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AU1598599A - Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases - Google Patents

Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases

Info

Publication number
AU1598599A
AU1598599A AU15985/99A AU1598599A AU1598599A AU 1598599 A AU1598599 A AU 1598599A AU 15985/99 A AU15985/99 A AU 15985/99A AU 1598599 A AU1598599 A AU 1598599A AU 1598599 A AU1598599 A AU 1598599A
Authority
AU
Australia
Prior art keywords
gene therapy
related diseases
therapy vectors
treating angiogenesis
angiogenic gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU15985/99A
Other languages
English (en)
Inventor
Thomas Bachelot
Philippe Leboulch
Robert James Pawliuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Bluebird Bio Inc
Original Assignee
Massachusetts Institute of Technology
Genetix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology, Genetix Pharmaceuticals Inc filed Critical Massachusetts Institute of Technology
Publication of AU1598599A publication Critical patent/AU1598599A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU15985/99A 1997-11-20 1998-11-20 Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases Abandoned AU1598599A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97542497A 1997-11-20 1997-11-20
US08975424 1997-11-20
PCT/US1998/024950 WO1999026480A1 (fr) 1997-11-20 1998-11-20 Vecteurs de therapie genique anti-angiogenique et leurs applications dans le cadre du traitement d'affections liees a l'angiogenese

Publications (1)

Publication Number Publication Date
AU1598599A true AU1598599A (en) 1999-06-15

Family

ID=25523018

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15985/99A Abandoned AU1598599A (en) 1997-11-20 1998-11-20 Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases

Country Status (2)

Country Link
AU (1) AU1598599A (fr)
WO (1) WO1999026480A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797488B1 (en) 1997-12-08 2004-09-28 Beth Israel Deaconess Medical Center Methods of producing anti-angiogenic proteins
JP2001526031A (ja) * 1997-12-08 2001-12-18 ベス イスラエル ディーコネス メディカル センター レスチンおよびその使用方法
ES2316194T3 (es) 1998-10-28 2009-04-01 Cornell Research Foundation, Inc. Metodos para la regulacion de la angiogenesis y la integridad vascular utilizando los ligandos bdnf, nt-3 y nt-4.
WO2001002434A1 (fr) * 1999-07-02 2001-01-11 Bayer Ag Modulation de l'angiogenese au moyen d'angiootensine-7 antiangiogenique et de polynucleotides codant pour cette substance
US20020115202A1 (en) * 1999-08-13 2002-08-22 Paul Hallenbeck Adenoviral vectors including dna sequences encoding angiogenic inhibitors
WO2001019989A2 (fr) * 1999-09-14 2001-03-22 Entremed, Inc. Procede de preparation et de purification d'une proteine d'endostatine¿tm?
US6821775B1 (en) 2000-02-11 2004-11-23 Genvec, Inc. Viral vector encoding pigment epithelium-derived factor
WO2001058494A2 (fr) * 2000-02-11 2001-08-16 Genvec, Inc. Matieres et procedes destines au traitement de troubles oculaires
WO2002020813A2 (fr) * 2000-09-05 2002-03-14 Karolinska Innovations Ab Materiaux et procedes concernant des inhibiteurs de croissance cellulaire endotheliale
JP4689144B2 (ja) * 2001-02-22 2011-05-25 ノバルティス アーゲー 眼球血管新生を処置するための方法
US20030158112A1 (en) 2002-02-15 2003-08-21 Johns Hopkins University School Of Medicine Selective induction of apoptosis to treat ocular disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1636594B (zh) * 1994-04-26 2012-08-29 儿童医学中心公司 血管生成抑制素和用于抑制血管生成的方法
US5639725A (en) * 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
DE69637179T2 (de) * 1995-04-26 2008-04-10 The Children's Medical Center Corp., Boston Angiostatinfragmente und verfahren für deren verwendung
EP0857210B1 (fr) * 1995-10-23 2003-09-03 The Children's Medical Center Corporation Compositions therapeutiques anti-angiogenese et procedes associes
DK0869970T3 (da) * 1995-12-13 2004-07-05 Abbott Lab Endothelcelleprolifereringsinhibitor og dens anvendelse
WO1997041824A2 (fr) * 1996-05-03 1997-11-13 Abbott Laboratories Nouveaux peptides anti-angiogeniques, polypeptides les codant et procedes d'inhibition de l'angiogenese
KR20010020342A (ko) * 1997-04-28 2001-03-15 자끄 사비나 종양치료용 맥관형성 길항제의 아데노바이러스-매개 종양내 전달방법

Also Published As

Publication number Publication date
WO1999026480A1 (fr) 1999-06-03

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase