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AU1964799A - Benzamine derivatives - Google Patents

Benzamine derivatives Download PDF

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Publication number
AU1964799A
AU1964799A AU19647/99A AU1964799A AU1964799A AU 1964799 A AU1964799 A AU 1964799A AU 19647/99 A AU19647/99 A AU 19647/99A AU 1964799 A AU1964799 A AU 1964799A AU 1964799 A AU1964799 A AU 1964799A
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AU
Australia
Prior art keywords
methyl
phenyl
formula
ylmethyl
oxadiazol
Prior art date
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Application number
AU19647/99A
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AU744002B2 (en
Inventor
Soheila Anzali
Sabine Bernotat-Danielowski
Hans-Peter Buchstaller
Dieter Dorsch
Joachim Gante
Horst Juraszyk
Werner Mederski
Guido Melzer
Hanns Wurziger
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

WO 99/31092 PCT/EP98/07673 BENZAMIDINE DERIVATIVES AS COAGULATION FACTOR XA INHIBITOR The invention relates to compounds of the formula I 5 R1 R2O R3 in which 10 R is -C(=NH)-NH 2 which can also be monosubstituted by -COA, -CO-[C(Rs) 2 ]m-Ar, -COOA, -OH or by a conventional amino-protective group, { N, { N or HN4 N~~ 3 O CH 3 15 R 2 is H, A, OR 5 , N(R 5
)
2 , NO 2 , CN, Hal, NR'COA, NHCOAr,
NHSO
2 A, NHSO 2 Ar, COOR 5 , CON (R 5
)
2 , CONHAr, COR 5 , COAr, S (0) A or S (O) nAr, R 3 is R 5 or -[C(R-) 2 m-COORs, 20
R
3 and X together are also -CO-N-, thus forming a 5 membered ring, where R 3 is -C=O and X is N, R 4 is A, cycloalkyl,
-[C(R
5
)
2 ]mAr, -[C(R) 2 1mHet or 25 -CRs=CRs-Ar, Rs 5 is H, A or benzyl, X is 0, NR 5 or CH 2 , -17 -2 Y is 0, NR 5 , N[C(R 5
)
2 1m-Ar, N[C(R 5
)
2 1m-Het, -N N-I N [ C (Rs) 21 .m-COORs, _N/ RS RS \S'I N " N , 5 N [C (R) 2 1m-CON(R 5 ) 2, N [C (R 5 ) 2 1m-CONR 5 Ar or N [C (R 5 2]m CONAr 2 , 10 W is a bond, -S0 2 -, -CO-, -COO- or -CONR 5 -, A is alkyl having 1-20 C atoms in which one or two
CH
2 groups can be replaced by 0 or S atoms or by -CRE =CR 5 - groups and/or 1-7 H atoms can be replaced 15 by F, Ar is naphthyl or phenyl which is unsubstituted or mono-, di- or trisubstituted by R1, A, Ar', OR,
N(R
5
)
2 , NO 2 , CN, Hal, NHCOA, NHCOAr', NHSO 2 A, 20 NHSO 2 Ar', COORs, CON(Rs) 2 , CONHAr', CORs, COAr', S(0) A or S(0) Ar, Ar' is naphthyl or phenyl which is unsubstituted or mono-, di- or trisubstituted by R 1 , A, ORs, N(Rs) 2 , 25 NO 2 , CN, Hal, NHCOA, COOR', CON(Rs) 2 , COR 5 or S (0) ,A, Het is a mono- or bicyclic saturated or unsaturated heterocyclic ring system which contains one, two, 30 three or four identical or different hetero atoms such as nitrogen, oxygen and sulfur and which is unsubstituted or mono-. or polysubstituted by Hal, A, Ar', OR 5 , COOR 5 , CN, N(Rs) 2 , NO 2 , NHCOA, NHCOAr' and/or carbonyl oxygen, 35 -3 Hal is F, Cl, Br or I, m is 0, 1, 2, 3 or 4, 5 n is 0, 1 or 2, and salts thereof. The invention also provides the optically active forms, 10 the racemates, the diastereomers and the hydrates and solvates of these compounds. The invention was based on the object of discovering novel compounds having valuable properties, in 15 particular those which can be used for preparing medicaments. It has been found that the compounds of the formula I and their salts have very useful pharmacological 20 properties, coupled with good tolerability. In particular, they have factor Xa-inhibiting properties and can therefore be employed for combating and preventing thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammations, 25 apoplexy, angina pectoris, restenosis after angioplasty and claudicatio intermittens. Aromatic amidine derivatives having antithrombotic action are known, for example, from EP 0 540 051 B1. 30 Cyclic guanidines for the treatment of thromboembolic disorders are described, for example, in WO 97/08165. Aromatic heterocycles having factor Xa-inhibiting activity are known, for example, from WO 96/10022. 35 The antithrombotic and anticoagulant effect of the compounds according to the-- invention is attributed to the inhibiting action on the activated coagulation protease, known under the name factor Xa, or to the -4 inhibition of other activated serine proteases such as factor VIIa, factor IXa or thrombin. Factor Xa is one of the proteases which is involved in the complex process of blood coagulation. Factor Xa 5 catalyses the conversion of prothrombin into thrombin. Thrombin cleaves fibrinogen into fibrin monomers which, after crosslinking, contribute fundamentally to thrombus formation. An activation of thrombin can result in the occurrence of thromboembolic disorders. 10 An inhibition of thrombin, however, can inhibit the fibrin formation involved in the formation of a thrombus. The inhibition of thrombin can be measured, for example, by the method of G. F. Cousins et al. in 15 Circulation 1996, 94, 1705-1712. Inhibition of factor Xa can thus prevent thrombin formation. The compounds of the formula I according to the 20 invention and their salts intervene in the blood coagulation process by inhibiting factor Xa and thus inhibit the formation of thrombi. The compounds of the formula I according to the 25 invention can furthermore function as inhibitors of the blood clotting factors factor VIIa, factor IXa and thrombin of the blood clotting cascade. The inhibition of factor Xa by the compounds according 30 to the invention and the measurement of the anti coagulating and antithrombotic activity can be determined by customary in vitro or in vivo methods. A suitable method is described, for example, by J. Hauptmann et al. in Thrombosis and Haemostasis 63, 35 220-223 (1990). The inhibition of factor Xa can also be measured, for example, by the method of T. Hara et al. in Thromb. Haemostas. 71, 314-319 (1994).
-5 The blood clotting factor VIIa initiates, after binding to tissue factor, the extrinsic part of the blood clotting cascade and contributes to the activation of 5 factor X to factor Xa. An inhibition of factor VIIa thus prevents the formation of factor Xa and thus a subsequent formation of thrombin. The inhibition of factor VIIa by the compounds according to the invention and the determination of the 10 anticoagulant and antithrombotic activity can be determined using customary in vitro or in vivo methods. A customary process for measuring the inhibition of factor VIIa is described, for example, by H. F. Ronning et al. in Thrombosis Research 1996, 84, 73-81. 15 The compounds of the formula I can be employed as medicaments in human and veterinary medicine, in particular for combating and preventing thromboembolic disorders such as thrombosis, myocardial infarction, 20 arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis after angioplasty and claudicatio intermittens. The invention provides the compounds of the formula I 25 and their salts, and also a process for preparing compounds of the formula I according to Claim 1 and their salts, characterized in that a) they are liberated from one of their functional 30 derivatives by treatment with a solvolysing or hydrogenolysing agent, by i) liberating an amidino group from its oxadiazole derivative by hydrogenolysis, 35 ii) replacing a conventional amino-protective group by treatment with a solvolysing or hydrogenolysing agent with hydrogen or -6 liberating an amino group which is protected by a conventional protective group, or 5 b) that for preparing compounds of the formula I in which R 1 is { N' { 'N'O HN4 or N 0
CH
3 10
R
3 and X together are -CO-N-, thus forming a 5 membered ring, Y is NR 5 , -N N-, -N N or 15 R5
R
5 N N W is -SO 2 - or -CO-, 20 and R 2 and R 4 are as defined in Claim 1, a compound of the formula II RI 2 H R R3-O 25 in which -7
R
1 is or HN-4 o 0 CH3 R3 and X together are -CO-N-, thus forming a 5 5 membered ring, Y is NR', -N N- N,-N or
R
5 10 and R 2 and R 5 are as defined in Claim 1, is reacted with a compound of the formula III
R
4 -W-L III 15 in which W is -SO 2 - or -CO-, 20 R4 is as defined in Claim 1, and L is Cl, Br, I or a free or a reactive functionally derivatized OH group, 25 or c) that for preparing compounds of the formula I -8 N,(N in which R' is HN or N O
CH
3
R
3 and X together are -CO-N-, thus forming a 5 membered ring, 5 Y is 0, W is a bond, and R 2 and R 4 are as defined in Claim 1, 10 a compound of the formula II R1 II X Y'H R3 in which 15 {"' N'O N, R' is HN or N 0
CH
3 R3 and X together are -CO-N-, thus forming a 5 membered ring, 20 Y is 0, and R 2 is as defined in Claim 1, is reacted with a compound of the formula IV 25 R 4 -W-OH - IV in which -9 W is a bond, and R 4 is as defined in Claim 1, 5 or d) that for preparing compounds of the formula I {" -N' N, {-14.f in which
R
1 is HN or N , O
CH
3 10
R
3 and X together are -CO-N-, thus forming a 5 membered ring, Y is -N N-, 15 W is a bond, R 4 is - [C (R 5 ) 2 ]Ar or -[C(R 5 )21mHet, 20 m is 0, and R 2 is as defined in Claim 1, a compound of the formula V 25 RI v OX L R2 R3lO in which - 10 { N'O { 'N, R1 is HN4 or N-$ 0 CH3
R
3 and X together are -CO-N-, thus forming a 5 5 membered ring, and L is Cl, Br, I or a free or a reactive functionally derivatized OH group, 10 and R 2 is as defined in Claim 1, is reacted with a compound of the formula VI
R
4 -W-Y-H VI 15 in which W is a bond, Y is -N N-, 20 R 4 is -[C(R 5
)
2 ]mAr or -[C(R ) 2 ] mHet and m is 0, 25 or e) that for preparing compounds of the formula I {~N% .. { N% in which R1 is HN or N 30 0 CH 3 - 11 R 3 and X together are -CO-N-, thus forming a 5 membered ring, Y is NR 5 , -N N- , -N N or 5 5 R5 \ RS N N W is -CONH-, 10 and R 2 and R 4 are as defined in Claim 1, a compound of the formula II RH R R30'O 15 in which R1 is HN4 or N 0 CH3 20 R 3 and X together are -CO-N-, thus forming a 5 membered ring, Y -is NR5, -N N- -N N or R5 - 12 R5 R5 N N and R 2 and R 5 are as as defined in Claim 1, 5 is reacted with a compound of the formula VII
R
4 -N=C=O VII in which 10 R 4 is as defined in Claim 1, or 15 f) that for preparing compounds of the formula I { N in which
R
1 is
HN
4 or N-= , O C3 R3 and X together are -CO-N-, thus forming a 5 20 membered ring, Y is N[C(Rs) 2 ]m-COOR 5 , W is SO 2 , 25 and R 2 and R 4 are as defined in Claim 1, a compound of the formula II - 13 RI X Y'H R3-0 in which { N'N, R is or 5 0 CH 3 R3 and X together are -CO-N-, thus forming a 5 membered ring, 10 Y is N[C(R 5
)
2 ]m-COOR 5 , and R 2 and R 5 are as defined in Claim 1, is reacted with a compound of the formula VIII 15
R
4 -S0 2 -L VIII in which 20 L is Cl, Br, I or a free or a reactive functionally derivatized OH group, and R 4 is as defined in Claim 1, 25 or g) that for preparing compounds of the formula I in which X is NH and - 14 R 3 is H and R', R 2 , R 4 , Y and W are as defined in Claim 1, 5 these compounds are liberated from their oxazolidinone derivatives by treatment with a solvolysing or hydrogenolysing agent, or 10 h) that for preparing compounds of the formula I in which R 1 is -C(=NH) -NH 2 , 15 a cyano group is converted into an amidino group, or i) in a compound of the formula I, one or more 20 radicals Y, R1, R 2, R 3 and/or R 4 are converted into one or more radicals R1, R 2 , R3 and/or R 4 , by, for example, 25 i) hydrolysing an ester group to give a carboxyl group, ii) reducing a nitro group, 30 iii) acylating an amino group, and/or k) converting a base or acid of the formula I into 35 one of its salts. For all Ehe radicals which occur several times, such 5 as, for example, Rs, the meanings thereof are independent of one another.
- 15 Hereinabove and hereinbelow, the radicals or parameters L, W, X, Y, R 1 , R 2 , R', R 4 , Rs, m and n have the meanings given for the formulae I to VIII, unless expressly 5 stated otherwise. Solvates is [sic] addition compounds with, for example, organic inert solvents, such as, for example, with alcohols such as methanol, ethanol or propanol. 10 In the above formulae, A is alkyl, is linear or branched, and has 1 to 20, preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 C atoms. A is preferably methyl, furthermore ethyl, propyl, isopropyl, butyl, isobutyl, 15 sec-butyl or tert-butyl, furthermore also pentyl, 1-, 2- or 3-methylbutyl, 1,1-, 1,2- or 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-, 2-, 3- or 4-methylpentyl, 1,1-, 1,2-, 1,3-, 2,2-, 2,3- or 3,3-dimethylbutyl, 1 or 2-ethylbutyl, 1-ethyl-1-methylpropyl, 1-ethyl-2 20 methylpropyl, 1,1,2- or 1,2,2-trimethylpropyl, heptyl, octyl, nonyl or decyl. A is furthermore, for example, trifluoromethyl, pentafluoroethyl, allyl or crotyl. 25 ORs is OH, OA or benzyloxy, with OA preferably being methoxy, ethoxy, propoxy, butyloxy or hexyloxy. Cycloalkyl is preferably cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl. Cycloalkyl is, 30 for example, also the radical of a bicyclic terpene, such as, for example, 3-menthyl; particular preference is given to the camphor-10-yl radical. COR' is acyl and is preferably formyl, acetyl, 35 propionyl, furthermore also butyryl, pentanoyl or hexanoyl. Hal is preferably F, Cl or Br, but also I.
(K)
- 16 R2 is preferably H, fluorine, chlorine, bromine, iodine, hydroxyl, methoxy, ethoxy, propoxy, nitro, amino, methylamino, dimethylamino, ethylamino, diethyl amino, acetamido, sulfonamido, methylsulfonamido, 5 phenylsulfonamido, methylthio, ethylthio, methyl sulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, phenylsulfinyl, phenylsulfonyl, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, furthermore also acyl or benzoyl. 10 R2 is, in particular, H.
R
3 is preferably A, benzyl, CH 2 COOH or CH 2 COOA, but in particular H.
