ATE544463T1 - Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungen - Google Patents
Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungenInfo
- Publication number
- ATE544463T1 ATE544463T1 AT05851326T AT05851326T ATE544463T1 AT E544463 T1 ATE544463 T1 AT E544463T1 AT 05851326 T AT05851326 T AT 05851326T AT 05851326 T AT05851326 T AT 05851326T AT E544463 T1 ATE544463 T1 AT E544463T1
- Authority
- AT
- Austria
- Prior art keywords
- scf
- treatment
- polypeptide
- brain
- combination
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title abstract 3
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 210000004556 brain Anatomy 0.000 title abstract 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 abstract 3
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 201000006474 Brain Ischemia Diseases 0.000 abstract 2
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 2
- 206010008118 cerebral infarction Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000007658 neurological function Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62518904P | 2004-11-05 | 2004-11-05 | |
| PCT/US2005/039792 WO2006055260A2 (en) | 2004-11-05 | 2005-11-04 | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE544463T1 true ATE544463T1 (de) | 2012-02-15 |
Family
ID=36407603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05851326T ATE544463T1 (de) | 2004-11-05 | 2005-11-04 | Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungen |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20060153799A1 (de) |
| EP (1) | EP1817047B1 (de) |
| AT (1) | ATE544463T1 (de) |
| AU (1) | AU2005306894B2 (de) |
| CA (1) | CA2586365A1 (de) |
| WO (1) | WO2006055260A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2629775A1 (en) | 2005-11-14 | 2007-05-24 | Enterprise Partners Venture Capital | Stem cell factor therapy for tissue injury |
| DE102006004142A1 (de) * | 2006-01-27 | 2007-08-02 | Axaron Bioscience Ag | Neue therapeutische Indikationen von Koloniestimulierenden Faktoren |
| US9770485B2 (en) * | 2006-02-21 | 2017-09-26 | Academia Sinica | Methods for rescuing learning and/or memory deficits caused by alzheimer's disease by G-CSF |
| US7618938B2 (en) * | 2007-02-07 | 2009-11-17 | Academia Sinica | Treating cerebrovascular diseases with erythropoietin and granulocyte-colony stimulating factor jointly |
| US9132168B2 (en) | 2008-08-05 | 2015-09-15 | University Of South Florida | Methods of treating cognitive impairment |
| RU2011108560A (ru) | 2008-08-05 | 2012-09-10 | Юниверсити Оф Саут Флорида (Us) | Способы лечения когнитивного нарушения |
| KR20100020125A (ko) * | 2008-08-12 | 2010-02-22 | 한양대학교 산학협력단 | G-csf를 유효성분으로 하는 신경병증성 통증 예방 또는치료제 |
| CN102260343A (zh) | 2010-05-25 | 2011-11-30 | 健能隆医药技术(上海)有限公司 | 重组人g-csf二聚体在治疗神经损伤疾病中的用途 |
| AU2012289433B2 (en) | 2011-07-25 | 2017-07-27 | Evive Biotechnology (Shanghai) Ltd | Use of G-CSF dimer in preparation of medicament for treatment of neurodegenerative diseases |
| CN107260760B (zh) | 2013-02-06 | 2021-08-31 | Nc医学研究公司 | 用于治疗神经变性的细胞疗法 |
| LT6161B (lt) | 2013-09-27 | 2015-06-25 | Uab Profarma | Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas |
| US10039808B2 (en) | 2014-10-22 | 2018-08-07 | Michael Chez | Method of treating or improving neurological function in a human subject |
| US9925244B1 (en) | 2015-02-17 | 2018-03-27 | Michael Chez | Treatment of warts in non-immunosuppressed patients |
| WO2019200240A1 (en) | 2018-04-13 | 2019-10-17 | Board Of Regents, The University Of Texas System | Transmembrane stem cell factor (tm-scf) lipid nanocarriers and methods of use thereof |
| WO2023158681A1 (en) * | 2022-02-16 | 2023-08-24 | Vasogenesis Inc. | Methods of using a blood cell growth factor to treat impaired blood flow |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| DK203187A (da) | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| WO1988001297A1 (en) | 1986-08-11 | 1988-02-25 | Cetus Corporation | Expression of g-csf and muteins thereof |
| US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| DK174044B1 (da) | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid....... |
| US5362853A (en) * | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| NZ229098A (en) | 1988-05-13 | 1992-10-28 | Amgen Inc | (bg-csf) bovine granulocyte colony stimulating factor, recombinant methods and pharmaceuticals |
