventor

Marc Goldford

Original Assignee

Trinity Biotech Mfg Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-07

Filing date

1999-10-07

Publication date

2005-12-15

1999-10-07 Application filed by Trinity Biotech Mfg Ltd filed Critical Trinity Biotech Mfg Ltd

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE313068T1 publication Critical patent/ATE313068T1/de

Links

102000002262 Thromboplastin Human genes 0.000 title abstract 11
108010000499 Thromboplastin Proteins 0.000 title abstract 11
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 10
239000003153 chemical reaction reagent Substances 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 3
239000012528 membrane Substances 0.000 abstract 3
102000015081 Blood Coagulation Factors Human genes 0.000 abstract 2
108010039209 Blood Coagulation Factors Proteins 0.000 abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
239000003114 blood coagulation factor Substances 0.000 abstract 2
-1 Ca++ ions Chemical class 0.000 abstract 1
206010053567 Coagulopathies Diseases 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
230000035602 clotting Effects 0.000 abstract 1
238000011026 diafiltration Methods 0.000 abstract 1
230000000717 retained effect Effects 0.000 abstract 1
230000035945 sensitivity Effects 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Urology & Nephrology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Sampling And Sample Adjustment (AREA)

AT99956522T 1998-10-07 1999-10-07 Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben ATE313068T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10341798P	1998-10-07	1998-10-07
PCT/US1999/023369 WO2000020835A2 (en)	1998-10-07	1999-10-07	Thromboplastin reagents and methods for preparing and using such reagents

Publications (1)

Publication Number	Publication Date
ATE313068T1 true ATE313068T1 (de)	2005-12-15

Family

ID=22295068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99956522T ATE313068T1 (de)	1998-10-07	1999-10-07	Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben

Country Status (9)

Country	Link
US (1)	US6391609B1 (de)
EP (1)	EP1127259B1 (de)
JP (1)	JP2002526557A (de)
AT (1)	ATE313068T1 (de)
AU (1)	AU1311800A (de)
CA (1)	CA2342606A1 (de)
DE (1)	DE69928961T2 (de)
ES (1)	ES2252986T3 (de)
WO (1)	WO2000020835A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE428439T1 (de)	2001-12-21	2009-05-15	Novo Nordisk Healthcare Ag	Flüssige zusammensetzung aus faktor vii polypeptiden
WO2004000347A1 (en)	2002-06-21	2003-12-31	Novo Nordisk A/S	Stabilised solid compositions of factor vii polypeptides
US7897734B2 (en)	2003-03-26	2011-03-01	Novo Nordisk Healthcare Ag	Method for the production of proteins
ES2382157T3 (es)	2003-06-25	2012-06-05	Novo Nordisk Health Care Ag	Composición líquida de polipépttidos del factor VII
US7148067B2 (en) *	2004-08-31	2006-12-12	The Board Of Trustees Of The University Of Illinois	Thromboplastin reagents
JP2008530208A (ja) *	2005-02-16	2008-08-07	ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ	万能前凝固薬
ATE505488T1 (de) *	2005-03-04	2011-04-15	Univ Illinois	Modulator von coagulationskaskaden und fibrinolytischen kaskaden
JPWO2006129703A1 (ja) *	2005-05-31	2009-01-08	学校法人久留米大学	活性化部分トロンボプラスチン時間の検査方法
JP4897437B2 (ja) *	2006-11-17	2012-03-14	株式会社日立製作所	低分子化合物溶液循環型フローｎｍｒ装置
EP2121753A2 (de) *	2007-02-14	2009-11-25	Amgen, Inc	Verfahren zur isolation von antikörpern durch ausscheidung
US8821861B2 (en)	2007-10-05	2014-09-02	The Board Of Trustees Of The University Of Illinois	Fibrin sealant
WO2009061697A1 (en)	2007-11-09	2009-05-14	The Board Of Trustees Of The University Of Illinois	Anticoagulant antagonist and hemophilia procoagulant
CN102065870B (zh) *	2008-04-16	2014-11-19	比奥根艾迪克Ma公司	使用聚亚烷基二醇和过渡金属分离生物大分子的方法
JP6116231B2 (ja) *	2012-12-25	2017-04-19	株式会社Ｌｓｉメディエンス	組織トロンボプラスチン含有血液凝固能測定試薬及び測定方法
WO2017139567A1 (en) *	2016-02-12	2017-08-17	Instrumentation Laboratory Company	A two component "mix and use" liquid thromboplastin reagent, methods of making, and methods of use thereof
CN110806374B (zh) *	2019-09-29	2022-05-20	杭州联科生物技术股份有限公司	一种Annexin V凋亡检测的Binding Buffer及其制备方法
CN115166268B (zh) *	2022-08-02	2025-07-04	南京颐兰贝生物科技有限责任公司	一种凝血酶原时间检测试剂及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA658579A (en)		1963-02-26	Ortho Pharmaceutical Corporation	Factor v from mammalian blood plasma
US2847350A (en)	1954-05-27	1958-08-12	Ortho Pharma Corp	Preparation of highly active thromboplastin
US3522148A (en)	1965-08-13	1970-07-28	Dade Reagents Inc	Stabilized thromboplastin preparation
BE787961A (fr)	1971-08-24	1973-02-26	Behringwerke Ag	Procede d'isolement d'une matiere thromboplastique et medicament contenant ladite matiere
US3980432A (en)	1973-04-02	1976-09-14	Behringwerke Aktiengesellschaft	Partial thromboplastin, its use as diagnostic agent and process for preparing it
ES431736A1 (es)	1973-11-13	1977-05-16	Behringwerke Ag	Procedimiento para la preparacion de un agente para diagnos-tico para el proposito de efectuar el control de la capaci- dad de coagulacion de la sangre.
US4361510A (en)	1980-05-27	1982-11-30	Cutter Laboratories, Inc.	Blood coagulation promoting product
DE3150596A1 (de)	1981-12-21	1983-06-30	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur herstellung von gewebsthromboplastin
US4495175A (en)	1982-08-05	1985-01-22	University Of Rochester	Preparation of highly purified human antihemophilic factor
US4755461A (en)	1986-04-17	1988-07-05	Bio/Data Corporation	Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US5017556A (en)	1986-11-04	1991-05-21	Genentech, Inc.	Treatment of bleeding disorders using lipid-free tissue factor protein
US5270451A (en)	1988-11-23	1993-12-14	Baxter Diagnostics Inc.	Extraction method for preparing thromboplastin reagents
DE68912115T2 (de)	1988-11-23	1994-08-11	Baxter Diagnostics Inc	Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien.
US5281528A (en) *	1989-12-18	1994-01-25	Warner-Lambert Company	Process for purified thromboplastin for ultra-pure thrombin preparation
US5254350A (en) *	1991-07-22	1993-10-19	Helena Laboratories Corporation	Method of preparing a thromboplastin extract
CA2080428C (en) *	1991-10-22	2004-01-27	Ray F. Ebert	A method for preparing a thromboplastin reagent from cultured cells that is suitable for use in the prothrombin time test
US5358853A (en)	1992-08-03	1994-10-25	Akzo Av	Liquid thromboplastin reagent
JPH07308190A (ja) *	1994-05-18	1995-11-28	Green Cross Corp:The	トロンビンの製造方法
US5506127A (en) *	1994-09-21	1996-04-09	Proba; Zbigniew	Therapeutic grade thrombin produced by chromatography