R
4 is preferably, for example, A, cycloalkyl, Ar, CH 2 Ar, 15 CH 2
CH
2 Ar, CH 2 Het, CH 2
CH
2 Het or CH=CH-Ar.
R
5 is H, A or benzyl, but in particular H. X is 0, NH, NA or N-benzyl, furthermore also CH 2 R 3 and X together are also -CO-N-, thus forming, together with the -CH 2 -CH-0- unit, a five-membered 20 ring. Y is preferably, for example, 0, NH, N-methyl, N-ethyl, N-Ar, N-CH 2 -Ar, N-Het, N-CH 2 -Het, N-COOA, N-CH 2 -COOA, N
CH
2 -COOH, N-CH 2 -COObenzyl,
-R
5 eRS -ND -N R R -N N-, N'ZNN , 25 \
NCH
2
-CONH
2 , NCH 2 -CONHA, NCH 2
-CONA
2 , NCH 2
-CONR
5 Ar or NCH 2 CONAr 2 30 W is preferably, for example, a bond, -SO 2 - or -CO-, furthermore also -COO- or -CONH-. Ar is preferably unsubstituted phenyl or naphthyl, furthermore preferably naphthyl or phenyl which is 35 mono-, di- or trisubstituted, for example by A, fluorine, chlorine, bromine, iodine, hydroxyl, methoxy, ethoxy, propoxy, butoxy, pentyloxy, hexyloxy, - 17 benzyloxy, phenethyloxy, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, phenylsulfinyl, phenylsulfonyl, nitro, amino, methylamino, ethylamino, dimethylamino, 5 diethylamino, formamido, acetamido, propionylamino, butyrylamino, methylsulfonamido, ethylsulfonamido, propylsulfonamido, butylsulfonamido, phenylsulfonamido, (4-methylphenyl) sulfonamido, carboxymethoxy, carboxyethoxy, methoxycarbonylmethoxy, methoxycarbonyl 10 ethoxy, hydroxymethoxy, hydroxyethoxy, methoxyethoxy, carboxyl, methoxycarbonyl, ethoxycarbonyl, cyano, phenylaminocarbonyl, acyl or benzoyl, furthermore also biphenyl. 15 Ar is therefore preferably, for example, o-, m- or p tolyl, o-, m- or p-ethylphenyl, o-, m- or p propylphenyl, o-, m- or p-isopropylphenyl, o-, m- or p tert-butylphenyl, o-, m- or p-hydroxyphenyl, o-, m- or p-nitrophenyl, o-, m- or p-aminophenyl, o-, m- or p-(N 20 methylamino)phenyl, o-, m- or p-acetamidophenyl, o-, m or p-methoxyphenyl, o-, m- or p-ethoxyphenyl, o-, m- or p-carboxyphenyl, o-, m- or p-methoxycarbonylphenyl, o-, m- or p- (N, N-dimethylamino) phenyl, o-, m- or p-(N ethylamino)phenyl, o-, m- or p-(N,N-diethylamino) 25 phenyl, o-, m- or p-acetylphenyl, o-, m- or p formylphenyl, o-, m- or p-fluorophenyl, o-, m- or p bromophenyl, o-, m- or p-chlorophenyl, o-, m- or p methylsulfonylphenyl, o-, m- or p-(phenyl sulfonamido)phenyl, o-, m- or p-(methylsulfonamido) 30 phenyl, o-, m- or p-methylthiophenyl, furthermore preferably 2,3-, 2,4-, 2,5-, 2,6-, 3,4- or 3,5 difluorophenyl, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- or 3,5 dichlorophenyl, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- or 3,5 dibromophenyl, 2,4- or 2,5-dinitrophenyl, 2,5- or 3,4 35 dimethoxyphenyl, 3-nitro-4-chlorophenyl, 3-amino-4 chloro-, 2-amino-3-chloro-,-- 2-amino-4-chloro-, 2-amino 5-chloro-, or 2-amino-6-chlorophenyl, 2-nitro-4-N,N dimethylamino- or 3-nitro-4-N,N-dimethylaminophenyl, 2,3-diaminophenyl, 2,3,4-, 2,3,5-, 2,3,6-, 2,4,6- or - 18 3,4,5-trichlorophenyl, 2,4,6-trimethoxyphenyl, 2 hydroxy-3, 5-dichlorophenyl, p-iodophenyl, 3, 6-dichloro 4-aminophenyl, 4-fluoro-3-chlorophenyl, 2-fluoro-4 bromophenyl, 2,5-difluoro-4-bromophenyl, 3-bromo-6 5 methoxyphenyl, 3-chloro-6-methoxyphenyl, 3-chloro-4 acetamidophenyl, 3-fluoro-4-methoxyphenyl, 3-amino-6 methylphenyl, 3-chloro-4-acetamidophenyl or 2,5 dimethyl-4-chlorophenyl. 10 Ar is very particularly preferably phenyl which is unsubstituted or mono-, di- or trisubstituted by amino, OR , Hal, CN, alkyl having 1-10 carbon atoms, CF 3 ,
CH
3
SO
2 , OCF 3 , acetamido, -C(=NH)-NH 2 , methoxycarbonyl or ethoxycarbonyl, furthermore naphthyl which is mono 15 substituted by Hal, dimethylamino or alkoxy having 1-6 carbon atoms and also unsubstituted biphenyl. Ar' is in particular, for example, phenyl or naphthyl, furthermore preferably, for example, o-, m- or p-tolyl, 20 o-, m- or p-ethylphenyl, o-, m- or p-propylphenyl, o-, m- or p-isopropylphenyl, o-, m- or p-tert-butylphenyl, o-, m- or p-hydroxyphenyl, o-, m- or p-nitrophenyl, o-, m- or p-aminophenyl, o-, m- or p-(N-methylamino)phenyl, o-, m- or p-acetamidophenyl, o-, m- or p-methoxyphenyl, 25 o-, m- or p-ethoxyphenyl, o-, m- or p-carboxyphenyl, o-, m- or p-methoxycarbonylphenyl, o-, m- or p-(N,N dimethylamino)phenyl, o-, m- or p- (N-ethylamino) phenyl, o-, m- or p-(N,N-diethylamino)phenyl, o-, m- or p acetylphenyl, o-, m- or p-formylphenyl, o-, m- or p 30 fluorophenyl, o-, m- or p-bromophenyl, o-, m- or p chlorophenyl or o-, m- or p-methylsulfonylphenyl. Het is preferably, for example, 2- or 3-furyl, 2- or 3 thienyl, 1-, 2- or 3-pyrrolyl, 1-, 2-, 4- or 5 35 imidazolyl, 1-, 3-, 4- or 5-pyrazolyl, 2-, 4- or 5 oxazolyl, 3-, 4- or 5-isoxazolyl, 2-, 4- or 5 thiazolyl, 3-, 4- or 5-isothiazolyl, 2-, 3- or 4 pyridyl, 2-, 4-, 5- or 6-pyrimidinyl, furthermore preferably 1,2,3-triazol-1-, -4- or -5-yl, 1,2,4- - 19 triazol-l-, -3- or -5-yl, 1- or 5-tetrazolyl, 1,2,3 oxadiazol-4- or -5-yl, 1,2,4-oxadiazol-3- or -5-yl, 1,3,4-thiadiazol-2- or -5-yl, 1,2,4-thiadiazol-3- or -5-yl, 1,2,3-thiadiazol-4- or -5-yl, 3- or 4 5 pyridazinyl, pyrazinyl, 1-, 2-, 3-, 4-, 5-, 6- or 7 indolyl, 4- or 5-isoindolyl, 1-, 2-, 4- or 5 benzimidazolyl, 1-, 3-, 4-, 5-, 6- or 7-benzopyrazolyl, 2-, 4-, 5-, 6- or 7-benzoxazolyl, 3-, 4-, 5-, 6- or 7 benzisoxazolyl, 2-, 4-, 5-, 6- or 7-benzothiazolyl, 2-, 10 4-, 5-, 6- or 7-benzisothiazolyl, 4-, 5-, 6- or 7-benz 2,1,3-oxadiazolyl, 2-, 3-, 4-, 5-, 6-, 7- or 8 quinolyl, 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolyl, 3-, 4-, 5-, 6-, 7- or 8-cinnolinyl, 2-, 4-, 5-, 6-, 7- or 8-quinazolinyl, 5- or 6-quinoxalinyl, 2-, 3-, 5-, 6-, 15 7- or 8-2H-benzo[1,4]oxazinyl, furthermore preferably 1,3-benzodioxol-5-yl, 1,4-benzodioxan-6-yl, 2,1,3 benzothiadiazol-4- or -5-yl or 2,1,3-benzoxadiazol-5 yl. The heterocyclic radicals may also be partially or 20 fully hydrogenated. Het may also be, for example, 2,3-dihydro-2-, -3-, -4 or -5-furyl, 2,5-dihydro-2-, -3-, -4- or -5-furyl, tetrahydro-2- or -3-furyl, 1,3-dioxolan-4-yl, tetrahydro-2- or -3-thienyl, 2,3-dihydro-l-, -2-, -3-, 25 -4- or -5-pyrrolyl, 2,5-dihydro-l-, -2-, -3-, -4- or -5-pyrrolyl, 1-, 2- or 3-pyrrolidinyl, tetrahydro-l-, -2- or -4-imidazolyl, 2,3-dihydro-1-, -2-, -3-, -4- or -5-pyrazolyl, tetrahydro-l-, -3- or -4-pyrazolyl, 1,4 dihydro-l-, -2-, -3- or -4-pyridyl, 1,2,3,4-tetrahydro 30 1-, -2-, -3-, -4-, -5- or -6-pyridyl, 1-, 2-, 3- or 4 piperidinyl, 2-, 3- or 4-morpholinyl, tetrahydro-2-, -3- or -4-pyranyl, 1,4-dioxanyl, 1,3-dioxan-2-, -4- or -5-yl, hexahydro-l-, -3- or -4-pyridazinyl, hexahydro 1-, -2-, -4- or -5-pyrimidinyl, 1-, 2- or 3 35 piperazinyl, 1,2,3,4-tetrahydro-l-, -2-, -3-, -4-, -5-, -6-, -7- or -8-quinolyl, -- 1,2,3,4-tetrahydro-1-, -2-, -3-, -4-, -5-, -6-, -7- or -8-isoquinolyl, 2-, 3-, 5-, 6-, 7- or 8-3,4-dihydro-2H-benzo[1,4]oxazinyl, further more preferably 2,3-methylenedioxyphenyl, 3,4- - 20 methylenedioxyphenyl, 2, 3-ethylenedioxyphenyl, 3,4 ethylenedioxyphenyl, 3,4- (difluoromethylenedioxy) phenyl, 2,3-dihydrobenzofuran-5- or -6-yl, 2,3- (2-oxo methylenedioxy)phenyl or else 3,4-dihydro-2H-1,5 5 benzodioxepin-6- or -7-yl, furthermore preferably 2,3 dihydrobenzofuranyl or 2,3-dihydro-2-oxofuranyl. Het is unsubstituted or mono- or polysubstituted by Hal, A, Ar', COOR 5 , CN, N(R 5
)
2 , NO 2 , Ar-CONH-CH 2 10 "Poly" means di, tri, tetra or penta. Het is very particularly preferably thiazole-2-, 4- or -5-yl, thiophen-2- or -5-yl, chroman-6-yl, pyridin-2-, -3- or -4-yl, pyrimidin-2- or -5-yl, benzothiophen 2-yl, 1,3-benzodioxol-4- or -5-yl, 1,4-benzodioxan-5 15 or -6-yl, 2,1,3-benzothiadiazol-4- or -5-yl which is unsubstituted or mono- or polysubstituted by Hal, A, phenyl, OR , COOR 5 , CN, N(Rs) 2 , NO 2 , NHCOA, NHCOphenyl and/or carbonyl oxygen. 20 The compounds of the formula I may have one or more chiral centres and may therefore be present in various stereoisomeric forms. The formula I embraces all of these forms. 25 Consequently, the invention provides in particular those compounds of the formula I in which at least one of the abovementioned radicals has one of the preferred meanings given above. Some preferred groups of compounds can be expressed by the following moieties Ia 30 to Ii which correspond to the formula I and where the radicals which are not defined more specifically have the meaning given for the formula I, but where in Ia R 2 is H; 35 in Ib R 3 is R 5 or - (CH 2 )m-COOR in Ic R 4 is A, cycloalkyl,
-(CH
2 )nAr [sic],
(CH
2 )mHet or -CH=CH-Ar; - 21 in Id Y is 0, NRs, N(CH 2 )m-Ar,
N(CH
2 )m-Het,
N(CH
2 )mCOOR 5 , -N N-, 5
R
5
R
5 -NQ-N 5or 10 in Ie A is alkyl having 1-20 C atoms in which one or two CH 2 groups may be replaced by -CH=CH- groups and/or 1-7 H atoms may be replaced by F; 15 in If Ar is naphthyl or phenyl which is unsubstituted or mono-, di- or 1 5 trisubstituted by R1, A, phenyl, OR ,
N(R
5
)
2 , NO 2 , CN, Hal, NHCOA, NHCOphenyl,
NHSO
2 A, NHSO 2 phenyl, COORs,
CON(R
5
)
2 , 20 CONHphenyl, CORs, COphenyl, S (0),A or S (O)nAr; in Ig Ar' is phenyl; 25 in Ih Het is thiazol-2-, -4- or -5-yl, thiophen-2 or -5-yl, chroman-6-yl, pyridin-2-, -3 or -4-yl, pyrimidin-2- or -5-yl, benzothiophen-2-yl, 1,3-benzodioxol-4 or -5-yl, 1,4-benzodioxan-5- or -6-yl or 30 2 ,1,3-benzothiadiazol-4- or -5-yl which is unsubstituted or mono- or polysubstituted by Hal, A, phenyl, OR5, COORs, CN, N(R 5
)
2 , NO 2 , NHCOA, NHCOphenyl and/or carbonyl oxygen; 35 - 22 in Ii R is -C(=NH)-NH 2 , which can also be monosubstituted by -COA, -CO-(CH 2 )m-Ar, -COOA or OH, or is N=, 5
CH
3 R2 is H,
R
3 is R 5 or -(CH 2 )m-COORs R3 and X together are also -CO-N-, thus forming 10 a 5-membered ring, R 4 is A, cycloalkyl,
-(CH
2 ).Ar, -(CH 2 )mHet or -CH=CH-Ar,
R
5 is H, A or benzyl, X is 0, NR 5 or CH 2 , 15 Y is 0, NR 5 , N(CH 2 )m-Ar, N(CH 2 )m-Het, N (CH 2 ) m-COOR 5 , -N N-,
R
5
R
5 5 or N N , 20
NCH
2
-CONH
2 , NCH 2 -CONHA, NCH 2
-CONA
2 , NCH 2 CONR Ar or NCH 2 -CONAr 2 , W is a bond, -SO 2 -, -CO-, -COO- or -CONH-, A is alkyl having 1-20 C atoms in which 25 one or two CH 2 groups may be replaced by -CH=CH- groups and/or 1-7 H atoms may be replaced by F, Ar is phenyl which is unsubstituted or mono-, di- or trisubstituted by NH 2 , OR 30 Hal, CN, alkyl having 1-10 carbon atoms,
CF
3 , CH 3
SO
2 , OCF 3 , acetamido,
-C(=NH)-NH
2 , methoxycarbonyl or ethoxycarbonyl, - 23 furthermore naphthyl which is mono substituted by Hal, dimethylamino or methoxy and also unsubstituted biphenyl. Het is thiazol-2-, -4- or -5-yl, thiophen-2 5 or -5-yl, chroman-6-yl, pyridin-2-, -3 or -4-yl, pyrimidin-2- or -5-yl, benzothiophen-2-yl, 1,3-benzodioxol-4 or -5-yl, 1,4-benzodioxan-5- or - 6 -yl, 2,1,3-benzothiadiazol-4- or -5-yl which 10 is unsubstituted or mono- or polysubstituted by Hal, A, phenyl, OR5
COOR
5 , CN, N(R 5
)
2 , NO 2 , NHCOA, NHCOphenyl and/or carbonyl oxygen. 15 The compounds of the formula I and also the starting materials for their preparation are otherwise prepared by methods known per se, such as are described in the literature (for example in the standard works such as Houben-Weyl, Methoden der organischen Chemie [Methods 20 of Organic Chemistry], Georg-Thieme-Verlag, Stuttgart), and in particular under the reaction conditions which are known and suitable for the reactions mentioned. In these reactions, variants which are known per se and are not mentioned here in more detail can also be 25 utilized. If desired, the starting materials can also be formed in situ, so that they are not isolated from the reaction mixture but are immediately reacted further to 30 give the compounds of the formula I. Compounds of the formula I can preferably be obtained by liberating the compounds of the formula I from one of their functional derivatives by treatment with a 35 solvolysing or hydrogenolysing agent. Preferred~ starting materials for the solvolysis or hydrogenolysis are those which otherwise correspond to the formula I but, instead _of one or more free amino - 24 and/or hydroxyl groups, contain corresponding protected amino and/or hydroxyl groups, preferably those which, instead of an H atom which is bonded to an N atom, carry an amino-protective group, in particular those 5 which, instead of an HN group, carry an R' -N group, in which R' is an amino-protective group, and/or those which, instead of the H atom of a hydroxyl group, carry a hydroxyl-protective group, for example those which correspond to the formula I but, instead of a -COOH 10 group, carry a group -COOR", in which R" is a hydroxyl protective group. Preferred starting materials also include the oxadiazole derivatives which can be converted into the 15 corresponding amidino compounds. The introduction of the oxadiazole group is effected, for example, by reacting the cyano compounds with hydroxylamine and reaction with phosgene, dialkyl 20 carbonate, chloroformic ester, N,N'-carbonyldiimidazole or acetic anhydride. It is also possible for several - identical or different - protected amino and/or hydroxyl groups to 25 be present in the molecule of the starting material. If the protective groups present differ from one another, in many cases they can be cleaved off selectively. The term "amino-protective group" is generally known 30 and relates to groups which are suitable for protecting (blocking) an amino group from chemical reactions but which can easily be removed after the desired chemical reaction has been carried out at other sites of the molecule. Typical such groups are, in particular, 35 unsubstituted or substituted acyl, aryl, aralkoxymethyl or aralkyl groups. Since -the amino-protective groups are removed after the desired reaction (or reaction sequence), their nature and size is otherwise not critical; however, those having 1-20, in particular 1-8 - 25 C atoms are preferred. The term "acyl group" is to be interpreted in the broadest sense in connection with the present process. It includes acyl groups derived from aliphatic, araliphatic, aromatic or heterocyclic 5 carboxylic acids or sulfonic acids, and in particular alkoxycarbonyl, aryloxycarbonyl and, above all, aralkoxycarbonyl groups. Examples of such acyl groups are alkanoyl, such as acetyl, propionyl or butyryl; aralkanoyl, such as phenylacetyl; aroyl, such as 10 benzoyl or toluyl; aryloxyalkanoyl, such as POA; alkoxycarbonyl, such as methoxycarbonyl, ethoxycarbonyl, 2,2,2-trichloroethoxycarbonyl, BOC (tert-butyloxycarbonyl), 2-iodoethoxycarbonyl; aralkyl oxycarbonyl such as CBZ ("carbobenzoxy"), 15 4-methoxybenzyloxycarbonyl, FMOC; arylsulfonyl such as Mtr. Preferred amino-protective groups are BOC and Mtr, and furthermore CBZ, Fmoc, benzyl and acetyl. The term "hydroxyl-protective group" is also generally 20 known and relates to groups which are suitable for protecting a hydroxyl group from chemical reactions but which can easily be removed after the desired chemical reaction has been carried out at other sites of the molecule. Typical such groups are the abovementioned 25 unsubstituted or substituted aryl, aralkyl or acyl groups, and furthermore also alkyl groups. The nature and the size of the hydroxyl-protective groups is not critical, since they are removed again after the desired chemical reaction or reaction sequence; groups 30 having 1-20, in particular 1-10 C atoms are preferred. Examples of hydroxyl-protective groups are, inter alia, benzyl, p-nitrobenzoyl, p-toluenesulfonyl, tert-butyl and acetyl, benzyl and tert-butyl being particularly preferred. 35 The liberation of the compounds of the formula I from their functional derivatives is effected - depending on the protective group used - for example with strong acids, expediently with TFA or perchloric acid, but - 26 also with other strong inorganic acids, such as hydrochloric acid or sulfuric acid, strong organic carboxylic acids, such as trichloroacetic acid, or sulfonic acids, such as benzene- or p-toluenesulfonic 5 acid. The presence of an additional inert solvent is possible but not always necessary. Suitable inert solvents are, preferably, organic solvents, for example carboxylic acids, such as acetic acid, ethers, such as tetrahydrofuran or dioxane, amides, such as DMF, 10 halogenated hydrocarbons, such as dichloromethane, or furthermore also alcohols, such as methanol, ethanol or isopropanol, and water. Mixtures of the abovementioned solvents are furthermore possible. TFA is preferably used in excess without addition of a further solvent, 15 and perchloric acid is used in the form of a mixture of acetic acid and 70% perchloric acid in a ratio of 9:1. The reaction temperatures for the cleavage are expediently between about 0 and about 500, and the reaction is preferably carried out at between 15 and 20 300 (room temperature). The groups BOC, OBut and Mtr can preferably be cleaved off, for example, with TFA in dichloromethane or with about 3 to 5N HCl in dioxane at 15-300, and the FMOC 25 group can be cleaved off with an approximately 5 to 50% solution of dimethylamine, diethylamine or piperidine in DMF at 15-300. Protective groups which can be removed by 30 hydrogenolysis (for example CBZ, benzyl or the liberation of the amidino group from its oxadiazole derivative) can be cleaved off, for example, by treatment with hydrogen in the presence of a catalyst (for example a noble metal catalyst, such as palladium, 35 expediently on a support, such as carbon). Suitable solvents for this reaction- are those mentioned above, in particular, for example, alcohols, such as methanol or ethanol, or amides, such as DMF. The hydrogenolysis is generally carried out at _temperatures between about - 27 0 and 1000 under pressures between about 1 and 200 bar, preferably at 20-30* and 1-10 bar. Hydrogenolysis of the CBZ group is effected readily, for example, on 5 10% Pd/C in methanol or with ammonium formate (instead 5 of hydrogen) on Pd/C in methanol/DMF at 20-30*. Compounds of the formula I in which R1 is or HN4 N O
CH
3 10 R 3 and X together are -CO-N-, thus forming a 5-membered ring, Y is NR 5 -N or
R
5 5 R5 R5 N N1 15 W is -SO 2 - or -CO-, and R 2 and R 4 are as defined in Claim 1, 20 can preferably be obtained by reacting compounds of the formula II with compounds of the formula III. In the compounds of the formula III, L is preferably Cl, Br, I or a reactively modified OH group, such as, 25 for example, an activated ester, an imidazolide or alkylsulfonyloxy having 1-6 C atoms (preferably methylsulfonyloxy), or arylsulfonyloxy having 6-10 C atoms (preferably phenyl- or p-tolylsulfonyloxy).
- 28 The reaction is generally carried out in an inert solvent, in the presence of an acid binder, preferably an alkali metal hydroxide, carbonate or bicarbonate or an alkaline earth metal hydroxide, carbonate or 5 bicarbonate, or of another salt of a weak acid of the alkali metals or alkaline earth metals, preferably of potassium, sodium, calcium or caesium. The addition of an organic base such as triethylamine, dimethylaniline, pyridine or quinoline or of an excess of the amine 10 component of the formula II or of the alkylation derivative of the formula III may also be favourable. Depending on the conditions used, the reaction time is between several minutes and 14 days, the reaction temperature is between approximately 00 and 1500, 15 usually between 200 and 1300. Suitable inert solvents are, for example, hydrocarbons, such as hexane, petroleum ether, benzene, toluene or xylene; chlorinated hydrocarbons, such as 20 trichloroethylene, 1,2-dichloroethane, carbon tetra chloride, chloroform or dichloromethane; alcohols, such as methanol, ethanol, isopropanol, n-propanol, n-butanol or tert-butanol; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran (THF) or 25 dioxane; glycol ethers, such as ethylene glycol monomethyl or monoethyl ether (methylglycol or ethylglycol) or ethylene glycol dimethyl ether (diglyme); ketones, such as acetone or butanone; amides, such as acetamide, dimethylacetamide,
N
30 methylpyrrolidone (NMP) or dimethylformamide (DMF); nitriles, such as acetonitrile; sulfoxides, such as dimethyl sulfoxide (DMSO); carbon disulfide; carboxylic acids, such as formic acid or acetic acid; nitro compounds, such as nitromethane or nitrobenzene; 35 esters, such as ethyl acetate, or mixtures of the solvents mentioned.