| US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| SE464482C (sv) | 1989-08-25 | 1997-09-08 | Teknoskand Invent Ab | Med spärr försett svängarmsbeslag till fönster, luckor o d |
| WO1991005798A1 (en) * | 1989-10-10 | 1991-05-02 | Amgen Inc. | Compositions and methods for treating or preventing infections in canine and feline animals |
| US6248319B1 (en) * | 1989-10-16 | 2001-06-19 | Krisztina M. Zsebo | Method for increasing hematopoietic progenitor cells by stem cell factor polypeptides |
| EP0676470A1 (de) * | 1989-10-16 | 1995-10-11 | Amgen Inc. | Stammzellenfaktor |
| US6204363B1 (en) * | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
| WO1991005795A1 (en) | 1989-10-16 | 1991-05-02 | Amgen Inc. | Stem cell factor |
| US6207454B1 (en) * | 1989-10-16 | 2001-03-27 | Amgen Inc. | Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide |
| NZ236819A (en) | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
| JPH04164098A (ja) | 1990-03-07 | 1992-06-09 | Kirin Amgen Inc | 化学修飾顆粒球コロニー刺激因子誘導体 |
| GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| DE4014750A1 (de) | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
| US5241072A (en) | 1990-05-25 | 1993-08-31 | Genzyne Corporation | Oligosaccharide oxazolines, oligosaccharide conjugates and methods of preparation thereof |
| EP0536317A1 (de) | 1990-06-25 | 1993-04-14 | Immunex Corporation | Wachstumsfaktor der mastzellen |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| US20030125519A1 (en) | 1990-08-27 | 2003-07-03 | Peter Besmer | Ligand for the c-kit receptor and methods of use thereof |
| WO1992004455A1 (en) | 1990-08-29 | 1992-03-19 | Genetics Institute, Inc. | Multidomain hematopoiesis stimulators |
| WO1992006116A1 (en) | 1990-09-28 | 1992-04-16 | Ortho Pharmaceutical Corporation | Hybrid growth factors |
| DE4105480A1 (de) | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| EP0601043B1 (de) | 1991-08-30 | 1998-11-25 | Fred Hutchinson Cancer Research Center | Hybride cytokine |
| FR2686900B1 (fr) | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant. |
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| PT726778E (pt) | 1994-02-08 | 2001-12-28 | Amgen Inc | Sistema de administracao oral de proteinas g-csf modificadas quimicamente |
| US5525708A (en) | 1994-03-28 | 1996-06-11 | Cytomed, Inc. | Covalent dimer of kit ligand |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6017876A (en) * | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| JP4891477B2 (ja) | 1997-10-02 | 2012-03-07 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー.ヴェー. | 血管新生及び/または既存細動脈網から側枝動脈及び/または他の動脈の発達の調節に関する方法 |
| AU782580B2 (en) | 2000-01-10 | 2005-08-11 | Maxygen, Inc. | G-CSF conjugates |
| US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| DE10033219A1 (de) * | 2000-07-07 | 2002-01-24 | Univ Heidelberg | Neuroprotektive Wirkung von Granulocyten-Colony Stimmulierendem Faktor (G-CSF) |
| MXPA04000231A (es) | 2001-07-11 | 2004-05-04 | Maxygen Holdings Ltd | Conjugados del factor de estimulacion de colonias de granulocitos. |
| AU2002332041A1 (en) | 2001-10-05 | 2003-04-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7605128B2 (en) * | 2002-02-14 | 2009-10-20 | Buck Institute For Age Research | Neurogenerative or neurotrophic factors for mitigating a symptom of ischemia |
| AU2003268484A1 (en) * | 2002-09-06 | 2004-03-29 | The General Hospital Corporation | Delivery of therapeutics to the brain and spinal cord |
| US7785601B2 (en) * | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
-
2005
- 2005-11-04 AT AT05851326T patent/ATE544463T1/de active
- 2005-11-04 EP EP05851326A patent/EP1817047B1/de not_active Not-in-force
- 2005-11-04 CA CA002586365A patent/CA2586365A1/en not_active Abandoned
- 2005-11-04 WO PCT/US2005/039792 patent/WO2006055260A2/en active Application Filing
- 2005-11-04 US US11/267,820 patent/US20060153799A1/en not_active Abandoned
- 2005-11-04 AU AU2005306894A patent/AU2005306894B2/en not_active Ceased
-
2010
- 2010-02-26 US US12/714,068 patent/US8524655B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2586365A1 (en) | 2006-05-26 |
| WO2006055260A3 (en) | 2006-07-27 |
| US20100286039A1 (en) | 2010-11-11 |
| US20060153799A1 (en) | 2006-07-13 |
| AU2005306894B2 (en) | 2011-11-24 |
| AU2005306894A1 (en) | 2006-05-26 |
| WO2006055260A2 (en) | 2006-05-26 |
| EP1817047A2 (de) | 2007-08-15 |
| US8524655B2 (en) | 2013-09-03 |
| EP1817047B1 (de) | 2012-02-08 |
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