ATE440135T1 - Fortgeschrittener mikroorganismus zur produktion von 1,2-propandiol - Google Patents
Fortgeschrittener mikroorganismus zur produktion von 1,2-propandiolInfo
- Publication number
- ATE440135T1 ATE440135T1 AT05717405T AT05717405T ATE440135T1 AT E440135 T1 ATE440135 T1 AT E440135T1 AT 05717405 T AT05717405 T AT 05717405T AT 05717405 T AT05717405 T AT 05717405T AT E440135 T1 ATE440135 T1 AT E440135T1
- Authority
- AT
- Austria
- Prior art keywords
- strain
- propanediol
- production
- gene
- methylglyoxal
- Prior art date
Links
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 4
- 235000013772 propylene glycol Nutrition 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 101150080369 tpiA gene Proteins 0.000 abstract 2
- ABVQGNDUHAQLBS-UHFFFAOYSA-N 2-oxopropanal propanal Chemical compound CCC=O.CC(=O)C=O ABVQGNDUHAQLBS-UHFFFAOYSA-N 0.000 abstract 1
- 101100280051 Brucella abortus biovar 1 (strain 9-941) eryH gene Proteins 0.000 abstract 1
- 101100235161 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) lerI gene Proteins 0.000 abstract 1
- 230000001851 biosynthetic effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0400214A FR2864967B1 (fr) | 2004-01-12 | 2004-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
| PCT/FR2005/000070 WO2005073364A2 (fr) | 2004-01-12 | 2005-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE440135T1 true ATE440135T1 (de) | 2009-09-15 |
Family
ID=34684930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05717405T ATE440135T1 (de) | 2004-01-12 | 2005-01-12 | Fortgeschrittener mikroorganismus zur produktion von 1,2-propandiol |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8252579B2 (de) |
| EP (2) | EP2192180A1 (de) |
| JP (1) | JP4613177B2 (de) |
| KR (1) | KR101229525B1 (de) |
| CN (1) | CN1910278B (de) |
| AT (1) | ATE440135T1 (de) |
| BR (1) | BRPI0506790B1 (de) |
| CA (1) | CA2547695C (de) |
| DE (1) | DE602005016073D1 (de) |
| DK (1) | DK1704230T3 (de) |
| ES (1) | ES2329914T3 (de) |
| FR (1) | FR2864967B1 (de) |
| PL (1) | PL1704230T3 (de) |
| PT (1) | PT1704230E (de) |
| RU (1) | RU2407793C2 (de) |
| SI (1) | SI1704230T1 (de) |
| WO (1) | WO2005073364A2 (de) |
| ZA (1) | ZA200605440B (de) |
Families Citing this family (96)
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| EP2400027A1 (de) | 2006-10-31 | 2011-12-28 | Metabolic Explorer | Verfahren zur biologischen Herstellung von 1,3-Propandiol aus Glycerol mit hohem Ertrag |
| AU2007332241A1 (en) * | 2006-12-15 | 2008-06-19 | Biofuelchem Co., Ltd. | Enhanced butanol producing microorganisms and method for preparing butanol using the same |
| US20100062505A1 (en) * | 2006-12-21 | 2010-03-11 | Gevo, Inc. | Butanol production by metabolically engineered yeast |
| WO2008091627A2 (en) * | 2007-01-22 | 2008-07-31 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
| GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
| KR100971792B1 (ko) * | 2007-02-08 | 2010-07-23 | 바이오퓨얼켐 주식회사 | Butyryl-CoA를 중간체로 하여 부탄올을 생합성하는 능력을가지는 효모를 이용하여 부탄올을 제조하는 방법 |
| JP2011510611A (ja) | 2007-02-09 | 2011-04-07 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 組換え微生物によるバイオ燃料の生成 |
| US8067214B2 (en) | 2007-03-16 | 2011-11-29 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| MX2009010154A (es) * | 2007-03-20 | 2009-10-12 | Univ Florida | Materiales y metodos para la produccion eficiente de succinato y malato. |