- 29 The starting materials of the formulae II and III are generally known. Those which are novel, however, can be prepared by methods known per se. 5 Compounds of the formula I in which R 1 is { or HN4 N O CH 3
R
3 and X together are -CO-N-, thus forming a 5-membered ring, 10 Y is 0, W is a bond, and R 2 and R 4 are as defined in Claim 1, can preferably be obtained by reacting compounds of the formula II in which Y is 0 with compounds of the 15 formula IV in a Mitsunobu reaction in the presence of, for example, triphenylphosphine and diethylazo dicarboxylate in an inert solvent. The starting materials of the formula II in which Y is 20 0, and those of the formula IV, are generally known. Those which are novel, however, can be prepared by methods known per se. Compounds of the formula I 25 in which R1 is { or HN+ N O CH
R
3 and X together are -CO-N-, thus forming a 5-membered ring, - 30 Y is -N N-, W is a bond, R 4 is -[C(R 5
)
2 ]mAr or -[C(R 5
)
2 ]mHet, 5 n [sic] is 0 and R 2 is as defined in Claim 1, can preferably be obtained by reacting compounds of the formula V with compounds of the formula VI. 10 In the compounds of the formula V L is preferably Cl, Br, I or a reactively modified OH group, such as, for example, an activated ester, an imidazolide or alkylsulfonyloxy having 1-6 C atoms (preferably methylsulfonyloxy), or arylsulfonyloxy having 6-10 C 15 atoms (preferably phenyl- or p-tolylsulfonyloxy). The reaction of the compounds of the formula V with compounds of the formula VI is preferably carried out in an inert solvent and at temperatures as indicated 20 above. The starting materials of the formulae V and VI are generally known. Those which are novel, however, can be prepared by methods known per se. 25 Compounds of the formula I in which R' is { 'or HN-4N~ O CH3
R
3 and X together are -CO-N-, thus forming a 5-membered 30 ring, - 31 y is/ or is NR, -N N-,-N -N \5 R5 R5 NVN 5 W is -CONH-, and R 2 and R 4 are as defined in Claim 1, can preferably be obtained by reacting compounds of the formula II in which R 1 is { or HN4 N~ O CHa 10 R 3 and X together are -CO-N-, thus forming a 5-membered ring, is NR 5 , -N N-,-NN \ or N W is -CONH-, and R 2 and R 5 are as defined in Claim 1, with compounds of the formula VII. 20 The reaction of these compounds of the formula II in which W is -CONH- with compounds of the formula VII is preferably carried out in an inert solvent and at temperatures as indicated above. 25 - 32 The starting materials of the formula II in which W is -CONH- and of the formula VII are generally known. Those which are novel, however, can be prepared by methods known per se. 5 Compounds of the formula I {. N {,N. in which R' is 0 'O or HN- N--0 O
CH
3
R
3 and X together are -CO-N-, thus forming a 5-membered ring, 10 Y is N[C(R 5
)
2 ]m-COOR 5 , W is SO 2 , and R 2 and R 4 are as defined in Claim 1 can preferably be obtained by reacting compounds of the formula II 15 in which
R
1 is ' 0 or O HN4 N~-5 O
CH
3 R3 and X together are -CO-N-, thus forming a 5-membered ring, Y is N[C(Rs) 2 ]m-COORs 20 and R 2 and R 5 are as defined in Claim 1, with compounds of the formula VIII. In the compounds of the formula VIII, L is preferably Cl, Br, I or a reactively derivatized OH group, such 25 as, for example, an activated ester, an imidazolide or alkylsulfonyloxy having 1-6 C atoms (preferably methylsulfonyloxy) or arylsulfonyloxy having 6-10 C atoms (preferably phenyl or- p-tolylsulfonyloxy). 30 The reaction of the compounds of the formula II in which Y is N[C(R 5
)
2 ]m-COOR with compounds of the - 33 formula VIII is preferably carried out in an inert solvent and at the temperatures given above. Compounds of the formula I in which 5 X is NH and R3 is H and R1, R 2 , R 4 , Y and W are as defined in Claim 1, can be liberated from their oxazolidinone derivatives by treatment with a solvolysing or hydrogenolyzing 10 agent. This is carried out under conditions like those described under "protective group removal". Compounds of the formula I in which R 1 is -C(=NH)-NH 2 can furthermore be obtained from the corresponding 15 cyano compound. The conversion of a cyano group into an amidino group is carried out by reaction with, for example, hydroxylamine and subsequent reduction of the N-hydroxamidine with hydrogen in the presence of a 20 catalyst, such as, for example, Pd/C. To prepare an amidine of the formula I (R' = -C(=NH)
NH
2 ), ammonia can also be added onto a nitrile of the formula I (R 1 = CN). The addition is preferably carried out in several stages by a procedure in which, in a 25 manner known per se, a) the nitrile is converted with
H
2 S into a thioamide, which is converted with an alkylating agent, for example CH 3 I, into the corresponding S-alkyl-imidothioester, which in turn reacts with NH 3 to give the amidine, b) the nitrile is 30 converted with an alcohol, for example ethanol, in the presence of HCl into the corresponding imidoester, and this is treated with ammonia, or c) the nitrile is reacted with lithium bis(trimethylsilyl)amide and the product is then hydrolysed. 35 Furthermore, it is possible to convert a compound of the formula I i nto another compound of the formula I by 1 2 3 4 converting one or more radicals Y, R, R , R and/or R into one or more radicals Y, R', R , R 3 and/or R , for - 34 example by acylating an amino group or reducing nitro groups (for example by hydrogenation over Raney nickel or Pd/carbon in an inert solvent, such as methanol or ethanol) to amino groups. 5 Esters can be hydrolysed, for example with acetic acid or with NaOH or KOH in water, water-THF or water dioxane at temperatures between 0 and 1000. 10 It is furthermore possible to acylate free amino groups in a customary manner with an acyl chloride or acid anhydride or to alkylate with an unsubstituted or substituted alkyl halide, expediently in an inert solvent, such as dichloromethane or THF, and/or in the 15 presence of a base, such as triethylamine or pyridine, at temperatures between -60 and +300. A base of the formula I can be converted into the associated acid addition salt with an acid, for example 20 by reaction of equivalent amounts of the base and the acid in an inert solvent, such as ethanol, and subsequent evaporation. Acids which give physiologically acceptable salts are particularly suitable for this reaction. Thus, it is possible to use 25 inorganic acids, for example sulfuric acid, nitric acid, hydrohalic acids, such as hydrochloric acid or hydrobromic acid, phosphoric acids, such as orthophosphoric acid, sulfaminic acid, or furthermore organic acids, in particular aliphatic, alicyclic, 30 araliphatic, aromatic or heterocyclic mono- or polybasic carboxylic, sulfonic or sulfuric acids, for example formic acid, acetic acid, propionic acid, pivalic acid, diethylacetic acid, malonic acid, succinic acid, pimelic acid, fumaric acid, maleic acid, 35 lactic acid, tartaric acid, malic acid, citric acid, gluconic acid, ascorbic- acid, nicotinic acid, isonicotinic acid, methane- or ethanesulfonic acid, ethanedisulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, -p-toluenesulfonic acid, - 35 naphthalene-mono- or -disulfonic acids and lauryl sulfuric acid. Salts with physiologically unacceptable acids, for example picrates, can be used for isolation and/or purification of the compounds of the formula I. 5 On the other hand, compounds of the formula I can be converted with bases (for example sodium hydroxide, potassium hydroxide, sodium carbonate or potassium carbonate) into the corresponding metal, in particular 10 alkali metal or alkaline earth metal salts or into the corresponding ammonium salts. It is also possible to use physiologically acceptable organic bases, such as, for example, ethanolamine. 15 Owing to their molecular structure, the compounds of the formula I according to the invention can be chiral and can consequently be present in various enantiomeric forms. They may therefore be present in racemic or in optically active form. 20 Since the pharmaceutical activity of the racemates and/ or the stereoisomers of the compounds according to the invention may differ, it may be desirable to use the enantiomers. In these cases, the end product or even 25 the intermediates may be separated into enantiomeric compounds using chemical or physical means known to the person skilled in the art, or they may even be employed as such in the synthesis. 30 In the case of racemic amines, diastereomers are formed from the mixture by reaction with an optically active separating agent. Suitable separating agents are, for example, optically active acids, such as the R- and S-forms of tartaric acid, diacetyltartaric acid, 35 dibenzoyltartaric acid, mandelic acid, malic acid, lactic acid, suitable N-protected amino acids (for example N-benzoylproline or N-benzenesulfonylproline) or the various optically active camphorsulfonic acids. A chromatographic separation of the enantiomers can - 36 also be advantageously carried out with the aid of an optically active separating agent (for example dinitrobenzoylphenylglycine, cellulose triacetate or other carbohydrate derivatives or chiral derivatized 5 methacrylate polymers immobilized on silica gel). Solvents which are suitable for this purpose are aqueous or alcoholic solvent mixtures, such as, for example, hexane/isopropanol/acetonitrile, for example in the ratio 82:15:3. 10 The invention furthermore provides the use of the compounds of the formula I and/or their physiologically acceptable salts for the preparation of pharmaceutical formulations, in particular by a non-chemical route. 15 For this purpose, they can be brought into a suitable dosage form together with at least one solid, liquid and/or semi-liquid carrier or auxiliary, and if appropriate in combination with one or more further active compounds. 20 The invention furthermore provides pharmaceutical formulations comprising at least one compound of the formula I and/or one of its physiologically acceptable salts. 25 These formulations can be used as medicaments in human or veterinary medicine. Possible carriers are organic or inorganic substances which are suitable for enteral (for example oral), parenteral or topical 30 administration and do not react with the novel compounds, for example water, vegetable oils, benzyl alcohols, alkylene glycols, polyethylene glycols, glycerol triacetate, gelatine, carbohydrates, such as lactose or starch, magnesium stearate, talc and 35 petroleum jelly. Tablets, pills, coated tablets, capsules, powders, granules, syrups, juices or drops are used, in particular, for oral administration, suppositories are used for rectal administration, solutions, preferably oily _or aqueous solutions, and - 37 furthermore suspensions, emulsions or implants are used for parenteral administration, and ointments, creams or powders are used for topical administration. The novel compounds can also be lyophilized and the resulting 5 lyophilisates can be used, for example, for the preparation of injection formulations. The formulations mentioned can be sterilized and/or comprise auxiliaries, such as lubricants, preservatives, stabilizers and/or wetting agents, emulsifiers, salts 10 for influencing the osmotic pressure, buffer substances, dyestuffs, flavourings and/or several further active compounds, for example one or more vitamins. 15 The compounds of the formula I and their physiologically acceptable salts can be employed for combating and preventing thromboembolic disorders, such as thrombosis, myocardial infarction, arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis 20 after angioplasty and claudicatio intermittens. For this purpose, the substances according to the invention are usually preferably administered in dosages of between about 1 and 500 mg, in particular 25 between 5 and 100 mg per dosage unit. The daily dosage is preferably between about 0.02 and 10 mg/kg of body weight. However, the specific dose for each patient depends on the most diverse factors, for example on the activity of the specific compound employed, on the age, 30 body weight, general state of health, sex, diet, on the administration time and route, and on the rate of excretion, medicament combination and severity of the particular disease to which the therapy applies. Oral administration is preferred. 35 All temperatures hereinabove and hereinbelow are given in OC. In the ~following examples, "customary work-up" means: water is added, if necessary, the pH is brought to values of between 2 and 10, if necessary, depending - 38 on the structure of the end product, the mixture is extracted with ethyl acetate or dichloromethane, the organic phase is separated off, dried over sodium sulfate and evaporated and the residue is purified by 5 chromatography over silica gel and/or crystallization. Rf values are for silica gel; mobile phase: ethyl acetate/methanol 9:1. Mass spectrometry (MS): 10 EI (electron impact ionization) M' FAB (fast atom bombardment) (M+H)* Example 1 15 A solution of 100 mg of 3 -[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl] -5-piperazin-1-ylmethyl oxazolidin-2-one ("A") [obtainable by reaction of 3-[4 (5-methyl-[1,2,4]oxadiazol-3-yl)phenyll-2-oxoxazolidin 5-ylmethyl methanesulphonate with 1-tert 20 butoxycarbonylpiperazine and sodium bicarbonate in acetonitrile; removal of the BOC group with HCl/dioxane and subsequent treatment with sodium hydroxide solution] and 110 mg of 2 ,4, 6 -trichlorobenzenesulphonyl chloride in 10 ml of dichloromethane is admixed with 25 400 mg of 4 -dimethylaminopyridine on polystyrene and stirred at room temperature for 18 hours. The mixture is filtered and the solvent is removed, giving 3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]5-[ 4
-(
2 4 ,6-tri chlorophenylsulfonyl) piperazin-1-ylmethyl] oxazolidin-2 30 one, FAB 586/588. Similarly, reaction of "A" with 4-biphenylylsulfonyl chloride gives 35 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenylj-5 [4- ( 4 -biphenylylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; - 39 with 2-phenylvinylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- (2-phenylvinylsulfonyl)piperazin-1-ylmethylJ oxazolidin-2-one; 5 with 2-nitrophenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- ( 2 -nitrophenylsulfonyl)piperazin-1-ylmethylJ oxazolidin-2-one; 10 with 2, 5-dimethoxyphenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,41 -oxadiazol-3-yl)phenyl] -5 [4- (2, 5-dimethoxyphenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 15 with 2-naphthylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-( 2 -naphthylsulfonyl)piperazin-1-ylmethyl]oxazolidin 2-one; 20 with 2 -chloro-4-fluorophenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl -5 [4- ( 2 -chloro-4-fluorophenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; 25 with (2-acetamido-4-methylthiazol-5-yl) sulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- ( (2-acetamido-4-methylthiazol-5-yl) sulfonyl) 30 piperazin-1-ylmethyl]oxazolidin-2-one; with 2-cyanophenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- ( 2 -cyanophenylsulfonyl)piperazin-1-ylmethylJ 35 oxazolidin-2-one; with 5-nitro-2-methylphenylsulfonyl chloride gives - 40 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(5-nitro-2-methylphenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; 5 with benzylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 (4-benzylsulfonylpiperazin-l-ylmethyl)oxazolidin-2-one; with decylsulfonyl chloride gives 10 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 (4-decylsulfonylpiperazin-1-ylmethyl)oxazolidin-2-one; with 2-trifluoromethylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 15 [4-(2-trifluoromethylphenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; with 3-chloro-4-fluorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 20 [4-(3-chloro-4-fluorophenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; with 4-chloro-2,5-dimethylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 25 [4-( 4 -chloro-2,5-dimethylphenylsulfonyl)piperazin-l ylmethyl]oxazolidin-2-one; with 2-fluorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 30 [4-(2-fluorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; with 3,4-dibromophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 35 [4-(3,4-dibromophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; with 3-chlorophenylsulfonyl chloride gives - 41 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-( 3 -chlorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 5 with 2 ,6-dichlorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(2,6-dichlorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 10 with 3,4-dichlorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(3, 4 -dichlorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 15 with 3,5-dichlorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(3,5-dichlorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 20 with 2-naphthylcarbonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-( 2 -naphthylcarbonyl)piperazin-1-ylmethyl]oxazolidin 2-one; 25 with methylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 (4-methylsulfonylpiperazin-l-ylmethyl)oxazolidin-2-one; with 2 -methylsulfonylphenylsulfonyl chloride gives 30 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-( 2 -methylsulfonylphenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; with 2-nitrobenzylsulfonyl chloride gives 35 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(2-nitrobenzylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; - 42 with (4-methoxycarbonyl-3-methoxythiophen-2 -yl) sulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-((4-methoxycarbonyl-3-methoxythiophen-2 5 yl) sulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; with 3-trifluoromethylphenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4-(3-trifluoromethylphenylsulfonyl)piperazin-1-yl 10 methyl]oxazolidin-2-one; with 4-trifluoromethoxyphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4- (4-trifluoromethoxyphenylsulfonyl)piperazin-1-yl methyl] oxazolidin-2-one; 15 with (lS) - (camphor-10-yl) sulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- (( (lS) camphor-10-yl) sulfonyl)piperazin-1-ylmethyl] oxazolidin-2 -one; 20 with (1R) - (camphor-10-yl) sulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4- ( ( (lR)camphor-10-yl)sulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 25 with (2,2,5,7,8-pentamethylchroman-6-yl)sulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(( 2 ,2,5,7,8-pentamethylchroman-6-yl)sulfonyl) 30 piperazin-1-ylmethyl]oxazolidin-2-one; with 4-isopropylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-isopropylphenylsulfonyl)piperazin-1-ylmethyl] 35 oxazolidin-2-one; with 4-tert-butylphenylsulfonyl chloride gives - 43 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-tert-butylphenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 5 with 4-butylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-butylphenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 10 with 3
,
5 -dinitro-4-methoxyphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(3,5-dinitro-4-methoxyphenylsulfonyl)piperazin-1 ylmethylloxazolidin-2-one; 15 with ethylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenylJ-5 (4-ethylsulfonylpiperazin-1-ylmethyl)oxazolidin-2-one; with 4-nitrophenylsulfonyl chloride gives 20 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyll-5 [4-(4-nitrophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; with 2-trifluoromethoxyphenylsulfonyl chloride gives 25 3
-[
4 -(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(2-trifluoromethoxyphenylsulfonyl)piperazin-- 1 ylmethyl]oxazolidin-2-one; with 2
,
4 -dinitrophenylsulfonyl chloride gives 30 3
-[
4 -(5-methyl-[1,2,4-oxadiazol-3-yl)phenyl]-5 [4-(2,4-dinitrophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; with isopropylsulfonyl chloride gives 35 3
-[
4 -(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 (4-isopropylsulfonylpiperazin-1-ylmethyl)oxazolidin-2 one; with 4-ethylphenylsulfonyl chloride gives - 44 3-[4-(5-methyl-[1,2,4J-oxadiazol-3-yl)phenyl]-5 [4- (4-ethylphenylsulfonyl)piperazin-1-ylmethyl oxazolidin-2-one; 5 with 4-bromo-2-trifluoromethoxyphenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- ( 4 -bromo-2-trifluoromethoxyphenylsulfonyl)piperazin 1-ylmethyl]oxazolidin-2-one; 10 with 2,3,4-trifluorophenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyll -5 [4- (2,3,4-trifluorophenylsulfonyl)piperazin-l ylmethyl]oxazolidin-2-one; 15 with 3,4-difluorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(3,4-difluorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 20 with 2,2,2-trifluoroethylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(2,2,2-trifluoroethylsulfonyl)piperazin-l ylmethyl]oxazolidin-2-one; 25 with 3-nitro-4-methylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(3-nitro-4-methylphenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; 30 with 2-nitro-6-chlorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(2-nitro-6-chlorophenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; 35 with 2, 5-dimethoxyphenylacetyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- (2, 5-dimethoxyphenylacetyl)piperazin-1-ylmethyl] oxazolidin-2-one; - 45 with 3,4-dichlorobenzoyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- (3,4-dichlorobenzoyl)piperazin-1-ylmethyl] 5 oxazolidin-2-one; with 3-fluorobenzoyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(3-fluorobenzoyl)piperazin-1-ylmethyl]oxazolidin-2 10 one; with 4-trifluoromethoxybenzoyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4-(4-trifluoromethoxybenzoyl)piperazin-1-ylmethyl] 15 oxazolidin-2-one; with 3-pyridylcarbonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4-(3-pyridylcarbonyl)piperazin-1-ylmethyl]oxazolidin 20 2-one; with 2-benzothienylcarbonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(2-benzothienylcarbonyl)piperazin-1-ylmethyl] 25 oxazolidin-2-one; with 4-chlorophenylacetyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-chlorophenylacetyl)piperazin-1-ylmethyl] 30 oxazolidin-2-one; with 1-naphthylcarbonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyll-5 [4-(1-naphthylcarbonyl)piperazin-1-ylmethyl]oxazolidin 35 2-one; with (1,3-benzodioxol-5-yl)carbonyl chloride gives - 46 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-((1,3-benzodioxol-5-yl)carbonyl)piperazin-1-yl methyl]oxazolidin-2-one; 5 with 3-nitrobenzoyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(3-nitrobenzoyl)piperazin-1-ylmethyl]oxazolidin-2 one; 10 with 4-biphenylylcarbonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-biphenylylcarbonyl)piperazin-1-ylmethyl] oxazolidin-2-one; with cyclopentylcarbonyl chloride gives 15 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(cyclopentylcarbonyl)piperazin-1-ylmethyl] oxazolidin-2-one; with [5-chloro-l-(4-methylphenyl)-lH-pyrazol-4-yl] 20 sulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4-[5-chloro-l-(4-methylphenyl)-lH-pyrazol-4 yl)sulfonyl]piperazin-1-ylmethyl}oxazolidin-2-one; 25 with 4-chlorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-chlorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 30 with 5,7,7-trimethyl-2-(1,3,3-trimethylbutyl)octyl sulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4-[5,7,7-trimethyl-2-(1,3,3-trimethylbutyl)octyl sulfonyl]piperazin-1-ylmethyl}oxazolidin-2-one; 35 with 2-butoxy-5-(1,1-dimethylpropyl)phenylsulfonyl chloride gives - - 47 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4-[2-butoxy-5-(1,1-dimethylpropyl)phenylsulfonyl] piperazin-1-ylmethyl}oxazolidin-2-one; 5 with 2-butoxy-5-(1,1,3,3-tetramethylbutyl)phenyl sulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4-[2-butoxy-5-(1,1,3,3-tetramethylbutyl)phenyl sulfonyl]piperazin-1-ylmethyl}oxazolidin-2-one; 10 with 2-nitro-4-trifluoromethylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-( 2 -nitro-4-trifluoromethylphenylsulfonyl)piperazin 15 1-ylmethyl]oxazolidin-2-one; with 4-bromo-2-ethylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-bromo-2-ethylphenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; 20 with 4-trifluoromethylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-trifluoromethylphenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; 25 with 4-trifluoromethylphenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-trifluoromethylphenylsulfonyl)piperazin-1-yl methyl]oxazolidin-2-one; 30 with 3,4-difluorophenylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-( 3 ,4-difluorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 35 with 1-naphthylsulfonyl chloride gives 3-[4--(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(l-naphthylsulfonyl)piperazin-1-ylmethyl]oxazolidin 2-one; - 48 with 4-methoxyphenylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- (4-methoxyphenylsulfonyl)piperazin-1-ylmethyl] 5 oxazolidin-2-one; with 4-tolylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(4-tolylsulfonyl)piperazin-1-ylmethyl]oxazolidin-2 10 one; with 4-propylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4-(4-propylsulfonyl)piperazin-1-ylmethyl]oxazolidin-2 15 one; with 6-chloro-2-naphthylsulfonyl chloride gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4- (6-chloro-2-naphthylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 20 with 2-(naphth-1-yl)ethylsulfonyl chloride gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4- [2- (naphth-1-yl)ethylsulfonyl]piperazin-l ylmethyl}oxazolidin-2-one; 25 with isobutyl chloroformate gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-isobutyloxycarbonyl)piperazin-1-ylmethyl] oxazolidin 2-one. 30 Example 2 A solution of 100 mg of 3- [4- (5-methyl- [1,2,4] oxadiazol-3-yl)phenyl] -5- [4- (2,4,6-trichlorophenyl 35 sulfonyl)piperazin-1-ylmethyl]oxazolidin-2-one in 15 ml of methanol is admixed with 100 mg of Raney nickel and a drop of acetic acid and hydrogenated at room temperature for 8 hours. The catalyst is filtered off and the solvent is removed. This gives 4-{2-oxo-5-[4- - 49 (2,4,6-trichlorophenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 546/548. 5 Similarly, the benzamidine derivatives below are obtained from the compounds obtained in Example 1 by hydrogenation 4-{2-oxo-5-[4-(4-biphenylylsulfonyl)piperazin-1 10 ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 520; 4-{2-oxo-5- [4- (2-phenylethylsulfonyl)piperazin-l ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, 15 FAB 472; 4-{2-oxo-5- [4- (2-aminophenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 459; 20 4-{2-oxo-5-[4-(2,5-dimethoxyphenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 504; 25 4-{2-oxo-5- [4- (2-naphthylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 494; 4-{2-oxo-5- [4- (2-chloro-4-fluorophenylsulfonyl) 30 piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 496; 4-{2-oxo-5- [4-((2-acetamido-4-methylthiazol-5-yl) sulfonyl)piperazin-1-ylmethyl]oxazolidin-3-yl} 35 benzamidine, trifluoroacetate, FAB 522; 4-{2-oxo-5- [4- (2-cyanophenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 469; - 50 4-{2-oxo-5- [4- (5-amino-2-methylphenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl)benzamidine, trifluoroacetate, FAB 473; 5 4-{2-oxo-5-(4-benzylsulfonylpiperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 458; 10 4-{2-oxo-5-(4-decylsulfonylpiperazin-1 ylmethyljoxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 508; 4-{2-oxo-5-[4-(2-trifluoromethylphenylsulfonyl) 15 piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 512; 4-{2-oxo-5- [4- (3-chloro-4-fluorophenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, 20 trifluoroacetate, FAB 496; 4-{2-oxo-5- [4- (4-chloro-2,5-dimethylphenyl sulfonyl)piperazin-1-ylmethyl]oxazolidin-3-yl} benzamidine, trifluoroacetate, FAB 506; 25 4-{2-oxo-5- [4- (2-fluorophenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 462; 4-{2-oxo-5-[4-(3,4-dibromophenylsulfonyl) 30 piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 600/602/604; 4-{2-oxo-5-[4-(3-chlorophenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, 35 FAB 478; 4-{2-oxo-5-[4- (2,6-dichlorophenylsulfonyl) piperazin-1-ylmethyl] oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 512; - 51 4-{2-oxo-5-[4-(3,4-dichlorophenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 512; 5 4-{2-oxo-5-[4-(3,5-dichlorophenylsulfonyl) piperazin-1-ylmethylloxazolidin-3-yl}benzamidine, acetate, FAB 512; 4-{2-oxo-5-[4-(2-naphthylcarbonyl)piperazin-1 10 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 458;. 4-{2-oxo-5-(4-methylsulfonylpiperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 382; 15 4-{2-oxo-5-[4-(2-methylsulfonylphenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 522; 4-{2-oxo-5-[4-(2-aminobenzylsulfonyl)piperazin-1 20 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 473; 4-{2-oxo-5-[4-((4-methoxycarbonyl-3-methoxythio phen-2-yl)sulfonyl)piperazin-1-ylmethyl]oxazolidin-3 yl}benzamidine, acetate, FAB 538; 25 4-{2-oxo-5-[4-(3-trifluoromethylphenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 512; 30 4-{2-oxo-5-[4-(4-trifluoromethoxyphenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 528; 4-{2-oxo-5-[4-(((iS)-camphor-10-yl)sulfonyl) 35 piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 518; - 52 4-{2-oxo-5-[4-(((1R)-camphor-10-yl)sulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 518; 5 4-{2-oxo-5-[4-((2,2,5,7,8-pentamethylchroman-6 yl)sulfonyl)piperazin-1-ylmethyl]oxazolidin-3-yl} benzamidine, acetate, FAB 570; 4-{2-oxo-5-[4-(4-isopropylphenylsulfonyl) 10 piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 486; 4-{2-oxo-5-[4-(4-tert-butylphenylsulfonyl) piperazin-1-ylmethylloxazolidin-3-yl}benzamidine, 15 acetate; 4-{2-oxo-5-[4-(4-butylphenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 500; 20 4-{2-oxo-5-[4-(3,5-diamino-4-methoxyphenyl sulfonyl)piperazin-1-ylmethyl]oxazolidin-3-yl} benzamidine, acetate, FAB 504; 4-{2-oxo-5-(4-ethylsulfonylpiperazin-1-yl 25 methyl]oxazolidin-3-yl}benzamidine, acetate, FAB 396; 4-{2-oxo-5-[4-(4-nitrophenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 459; 30 4-{2-oxo-5-[4-(2-trifluoromethoxyphenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 528; 4-{2-oxo-5-[4-(2,4-diaminophenylsulfonyl) 35 piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 474; 4-{2-oxo-5- (4-isopropylsulfonylpiperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 410; -53 4-{2-oxo-5- [4- (4-ethylphenylsulfonyl)piperazin-1 ylmethyl] oxazolidin-3-yl~benzamidine, trifluoroacetate, FAB 472; 5 4-{2-oxo-5- [4- (4-bromo-2-trifluoromethoxyphenyl sulfonyl)piperazin-1-ylmethyl] oxazolidin-3-yl} benzamidine, acetate, FAB 606/608; 10 4-{2-oxo-5-[4-(2,3,4-trifluorophenylsulfonyl) piperazin-1-ylmethyl] oxazolidin-3-yl }benzamidile, acetate, FAB 498; 4-{2-oxo-5- [4- (3,4-difluorophenylsulfonyl) 15 piperazin-1-ylmethyl] oxazolidin-3-yl~benzamidine, acetate, FAB 480; 4-{2-oxo-5-[4-(2,2,2-trifluoroethylsulfonyl) piperazin-1--ylmethyl] oxazolidin-3-yllbenzamidine, 20 trifluoroacetate, FAB 450; 4-{2-oxo-5-[4-(3-amino-4-methylphenylsulfonyl) piperazin-1-ylmethyl] oxazolidin-3 -yl }benzamidine, trifluoroacetate, FAB 473; 25 4-{2-oxo-5- [4- (2-amino-6-chlorophenylsulfonyl) piperazin-1-ylmethyl] oxazolidin-3-yl~benzamidine, trifluoroacetate, FAB 585; 30 4-{2-oxo-5-[4-(2,5-dimethoxyphenylacetyl) piperazin-1-ylmethyl] oxazolidin-3-yllbenzamidine, acetate, FAB 482; 4-{2-oxo-5- [4- (3,4-dichlorobenzoyl)piperazin-l 35 ylmethylloxazolidin-3-yl~benzamidine, acetate, FAB 476; - 54 4-{2-oxo-5-[4-(3-fluorobenzoyl)piperazin-l ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 426; 4-{2-oxo-5-[4-(4-trifluoromethoxybenzoyl) 5 piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 492; 4-{2-oxo-5-[4-(3-pyridylcarbonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 409; 10 4-{2-oxo-5-[4-(2-benzothienylcarbonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 463; 4-{2-oxo-5-[4-(4-chlorophenylacetyl)piperazin-1 15 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 456; 4-{2-oxo-5-[4-(1-naphthylcarbonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 458; 20 4-{2-oxo-5-[4-((1,3-benzodioxol-5-yl)carbonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 452; 4-{2-oxo-5-[4-(3-aminobenzoyl)piperazin-1-yl 25 methyl]oxazolidin-3-yl}benzamidine, acetate, FAB 423; 4-{2-oxo-5-[4-(4-biphenylylcarbonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 484; 30 4-{2-oxo-5-[4-(cyclopentylcarbonyl)piperazin-1 ylmethyl]oxazolidin-3-yl)benzamidine, acetate, FAB 400; 4-{2-oxo-5-{4-[5-chloro-1-(4-methylphenyl)-1H pyrazol-4-yl)sulfonyl]piperazin-1-ylmethyl}oxazolidin 35 3-yl}benzamidine, acetate, FAB 558; 4-{2-oxo-5- [4-(4-chlorophenylsulfonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 478; - 55 4-{2-oxo-5-{4-[5,7,7-trimethyl-2-(1,3,3-trimethyl butyl)octylsulfonyllpiperazin-1-ylmethyl}oxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 620; 5 4-{2-oxo-5-{4-[2-butoxy-5-(1,1-dimethylpropyl) phenylsulfonyl]piperazin-1-ylmethyl}oxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 586; 10 4-{2-oxo-5-{4-[2-butoxy-5-(1,1,3,3-tetramethyl butyl)phenylsulfonyl]piperazin-1-ylmethyl}oxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 628; 4-{2-oxo-5-[4-(2-amino-4-trifluoromethylphenyl 15 sulfonyl)piperazin-1-ylmethyl]oxazolidin-3 yl}benzamidine, trifluoroacetate; 4-{2-oxo-5- [4- (4-bromo-2-ethylphenylsulfonyl) piperazin-1-ylmethyl] oxazolidin-3-yl}benzamidine, 20 trifluoroacetate, FAB 550/552; 4-{2-oxo-5- [4- (4-trifluoromethylphenylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 512; 25 4-{2-oxo-5- [4- (6-chloro-2-naphthylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 528; 30 4-{2-oxo-5- [4- (isobutyloxycarbonyl)piperazin-1 ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 404. Similarly, reaction of 3-[3-(5-methyl-[1,2,4]-oxa diazol-3-yl)phenyl]-5-piperazin-1-ylmethyloxazolidin 35 2-one with 6-chloro-2-naphthylsulfonyl chloride and subsequent hydrogenation gives the compound - 56 3-{2-oxo-5-[4-(6-chloro-2-naphthylsulfonyl) piperazin-1-ylmethyl]oxazolidin-3-yl}benzamidine, m.p. 118C. 5 Similarly, reaction of 3-[4-(5-methyl- [1,2,4]-oxa diazol-3-yl)phenyll -5-piperazin-1-ylmethyloxazolidin-2 one with 6-methoxy-2-naphthylsulfonyl chloride and subsequent hydrogenation gives the compound 10 4-{2-oxo-5-[4-(6-methoxy-2-naphthylsulfonyl) piperazin-1-ylmethyl] oxazolidin-3-yl}benzamidine. Similarly, reaction of 3-[4-(5-methyl-[1,2,4]-oxa diazol-3-yl)phenyl]-5-piperazin-1-ylmethyloxazolidin-2 15 one with 2-fluorobenzyl chloride and subsequent hydrogenation gives the compound 4-{2-oxo-5-[4-(2-fluorobenzyl)piperazin-1-yl methyl]oxazolidin-3-yl}benzamidine. 