1999
- 1999-10-07 EP EP99956522A patent/EP1127259B1/de not_active Expired - Lifetime
- 1999-10-07 AU AU13118/00A patent/AU1311800A/en not_active Abandoned
- 1999-10-07 CA CA002342606A patent/CA2342606A1/en not_active Abandoned
- 1999-10-07 US US09/413,683 patent/US6391609B1/en not_active Expired - Lifetime
- 1999-10-07 AT AT99956522T patent/ATE313068T1/de not_active IP Right Cessation
- 1999-10-07 DE DE69928961T patent/DE69928961T2/de not_active Expired - Fee Related
- 1999-10-07 WO PCT/US1999/023369 patent/WO2000020835A2/en active IP Right Grant
- 1999-10-07 ES ES99956522T patent/ES2252986T3/es not_active Expired - Lifetime
- 1999-10-07 JP JP2000574903A patent/JP2002526557A/ja active Pending

Also Published As

Publication number	Publication date
JP2002526557A (ja)	2002-08-20
DE69928961T2 (de)	2006-07-13
EP1127259B1 (de)	2005-12-14
ES2252986T3 (es)	2006-05-16
CA2342606A1 (en)	2000-04-13
WO2000020835A2 (en)	2000-04-13
WO2000020835A3 (en)	2000-08-03
EP1127259A4 (de)	2003-01-02
DE69928961D1 (de)	2006-01-19
EP1127259A2 (de)	2001-08-29
US6391609B1 (en)	2002-05-21
AU1311800A (en)	2000-04-26

Publication	Publication Date	Title
ATE313068T1 (de)	2005-12-15	Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben
DE69400874D1 (de)	1996-12-12	Verfahren zur herstellung von keramischen hohlfasermembranen zur mikorfiltration, ultrafiltration und gastrennung
DE68919324D1 (de)	1994-12-15	Verfahren zur Herstellung von isotropen mikroporösen Polysulfonmembranen.
DE59009658D1 (de)	1995-10-19	Verfahren zur herstellung von wässrigen dispersionen.
DE60131495D1 (de)	2008-01-03	Verfahren zur Herstellung von Composite-Membranen aus Perfluoropolymeren zur Gastrennung
DE60230672D1 (de)	2009-02-12	Nukleinsäureanreicherung
BR0007389A (pt)	2002-01-08	Processos para separação de um ou mais gases de uma mistura de gases e para produção de uma membrana de poliimida porosa e membrana de poliimida para separação de gases
AT381463B (de)	1986-10-27	Definierte poren aufweisende membran, verfahren zu ihrer herstellung und verwendung derselben
DE60317561D1 (de)	2007-12-27	Vorrichtung und verfahren zur herstellung von autologem thrombinserum
DE122007000082I1 (de)	2009-01-02	Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren
ATE397488T1 (de)	2008-06-15	Vorrichtung zur herstellung von liposomen
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DE69630570D1 (de)	2003-12-11	Verfahren zur Herstellung von gestützten Membranen
DE69831684D1 (de)	2006-02-02	Verfahren zur herstellung von virusfreien thrombin zur bereitung von fibrinkleber aus menschlichem plasma-pool
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DE60016889D1 (de)	2005-01-27	Zusammengesetzte Umkehrosmosemembranen und Verfahren zu ihrer Herstellung
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ATE243168T1 (de)	2003-07-15	Verfahren und vorrichtung zur behandlung von abwasser in einem bioreaktor, einer ultrafiltrationseinheit und einer membranfiltrationeinheit
DE3789309D1 (de)	1994-04-14	Enzymatische membran, verfahren zur herstellung und trennung von peptiden.
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Legal Events

Date	Code	Title	Description
2006-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties