ATE517097T1 - Thiazol- und oxazolsubstituierte arylamide - Google Patents
Thiazol- und oxazolsubstituierte arylamideInfo
- Publication number
- ATE517097T1 ATE517097T1 AT07822118T AT07822118T ATE517097T1 AT E517097 T1 ATE517097 T1 AT E517097T1 AT 07822118 T AT07822118 T AT 07822118T AT 07822118 T AT07822118 T AT 07822118T AT E517097 T1 ATE517097 T1 AT E517097T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazole
- oxazole substituted
- substituted arylamides
- arylamides
- oxazole
- Prior art date
Links
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85828306P | 2006-11-09 | 2006-11-09 | |
| PCT/EP2007/061771 WO2008055840A1 (en) | 2006-11-09 | 2007-10-31 | Thiazole and oxazole-substituted arylamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517097T1 true ATE517097T1 (de) | 2011-08-15 |
Family
ID=39149180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07822118T ATE517097T1 (de) | 2006-11-09 | 2007-10-31 | Thiazol- und oxazolsubstituierte arylamide |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7786110B2 (de) |
| EP (1) | EP2091927B1 (de) |
| JP (1) | JP5084839B2 (de) |
| KR (2) | KR101165936B1 (de) |
| CN (1) | CN101528717B (de) |
| AR (1) | AR063601A1 (de) |
| AT (1) | ATE517097T1 (de) |
| AU (1) | AU2007316681B2 (de) |
| BR (1) | BRPI0718714B8 (de) |
| CA (1) | CA2668399C (de) |
| CL (1) | CL2007003192A1 (de) |
| ES (1) | ES2367455T3 (de) |
| IL (1) | IL198301A (de) |
| MX (1) | MX2009004900A (de) |
| PE (1) | PE20081475A1 (de) |
| TW (1) | TW200829584A (de) |
| WO (1) | WO2008055840A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101528717B (zh) | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
| US8501933B2 (en) * | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
| WO2009058299A1 (en) | 2007-10-31 | 2009-05-07 | Merck & Co., Inc. | P2x3 receptor antagonists for treatment of pain |
| EP2215049B1 (de) * | 2007-10-31 | 2019-06-12 | Merck Sharp & Dohme Corp. | P2x3-rezeptorantagonisten zur schmerzbehandlung |
| PL2234976T3 (pl) * | 2007-12-17 | 2013-09-30 | Hoffmann La Roche | Nowe aryloamidy podstawione pirazolem |
| ES2570628T3 (es) * | 2007-12-17 | 2016-05-19 | Hoffmann La Roche | Nuevas arilamidas con sustitución imidazol |
| CN101903362B (zh) * | 2007-12-17 | 2013-07-17 | 霍夫曼-拉罗奇有限公司 | 四唑取代的芳基酰胺衍生物和它们作为p2x3和/或p2x2/3嘌呤能受体拮抗物的用途 |
| KR101284510B1 (ko) * | 2007-12-17 | 2013-07-23 | 에프. 호프만-라 로슈 아게 | 트리아졸 치환된 아릴아미드 유도체 및 ｐ２ｘ３ 및/또는 ｐ２ｘ２／３ 퓨린성 수용체 길항제로서의 용도 |
| CA2715835C (en) | 2008-02-29 | 2017-03-21 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
| WO2010033168A2 (en) * | 2008-09-18 | 2010-03-25 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
| CA2745290A1 (en) * | 2008-12-16 | 2010-06-24 | F. Hoffmann-La Roche Ag | Thiadiazole-substituted arylamides as p2x3 and p2x2/3 antagonists |
| CA2764956A1 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel biphenyl and phenyl-pyridine amides |
| CA2754654A1 (en) * | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel oxazolone and pyrrolidinone-substituted arylamides |
| US9045445B2 (en) * | 2010-06-04 | 2015-06-02 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US8698952B2 (en) | 2011-10-31 | 2014-04-15 | Lg Innotek Co., Ltd. | Camera module |
| US9732048B2 (en) * | 2012-12-07 | 2017-08-15 | Bayer Cropscience Ag | N-(isoxazol-3-yl)-aryl-carboxylic acid amides and use thereof as herbicides |
| EP2905282A1 (de) * | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituierte Thiazole oder Oxazole als P2X7-Rezeptorantagonisten |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| KR102548799B1 (ko) | 2014-12-09 | 2023-06-27 | 바이엘 악티엔게젤샤프트 | 1,3-티아졸-2-일 치환된 벤즈아미드 |
| KR20160138877A (ko) | 2015-05-26 | 2016-12-06 | (주)펠리테크 | 마이크로파를 이용한 세라믹 발열 하이브리드 건조기 |
| LT3512833T (lt) | 2016-09-15 | 2020-10-12 | Boehringer Ingelheim International Gmbh | Heteroarilo karboksamido junginiai kaip ripk2 inhibitoriai |
| EP3528813B1 (de) * | 2016-09-30 | 2025-04-16 | ABS Development 1, Inc. | P2x3- und/oder p2x2/3-verbindungen und verfahren |
| WO2020002090A1 (de) | 2018-06-25 | 2020-01-02 | Bayer Aktiengesellschaft | Substituierte thiazolylpyrrolone sowie deren salze und ihre verwendung als herbizide wirkstoffe |
| EP3757103A1 (de) * | 2019-06-27 | 2020-12-30 | Bayer AG | Analoga von 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluor-methyl)pyrimidin-5-yl]ethyl}benzamid zur behandlung von neurogenen krankheiten |
| CN115884970B (zh) * | 2020-09-24 | 2025-09-23 | 中国医药研究开发中心有限公司 | 芳基甲酰胺类化合物及其制备方法和医药用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277873B1 (en) | 1999-03-25 | 2001-08-21 | Dingwei Tim Yu | Oxadiazole antifungal agents |