20 Example 3 A solution of 100 mg of 3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl] -5- [4- (2,4,6-trichlorophenyl 25 sulfonyl)piperazin-1-ylmethyl]oxazolidin-2-one in 8 ml of methanol is admixed with 3 ml of 1N aqueous sodium hydroxide solution and stirred at 600 for 48 hours. This gives, after customary work-up, 3-[4-(5-methyl [1,2,4] -oxadiazol-3-yl)phenylamino] -1- [4- (2,6-dichloro 30 4-methoxyphenylsulfonyl)piperazin-1-yl]propan-2-ol, FAB 556/558. Similarly, 35 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4 (3,4-difluorophenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one gives - 57 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl amino] -1- [4- (3-fluoro-4-methoxyphenylsulfonyl) piperazin-1-yl]propan-2-ol; 5 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(1 naphthylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl) -phenyl amino]-1-[4-(1-naphthylsulfonyl)piperazin-1-yl]propan 10 2-ol; 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5- [4- (4 trifluoromethylphenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one gives 15 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl amino]-1-[4-(4-trifluoromethylphenylsulfonyl)piperazin 1-yl]propan-2-ol; 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(4 20 biphenylylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2 one gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl amino]-1-[4-(4-biphenylylsulfonyl)piperazin-1 yl] propan-2 -ol; 25 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5- [4- (3 trifluoromethylphenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl 30 amino]-1-[4-(3-trifluoromethylphenylsulfonyl)piperazin 1-yl]propan-2-ol; 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(4 trifluoromethoxyphenylsulfonyl)piperazin-1-ylmethyl] 35 oxazolidin-2-one gives 3-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino] 1- [4- (4-trifluoromethoxyphenylsulfonyl)piperazin-1 yl] propan-2-ol; - 58 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(4 isopropylphenylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl 5 amino]-1-[4-(4-isopropylphenylsulfonyl)piperazin-l yl]propan-2-ol; 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(4 butylphenylsulfonyl)piperazin-1-ylmethyl]oxazolidin-2 10 one gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl amino]-1-[4-(4-butylphenylsulfonyl)piperazin-l yl]propanol-2-ol; 15 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(4 methoxyphenylsulfonyl)piperazin-1-ylmethyl]oxazolidin 2-one gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl amino]-1-[4-(4-methoxyphenylsulfonyl)piperazin-1-yl] 20 propan-2-ol; 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(4 tolylsulfonyl)piperazin-1-ylmethyl]oxazolidin-2-one gives 25 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl amino]-1-[4-(4-tolylsulfonyl)piperazin-1-yl]propan-2 ol; 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(4 30 propylphenylsulfonyl)piperazin-1-ylmethylloxazolidin-2 one gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl amino]-1-[4-(4-propylphenylsulfonyl)piperazin-1-yl] propan-2-ol; 35 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(6 chloro-2-naphthylsulfonyl)piperazin-1-ylmethyl] oxazolidin-2-one gives - 59 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl amino]-1-[4-(6-chloro-2-naphthylsulfonyl)piperazin-1 yl] propan-2-ol; 5 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4-(2 phenylvinylsulfonyl) piperazin-1-ylmethyl] oxazolidin-2 one gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl amino] -1- [4- (2-phenylvinylsulfonyl)piperazin-l 10 yl]propan-2-ol; 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5-{4- [2 (naphth-1-yl)ethylsulfonyl]piperazin-1-ylmethyl} oxazolidin-2-one gives 15 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl amino]-l-{4-[2-(naphth-1-yl)ethylsulfonyl]piperazin-1 yl}propan-2-ol. Similarly, 4-{2-oxo-5-[4-(6-methoxy-2-naphthyl 20 sulfonyl)piperazin-1-ylmethyl]oxazolidin-3-yl}benz amidine gives the compound 4-{2-hydroxy-3- [4- (6-methoxynaphthalene-2 sulfonyl)piperazin-1-yl]propylamino}benzamidine, 25 diacetate, FAB 498 and 4-{2-oxo-5-[4-(2-fluorobenzyl)piperazin-1-yl methyl]oxazolidin-3-yl}benzamidine gives the compound 30 4-{2-hydroxy-3- [4- (2-fluorobenzyl)piperazin-1-yl] propylamino}benzamidine, acetate, FAB 386. Example 4 35 A solution of 60 mg of 3- [4- (5-methyl- [1,2,4] oxadiazol-3-yl)phenylamino]-1-[4-(2,6-dichloro-4 methoxyphenylsulfonyl)piperazin-1-yl]propan-2-ol in 5 ml of methanol is admixed with 50 mg of Raney nickel and a drop of acetic acid and hydrogenated at room - 60 temperature for 8 hours. The catalyst is filtered off and the solvent is removed. This gives 4-{3-[4-(2,6 dichloro-4-methoxyphenylsulfonyl)piperazin-1-ylI -2 hydroxypropylamino}benzamidine, acetate, FAB 516/518. 5 Similarly, the compounds below are obtained from the propan-2-ol derivatives listed under Example 3 by hydrogenation 10 4-{3- [4- (3-f luoro-4-methoxyphenylsulfonyl) piperazin-1-yl] -2-hydroxypropylamino}benzamidine, acetate, FAB 466; 4-{3- [4- (l-naphthylsulfonyl)piperazin-1-yl] -2 15 hydroxypropylamino}benzamidine, acetate, FAB 468; 4-{3-[4-(4-trifluoromethylphenylsulfonyl) piperazin-1-yl] -2-hydroxypropylamino}benzamidine, acetate, FAB 486; 20 4-{3-[4-(4-biphenylylsulfonyl)piperazin-1-yl]-2 hydroxypropylamino}benzamidine, acetate, FAB 494; 4-{3- [4- (3-trifluoromethylphenylsulfonyl) 25 piperazin-1-yl] -2-hydroxypropylamino}benzamidine, acetate, FAB 486; 4-{3- [4- (4-trifluoromethoxyphenylsulfonyl) piperazin-1-yl] -2-hydroxypropylamino}benzamidine, 30 acetate, FAB 502; 4-{3-[4-(4-isopropylphenylsulfonyl)piperazin-l yl]-2-hydroxypropylamino}benzamidine, acetate, FAB 460; 35 4-{3-[4-(4-butylphenylsulfonyl)piperazin-1-yl]-2 hydroxypropylamino}benzamidine, acetate, FAB 474; 4-{3- [4- (4-methoxyphenylsulfonyl)piperazin-1-yl] 2-hydroxypropylamino}benzamidine, acetate, FAB 448; - 61 4-{3-[4-(4-tolylsulfonyl)piperazin-1-yl]-2 hydroxypropylamino}benzamidine, acetate, FAB 432; 5 4-{3-[4-( 4 -propylphenylsulfonyl)piperazin-1-yl]-2 hydroxypropylamino}benzamidine, acetate, FAB 460; 4-{3-[4-( 6 -chloro-2-naphthylsulfonyl)piperazin-1 yl]- 2 -hydroxypropylaminolbenzamidine, acetate, FAB 502; 10 4-{3-[4-(2-phenylvinylsulfonyl)piperazin-1-yl]-2 hydroxypropylamino}benzamidine, acetate, FAB 446; 4-{3-{4-[2-(naphth-1-yl)ethylsulfonyl]piperazin-l 15 yl}-2-hydroxypropylamino}benzamidine, acetate, FAB 496. Example 5 A solution of 10.0 g of methyl {3-[4-(5-methyl-[1,2,4] 20 oxadiazol-3-yl)phenyl]- 2 -oxooxazolidin-5-yl}methane sulfonate, 6.73 g of 4-BOC-aminopiperidine and 8.5 g of sodium bicarbonate in 200 ml of acetonitrile is heated under reflux for 40 hours. Customary work-up 25 gives 5-(4-BOC-aminopiperidin-1-ylmethyl)-3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]oxazolidin-2-one. The BOC group is cleaved off using TFA in dichloromethane, giving 5-(4-aminopiperidin-1-yl 30 methyl)-3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl] oxazolidin-2-one ("B"). Similarly to Example 1, reaction of "B" 35 with ( 3 -methoxy-4-methoxycarbonylthiophen-2-yl)sulfonyl chloride gives N-(1- {3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]- 2 -oxooxazolidin-S-ylmethyl}piperidin-4-yl)-(3 methoxy-4-methoxycarbonylthiophen-2-yl)sulfonamide - 62 i NOi N OH 0O . with benzenesulfonyl chloride gives 5 N-(l-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]-2-oxooxazolidin-5-ylmethyl}piperidin-4-yl) benzenesulfonamide; with 3, 4-dimethoxybenzenesulfonyl chloride gives 10 3,4-dimethoxy-N-(l-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} piperidin-4-yl)benzenesulfonamide; with butylsulfonyl chloride gives 15 N-(1-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl] -2-oxooxazolidin-5-ylmethyl}piperidin-4-yl) butylsulfonamide; with 2,4,6-trimethylbenzenesulfonyl chloride gives 20 2,4,6-trimethyl-N-(1-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} piperidin-4-yl)benzenesulfonamide; with phenylvinylsulfonyl chloride gives 25 phenylvinyl-N-(1-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl] -2-oxooxazolidin-5-ylmethyl} piperidin-4-yl)sulfonamide; with 2-methylsulfonylbenzenesulfonyl chloride gives 30 2-methylsulfonyl-N-(1-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} piperidin-4 -yl) benzenesul fonamide; with 4-biphenylglsulfonyl chloride gives - 63 4-biphenylyl-N-(l-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} piperidin-4-yl)sulfonamide; 5 with 5-dimethylamino-l-naphthylsulfonyl chloride gives 5-dimethylamino-N-(l-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} piperidin-4-yl)-l-naphthylsulfonamide; 10 with 1-naphthylsulfonyl chloride gives N-(l-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]-2-oxooxazolidin-5-ylmethyl}piperidin-4-yl)-1 naphthylsulfonamide. 15 By hydrogenation similarly to Example 2, these give the compounds below 4-{5-[4-((3-methoxy-4-methoxycarbonylthiophen-2 yl)sulfonylamino)piperidin-l-ylmethyl]-2-oxooxazolidin 20 3-yl}benzamidine, acetate, FAB 552; 4-{5-[4-(benzenesulfonylamino)piperidin-1-yl methyl]-2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 458; 25 4-{5-[4-(3,4-dimethoxybenzenesulfonyl amino)piperidin-1-ylmethyl]-2-oxooxazolidin-3 yl}benzamidine, acetate, FAB 518; 30 4-{5-[4-(butylsulfonylamino)piperidin-1-ylmethyl] 2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 438; 4-{5-[4-(2,4,6-trimethylbenzenesulfonylamino) piperidin-1-ylmethyl]-2-oxooxazolidin-3-yl}benzamidine, 35 acetate, FAB 500; 4-{5- [4-(phenylethylsulfonylamino)piperidin-l ylmethyl]-2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 486; - 64 4- {5- [4- (2-methylsulfonylbenzenesulfonylamino) piperidin-1-ylmethyl]-2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 536; 5 4-{5-[4-(4-biphenylylsulfonylamino)piperidin-l ylmethyl]-2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 533; 10 4-{5- [4- (5-dimethylamino-1-naphthylsulfonyl amino) piperidin-1-ylmethyl] -2-oxooxazolidin-3 yl}benzamidine, acetate, FAB 551; 4-{5-[4-(l-naphthylsulfonylamino)piperidin-1-yl 15 methyl] -2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 458. Example 6 20 A solution of 10.0 g of methyl {3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl}methane sulfonate, 7.4 g of N,N'-dimethylethylenediamine and 8.5 g of sodium bicarbonate in 400 ml of acetonitrile is heated under reflux for 40 hours. Customary work-up 25 gives 5-{[methyl-(2-methylaminoethyl)aminolmethyl}-3 [4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]oxazolidin 2-one ("C"). NH ,JN "C"1 0 30 Similarly to Example 1, reaction of "C" with 2,4,6-trichlorophenylsulfonyl chloride gives 2,4,6-trichloro-N-methyl-N-[2-(methyl-{3-[4-(5 35 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin 5-ylmethyl} amino) ethyl] benzenesulfonamide - 65 a-N N 0 C N S 0 0 OC O , 1 Cl CI with 2 -trifluoromethoxyphenylsulfonyl chloride gives 5 2 -trifluoromethoxy-N-methyl-N- [2- (methyl-{3- [4- (5 methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -2-oxooxazolidin 5-ylmethyl }amino) ethyl] benzenesulfonamide; with 2,4, 6-trichlorophenylsulfonyl chloride gives 10 2 ,4,6-trichloro-N-methyl-N- [2-(methyl-{3-[4-(5 methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -2-oxooxazolidin 5-ylmethyl}amino)ethyl]benzenesulfonamide; with 4-trifluoromethylphenylsulfonyl chloride gives 15 4-trifluoromethyl-N-methyl-N- [2- (methyl-{3- [4- (5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin 5-ylmethyl} amino) ethyl] benzenesulfonamide; with 4 -isopropylphenylsulfonyl chloride gives 20 4 -isopropyl-N-methyl-N- [2- (methyl-{3- [4- (5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl }amino) ethyl] benzenesulfonamide; with 4 -propylphenylsulfonyl chloride gives 25 4 -propyl-N-methyl-N- [2- (methyl-{3- [4- (5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]- 2 -oxooxazolidin-5 ylmethyl}amino)ethyl]benzenesulfonamide; with 4 -acetamidophenylsulfonyl chloride gives 30 4-acetamido-N-methyl-N- [2- (methyl-{3- [4- (5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino) ethyl]benzenesulfonamide; with 2-naphthylsulfonyl chloride gives -66 N-methyl-N-[2-(methyl-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino)ethyl]-2-naphthylsulfonamide; 5 with 3-trifluoromethylphenylsulfonyl chloride gives 3-trifluoromethyl-N-methyl-N-[2-(methyl-{3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin 5-ylmethyl}amino)ethyl]benzenesulfonamide; 10 with 4-chloro-3-nitrophenylsulfonyl chloride gives 4-chloro-3-nitro-N-methyl-N-[2-(methyl-{3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin 5-ylmethyl}amino)ethyl]benzenesulfonamide; 15 with phenylvinylsulfonyl chloride gives N-methyl-N-[2-(methyl-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino)ethyl]phenylvinylsulfonamide; 20 with benzylsulfonyl chloride gives 4-trifluoromethyl-N-methyl-N-[2-(methyl-{3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin 5-ylmethyl}amino)ethyl]benzylsulfonamide; 25 with tolylsulfonyl chloride gives 4-methyl-N-methyl-N-[2-(methyl-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl amino)ethyl]benzenesulfonamide; 30 with 4-methoxyphenylsulfonyl chloride gives 4-methoxy-N-methyl-N-[2-(methyl-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino)ethyl]benzenesulfonamide; 35 with 1-naphthylsulfonyl chloride gives N-methyl-N-[2-(methyl-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino)ethyl]-l-naphthylsulfonamide; - 67 with 4-biphenylylsulfonyl chloride gives N-methyl-N- [2- (methyl-{3- [4- (5-methyl- [1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino)ethyl]-4-biphenylylsulfonamide; 5 with 3, 4-difluorophenylsulfonyl chloride gives 3,4-difluoro-N-methyl-N- [2- (methyl-{3- [4- (5 methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -2-oxooxazolidin 5-ylmethyl}amino)ethyl]benzenesulfonamide; 10 with 4-pentylphenylsulfonyl chloride gives 4-pentyl-N-methyl-N- [2- (methyl-{3- [4- (5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino)ethyl]benzenesulfonamide; 15 with 4-butylphenylsulfonyl chloride gives 4-butyl-N-methyl-N-[2-(methyl-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl amino)ethyl]benzenesulfonamide; 20 with 4-methylsulfonylphenylsulfonyl chloride gives 4-methylsulfonyl-N-methyl-N-[2-(methyl-{3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin 5-ylmethyl amino)ethyl]benzenesulfonamide; 25 with 6-chloro-2-naphthylsulfonyl chloride gives 6-chloro-N-methyl-N-[2-(methyl-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}amino)ethyl]-2-naphthylsulfonamide; 30 By hydrogenation similarly to Example 2, these give the compounds below 4-{5-[(methyl-{2-[methyl-(2,4,6-trichlorobenzene 35 sulfonyl)aminoethyl}amino)methyl]-2-oxooxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 548/550 - 68 H N N / ' N O C I 0 0 % CI CI 4-{5- [(methyl-{2- [methyl- (2-trifluoromethoxy 5 benzenesulfonyl)amino]ethyl}amino)methyl]-2-oxo oxazolidin-3-yl}benzamidine, acetate, FAB 530; 4-{5-[(methyl-{2-[methyl-(4-trifluoromethyl benzenesulfonyl)amino]ethyl}amino)methyl]-2 10 oxooxazolidin-3-yl)benzamidine, acetate, FAB 514; 4-{5-[(methyl-{2-[methyl-(4-isopropylbenzene sulfonyl)amino]ethyllamino)methyl]-2-oxooxazolidin-3 yl}benzamidine, acetate, FAB 488; 15 4-{5-[(methyl-{2-[methyl-(4-propylbenzene sulfonyl)aminoethyl)amino)methyl]-2-oxooxazolidin-3 yl)benzamidine, acetate, FAB 488; 20 4-{5- [(methyl-{2- [methyl- (4-acetamidobenzene sulfonyl)amino]ethyl}amino)methyl]-2-oxooxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 503; 4-{5-[(methyl-{2-[methyl-(2-naphthylsulfonyl) 25 amino]ethyl}amino)methyl]-2-oxooxazolidin-3-yl} benzamidine, acetate, FAB 496; 4-{5-[(methyl-{2-[methyl-(3-trifluoromethyl benzenesulfonyl)amino]ethyl)amino)methyl]-2 30 oxooxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 514; 4-{5- [(methyl-{2- [methyl- (3-amino-4 chlorobenzenesulfonyl)amino]ethyl}amino)methyl]-2 35 oxooxazolidin-3-yl}benzamidine, acetate, FAB 495; - 69 4-{5-[(methyl-{2-[methyl(phenylethylsulfonyl) amino]ethyl}amino)methyl]-2-oxooxazolidin-3-yl} benzamidine, trifluoroacetate, FAB 474; 5 4-{5-[(methyl-{2-[methyl(benzylsulfonyl)amino] ethyllamino)methyl]-2-oxooxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 460; 10 4-{5-[(methyl-{2-[methyl-(4-tolylsulfonyl)amino] ethyllamino)methyl]-2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 460; 4-{5-[(methyl-{2-[methyl-(4-methoxybenzene 15 sulfonyl)amino]ethyl}amino)methyl]-2-oxooxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 476; 4-{5-[(methyl-{2-[methyl-(1-naphthylsulfonyl) amino]ethyl}amino)methyl]-2-oxooxazolidin-3-yl} 20 benzamidine, trifluoroacetate, FAB 496; 4-{5-[(methyl-{2-[methyl-(4-biphenylylsulfonyl) amino]ethyl}amino)methyl]-2-oxooxazolidin-3-yl} benzamidine, trifluoroacetate, FAB 522; 25 4-{5-[(methyl-{2-[methyl-(3,4 difluorobenzenesulfonyl)amino]ethyl)amino)methyl]-2 oxooxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 516; 30 4-{5-[(methyl-{2-[methyl-(4-pentylbenzene sulfonyl)amino]ethyl}amino)methyl]-2-oxooxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 516; 35 4-{5-[(methyl-{2-[methyl-(4 butylbenzenesulfonyl)amino]ethyl}amino)methyl]-2 oxooxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 502; -70 4-{5-[(methyl-{2-[methyl-(4-methylsulfonyl benzenesulfonyl)amino]ethyl}amino)methyl]-2 oxooxazolidin-3-yl}benzamidine, trifluoroacetate, FAB 502; 5 4-{5- [(methyl-{2- [methyl- (6-chloro-2-naphthyl sulfonyl)amino]ethyl}amino)methyl]-2-oxooxazolidin-3 yl}benzamidine, trifluoroacetate, FAB 530. 10 Similarly to Examples 3 and 4, 6-chloro-N-methyl-N-[2-(methyl-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} amino)ethyl]-2-naphthylsulfonamide gives the compound 15 4-[3-({2-[(6-chloro-2-naphthylsulfonyl)methyl amino] ethyl methylamino) -2-hydroxypropylamino] benzamidine, acetate, FAB 504 H HN N N 20 0 20 and 7-methoxy-N-methyl-N-[2-(methyl-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl methyl}amino)ethyl]-2-naphthylsulfonamide gives the compound 25 4-[3-({2-[(7-methoxy-2-naphthylsulfonyl)methyl amino] ethyl}methylamino) -2-hydroxypropylamino] benz amidine, acetate, FAB 500. 30 Similar to Example 3, cleavage of the oxazolidinone ring of 4- {5- [(methyl- {2- [methyl- (4 -biphenylylsulfonyl) amino] ethyl}amino)methyl]-2-oxooxazolidin-3-yl}benzamidine, 35 - 71 4-{5-[(methyl-{2-[methyl-(4-isopropylbenzenesulfonyl) amino]ethyl}amino)methyl]-2-oxooxazolidin-3-yl} benzamidine, 5 4-{5-[(methyl-{2-[methyl-(1-naphthylsulfonyl)amino] ethyl}amino)methyl]-2-oxooxazolidin-3-yl}benzamidine, give the compounds below 10 4-[3-({2-[(4-biphenylylsulfonyl)methylamino] ethyl }methylamino) -2-hydroxypropylamino] benzamidine, diacetate, EI 460 (M' -NH 2 ) ; 15 4-[3-({2-[(4-isopropylbenzenesulfonyl)methyl amino] ethyl}methylamino) -2-hydroxypropylamino] benzamidine, diacetate, EI 461; 4-[3-({2-[(1-naphthylsulfonyl)methylamino]ethyl) 20 methylamino) -2-hydroxypropylamino] benzamidine, diacetate, EI 469. Example 7 25 A solution of 10.6 g of methyl {3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl}methane sulfonate and 3.17 g of sodium azide in 50 ml of acetonitrile is heated under reflux for 40 hours. Customary work-up gives 5-azidomethyl-3-[4-(5-methyl 30 [1,2,4]-oxadiazol-3-yl)phenyl]oxazolidin-2-one. 7.7 g of azido compound are suspended in ethylene glycol dimethyl ether, 3.6 ml of trimethyl phosphite are then added and the mixture is stirred under reflux for 1.5 hours. 4.9 ml of half-concentrated HCl are 35 added and the mixture is boiled for a further 3 hours. Customary work-up gives 5-aminomethyl-3- [4- (5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]oxazolidin-2-one, hydrochloride.
