ATE446085T1 - Partikel zur verwendung in einer pharmazeutischen zusammensetzung - Google Patents
Partikel zur verwendung in einer pharmazeutischen zusammensetzungInfo
- Publication number
- ATE446085T1 ATE446085T1 AT01998327T AT01998327T ATE446085T1 AT E446085 T1 ATE446085 T1 AT E446085T1 AT 01998327 T AT01998327 T AT 01998327T AT 01998327 T AT01998327 T AT 01998327T AT E446085 T1 ATE446085 T1 AT E446085T1
- Authority
- AT
- Austria
- Prior art keywords
- particles
- pharmaceutical composition
- dry powder
- additive material
- active particles
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000654 additive Substances 0.000 abstract 2
- 230000000996 additive effect Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229940112141 dry powder inhaler Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0029261A GB0029261D0 (en) | 2000-11-30 | 2000-11-30 | Method of making particles for use in a pharmaceutical composition |
| GB0030946A GB0030946D0 (en) | 2000-12-19 | 2000-12-19 | Method of making particles for use in a pharmaceutical composition |
| GB0124009A GB0124009D0 (en) | 2001-10-05 | 2001-10-05 | Particles for use in a pharmaceutical composition |
| PCT/GB2001/005305 WO2002043700A2 (en) | 2000-11-30 | 2001-11-30 | Particles for use in a pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446085T1 true ATE446085T1 (de) | 2009-11-15 |
Family
ID=27255994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01998327T ATE446085T1 (de) | 2000-11-30 | 2001-11-30 | Partikel zur verwendung in einer pharmazeutischen zusammensetzung |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8580306B2 (de) |
| EP (3) | EP2292212A3 (de) |
| AT (1) | ATE446085T1 (de) |
| AU (1) | AU2002220857A1 (de) |
| DE (1) | DE60140268D1 (de) |
| ES (2) | ES2334642T5 (de) |
| PT (1) | PT1337239E (de) |
| WO (1) | WO2002043700A2 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9515182D0 (en) * | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| GB0009469D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
| US7744855B2 (en) | 2000-06-27 | 2010-06-29 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| ATE446085T1 (de) * | 2000-11-30 | 2009-11-15 | Vectura Ltd | Partikel zur verwendung in einer pharmazeutischen zusammensetzung |
| DK1337240T4 (en) | 2000-11-30 | 2015-01-05 | Vectura Ltd | A process for the preparation of particles for use in a pharmaceutical composition |
| DK2283818T3 (en) † | 2000-11-30 | 2017-10-16 | Vectura Ltd | Process for preparing particles for use in a pharmaceutical composition |
| US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
| US20060147389A1 (en) * | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| US20120321717A1 (en) * | 2003-04-14 | 2012-12-20 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| GB0321607D0 (en) | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| GB0426301D0 (en) * | 2004-11-30 | 2004-12-29 | Vectura Ltd | Pharmaceutical formulations |
| GB0525254D0 (en) | 2005-12-12 | 2006-01-18 | Jagotec Ag | Powder compositions for inhalation |
| US20070148211A1 (en) * | 2005-12-15 | 2007-06-28 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for oral administration |
| GB0712316D0 (en) * | 2007-06-26 | 2007-08-01 | Entripneur Ltd | A novel powder and its method of manufacture |
| EP2296628B1 (de) | 2008-05-22 | 2014-05-14 | 3M Innovative Properties Company | Verfahren zur herstellung von fliessfähigen pulverförmigen arzneimittelzusammensetzungen |
| EP2309978B1 (de) | 2008-06-26 | 2018-12-26 | 3M Innovative Properties Company | Pharmazeutische trockenpulver-zusammensetzungen zur pulmonalen verabreichung und herstellungsverfahren dafür |
| WO2010002613A2 (en) | 2008-07-02 | 2010-01-07 | 3M Innovative Properties Company | Method of making a dry powder pharmaceutical composition |
| US11116721B2 (en) | 2009-02-26 | 2021-09-14 | Glaxo Group Limited | Pharmaceutical formulations comprising 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl) phenol |
| GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
| PH12012501064B1 (en) * | 2009-12-14 | 2017-09-27 | Chiesi Farm Spa | Antibiotic microparticles for inhalation |
| AU2013246926B2 (en) | 2012-04-13 | 2016-07-21 | Glaxosmithkline Intellectual Property Development Limited | Aggregate particles |
| JP5087182B1 (ja) * | 2012-06-13 | 2012-11-28 | クリニプロ株式会社 | 吸入用パウダーの製造方法 |
| EP3209287A4 (de) * | 2014-10-20 | 2018-06-13 | RX Analytic Inc. | Arzneimittelhaltige mikropartikel |
