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ATE324894T1 - Beta-d-2', 3' -didehydro-2', 3' -didesoxy-5- fluorocytidin für die verwendung in der behandlung von hiv infektionen - Google Patents

Beta-d-2', 3' -didehydro-2', 3' -didesoxy-5- fluorocytidin für die verwendung in der behandlung von hiv infektionen

Info

Publication number
ATE324894T1
ATE324894T1 AT00904529T AT00904529T ATE324894T1 AT E324894 T1 ATE324894 T1 AT E324894T1 AT 00904529 T AT00904529 T AT 00904529T AT 00904529 T AT00904529 T AT 00904529T AT E324894 T1 ATE324894 T1 AT E324894T1
Authority
AT
Austria
Prior art keywords
beta
d4fc
hiv
didesoxy
fluorocytidine
Prior art date
Application number
AT00904529T
Other languages
English (en)
Inventor
Raymond F Schinazi
Jennifer Hammond
John W Mellors
Dennis C Liotta
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Application granted granted Critical
Publication of ATE324894T1 publication Critical patent/ATE324894T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00904529T 1999-01-22 2000-01-21 Beta-d-2', 3' -didehydro-2', 3' -didesoxy-5- fluorocytidin für die verwendung in der behandlung von hiv infektionen ATE324894T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11677399P 1999-01-22 1999-01-22

Publications (1)

Publication Number Publication Date
ATE324894T1 true ATE324894T1 (de) 2006-06-15

Family

ID=22369127

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00904529T ATE324894T1 (de) 1999-01-22 2000-01-21 Beta-d-2', 3' -didehydro-2', 3' -didesoxy-5- fluorocytidin für die verwendung in der behandlung von hiv infektionen

Country Status (21)

Country Link
EP (1) EP1143976B9 (de)
JP (1) JP2002535278A (de)
KR (1) KR100745408B1 (de)
CN (2) CN101219148A (de)
AT (1) ATE324894T1 (de)
AU (1) AU781281B2 (de)
BR (1) BR0007627A (de)
CA (1) CA2360039C (de)
DE (1) DE60027691T2 (de)
DK (1) DK1143976T3 (de)
ES (1) ES2263449T3 (de)
HK (1) HK1040064B (de)
IL (1) IL144382A (de)
MX (1) MXPA01007359A (de)
NO (1) NO323586B1 (de)
NZ (1) NZ528156A (de)
PL (1) PL198237B1 (de)
PT (1) PT1143976E (de)
RU (1) RU2254133C2 (de)
WO (1) WO2000043014A2 (de)
ZA (1) ZA200105971B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04012754A (es) * 2002-06-27 2005-03-23 Medivir Ab Interaccion sinergica de abacavir y alovudina.
EP1694300A4 (de) * 2003-12-09 2009-04-29 Pharmasset Inc Dosierverfahren für beta-d-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidin-anitvirale therapie
US7741334B2 (en) 2004-04-01 2010-06-22 Achillion Pharmaceuticals, Inc. Low dose therapy for treating viral infections
US20060084628A1 (en) * 2004-10-19 2006-04-20 Achillion Pharmaceuticals Combination therapy for treating viral infections
US8091224B2 (en) * 2008-10-06 2012-01-10 GE Intelligent Platforms Embedded Systems, Inc. Method for coupling a battery within an embedded system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU707246A1 (ru) * 1978-09-29 1980-12-23 Институт Биоорганической Химии Ан Белорусской Сср Способ получени хлоргидрата 2"2 -ангидро-1- - -арабинофуранозил - 5-фторцитозина
NL8901258A (nl) * 1989-05-19 1990-12-17 Stichting Rega V Z W 5-halogeno-2',3'-dideoxycytidinederivaten in geneesmiddelen voor het behandelen van retrovirus-infecties.
RU2092177C1 (ru) * 1994-08-19 1997-10-10 Научно-производственное объединение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений" Средство, обладающее действием против инфекционных агентов
FR2729390A1 (fr) * 1995-01-18 1996-07-19 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5869461A (en) * 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
EP1089741A1 (de) * 1998-06-24 2001-04-11 Emory University Verwendung von 3'-azido-2',3'-dideoxyuridin in kombination mit weiteren anti-hiv mitteln zur herstellung eines medikaments zur behandlung von hiv

Also Published As

Publication number Publication date
NZ528156A (en) 2005-03-24
WO2000043014A8 (en) 2001-01-18
WO2000043014A2 (en) 2000-07-27
NO323586B1 (no) 2007-06-11
NO20013599D0 (no) 2001-07-20
PT1143976E (pt) 2006-09-29
ES2263449T3 (es) 2006-12-16
IL144382A0 (en) 2002-05-23
KR100745408B1 (ko) 2007-08-02
CN1337880A (zh) 2002-02-27
DK1143976T3 (da) 2006-09-04
PL198237B1 (pl) 2008-06-30
CA2360039A1 (en) 2000-07-27
KR20020068260A (ko) 2002-08-27
HK1040064B (en) 2006-07-21
WO2000043014A3 (en) 2000-11-30
JP2002535278A (ja) 2002-10-22
CN101219148A (zh) 2008-07-16
EP1143976B9 (de) 2007-02-14
AU2627000A (en) 2000-08-07
RU2254133C2 (ru) 2005-06-20
DE60027691D1 (de) 2006-06-08
CA2360039C (en) 2009-11-24
EP1143976A2 (de) 2001-10-17
MXPA01007359A (es) 2003-09-22
BR0007627A (pt) 2002-04-09
AU781281B2 (en) 2005-05-12
DE60027691T2 (de) 2007-04-12
IL144382A (en) 2007-02-11
ZA200105971B (en) 2002-10-21
HK1040064A1 (en) 2002-05-24
NO20013599L (no) 2001-09-20
EP1143976B1 (de) 2006-05-03

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