- 72 The compound is suspended in dichloromethane, admixed with basic ion exchanger and stirred for 2 hours. Removal of the ion exchanger and the solvent gives 5 aminomethyl-3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) 5 phenyl]oxazolidin-2-one ("D"). Similarly to Example 1, reaction of "D" with 3,4-difluorobenzenesulfonyl chloride gives 10 3,4-difluoro-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol 3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}benzene sulfonamide; with 4-methoxybenzenesulfonyl chloride gives 15 4-methoxy-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}benzenesulfon amide; with 4-chloro-3-nitrobenzenesulfonyl chloride gives 20 4-chloro-3-nitro-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide; with butylsulfonyl chloride gives 25 N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]2 oxooxazolidin-5-ylmethyl}butylsulfonamide; with 3-trifluoromethylbenzenesulfonyl chloride gives 3-trifluoromethyl-N-{3- [4- (5-methyl- [1,2,4] 30 oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide; with 2-naphthylsulfonyl chloride gives N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]2 35 oxooxazolidin-5-ylmethyl}-2-naphthylsulfonamide. Similarly to Example 2, the compounds below are obtained by hydrogenation of the sulfonamides - 73 4-{5-[(3,4-difluorobenzenesulfonylamino)methyl]-2 oxooxazolidin-3-yl}benzamidine, acetate, FAB 411; 4- {5- [4-methoxybenzenesulfonylamino) methyl] -2 5 oxooxazolidin-3-yl}benzamidine, acetate, FAB 405; 4-{5-[(3-amino-4-chlorobenzenesulfonylamino) methyl] -2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 424; 10 4-{5-[(butylsulfonylamino)methyl]-2-oxooxazolidin 3-yl}benzamidine, acetate, FAB 355; 4-{5-[(3-trifluoromethylbenzenesulfonylamino) 15 methyl] -2-oxooxazolidin-3-yl}benzamidine, acetate, FAB 443; 4-{5-[(2-naphthylsulfonylamino)methyl]-2 oxooxazolidin-3-yl}benzamidine, acetate, FAB 425. 20 Example 8 Similarly to Examples 3 and 4, 25 3,4-difluoro-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]-2-oxooxazoloidin-5-ylmethyl}benzenesulfonamide gives 4-[3-(3,4-difluorobenzenesulfonylamino)-2 hydroxypropylamino]benzamidine, acetate, FAB 385 30 0 NN- F F N-S /\ 0 4-methoxy-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl] -2-oxooxazolidin-5-ylmethyl}benzenesulfonamide 35 gives - 74 4- [3- (4-methoxybenzenesulfonylamino) -2-hydroxy propylamino Jbenzamidine; 4-chloro-3-nitro-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 5 yl) phenyl] -2-oxooxazolidin-5-ylmethyl }benzene sulfonamide gives 4-[3-(3-amino-4-chlorobenzenesulfonylamino)-2 hydroxypropylamino] benzamidine; 10 N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxo oxazolidin-5-ylmethyl}butylsulfonamide gives 4- [3- (butylsulfonylamino) -2 -hydroxypropylamino benzamidine, acetate, FAB 329; 15 3-trifluoromethyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol 3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl}benzene sulfonamide gives 4-[3-(3-trifluoromethylbenzenesulfonylamino)-2 hydroxypropylamino]benzamidine, acetate, FAB 417; 20 N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxo oxazolidin-5-ylmethyl}-2-propylsulfonamide gives 4- [3- (propylsulfonylamino) -2-hydroxypropylamino] benzamidine, acetate, FAB 391. 25 Example 9 A solution of 30.0 g of methyl {3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl}methane 30 sulfonate and 300 ml of aqueous methylamine solution in 300 ml of THF is heated under pressure at 800C for 18 hours. Customary work-up gives 5-methylaminomethyl-3 [4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenylloxazolidin 2-one ("E"). 35 Similarly to Example 1, reaction of "E" with butylsulfonyl chloride gives - 75 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-ylmethyl}butylsulfonamide; with 4-isopropylbenzenesulfonyl chloride gives 5 4-isopropyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide; with 3-trifluoromethylbenzenesulfonyl chloride gives 10 3-trifluoromethyl-N-methyl-N-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl methyl}benzenesulfonamide; with phenylvinylsulfonyl chloride gives 15 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-ylmethyl}phenylvinyl sulfonamide; with 2-naphthylsulfonyl chloride gives 20 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-ylmethyl}-2-naphthyl sulfonamide; with 4-propylbenzenesulfonyl chloride gives 25 4-propyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide; with 4-methoxybenzenesulfonyl chloride gives 30 4-methoxy-N-methyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide; with 2,4,6-trimethylbenzenesulfonyl chloride gives 35 2,4,6-trimethyl-N-methyl-N-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl} benzenesulfonamide; with benzoyl chloride gives - 76 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-ylmethyl}benzamide; with 2-naphthylcarbonyl chloride gives 5 N-methyl-N-{3-[4-(5-methyl-[1,2,4-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-ylmethyl}-2-naphthyl carboxamide; with cyclohexylcarbonyl chloride gives 10 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-ylmethyl}cyclohexyl carboxamide; with 4-biphenylylcarbonyl chloride gives 15 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-ylmethyl}-4-biphenylyl carboxamide; with 4-chlorobenzoyl chloride gives 20 4-chloro-N-methyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzamide; with 4-(1,1-dimethylpropyl)benzenesulfonyl chloride 25 gives 4-(1,1-dimethylpropyl)-N-methyl-N-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyl}benzenesulfonamide; 30 with 3,4-difluorobenzenesulfonyl chloride gives 3,4-difluoro-N-methyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide; 35 with 4-tert-butylbenzenesulfonyl chloride gives 4-tert-butyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol -3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide; - 77 with 4 -trifluoromethylbenzenesulfonyl chloride gives 4-trifluoromethyl-N-methyl-N-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5 ylmethyllbenzenesulfonamide; 5 with 4-pentylbenzenesulfonyl chloride gives 4-pentyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]
-
2 -oxooxazolidin-5-ylmethyl} benzenesulfonamide; 10 with 1-naphthylsulfonyl chloride gives N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl] - 2 -oxooxazolidin-5-ylmethyl} -1 naphthylsulfonamide. 15 Similarly to Example 2, the compounds below are obtained 5-{5- [((butylsulfonyl)methylamino) methyl] -2 20 oxooxazolidin-3-yl}benzamidine, acetate, FAB 369 0 H II 5- 5-[((4-isopropylbenzenesulfonyl)methylamino) 25 methyl] - 2 -oxooxazolidin-3-yl}benzamidine, acetate, FAB 431; 5-{5- [((3-trifluoromethylbenzenesulfonyl)methyl amino)methyl]- 2 -oxooxazolidin-3-yl}benzamidine, 30 acetate, FAB 457; 5- {5- [((phenylethylsulfonyl)methylamino) methyl] -2 oxooxazolidin-3-yl}benzamidine, acetate, FAB 417; 35 5-{5- [((2-naphthylsulfonyl)methylamino)methyl] -2 oxooxazolidin-3-yl}benzamidine; - 78 5-{5-[((4-propylbenzenesulfonyl)methylamino) methyl]-2-oxooxazolidin-3-yl}benzamidine; 5 5- {5- [( (4-methoxybenzenesulfonyl)methylamino) methyl]-2-oxooxazolidin-3-yl}benzamidine; 5-{5-[((2,4,6-trimethylbenzenesulfonyl)methyl amino)methyl]-2-oxooxazolidin-3-yl}benzamidine; 10 5-{5-[(benzoylmethylamino)methyl]-2-oxooxazolidin 3-yl benzamidine; 5-{5-[(2-naphthylcarbonylmethylamino)methyl]-2 15 oxooxazolidin-3-yl}benzamidine; 5-{5- [(cyclohexylcarbonylmethylamino) methyl] -2 oxooxazolidin-3-yl}benzamidine; 20 5-{5-[(4-biphenylylcarbonylmethylamino)methyl]-2 oxooxazolidin-3-yl}benzamidine; 5-{5-[(4-chlorobenzoylmethylamino)methyl]-2-oxo oxazolidin-3-yl}benzamidine. 25 Similarly, methyl {3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidin-5-yl}methanesulfonate and butylamine give the compound 5-butylaminomethyl-3-[4 (5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]oxazolidin-2 30 one ("E-1") Reaction of "E-1" with 6-chloro-2-naphthylsulfonyl chloride gives 35 6-chloro-N-butyl-N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl] -2-oxooxazolidin-5-ylmethyl}-2 naphthylsulfonamide; with 4-biphenylylsulfonyl chloride gives - 79 N-butyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]-2-oxooxazolidin-5-ylmethyl}-4-biphenylyl sulfonamide; 5 with 2-naphthylsulfonyl chloride gives N-butyl-N-{3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl) phenyl]-2-oxooxazolidin-5-ylmethyl}-2-naphthylsulfon amide. 10 Example 10 Similarly to Examples 3 and 4, N-methyl-N-{3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl) 15 phenyl]-2-oxooxazolidin-5-ylmethyl}butylsulfonamide gives 4-{3- [(butane-l-sulfonyl)methylamino] -2-hydroxy propylamino)benzamidine 0 H~I I HNN 20N OH 202 4-isopropyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxa diazol-3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}benzene 25 sulfonamide gives 4- {3- [(4-isopropylbenzenesulfonyl)methylamino] -2 hydroxypropylamino)benzamidine, acetate, FAB 405; 3-trifluoromethyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4] 30 oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl} benzenesulfonamide gives 4- {3- [(3-trifluoromethylbenzenesulfonyl)methyl amino] -2-hydroxypropylamino}benzamidine, acetate, FAB 431; 35 N-methyl-N-{3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl) phenyl]- 2 -oxooxazolidin-5-ylmethyl}phenylvinylsulfon amide gives - 80 4- {3- [(phenylethylsulfonyl)methylamino] -2 hydroxypropylamino}benzamidine; N-methyl-N-{3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl) 5 phenyl]- 2 -oxooxazolidin-5-ylmethyl}-2-naphthylsulfon amide gives 4- {3- [(2-naphthylsulfonyl)methylamino] -2-hydroxy propylamino}benzamidine, acetate, FAB 413; 10 6-chloro-N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol 3-yl)phenyl] - 2 -oxooxazolidin-5-ylmethyl} -2-naphthyl sulfonamide gives 4-{3- [(6-chloro-2-naphthylsulfonyl)methylamino] -2 hydroxypropylamino}benzamidine, acetate, FAB 447; 15 4-propyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol 3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}benzene sulfonamide gives 4-{3-[(4-propylbenzenesulfonyl)methylamino]-2 20 hydroxypropylamino}benzamidine, acetate, FAB 405; 4-methoxy-N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol 3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}benzenesulfon amide gives 25 4- {3- [(4-methoxybenzenesulfonyl)methylamino] -2 hydroxypropylamino}benzamidine, acetate, FAB 393; 2
,
4
,
6 -trimethyl-N-methyl-N-{3-[4-(5-methyl-[1,2, 4
]
oxadiazol-3-yl)phenyl]
-
2 -oxooxazolidin-5-ylmethyl} 30 benzenesulfonamide gives 4- {3- [(2,4, 6 -trimethylbenzenesulfonyl)methyl amino] - 2 -hydroxypropylamino}benzamidine, acetate, FAB 405; 35 5-{5-[(benzoylmethylamino)methyl]-2-oxooxazolidin-3 yl}benzamidine gives 4- {3- [(benzoylmethylamino] -2-hydroxypropylamino} benzamidine; 40 5- {5- [(2-naphthylcarbonylmethylamino) methyl] -2-oxo oxazolidin-3-yl}benzamidine gives - 81 4-{3-[(2-naphthylcarbonylmethylamino]-2-hydroxy propylamino}benzamidine; 5-{5-[(cyclohexylcarbonylmethylamino)methyl]-2-oxo 5 oxazolidin-3-yl}benzamidine gives 4-{3-[(cyclohexylcarbonylmethylamino]-2-hydroxy propylamino}benzamidine; 5-{5-[(4-biphenylylcarbonylmethylamino)methyl]-2-oxo 10 oxazolidin-3-yl}benzamidine gives 4-{3-[(4-biphenylylcarbonylmethylamino]-2-hydroxy propylamino}benzamidine; 5-{5-[(4-chlorobenzoylmethylamino)methyl]-2-oxo 15 oxazolidin-3-yl}benzamidine gives 4-{3-[(4-chlorobenzoylmethylamino]-2-hydroxy propylamino}benzamidine; 4-(1,1-dimethylpropyl)-N-methyl-N-{3-[4-(5-methyl 20 [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl methyl}benzenesulfonamide gives 4-{3-[(4-(1,1-dimethylpropyl)benzenesulfonyl) methylamino]
-
2 -hydroxypropylamino}benzamidine, acetate, FAB 433; 25 3,4-difluoro-N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxa diazol-3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}benzene sulfonamide gives 4-{3-[(3-fluoro-4-methoxybenzenesulfonyl)methyl 30 amino]- 2 -hydroxypropylamino}benzamidine, acetate, FAB 411; 4 -tert-butyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxa diazol-3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}benzene 35 sulfonamide gives 4-{3-[(4-tert-butylbenzenesulfonyl)methylamino]-2 hydroxypropylamino}benzamidine, acetate, FAB 419; 4-trifluoromethyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4] 40 oxadiazol-3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl} benzenesulfonamide gives - 82 4-{3-[(4-trifluoromethylbenzenesulfonyl)methyl amino]- 2 -hydroxypropylamino)benzamidine, acetate, FAB 431; 5 4-pentyl-N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol 3-yl)phenyl]- 2 -oxooxazolidin-5-ylmethyllbenzenesulfon amide gives 4-{3-[(4-pentylbenzenesulfonyl)methylamino]-2 hydroxypropylamino}benzamidine, acetate, FAB 433; 10 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]- 2 -oxooxazolidin-5-ylmethyl)-1-naphthylsulfon amide gives 4-{3-[(l-naphthylsulfonyl)methylamino]-2-hydroxy 15 propylamino}benzamidine, acetate, FAB 413; 6-chloro-N-butyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]- 2 -oxooxazolidin-5-ylmethyl}-2-naphthyl sulfonamide gives 20 4-{3-[(6-chloro-2-naphthylsulfonyl)butylamino]-2 hydroxypropylamino)benzamidine; N-butyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]- 2 -oxooxazolidin-5-ylmethyl}-4-biphenylyl 25 sulfonamide gives 4-{3-[(4-biphenylylsulfonyl)butylaminol-2 hydroxypropylamino}benzamidine; N-butyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) 30 phenyl]- 2 -oxooxazolidin-5-ylmethyl}-2-naphthylsulfon amide gives 4-{3-[(2-naphthylsulfonyl)butylamino]-2-hydroxy propylamino}benzamidine. 35 N-methyl-N-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl) phenyl]- 2 -oxooxazolidin-5-ylmethyl}-(7-methoxy 2-naphthyl)sulfonamide gives - 83 4- {3- [(7-methoxy-2-naphthylsulfonyl) methylamino] 2-hydroxypropylamino}benzamidine, acetate, FAB 443; N-methyl-N-{3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl) 5 phenyl] -2-oxooxazolidin-5-ylmethyl} - (6-methoxy 2-naphthyl)sulfonamide gives 4- {3- [( 6 -methoxy-2-naphthylsulfonyl)methylamino] 2-hydroxypropylamino}benzamidine, acetate, FAB 443. 10 Example 11 A solution of 10.9 g of 3 -(4-cyanophenyl)-5-hydroxy methyloxazolidin-2-one ("F"), 5.9 g of 3-cyanophenol, 15 26.2 g of triphenylphosphine and 13.1 g of diethyl azo dicarboxylate in 250 ml of THF is stirred under an atmosphere of protective gas for 4 hours. Customary work-up gives 3- (4-cyanophenyl) -5- [(3-cyanophenoxy) methylloxazolidin-2-one. 20 A solution of 8.5 g of the dicyano compound, 5.5 g of hydroxylammonium chloride and 11.2 g of sodium carbonate in 130 ml of DMF is stirred at 600C for 3 hours. Customary work-up gives 3- (4-N-hydroxyamidino 25 phenyl) -5- [(3-N-hydroxyamidinophenoxy) methyl] oxazolidin-2-one. Similarly to Example 2, by hydrogenation, this gives the compound 3- (4-amidinophenyl) -5- [(3 30 amidinophenoxy)methyl]oxazolidin-2-one, diacetate, m.p. 159-160 0 C, FAB 354. Similarly, reaction of "F" 35 with 4' -hydroxybiphenyl-4-carbonitrile, reaction with hydroxylammonium chloride and reduction gives the compound 3- (4-amidinophenyl) -5- [(4' -amidino-4-biphenylyl oxy)methyl]oxazolidin-2-one, diacetate, m.p. 214-224*C; - 84 with 4-cyanophenol, reaction with hydroxylammonium chloride and reduction gives the compound 3- (4-amidinophenyl) -5- [(4-amidinophenoxy) methyl] 5 oxazolidin-2-one, diacetate, m.p. 1640C (decomposi tion); with 4-cyano-N- (ethoxycarbonyl) benzenesulfonamide gives the compound 10 N- [3- (4-cyanophenyl)
-
2 -oxooxazolidin-5-ylmethyl N-ethoxycarbonyl-4-cyanobenzenesulfonamide, diacetate, FAB 489. Example 12 15 A solution of 400 mg of methyl {3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]
-
2 -oxooxazolidin-5-yl}methane sulfonate, 240 mg of phenylpiperazine and 120 mg of sodium bicarbonate in 10 ml of acetonitrile is heated 20 at 80 0 C for 18 hours. Customary work-up gives 3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-(4-phenyl piperazin-1-ylmethyl)oxazolidin-2-one. By hydrogenation similarly to Example 2, this gives 25 4- [2-oxo-5- (4-phenylpiperazin-1-ylmethyl)oxazoli din-3-yl]benzamidine, acetate, FAB 380. Similarly, the reaction of "A" with 5-bromomethylbenzo [2,1,3]-thiadiazole gives the compound 30 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(benzo-[2,1,3]-thiadiazol-5-ylmethyl)piperazin-1-yl methyl] oxazolidin-2-one. By hydrogenation similarly to Example 2, this gives 35 4-{2-oxo-5-[4-(benzo-[2,1,3]-thiadiazol-5-yl methyl)piperazin-1-ylmethyl]oxazolidin-3-yl}benz amidine, acetate, FAB 512.
- 85 Similarly, reaction of methyl {3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl] -2-oxooxazolidin-5-yl}methane sulfonate 5 with 2-piperazin-1-ylpyrimidine gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4- (pyrimidin-2-yl)piperazin-1-ylmethyl] oxazolidin-2 one, 10 with benzylpiperazine gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-benzylpiperazin-1-ylmethyl]oxazolidin-2-one, with (benzo-[2,1,3]-thiadiazol-5-yl)piperazine gives 15 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4- (benzo- [2,1,3] -thiadiazol-5-yl)piperazin-1-yl methyl]oxazolidin-2-one. Similarly to Examples 3 and 4, the cleavage of the 20 oxazolidinone ring and the oxadiazole ring of 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4 (pyrimidin-2-yl)piperazin-1-ylmethyl]oxazolidin-2-one gives 25 4-[2-hydroxy-3-(4-pyrimidin-2-ylpiperazin-1-yl) propylamino]benzamidine, acetate, FAB 356; of 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl-5-[4 benzylpiperazin-1-ylmethyl]oxazolidin-2-one gives 30 4-[2-hydroxy-3-(4-benzylpiperazin-1-yl)propyl amino]benzamidine, acetate, FAB 368; of 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4 (benzo- [2,1,3] -thiadiazol-5-yl)piperazin-1-ylmethyl] 35 oxazolidin-2-one gives 4-[2-hydroxy-3-(4-(benzo-[2,1,3]-thiadiazol-5-yl) piperazin-1-yl)propylamino]benzamidine, trifluoro acetate, FAB 412.