| DK3212212T3 (da) | 2014-10-31 | 2020-12-21 | Univ Monash | Pulverformulering |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| EP3340982B1 (de) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Verbindungen zur behandlung von immun- und entzündungserkrankungen |
| EP3455219A4 (de) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | Amingebundene c3-glutarimiddegronimere für zielproteinabbau |
| SG11201811491YA (en) | 2016-06-27 | 2019-01-30 | Achillion Pharmaceuticals Inc | Quinazoline and indole compounds to treat medical disorders |
| MX2019010381A (es) | 2017-03-01 | 2020-01-21 | Achillion Pharmaceuticals Inc | Compuestos farmaceuticos de arilo, heteroarilo y heterociclicos para el tratamiento de trastornos medicos. |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| BR112020006609A2 (pt) * | 2017-10-02 | 2020-10-06 | Board Of Regents, The University Of Texas System | composição inalável de clofazimina e seus métodos de uso |
| CN111902141A (zh) | 2018-03-26 | 2020-11-06 | C4医药公司 | 用于ikaros降解的羟脑苷脂结合剂 |
| EP3841086B1 (de) | 2018-08-20 | 2025-04-23 | Achillion Pharmaceuticals, Inc. | Pharmazeutische zusammensetzungen zur behandlung von medizinischen störungen im zusammenhang mit komplementfaktor d |
| JP7504088B2 (ja) | 2018-10-16 | 2024-06-21 | ジョージア ステイト ユニバーシティー リサーチ ファウンデーション インコーポレイテッド | 医学的障害の治療のための一酸化炭素プロドラッグ |
| US20230105108A1 (en) | 2019-12-19 | 2023-04-06 | Georgia State University Research Foundation, Inc. | Compounds for the treatment of bacterial infections and potentiation of antibiotics |
| EP4107166A4 (de) | 2020-02-20 | 2024-06-26 | Achillion Pharmaceuticals, Inc. | Heteroarylverbindungen zur behandlung von durch komplementfaktor d vermittelten störungen |
| KR20220166797A (ko) | 2020-03-05 | 2022-12-19 | 씨4 테라퓨틱스, 인코포레이티드 | Brd9의 표적화된 분해를 위한 화합물 |
| CN116437913A (zh) | 2020-09-23 | 2023-07-14 | 艾其林医药公司 | 用于治疗补体介导的病症的药物化合物 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB124009A (en) | 1918-01-12 | 1919-03-12 | Walter Edward Kimber | Improvements in and connected with the Manufacture of Tools for Turning, Planing, Boring and similar purposes. |
| GB1381872A (en) | 1971-06-22 | 1975-01-29 | Fisons Ltd | Pharmaceutical compositions for inhalation |
| US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| IT1204826B (it) | 1986-03-04 | 1989-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche per inalazione |
| US5320906A (en) * | 1986-12-15 | 1994-06-14 | Vestar, Inc. | Delivery vehicles with amphiphile-associated active ingredient |
| ATE77947T1 (de) * | 1987-04-09 | 1992-07-15 | Fisons Plc | Pentamidin enthaltende pharmazeutische zusammensetzungen. |
| JP2668880B2 (ja) | 1987-06-23 | 1997-10-27 | 日本油脂株式会社 | 被覆アミノ酸類の製造方法 |
| US5190764A (en) | 1988-03-03 | 1993-03-02 | Hokko Chemical Industry Co., Ltd. | Agent for imparting a sustained release property to a pesticide, a pesticide having a sustained release property and a process for the production thereof |
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| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| MX9603936A (es) * | 1994-03-07 | 1997-05-31 | Inhale Therapeutic Syst | Metodos y composiciones para el suministro pulmonar de insulina. |
| US5711934A (en) * | 1994-04-11 | 1998-01-27 | Abbott Laboratories | Process for the continuous milling of aerosol pharmaceutical formulations in aerosol propellants |
| US6103271A (en) * | 1994-12-02 | 2000-08-15 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microencapsulation and electrostatic processing method |
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| CN1088580C (zh) | 1994-12-22 | 2002-08-07 | 阿斯特拉公司 | 气溶胶药物制剂 |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| US5612053A (en) * | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5931809A (en) * | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| GB9515182D0 (en) * | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| DE19645359A1 (de) * | 1996-11-04 | 1998-05-07 | Bayer Ag | Verfahren zur Herstellung von Alkylhalogensilanen |
| DE69810355T2 (de) * | 1997-12-03 | 2003-10-30 | Britannia Pharmaceuticals Ltd., Redhill | Verwendung von phospholipiden zur herstellung eines arzneimittels zur behandlung von asthma |
| US6178414B1 (en) * | 1997-12-16 | 2001-01-23 | Nortel Networks Limited | Method and apparatus for updating and searching an ordered list of values stored within a memory resource |
| US6086376A (en) | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
| US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| PT1283036E (pt) | 1998-11-13 | 2008-03-06 | Jagotec Ag | Inalador de pó seco de dose múltipla com um reservatório de pó |
| US6984404B1 (en) | 1998-11-18 | 2006-01-10 | University Of Florida Research Foundation, Inc. | Methods for preparing coated drug particles and pharmaceutical formulations thereof |
| NZ511689A (en) | 1998-11-18 | 2003-03-28 | Univ Florida | Methods for preparing coated drug particles useful for treating respiratory disorders or pulmonary infections |
| GB9826783D0 (en) | 1998-12-04 | 1999-01-27 | Scherer Ltd R P | Inhalation powders |
| GB9827145D0 (en) * | 1998-12-09 | 1999-02-03 | Co Ordinated Drug Dev | Improvements in or relating to powders |
| US6542490B1 (en) * | 1999-01-29 | 2003-04-01 | Nortel Networks Limited | Data link control proctocol for 3G wireless system |
| IT1309592B1 (it) | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
| DK1158958T3 (da) | 1999-03-05 | 2007-10-08 | Chiesi Farma Spa | Forbedret pulverformulering til inhalering |
| AU4417500A (en) | 1999-04-14 | 2000-11-14 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
| US6406745B1 (en) | 1999-06-07 | 2002-06-18 | Nanosphere, Inc. | Methods for coating particles and particles produced thereby |
| ITMI991582A1 (it) | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
| US6197369B1 (en) * | 1999-09-30 | 2001-03-06 | New Jersey Institute Of Technology | Method of particle coating |
| GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0009468D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formulations for use in inhaler devices |
| GB0009469D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
| US7744855B2 (en) * | 2000-06-27 | 2010-06-29 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| US6404772B1 (en) * | 2000-07-27 | 2002-06-11 | Symbol Technologies, Inc. | Voice and data wireless communications network and method |
| NZ525054A (en) | 2000-10-09 | 2004-11-26 | 3M Innovative Properties Co | Medicinal aerosol formulations |
| DZ3477A1 (de) | 2000-10-12 | 2002-04-18 | ||
| ATE446085T1 (de) * | 2000-11-30 | 2009-11-15 | Vectura Ltd | Partikel zur verwendung in einer pharmazeutischen zusammensetzung |
| GB0124009D0 (en) | 2001-10-05 | 2001-11-28 | Vectura Ltd | Particles for use in a pharmaceutical composition |
| DK1337240T4 (en) * | 2000-11-30 | 2015-01-05 | Vectura Ltd | A process for the preparation of particles for use in a pharmaceutical composition |
| US20060147389A1 (en) | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| EP1663164A2 (de) | 2003-09-15 | 2006-06-07 | Vectura Limited | Verfahren zur herstellung von pharmazeutischen zusammensetzungen |
| GB0321607D0 (en) | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
-
2001
- 2001-11-30 AT AT01998327T patent/ATE446085T1/de active
- 2001-11-30 DE DE60140268T patent/DE60140268D1/de not_active Expired - Lifetime
- 2001-11-30 EP EP10185079A patent/EP2292212A3/de not_active Withdrawn
- 2001-11-30 PT PT01998327T patent/PT1337239E/pt unknown
- 2001-11-30 ES ES01998327.9T patent/ES2334642T5/es not_active Expired - Lifetime
- 2001-11-30 US US10/433,135 patent/US8580306B2/en not_active Expired - Lifetime
- 2001-11-30 EP EP01998327.9A patent/EP1337239B2/de not_active Expired - Lifetime
- 2001-11-30 EP EP09173566.2A patent/EP2168571B1/de not_active Expired - Lifetime
- 2001-11-30 ES ES09173566.2T patent/ES2689704T3/es not_active Expired - Lifetime
- 2001-11-30 WO PCT/GB2001/005305 patent/WO2002043700A2/en not_active Application Discontinuation
- 2001-11-30 AU AU2002220857A patent/AU2002220857A1/en not_active Abandoned
-
2013
- 2013-10-10 US US14/050,819 patent/US9585839B2/en not_active Expired - Fee Related
-
2017
- 2017-02-15 US US15/433,106 patent/US10238601B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1337239A2 (de) | 2003-08-27 |
| PT1337239E (pt) | 2010-01-26 |
| WO2002043700A3 (en) | 2002-10-24 |
| EP2168571B1 (de) | 2018-08-22 |
| ES2334642T3 (es) | 2010-03-15 |
| US8580306B2 (en) | 2013-11-12 |
| EP1337239B1 (de) | 2009-10-21 |
| US20040071635A1 (en) | 2004-04-15 |
| US9585839B2 (en) | 2017-03-07 |
| US10238601B2 (en) | 2019-03-26 |
| DE60140268D1 (de) | 2009-12-03 |
| EP2168571A3 (de) | 2011-11-16 |
| US20170216202A1 (en) | 2017-08-03 |
| AU2002220857A1 (en) | 2002-06-11 |
| EP2168571A2 (de) | 2010-03-31 |
| ES2334642T5 (es) | 2016-03-07 |
| US20140037737A1 (en) | 2014-02-06 |
| EP1337239B2 (de) | 2015-11-25 |
| WO2002043700A2 (en) | 2002-06-06 |
| EP2292212A2 (de) | 2011-03-09 |
| EP2292212A3 (de) | 2012-08-08 |
| ES2689704T3 (es) | 2018-11-15 |
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