| WO2001002379A1 (en) | 1999-06-30 | 2001-01-11 | Synaptic Pharmaceutical Corporation | Selective npy (y5) antagonists |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CA2410579C (en) | 2000-05-26 | 2010-04-20 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses |
| WO2002057425A2 (en) | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| TW200304808A (en) * | 2001-11-08 | 2003-10-16 | Elan Pharm Inc | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives |
| AU2003251524A1 (en) | 2002-06-17 | 2003-12-31 | Isis Pharmaceuticals, Inc. | Carbocyclic nucleoside analogs as RNA-antivirals |
| AP2005003212A0 (en) | 2002-06-28 | 2005-03-31 | Centre Nat Rech Scient | Modified 2' and 3' nucleoside prodrugs for treating flaviviridae infections. |
| US7662798B2 (en) | 2002-06-28 | 2010-02-16 | Idenix Pharmaceuticals, Inc. | 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| BR0316363A (pt) | 2002-11-15 | 2005-10-04 | Idenix Cayman Ltd | Nucleosìdeos 2'-ramificado e mutação de flaviviridae |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| US20070043512A1 (en) | 2003-03-26 | 2007-02-22 | Michael Rolph | Therapeutic and prophylactic compositions and uses therefor |
| CN1805945A (zh) | 2003-04-18 | 2006-07-19 | 麦克公司 | 作为钠通道阻滞剂的联芳基取代的噻唑、噁唑和咪唑 |
| ES2281801T3 (es) * | 2003-05-12 | 2007-10-01 | Pfizer Products Inc. | Inhibidores benzamida del receptor p2x7. |
| WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| PT1658302E (pt) | 2003-07-25 | 2010-10-25 | Centre Nat Rech Scient | Análogos do nucleósido purina para o tratamento de doenças provocadas por flaviviridae incluindo hepatite c |
| AU2005229331B2 (en) * | 2004-03-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as P2X3 and P2X2/3 antagonists |
| SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
| EP2038264B1 (de) | 2006-06-29 | 2016-10-26 | F.Hoffmann-La Roche Ag | Tetrazolsubstituierte arylamide |
| CN101528717B (zh) | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
| EP2215049B1 (de) | 2007-10-31 | 2019-06-12 | Merck Sharp & Dohme Corp. | P2x3-rezeptorantagonisten zur schmerzbehandlung |
-
2007
- 2007-10-31 CN CN2007800394586A patent/CN101528717B/zh active Active
- 2007-10-31 AT AT07822118T patent/ATE517097T1/de active
- 2007-10-31 AU AU2007316681A patent/AU2007316681B2/en not_active Ceased
- 2007-10-31 KR KR1020127002496A patent/KR101165936B1/ko active Active
- 2007-10-31 EP EP07822118A patent/EP2091927B1/de active Active
- 2007-10-31 KR KR1020097009417A patent/KR101152714B1/ko active Active
- 2007-10-31 MX MX2009004900A patent/MX2009004900A/es active IP Right Grant
- 2007-10-31 WO PCT/EP2007/061771 patent/WO2008055840A1/en active Application Filing
- 2007-10-31 ES ES07822118T patent/ES2367455T3/es active Active
- 2007-10-31 CA CA2668399A patent/CA2668399C/en active Active
- 2007-10-31 JP JP2009535681A patent/JP5084839B2/ja active Active
- 2007-10-31 BR BRPI0718714A patent/BRPI0718714B8/pt active IP Right Grant
- 2007-11-06 TW TW096141899A patent/TW200829584A/zh unknown
- 2007-11-06 CL CL200703192A patent/CL2007003192A1/es unknown
- 2007-11-07 AR ARP070104958A patent/AR063601A1/es unknown
- 2007-11-07 PE PE2007001531A patent/PE20081475A1/es not_active Application Discontinuation
- 2007-11-08 US US11/983,225 patent/US7786110B2/en active Active
-
2009
- 2009-04-22 IL IL198301A patent/IL198301A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0718714B8 (pt) | 2021-05-25 |
| TW200829584A (en) | 2008-07-16 |
| CN101528717B (zh) | 2013-04-24 |
| JP5084839B2 (ja) | 2012-11-28 |
| AU2007316681A1 (en) | 2008-05-15 |
| MX2009004900A (es) | 2009-05-19 |
| KR20120034766A (ko) | 2012-04-12 |
| WO2008055840A1 (en) | 2008-05-15 |
| KR101152714B1 (ko) | 2012-06-18 |
| US20080132494A1 (en) | 2008-06-05 |
| CN101528717A (zh) | 2009-09-09 |
| JP2010509264A (ja) | 2010-03-25 |
| AU2007316681B2 (en) | 2013-01-24 |
| IL198301A (en) | 2013-06-27 |
| KR101165936B1 (ko) | 2012-07-19 |
| CA2668399A1 (en) | 2008-05-15 |
| AR063601A1 (es) | 2009-02-04 |
| EP2091927A1 (de) | 2009-08-26 |
| US7786110B2 (en) | 2010-08-31 |
| PE20081475A1 (es) | 2008-10-18 |
| IL198301A0 (en) | 2010-02-17 |
| CA2668399C (en) | 2015-01-27 |
| BRPI0718714B1 (pt) | 2020-09-29 |
| KR20090086073A (ko) | 2009-08-10 |
| CL2007003192A1 (es) | 2008-06-20 |
| BRPI0718714A2 (pt) | 2013-11-26 |
| ES2367455T3 (es) | 2011-11-03 |
| EP2091927B1 (de) | 2011-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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