- 86 4-[3-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4 (3,5-dimethoxybenzyl)piperazin-1-ylmethyl]oxazolidin 2-one gives 4-{2-hydroxy-3- [4- (3,5-dimethoxybenzyl)piperazin 5 1-yl]propylamino}benzamidine, FAB 428. Similarly, reaction of methyl {3-[3-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl}methane sulfonate with 4-piperazin-1-ylpyridine gives 10 3
-[
3 -(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4- (pyridin-4-yl)piperazin-1-ylmethyl] oxazolidin-2-one which is converted by hydrogenation into 3-{2-oxo-5- [4- (pyridin-4-yl)piperazin-1-ylmethyl] oxazolidin-3-yl}benzamidine, acetate, FAB 381, m.p. 15 152-165 (decomp.). Example 13 A solution of 200 mg of "A" and 66 mg of butyl 20 isocyanate in 10 ml of dichloromethane is stirred for 4 hours. 400 mg of aminomethylpolystyrene are added, and the mixture is stirred for a further 12 hours. The polystyrene and solvent are removed, giving, after customary work-up, 3- [4- (5-methyl- [1,2,4] -oxadiazol-3 25 yl)phenyl]-5-(4-butylaminocarbonylpiperazin-1-yl methyl)oxazolidin-2-one. Similarly, reaction of "A" 30 with cyclohexyl isocyanate gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 [4-(cyclohexylaminocarbonyl)piperazin-1-ylmethyl] oxazolidin-2-one; 35 with 4-methoxyphenyl isocyanate gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4- [N- (4-methoxyphenyl) aminocarbonyl]piperazin-1-yl methyl}oxazolidin-2-one; - 87 with 4-trifluoromethylphenyl isocyanate gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4- [N- (4-trifluoromethylphenyl) aminocarbonyl] piperazin 1-ylmethyl}oxazolidin-2-one; 5 with 4-chlorophenyl isocyanate gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 {4- [N- (4-chlorophenyl) aminocarbonyl]piperazin-1-yl methyl}oxazolidin-2-one; 10 with 3-ethoxycarbonylphenyl isocyanate gives 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5 {4- [N- (3 -ethoxycarbonylphenyl) aminocarbonyl] piperazin 1-ylmethyl}oxazolidin-2-one; 15 with 1-naphthyl isocyanate gives 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5 [4-(naphth-1-ylaminocarbonyl)piperazin-1-ylmethyl] oxazolidin-2-one. 20 By hydrogenation similarly to Example 2, 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5-{4- [N (4-methoxyphenyl) aminocarbonyl] piperazin-1-ylmethyl} 25 oxazolidin-2-one gives 4-{2-oxo-5-{4- [N- (4-methoxyphenyl)aminocarbonyl] piperazin-1-ylmethyl}oxazolidin-3-yl}benzamidine, acetate, FAB 453 HN N N N H2N NT Hr0N-J 30 0 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5-{4- [N (4-trifluoromethylphenyl)aminocarbonyl]piperazin-1-yl methyl}oxazolidin-2-one gives 88 4-{2-oxo-5-{4- [N- (4-trifluoromethylphenyl)amino carbonyl]piperazin-1-ylmethyl}oxazolidin-3-yl}benz amidine, acetate, FAB 473; 5 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-{4-[N (4-chlorophenyl) aminocarbonyl]piperazin-1-ylmethyl} oxazolidin-2-one gives 4-{2-oxo-5-{4- [N- (4-chlorophenyl)aminocarbonyl] piperazin-1-ylmethyl}oxazolidin-3-yllbenzamidine, 10 acetate, FAB 457; 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-(4 butylaminocarbonylpiperazin-1-ylmethyI)oxazolidin-2-one gives 15 4-[2-oxo-5-(4-butylaminocarbonylpiperazin-1-yl methyl)oxazolidin-3-yl]benzamidine, acetate, FAB 403; 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5-{4- [N (3-ethoxycarbonylphenyl)aminocarbonyl]piperazin-1-yl 20 methyl}oxazolidin-2-one gives 4- {2-oxo-5- {4- [N- (3-ethoxycarbonylphenyl) amino carbonyl]piperazin-1-ylmethyl}oxazolidin-3-yl}benz amidine, acetate, FAB 495; 25 3 -[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-[4 (naphth-1-ylaminocarbonyl)piperazin-1-ylmethyl] oxazolidin-2-one gives 4-{2-oxo-5- [4- (naphth-1-ylaminocarbonyl)piperazin 1-ylmethyl]oxazolidin-3-yl}benzamidine, acetate, FAB 30 403. Similarly to Examples 3 and 4, 3-[4-(5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-5-(4 35 butylaminocarbonylpiperazin-1-ylmethyl)oxazolidin-2-one gives 4-[3- (4-butylaminocarbonylpiperazin-1-yl)-2 hydroxypropylamino]benzamidine, acetate, FAB 377; - 89 3- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] -5- [4 (cyclohexylaminocarbonyl) piperazin-1-ylmethyl] oxazolidin-2-one gives 4- [3- (4-cyclohexylaminocarbonylpiperazin-1-yl) -2 5 hydroxypropylamino]benzamidine, acetate, FAB 403 H\ \HN' N 0 H2N~k~ OH H~kN K 2 H 10 Example 14 A solution of 1 equivalent of methyl {3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl} methanesulfonate, 3 equivalents of glycine benzyl 15 ester, methanesulfonate, and 3 equivalents of sodium bicarbonate in acetonitrile is heated under reflux for 18 hours. Customary work-up gives benzyl{{3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin 5-ylmethyliamino)acetate ("G"). 20 Similarly to Example 1, reaction of "G" with 6-chloronaphth-2-ylsulfonyl chloride gives benzyl {N-[6-chloronaphth-2-ylsulfonyl]-N-{3-[4 (5-methyl-[1,2,4]-oxadiazol-3-yl)phenyl]-2-oxo 25 oxazolidin-5-ylmethyl)amino}acetate. By hydrogenation similarly to Example 2, this gives {N- [6-chloronaphth-2-ylsulfonyl] -N- [3- (4-amidino phenyl)-2-oxooxazolidin-5-ylmethyl]amino}acetic acid, 30 acetate, FAB 517, and benzyl {N-[6-chloronaphth-2-ylsulfonyl]-N-[3-(4 amidinophenyl) -2-oxooxazolidin-5-ylmethyl] amino) acetate. 35 Similarly, reaction of "G" - 90 with naphth-2-ylsulfonyl chloride and subsequent hydrogenation gives {N- [naphth-2-ylsulfonyl] -N- [3- (4-amidinophenyl) -2 oxooxazolidin-5-ylmethyl]amino}acetic acid, acetate, 5 FAB 483 OI 0 HN N O
H
2 N - N HO O with 4-methoxybenzenesulfonyl chloride and subsequent 10 hydrogenation gives {N- [4-methoxybenzenesulfonyl] -N- [3- (4-amidino phenyl)-2-oxooxazolidin-5-ylmethyl]amino}acetic acid, acetate, FAB 453; 15 with phenylvinylsulfonyl chloride and subsequent hydrogenation gives benzyl {N-[phenylvinylsulfonyl]-N-[3-(4-amino phenyl)-2-oxooxazolidin-5-ylmethyl]amino}acetate, acetate, FAB 549; 20 with 4-biphenylylsulfonyl chloride and subsequent hydrogenation gives {N- [4-biphenylylsulfonyl] -N- [3- (4-amidinophenyl) 2 -oxooxazolidin-5-ylmethyllIamino}acetic acid, acetate, 25 FAB 509; with 4-propylbenzenesulfonyl chloride and subsequent hydrogenation gives benzyl {N-[4-propylbenzenesulfonyl]-N-[3-(4 30 amidinophenyl)-2-oxooxazolidin-5 ylmethyl]amino}acetate, acetate, FAB 565.
- 91 Example 15 A solution of 4-oxiranylmethoxybenzonitrile and BOC piperazine in methanol is stirred under reflux for 4 5 hours. Customary work-up gives 4-[2-hydroxy-3-(4-BOC piperazin-1-yl)propoxybenzonitrile. The subsequent reaction with hydroxylamine hydrochloride affords N hydroxy-4- [2-hydroxy-3- (4-BOC-piperazin-1-yl)propoxy] benzamidine. Subsequent acylation with acetic anhydride 10 gives 2-acetoxy-l-(4-BOC-piperazin-1-yl)-3-[4-(5 methyl-[1,2,4]-oxadiazol-3-yl)phenoxy]propane. After removal of the BOC group with HCl in dioxane, reaction with 4-propylphenylsulfonyl chloride gives the compound 2-acetoxy-l- [4- (4-propylphenylsulfonyl)piperazin-1-yl] 15 3-[4-(5-methyl- [1,2,4]-oxadiazol-3-yl)phenoxy]propane. Reaction similarly to Examples 3 and 4 gives the compound 4-{2-hydroxy-3- [4- (4-propylphenylsulfonyl) piperazin-1-yl]propoxy}benzamidine 20 0 O N O The compounds below are obtained similarly 25 3-{2-hydroxy-3-[4-(4-biphenylylcarbonyl)piperazin 1-yl]propoxy}benzamidine, acetate, FAB 459; 3-{2-hydroxy-3-[4-(6-chloro-2-naphthylsulfonyl) 30 piperazin-1-yl]propoxy}benzamidine, acetate, FAB 503; 3-{2-hydroxy-3-[4-(2-naphthylsulfonyl)piperazin-l yl]propoxy}benzamidine, acetate, FAB 469; 35 3- {2-hydroxy-3- [4- (4-propylphenylsulfonyl) piperazin-1-yl]propoxy}benzamidine, acetate, FAB 461; - 92 3- {2-hydroxy-3- [4- (4-isopropylphenylsulfonyl) piperazin-1-yl]propoxy}benzamidine, acetate, FAB 461; 5 3-{2-hydroxy-3- [4- (4-methoxyphenylsulfonyl) piperazin-1-yl]propoxy}benzamidine, acetate, FAB 449; 3-{2-hydroxy-3- [4- (4-butylphenylsulfonyl) piperazin-1-yllpropoxy}benzamidine, acetate, FAB 399; 10 3-{2-hydroxy-3- [4-benzoylpiperazin-1-yl]propoxy} benzamidine, acetate, FAB 383; 3-{2-hydroxy-3- [4- (7-methoxy-2-naphthylsulfonyl) 15 piperazin-1-yl]propoxy}benzamidine, acetate, FAB 499; 3-{2-hydroxy-3-[4-(3,5-dimethoxybenzyl)piperazin 1-yl]propoxy}benzamidine, acetate, FAB 429; 20 3-{2-hydroxy-3- [4- (4-biphenylylsulfonyl)piperazin 1-yl]propoxy}benzamidine, diacetate, FAB 495; 3-{2-hydroxy-3-[4-(naphth-2-ylmethyl)piperazin-l yl]propoxy}benzamidine, diacetate, FAB 419; 25 3-{2-hydroxy-3-[4-(2-naphthylcarbonyl)piperazin 1-yl]propoxy}benzamidine, diacetate, FAB 433; 3-{2-hydroxy-3-[4-(4-biphenyl-4-ylmethyl) 30 piperazin-1-yl]propoxy}benzamidine, diacetate, FAB 445. Example 16 10.0 g of 3-oxiranylmethoxybenzonitrile ("H") and 7.1 g 35 of 3-cyanophenol together with 173 mg of caesium fluoride are molten at 130 0 C. Customary work-up gives 11.8 g of 1,3-bis-(3-cyanophenoxy)-2-hydroxypropane. Subsequent reaction with hydroxylammonium chloride gives 1,3-bis-[3-(N-hydroxyamidino)phenoxy]-2-hydroxy- - 93 propane. Hydrogenation similarly to Example 2 gives 1, 3-bis- (3-amidinophenoxy) -2-hydroxypropane, diacetate, FAB 329
H
2 N NH HN NH2 HO 5 Similarly, the compounds 1, 3-bis- (4-amidinophenoxy) -2-hydroxypropane, diacetate, FAB 329 10 and 1-(3-amidinophenoxy)-3-(4-amidinophenoxy) 2-hydroxypropane, are obtained. Similarly, reaction of "H" with the phenols below 15 4-chlorophenol, 4-methylphenol, phenol, 4-methoxyphenol, 20 4-cyclohexylphenol and subsequent reaction with hydroxylammonium chloride and hydrogenation 25 gives the compounds below 1- (3-amidinophenoxy) -2-hydroxy-3- (4-chloro phenoxy) propane, 1- (3-amidinophenoxy) -2-hydroxy-3- (4-methyl 30 phenoxy)propane, 1- (3-amidinophenoxy) -2-hydroxy-3 -phenoxypropane, 1- (3-amidinophenoxy) -2-hydroxy-3- (4-methoxy phenoxy) propane, - 94 1- (3-amidinophenoxy) -2-hydroxy-3- (4-cyclohexyl phenoxy) propane. Example 17 5 A solution of 1 equivalent of N-{3-[4-(5-methyl [1,2,4]-oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-yl methyl}-(6-chloro-2-naphthyl)sulfonamide ("I") [obtainable by reaction of 5-aminomethyl-3-[4-(5 10 methyl- [1,2,4] -oxadiazol-3-yl)phenyl [oxazolidin-2-one with 6-chloro-2-naphthylsulfonyl chloride], 1.1 equivalents each of N,N'-dimethylchloroacetamide and caesium carbonate in DMF is stirred at room temperature for 12 hours. Customary work-up gives 2-((6-chloro-2 15 naphthylsulfonyl)-{3-[4-(5-methyl-[1,2,4]-oxadiazol-3 yl)phenyl]-2-oxooxazolidine-5-ylmethyl}amino)-N,N' dimethylacetamide. Similarly to Examples 3 and 4, this gives the compound 20 2- [[3- (4-amidinophenylamino) -2-hydroxypropyl] - (6 chloro-2-naphthylsulfonyl)amino]-N,N'-dimethylacetamide CI 0 S HN Hr "\\ NH 25 Similarly, reaction of "I" with N,N'-diethylchloroacetamide, N,N'-dipropylchloroacetamide, N-phenylchloroacetamide, 30 N,N'-diphenylchloroacetamide and ethyl chloroacetate - 95 and subsequent cleavage of the oxazolidinone ring and the oxadiazole ring similarly to Examples 3 and 4 gives the compounds 5 2-[[3-(4-amidinophenylamino)-2-hydroxypropyl] (6-chloro-2-naphthylsulfonyl)amino]-N,N'-diethylacet amide, 2-[[3-(4-amidinophenylamino)-2-hydroxypropyl] 10 (6-chloro-2-naphthylsulfonyl)amino]-N,N'-dipropylacet amide, 2-[[3-(4-amidinophenylamino)-2-hydroxypropyl] (6-chloro-2-naphthylsulfonyl)amino]-N-phenylacetamide, 15 2-[[3-(4-amidinophenylamino)-2-hydroxypropyl] (6-chloro-2-naphthylsulfonyl)amino]-N,N'-dipenylacet amide and 20 2-[[3-(4-amidinophenylamino)-2-hydroxypropyl] (6-chloro-2-naphthylsulfonyl)amino]acetic acid, acetate FAB 491. Similarly, by reaction of N-{3-[4-(5-methyl-[1,2,4] 25 oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl)-(4 isopropylphenyl)sulfonamide with N,N'-dimethylchloroacetamide, N,N'-diethylchloroacetamide, 30 N,N'-dipropylchloroacetamide, N-phenylchloroacetamide, N,N'-diphenylchloroacetamide, benzyl bromide, iodobutane, 35 4-chloromethyl-2-methylthiazole, 4-methoxybenzyl bromide, ethyl chloroacetate, ethyl 4-chlorobutyrate, ethyl 3-chloromethylbenzoate, - 96 ethyl 4-chloromethylbenzoate, 3, 5-dimethoxybenzyl bromide, 4-(5-methyl-[1,2,4]-oxadiazol-3-yl)benzyl bromide, 3- (5-methyl- [1,2,4] -oxadiazol-3-yl)benzyl bromide and 5 2-fluorobenzyl bromide and subsequent cleavage of the oxazolidinone ring and the oxadiazole ring similarly to Examples 3 and 4 gives the compounds 10 2- [[3- (4-amidinophenylamino) -2-hydroxypropyl] (4-isopropylsulfonyl)amino]-N,N'[-dimethylacetamide, 2- [[3- (4-amidinophenylamino) -2-hydroxypropyl] 15 (4-isopropylsulfonyl)amino]-N,N'-diethylacetamide, 2- [[3- (4-amidinophenylamino) -2-hydroxypropyl] (4-isopropylsulfonyl)amino]-N,N'-dipropylacetamide, 20 2- [[3- (4-amidinophenylamino) -2 -hydroxypropyl] (4-isopropylsulfonyl)amino]-N-phenylacetamide, 2- [[3- (4-amidinophenylamino) -2-hydroxypropyl] (4-isopropylsulfonyl) amino] -N,N' -diphenylacetamide, 25 4-{(2-hydroxy)-3-[(4-isopropylbenzenesulfonyl) benzylamino]propylamino}benzamidine, acetate, FAB 481, 4-{(2-hydroxy)-3-[(4-isopropylbenzenesulfonyl) 30 butylamino]propylamino}benzamidine, acetate, FAB 447, 4-{(2-hydroxy)-3-[(4-isopropylbenzenesulfonyl) (2-methylthiazol-4-ylmethyl)amino]propylamino} benzamidine, acetate, FAB 502, 35 4-{ (2-hydroxy) -3- [(4-isopropylbenzenesulfonyl) -(4 methoxybenzyl)amino]propylamino}benzamidine, acetate, FAB 511, - 97 2- [[3- (4-amidinophenylamino) -2-hydroxypropyl] - (4 isopropylbenzenesulfonyl)amino]acetic acid, acetate, FAB 449, 5 4- [[3- (4-amidinophenylamino) -2-hydroxypropyl] -(4 isopropylbenzenesulfonyl) amino] butyric acid, diacetate, FAB 477, 3-{ [[3- (4-amidinophenylamino) -2-hydroxypropyl] 10 (4-isopropylbenzenesulfonyl)amino]methyl}benzoic acid, diacetate, FAB 525, 4-{ [[3- (4-amidinophenylamino) -2-hydroxypropyl] (4-isopropylbenzenesulfonyl)amino]methyl}benzoic acid, 15 diacetate, FAB 525 0 S HN N \\ 2 OH OH 0 4-{ (2-hydroxy) -3- [(4-isopropylbenzenesulfonyl) 20 (3,5-dimethoxybenzyl)amino]propylamino}benzamidine, diacetate, FAB 541, 4-{(2-hydroxy)-3-[(4-isopropylbenzenesulfonyl) (4-amidinobenzyl)amino]propylamino}benzamidine, tri 25 acetate, FAB 523, 4-{(2-hydroxy)-3-[(4-isopropylbenzenesulfonyl) (3-amidinobenzyl)amino]propylamino}benzamidine, triacetate, FAB-523 and - 98 4-{ (2-hydroxy) -3- [(4-isopropylbenzenesulfonyl) (2-fluorobenzyl)amino]propylamino}benzamidine, diacetate, FAB 499. 5 Similarly, reaction of "I" with iodoethane, benzyl bromide, 4-methoxybenzyl bromide, 10 2-bromomethylnaphthalene, 4-chloromethyl-2-methylthiazole and 4-methoxybenzyl chloride and subsequent cleavage of the oxazolidinone ring and 15 the oxadiazole ring similarly to Examples 3 and 4 gives the compounds 4-{3-[(6-chloro-2-naphthylsulfonyl)ethylamino] 2 -hydroxypropylamino} benzamidine 20 CI 0 4 S ONH O 4-{3-[(6-chloro-2-naphthylsulfonyl)benzylamino] 2 -hydroxypropylamino}benzamidine, 25 4-{3-[(6-chloro-2-naphthylsulfonyl)-(4-methoxy benzyl) amino] -2 -hydroxypropylamino}benzamidine, 4-{3-[(6-chloro-2-naphthylsulfonyl)-(naphth-2-yl methyl) amino] -2 -hydroxypropylamino}benzamidine, 4-{3-[(6-chloro-2-naphthylsulfonyl)-(2-methyl 30 thiazol-4-ylmethyl) amino] -2-hydroxypropylamino} benzamidine, diacetate, FAB. 544 and 4-{3- [(6-chloro-2-naphthylsulfonyl)-(4-methoxy benzyl) amino] -2-hydroxypropylamino}benzamidine, diacetate, FAB 553.