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| US20100279369A1 (en) * | 2007-03-23 | 2010-11-04 | Metabolic Explorer | Metabolically engineered microorganism useful for the production of acetol |
| WO2008116849A1 (en) * | 2007-03-23 | 2008-10-02 | Metabolic Explorer | New micro-organisms for the production of acetol obtained by a combination of evolution and rational design. |
| ES2525796T3 (es) * | 2007-03-23 | 2014-12-30 | Metabolic Explorer | Nuevos microorganismos para la producción de 1,2-propanodiol obtenidos mediante una combinación de evolución y diseño racional |
| JP2010521190A (ja) * | 2007-03-23 | 2010-06-24 | メタボリック エクスプローラー | １，２−プロパンジオールの製造に有用な、代謝的に操作された微生物 |
| US20090111154A1 (en) * | 2007-04-04 | 2009-04-30 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
| US7947483B2 (en) * | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| US8026386B2 (en) * | 2007-08-10 | 2011-09-27 | Genomatica, Inc. | Methods for the synthesis of olefins and derivatives |
| WO2009049274A2 (en) * | 2007-10-12 | 2009-04-16 | The Regents Of The University Of California | Microorganism engineered to produce isopropanol |
| EP2231857A2 (de) | 2007-12-17 | 2010-09-29 | Universiteit van Amsterdam | Lichtgesteuerte CO2-Reduktion in organischen Verbindungen, die als Brennstoffe oder industrielle Halbzeuge dienen, durch ein autotrophes Element mit einer fermentativen Genkassette |
| CN107090424A (zh) | 2008-01-22 | 2017-08-25 | 基因组股份公司 | 利用合成气或其它气态碳源和甲醇的方法和有机体 |
| WO2009103380A1 (en) * | 2008-02-21 | 2009-08-27 | Takata-Petri Ag | Airbag module for a motor vehicle |
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| EP2285973A4 (de) * | 2008-05-01 | 2012-04-25 | Genomatica Inc | Verfahren zur herstellung von methacrylsäure |
| US8129154B2 (en) * | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
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| RU2521502C2 (ru) * | 2008-07-28 | 2014-06-27 | Б.Р.Э.И.Н. БАЙОТЕКНОЛОДЖИ РИСЕРЧ ЭНД ИНФОРМЕЙШН НЕТВОРК АГ,Германия | Микробиологический способ получения 1,2-пропандиола |
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| BRPI0918483A2 (pt) | 2008-09-10 | 2020-07-14 | Genomatica, Inc | organismo microbiano que não ocorre naturalmente, e, método para produzir um composto |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| CA2738452C (en) | 2008-10-03 | 2016-06-21 | Metabolic Explorer | Method for purifying an alcohol from a fermentation broth using a falling film, a wiped film, a thin film or a short path evaporator |
| CA2741427A1 (en) * | 2008-11-07 | 2010-05-14 | Metabolic Explorer | Use of sucrose as substrate for fermentative production of 1,2-propanediol |
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| EP2414505B1 (de) | 2009-04-02 | 2019-05-22 | University of Florida Research Foundation, Inc. | Manipulation eines weges zur succinatherstellung |
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| KR102454204B1 (ko) * | 2009-04-30 | 2022-10-12 | 게노마티카 인코포레이티드 | 1,3-부탄다이올 생산 유기체 |
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| KR102621632B1 (ko) | 2014-05-12 | 2024-01-08 | 메타볼릭 익스플로러 | Ｎａｄｐｈ 의존성 아세톨 리덕타제 및 개선된 ｎａｄｐｈ 공급에 기반한 １,２-프로판디올의 생산을 위한 신규한 미생물 및 방법 |
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| BR112017021255A2 (pt) | 2015-04-07 | 2018-06-26 | Metabolic Explorer Sa | microrganismo modificado para a produção otimizada de 2,4-di-hidroxibutirato |
| ES2811337T3 (es) | 2015-04-07 | 2021-03-11 | Metabolic Explorer Sa | Microorganismo modificado para la producción optimizada de 2,4-dihidroxibutirato con eflujo de 2,4- dihidroxibutirato aumentado |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US10760100B2 (en) | 2015-07-27 | 2020-09-01 | Institut National Des Sciences Appliquees | Polypeptide having ferredoxin-NADP+ reductase activity, polynucleotide encoding the same and uses thereof |
| CN108026516A (zh) | 2015-08-07 | 2018-05-11 | 赢创德固赛有限公司 | 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产 |
| WO2017042602A1 (en) | 2015-09-10 | 2017-03-16 | Metabolic Explorer | New lactaldehyde reductases for the production of 1,2-propanediol |
| WO2017068385A1 (en) | 2015-10-23 | 2017-04-27 | Metabolic Explorer | Microorganism modified for the assimilation of levulinic acid |
| KR102771842B1 (ko) | 2015-11-27 | 2025-02-21 | 에보닉 오퍼레이션스 게엠베하 | L-메티오닌을 제조하는 방법 |
| WO2017211883A1 (en) * | 2016-06-07 | 2017-12-14 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to polyols |
| US10961499B2 (en) * | 2016-07-08 | 2021-03-30 | Metabolic Explorer | Method for the fermentative production of molecules of interest by microorganisms comprising genes coding sugar phosphotransferase system (PTS) |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3342873A1 (de) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Umsetzung von methylglyoxal zu hydroxyaceton unter verwendung von enzymen sowie ihre anwendungen |
| EP3470512A1 (de) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutierte phosphoserin-aminotransferase für die konversion von homoserin zu 4-hydroxy-2-ketobutyrat |
| BR112020009129A2 (pt) * | 2017-11-09 | 2020-10-20 | Braskem S.A. | processo para a recuperação de cetonas e glicóis a partir de fermentação |
| CN115261292B (zh) * | 2021-04-29 | 2023-06-09 | 中国科学院上海高等研究院 | 改造的克雷伯氏菌属细菌及其生产1,2-丙二醇的应用和方法 |
| CN115125263B (zh) * | 2022-05-31 | 2024-01-23 | 中国科学院天津工业生物技术研究所 | 解除pts依赖碳源对相关启动子阻遏的方法及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087140A (en) * | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
| RU2175351C2 (ru) * | 1998-12-30 | 2001-10-27 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") | Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот |
| DK1204755T3 (da) | 1999-08-18 | 2006-12-11 | Du Pont | Proces til biologisk produktion af 1,3-propandiol |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2005073364A2 (fr) | 2005-08-11 |
| SI1704230T1 (sl) | 2009-12-31 |
| US8252579B2 (en) | 2012-08-28 |
| EP2192180A1 (de) | 2010-06-02 |
| EP1704230A2 (de) | 2006-09-27 |
| US20070072279A1 (en) | 2007-03-29 |
| EP1704230B1 (de) | 2009-08-19 |
| BRPI0506790B1 (pt) | 2020-12-22 |
| FR2864967A1 (fr) | 2005-07-15 |
| BRPI0506790A (pt) | 2007-05-22 |
| ES2329914T3 (es) | 2009-12-02 |
| PT1704230E (pt) | 2009-10-14 |
| JP2007517517A (ja) | 2007-07-05 |
| CN1910278A (zh) | 2007-02-07 |
| ZA200605440B (en) | 2007-04-25 |
| DE602005016073D1 (de) | 2009-10-01 |
| RU2407793C2 (ru) | 2010-12-27 |
| PL1704230T3 (pl) | 2010-01-29 |
| CN1910278B (zh) | 2010-05-26 |
| JP4613177B2 (ja) | 2011-01-12 |
| CA2547695A1 (fr) | 2005-08-11 |
| FR2864967B1 (fr) | 2006-05-19 |
| DK1704230T3 (da) | 2009-11-02 |
| KR101229525B1 (ko) | 2013-02-04 |
| KR20060123490A (ko) | 2006-12-01 |
| WO2005073364A3 (fr) | 2005-09-29 |
| RU2006129295A (ru) | 2008-02-20 |
| CA2547695C (fr) | 2015-03-10 |
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