- 99 Similarly, reaction of N- {3- [4- (5-methyl- [1, 2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl) (4-methoxyphenyl) sulfonamide with iodobutane and 5 subsequent cleavage of the oxazolidinone and the oxadiazole ring similar to Example 3 and 4 gives the compound 4- {3- [(4 -methoxyphenylsulfonyl) butylamino] -2 -hydroxy 10 propylamino}benzamidine, acetate, FAB 435. Similarly, reaction of N-{3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenyl]-2-oxooxazolidin-5-ylmethyl) (2-naphthyl)sulfonamide with 15 iodobutane and iodoethane and subsequent cleavage of the oxazolidinone and the 20 oxadiazole ring similar to Example 3 and 4 gives the compounds 4-{3-[(2-naphthylsulfonyl)butylamino]-2-hydroxy propylamino}benzamidine, acetate, FAB 455 and 25 4-{3-[(2-naphthylsulfonyl)ethylamino]-2-hydroxy propylamino}benzamidine, acetate, FAB 427. Example 18 30 Similarly to Example 11, the appropriate cyano derivatives give, by reaction with hydroxylammonium chloride, the compounds below 35 3- (3-N-hydroxyamidinophenyl) -5- [(4-N-hydroxy amidinophenoxy)methyl]oxazolidin-2-one, m.p. 201-205*, 3- (3-N-hydroxyamidinophenyl) -5- [(3-N-hydroxy amidinophenoxy) methyl] oxazolidin-2-one, - 100 3- (4-N-hydroxyamidinophenyl) -5- [(3-N-hydroxy amidinobenzyloxy) methyl] oxazolidin-2 -one, 3- (3-N-hydroxyamidinophenyl) -5- [(3-N-hydroxy 5 amidinobenzyloxy)methyl]oxazolidin-2-one. Similarly to Example 2, these give, by hydrogenation, the compounds 10 3- (3-amidinophenyl) -5- [(4-amidinophenoxy) methyl] oxazolidin-2-one, diacetate, m.p. 150-1660 (decom position), FAB 354; 3-(3-amidinophenyl)-5-[(3-amidinophenoxy)methyl] 15 oxazolidin-2-one, diacetate, m.p. 312-3180; 3-(4-amidinophenyl)-5-[(3-amidinobenzyloxy) methyl]oxazolidin-2-one, triacetate, m.p. 189-205* (decomp.), FAB 368; 20 3- (3-amidinophenyl) -5- [(3-amidinobenzyloxy) methyl]oxazolidin-2-one, triacetate, m.p. 204-2220 (decomp.), FAB 368. 25 Example 19 Similarly to Example 16, reaction of 4-oxiranyl ethylbenzonitrile and 3-cyanophenol, subsequent reaction with hydroxylammonium chloride and hydro 30 genation gives the compound 4-[3-hydroxy-4-(3-amidino phenoxy)butyl]benzamidine, diacetate, FAB 327 NH HN NH 2
H
2 N 0
OH
- 101 Example 20 Under nitrogen, 10.0 g of 3-(5-methyl-[1,2,4] oxadiazol-3-yl)phenol is added to 50 ml of DMF and 5 2.6 g of sodium hydride are subsequently added at 00. 5.1 ml of epibromohydrin are added, and the mixture is stirred at room temperature for 24 hours. Customary work-up gives 5-methyl-3- (3-oxiranylmethoxyphenyl) [1,2,4]-oxadiazol. 10 8.0 g of the oxiranyl compound are dissolved in 400 ml of methanol and NH 3 gas is introduced for 6 hours. The mixture is stirred for another 16 hours, yielding, after removal of the solvent, 1-amino-3-[3-(5-methyl [1,2,4] -oxadiazol-3-yl)phenoxy]propan-2-ole ("AB"). 15 500 mg of "AB" and 434 mg of 4-methoxyphenylsulfonyl chloride together with 2.0 g of polymeric DMAP (1.6 mmol of dimethylaminopyridine/g of resin) in 5 ml of pyridine are stirred at room temperature for 24 hours. The resin is filtered off and the filtrate is 20 worked up as usual, giving N-{2-hydroxy-3-[3-(5-methyl [1,2,4]-oxadiazol-3-yl)phenoxy]propyl}-4-methoxy benzenesulfonamide. This gives, by hydrogenation similarly to Example 2, 25 the compound 3- [2-hydroxy-3- (4-methoxybenzenesulfonylamino) propoxy]benzamidine, acetate, FAB 380 0 0 H2N NH O% O H 2 N 0 N N . NH OH H 1:1 30 Similarly, reaction of "AB" with 4-isopropylphenylsulfonyl chloride, 2-naphthylsulfonyl chloride, 35 6-chloro-2-naphthylsulfonyl chloride, 7-methoxy-2-naphthylsulfonyl -chloride - 102 and subsequent hydrogenation gives the compounds below 5 3- [2-hydroxy-3- (4-isopropylbenzenesulfonylamino) propoxy]benzamidine, acetate, FAB 392; 3- [2-hydroxy-3- (2-naphthylsulfonylamino)propoxy] benzamidine, acetate, FAB 400; 10 3- [2-hydroxy-3- (6-chloro-2-naphthylsulfonylamino) propoxy]benzamidine, acetate, FAB 434; 3- [2-hydroxy-3- (7-methoxy-2-naphthylsulfonyl amino)propoxy]benzamidine, acetate, FAB 430; 15 Similarly, reaction of 1-amino-3-[4-(5-methyl-[1,2,4] oxadiazol-3-yl)phenoxy]propan-2-ole with 4-methoxyphenylsulfonyl chloride, 4-isopropylphenylsulfonyl chloride, 20 2-naphthylsulfonyl chloride, 6-chloro-2-naphthylsulfonyl chloride, 7 -methoxy-2-naphthylsulfonyl chloride and subsequent hydrogenation 25 gives the following compounds 4- [2-hydroxy-3- (4-methoxybenzenesulfonylamino) propoxy]benzamidine, acetate, FAB 380; 30 4- [2-hydroxy-3- (4-isopropylbenzenesulfonylamino) propoxy]benzamidine, acetate, FAB 392; 4- [2-hydroxy-3 - (2 -naphthylsulfonylamino) propoxy] benzamidine, acetate, FAB 400; 4- [2-hydroxy-3- (6-chloro-2-naphthylsulfonylamino) 35 propoxy]benzamidine, acetate, FAB 434; 4- [2-hydroxy-3- (7-methoxy-2-naphthylsulfonyl amino)propoxy]benzamidine, acetate, FAB 430.
- 103 Example 21 10.7 ml of sodium methoxide (30% strength in methanol) are added to 30 ml of methanol, 4-(5-methyl-[1,2,4] 5 oxadiazol-3-yl) aniline is added under nitrogen and the mixture is stirred at 450 for 10 minutes. The mixture is subsequently added to a suspension of 480 mg of paraformaldehyde and 20 ml of methanol, and the mixture is stirred at 60 0 C for 2 hours. The mixture is then 10 admixed with 440 mg of sodium borohydride and stirred at 600 for 1 hour. The mixture is subsequently admixed two more times with 1.44 g of paraformaldehyde, 3.1 g of sodium methoxide and 220 mg of sodium borohydride each time. 15 After [lacuna] hours, the mixture is hydrolyzed using 1N NaOH and worked up as usual. This gives, as a crude product, 1.93 g of N-methyl-4-(5-methyl-[1,2,4] oxadiazol-3-yl)aniline. 20 A solution of 1.35 g of 4 -(5-methyl-[1,2,4]-oxadiazol 3-yl)-N-methylaniline and 1.0 ml of epichlorohydrin in 5 ml of ethanol and 3.5 ml of water is boiled under reflux for 12 hours. Customary work-up gives 0.4 g of N-methyl-N-oxiranylmethyl-4-(5-methyl-[1,2,4]-oxa 25 diazol-3-yl)aniline. A solution of 0.39 g of N-methyl N-oxiranylmethyl-4- (5-methyl- [1,2,4] -oxadiazol-3-yl) aniline and 30 ml of methylamine (33% strength in ethanol) in 10 ml of ethanol is stirred at 65* for 15 hours. Customary work-up gives 0.44 g of 30 1-methylamino-3-{methyl-[4-(5-methyl-[1,2,4]-oxadiazol 3 -yl)phenyl]amino}propan-2 -ole ( "BC" ). 100 mg of "BC" and 87 mg of 4 -isopropylphenylsulfonyl chloride together with 300 mg of polymeric DMAP (1.6 mmol of dimethylaminopyridine/g of resin) in 5 ml 35 of dichloromethane are stirred at room temperature for 16 hours. The resin is filtered off and the filtrate is worked up as usual. This gives 109 mg of N-(2-hydroxy 3-{methyl- [4- (5-methyl- [1,2,4] -oxadiazol-3-yl)phenyl] amino}propyl)
-
4 -isopropyl-N-methylbenzenesulfonamide.
- 104 By hydrogenation similarly to Example 2, this gives the compound 4- ({2-hydroxy-3- [(4-isopropylbenzenesulfonyl)
-N
methylamino] propyl } -N-methylamino) benzamidine, acetate, 5 FAB 419 NH
H
2 N NOO N N OH Similarly, reaction of "BC" with 2-naphthylsulfonyl 10 chloride and subsequent hydrogenation gives the compound 4- ({2-hydroxy-3- [(naphth-2-ylsulfonyl) -N-methyl amino] propyl }-N-methylamino) benzamidine, diacetate, FAB 15 427. The following examples relate to pharmaceutical formulations: 20 Example A: injection vials A solution of 100 g of an active compound of the formula I and 5 g of disodium hydrogen phosphate in 3 1 of doubly distilled water is brought to pH 6.5 with 2 N hydrochloric acid and subjected to sterile filtration, 25 and injection vials are filled with the solution, lyophilized under sterile conditions and closed under sterile conditions. Each injection vial contains 5 mg of active compound. 30 Example B: suppositories A mixture of 20 g of an active compound of the formula I-with-100 g of soya lecithin and 1400 g of cocoa butter is melted, poured into moulds and allowed - 105 to cool. Each suppository contains 20 mg of active compound. Example C: solution 5 A solution is prepared from 1 g of an active compound of the formula I, 9.38 g of NaH 2
PO
4 -2H 2 0, 28.48 g of Na 2
HPO
4 -12H 2 0 and 0.1 g of benzalkonium chloride in 940 ml of doubly distilled water. It is brought to pH 6.8, topped up to 1 1 and sterilized by irradiation. 10 This solution can be used in the form of eyedrops. Example D: ointment 500 g of an active compound of the formula I are mixed with 99.5 g of vaseline under aseptic conditions. 15 Example E: tablets A mixture of 1 kg of active compound of the formula I, 4 kg of lactose, 1.2 kg of potato starch, 0.2 kg of talc and 0.1 kg of magnesium stearate is pressed into 20 tablets in the customary manner such that each tablet contains 10 mg of active compound. Example F: coated tablets Tablets are pressed analogously to Example E and are 25 then coated in the customary manner with a coating of sucrose, potato starch, talc, tragacanth gum and dyestuff. Example G: capsules 30 Hard gelatin capsules are filled with 2 kg of active compound of the formula I in the customary manner such that each capsule contains 20 mg of the active compound. 35 Example H: ampoules A solution of 1 kg of active compound of the formula I in 60 1 of doubly distilled water is subjected to sterile filtration, and ampoules are filled with the solution, lyophilized under sterile conditions and - 106 closed under sterile conditions. Each ampoule contains 10 mg of active compound.

Claims (5)

1. Compounds of the formula I R' R2 5 R3 in which R is -C (=NH) -NH 2 which can also be mono 10 substituted by -COA, -CO- [C (R ) 2 ]m-Ar, -COOA, -OH or by a conventional amino-protective group, { 0 or HN- N- O CH 3 R 2 is H, A, ORs, N(R 5 ) 2 , NO 2 , CN, Hal, NR 5 COA, 15 NHCOAr, NHSO 2 A, NHSO 2 Ar, COORs, CON (R 5 ) 2 , CONHAr, COR 5 , COAr, S (O) A or S (O) Ar, R3 is R 5 or -C(R 5 ) 2 ]m-COORs, 20 R 3 and X together are also -CO-N-, thus forming a
5-membered ring, where R 3 s -C=O and X is N, R 4 is A, cycloalkyl, -[C(Rs) 2 ]mAr, -[C(R ) 2 ]mHet or -CR 5 =CR 5 -Ar, 25 R 5 is'H, A or benzyl, X -- is -O, -NR 5 or CH 2 , - 108 Y is 0, NRs, N [C(R 5 ) 2 ]m-Ar, N[C(R 5 ) 2 m1-Het, -N N-, N [C (R 5 ) 2 ]m-COORs, / R5 R5 -N N 5 N [C (Rs) 2 ]m- CON (R 5 ) 2 , N [C (R 5 ) 2 ] m-CONR 5 Ar or N [C (R 5 ) 2] m-CONAr 2 , W is a bond, -SO 2 -, -CO-, -COO- or -CONR 5 -, 10 A is alkyl having 1-20 C atoms in which one or two CH 2 groups can be replaced by 0 or S atoms or by -CR 5 =CR 5 - groups and/or 1-7 H atoms can be replaced by F, 15 Ar is naphthyl or phenyl which is unsubstituted or mono-, di- or trisubstituted by R 1 , A, Ar', ORs, N(R 5 ) 2 , NO 2 , CN, Hal, NHCOA, NHCOAr' , NHSO 2 A, NHSO 2 Ar', COORs, CON (Rs) 2 , 20 CONHAr', COR , COAr', S (O) A or S (O) nAr, Ar' is naphthyl or phenyl which is unsubstituted or mono-, di- or trisubstituted by R , A, ORs N (R ) 2 , NO 2 , CN, Hal, NHCOA, COORs, CON (Rs) 2 , 25 COR 5 or S(O)nA, Het is a mono- or bicyclic saturated or unsaturated heterocyclic ring system which contains one, two, three or four identical or 30 different hetero atoms such as nitrogen, oxygen and sulfur and which is unsubstituted or mono- or polysubstituted by Hal, A, Ar', ORE, COOR 5 , CN, N(Rs) 2 , NO 2 , NHCOA, NHCOAr' -- and/or -carbonyl oxygen, 35 Hal is F, Cl, Br or I, - 109 m is 0, 1, 2, 3 or 4, n is 0, 1 or 2, 5 and salts thereof. 2. Compounds according to Claim 1, 10 a) 4-{3- [4- (2,6-dichloro-4-methoxybenzene sulfonyl) piperazin-1-yl] -2-hydroxypropyl amino)benzamidine; b) 4- {3- [(4-isopropylbenzenesulfonyl)methyl amino] -2 -hydroxypropylamino}benzamidine; 15 c) 4-{3-[4-(l-naphthylbenzenesulfonyl)piperazin 1-yl] -2 -hydroxypropylamino}benzamidine; d) 3-(4-amidinophenyl)-5-[(3-amidinophenoxy) methyl]oxazolidin-2-one 20 and salts thereof. 3. Process for preparing compounds of the formula I according to Claim 1 and salts thereof, characterized in that 25 a) they are liberated from one of their functional derivatives by treatment with a solvolysing or hydrogenolysing agent, by 30 i) liberating an amidino group from its oxadiazole derivative by hydrogenolysis, ii) replacing a conventional amino-protective group by treatment with a solvolysing or 35 hydrogenolysing agent with hydrogen or liberating an amino group which is protected by a conventional protective group, - 110 or b) that for preparing compounds of the formula I 5 in which R 1 is { N'O{ N' HN4 N- , C 0 or CH 3 R3 and X together are -CO-N-, thus forming a 10 5-membered ring, NR', -N N-, -Na N Y is or R5 /R5 N N 15 W is -SO 2 - or -CO-, and R 2 and R 4 are as defined in Claim 1, 20 a compound of the formula II RI R O3_1 in which 25 - 111 R' HN4 N R 1 is 0 or CH 3 R 3 and X together are -CO-N-, thus forming a 5 5-membered ring, /~\ / Y NR 5 , -N N- , -N N Y is or R5 /R5 10 and R 2 and R 5 are as defined in Claim 1, is reacted with a compound of the formula III 15 R 4-W-L III in which W is -SO 2 - or -CO-, 20 R 4 is as defined in Claim 1, and L is Cl, Br, I or a free or a reactive functionally derivatized OH group, 25 or c) that for preparing compounds of the formula I 30 in which R 1 is - 112 HN4 N-- ,H O or CH R3 and X together are -CO-N-, thus forming a 5 5-membered ring, Y is 0, W is a bond, and R 2 and R 4 are as defined in Claim 1, 10 a compound of the formula II RH 2 L ,.O Y R3 15 in which R 1 is R' HN4 N 0 or CH 3 20 R3 and X together are -CO-N-, thus forming a 5-membered ring, Y is 0, and R2 is as defined in Claim 1, 25 is reacted with a compound of the formula IV - 4'-W-OH IV \30 in which - 113 W is a bond, and R 4 is as defined in Claim 1, 5 or d) that for preparing compounds of the formula I 10 in which HN4 N= , R is 0 or CH3 R and X together are -CO-N-, thus forming a 15 5-membered ring, -N N-, Y is W is a bond, 20 R 4 is -[C(Rs) 2 1 mAr or -[C(R 5 ) 2 1mHet, m is 0, 25 and R 2 is as defined in Claim 1, a compound of the formula V Ri V - R 3 30 in which - 114 { -N, {.>,N'O HN N , R' is 0 or CH 3 R 3 and X together are -CO-N-, thus forming a 5 5-membered ring, and L is Cl, Br, I or a free or a reactive functionally derivatized OH group, 10 and R 2 is as defined in Claim 1, is reacted with a compound of the formula VI R 4-W-Y-H VI 15 in which W is a bond, -N N-, 20 Y is R 4 is -[C(Rs) 2 ]mAr or -[C(Rs) 2 ]mHet and m is 0, 25 or e) that for preparing compounds of the formula I in which 30 - 115 {..N. {> N'O HN N= ,H R 1 is 0 or 3 R3 and X together are -CO-N-, thus forming a 5-membered ring, 5 /~-\ NR, -N NN-,-NN Y is or R 5 R 5 N N 10 W is -CONH-, and R 2 and R 4 are as defined in Claim 1, a compound of the formula II 15 R R 0 R 3 in which HN NC 20 R' is 0 CH R3 and X together are -CO-N-, thus forming a 5-membered ring, - 116 /~~\ / NR 5 , -N N- , -N N Y is \R R 5 R 5 r N N or and R 2 and R 5 are as as defined in Claim 1, 5 is reacted with a compound of the formula VII R 4 -N=C=O VII 10 in which R 4 is as defined in Claim 1, or 15 f) that for preparing compounds of the formula I in which -' N, 0N' HN4 N ,= 20 R 1 is 0 or CH3 R3 and X together are -CO-N-, thus forming a 5-membered ring, 25 Y is N[C(Rs) 2 ]m-COOR, W is SO 2 , and R 2 and R 4 are as defined in Claim 1, 30 -- a compound of the formula II - 117 R1 R2 R 3 in which { N, { N'O R1 HN4 N=, 5 R 1 is 0 or CH3 R3 and X together are -CO-N-, thus forming a 5-membered ring, 10 Y is N[C(R 5 ) 2 ]m-COOR, and R 2 and R 5 are as defined in Claim 1, is reacted with a compound of the formula 15 VIII R 4-S0 2 -L VIII in which 20 L is Cl, Br, I or a free or a reactive functionally derivatized OH group, and R 4 is as defined in Claim 1, 25 or g) that for preparing compounds of the formula I 30 in which X is NH and - 118 R 3 is H and R', R 2 , R 4 , Y and W are as defined in Claim 1, 5 these compounds are liberated from their oxazolidinone derivatives by treatment with a solvolysing or hydrogenolyzing agent, 10 or h) that for preparing compounds of the formula I in which R 1 is -C (=NH) -NH 2 , 15 a cyano group is converted into an amidino group, or 20 I) in a compound of the formula I, one or more radicals Y, R', R2, R 3 and/or R 4 are converted into one or more radicals R', R 2 , R 3 and/or R 4 , 25 by, for example, i) hydrolysing an ester group to give a carboxyl group, 30 ii) reducing a nitro group, iii) acylating an amino group, and/or 35 k) converting a base or acid of the formula I into one of its salts. - 119 4. Process for preparing pharmaceutical formulations, characterized in that a compound of the formula I according to Claim 1 and/or one of its physiologically acceptable salts is brought into a 5 suitable dosage form together with at least one solid, liquid or semi-liquid carrier ,or auxiliary. 5. Pharmaceutical formulation, characterized by a content of at least one compound of the formula I 10 according to Claim 1 and/or one of its physiologically acceptable salts.
6. Compounds of the formula I according to Claim 1 and their physiologically acceptable salts for 15 combating thromboses, myocardial infarction, arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis after angioplasty and claudicatio intermittens. 20 7. Medicaments of the formula I according to Claim 1 and their physiologically acceptable salts as inhibitors of coagulation factor Xa.
8. Use of compounds of the formula I according to 25 Claim 1 and/or their physiologically acceptable salts for the preparation of a medicament.
9. Use of compounds of the formula I according to Claim 1 and/or their physiologically acceptable 30 salts in combating thromboses, myocardial infarction, arteriosclerosis, . inflammations, apoplexy, angina pectoris, restenosis after angioplasty and claudicatio intermittens.
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