[go: up one dir, main page]

AU2001286750A1 - Compositions and methods for exon profiling - Google Patents

Compositions and methods for exon profiling

Info

Publication number
AU2001286750A1
AU2001286750A1 AU2001286750A AU8675001A AU2001286750A1 AU 2001286750 A1 AU2001286750 A1 AU 2001286750A1 AU 2001286750 A AU2001286750 A AU 2001286750A AU 8675001 A AU8675001 A AU 8675001A AU 2001286750 A1 AU2001286750 A1 AU 2001286750A1
Authority
AU
Australia
Prior art keywords
compositions
methods
exon profiling
exon
profiling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001286750A
Other languages
English (en)
Inventor
Stephen H. Friend
Stewart Scherer
Daniel D. Shoemaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rosetta Inpharmatics LLC
Original Assignee
Rosetta Inpharmatics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Inpharmatics LLC filed Critical Rosetta Inpharmatics LLC
Publication of AU2001286750A1 publication Critical patent/AU2001286750A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2001286750A 2000-08-25 2001-08-24 Compositions and methods for exon profiling Abandoned AU2001286750A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22796600P 2000-08-25 2000-08-25
US22790200P 2000-08-25 2000-08-25
US60/227,902 2000-08-25
US60/227,966 2000-08-25
US09/724,538 US7807447B1 (en) 2000-08-25 2000-11-28 Compositions and methods for exon profiling
US09/724,538 2000-11-28
PCT/US2001/026541 WO2002016650A2 (fr) 2000-08-25 2001-08-24 Compositions et methodes d'evaluation des niveaux d'expression des exons

Publications (1)

Publication Number Publication Date
AU2001286750A1 true AU2001286750A1 (en) 2002-03-04

Family

ID=27397782

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001286750A Abandoned AU2001286750A1 (en) 2000-08-25 2001-08-24 Compositions and methods for exon profiling

Country Status (5)

Country Link
US (1) US7807447B1 (fr)
EP (1) EP1349957A2 (fr)
AU (1) AU2001286750A1 (fr)
CA (1) CA2420525A1 (fr)
WO (1) WO2002016650A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE503023T1 (de) 2001-06-18 2011-04-15 Rosetta Inpharmatics Llc Diagnose und prognose von brustkrebspatientinnen
US7171311B2 (en) 2001-06-18 2007-01-30 Rosetta Inpharmatics Llc Methods of assigning treatment to breast cancer patients
US7833779B2 (en) 2001-07-25 2010-11-16 Jivan Biologies Inc. Methods and systems for polynucleotide detection
US7340349B2 (en) * 2001-07-25 2008-03-04 Jonathan Bingham Method and system for identifying splice variants of a gene
US7418351B2 (en) 2002-01-31 2008-08-26 Rosetta Inpharmatics Llc Methods for analysis of measurement errors in measured signals
US7996155B2 (en) 2003-01-22 2011-08-09 Microsoft Corporation ANOVA method for data analysis
GB0303006D0 (en) * 2003-02-10 2003-03-12 Genomica Sau A method to detect polymeric nucleic acids
US8609830B2 (en) 2003-05-16 2013-12-17 Merck Sharp & Dohme Corp. Methods and compositions for RNA interference
US20040234963A1 (en) * 2003-05-19 2004-11-25 Sampas Nicholas M. Method and system for analysis of variable splicing of mRNAs by array hybridization
WO2005086891A2 (fr) 2004-03-05 2005-09-22 Rosetta Inpharmatics Llc Classification de patients du cancer du sein utilisant une combinaison de criteres cliniques et d'ensembles genetiques informatifs
US7881872B2 (en) 2004-03-12 2011-02-01 Microsoft Corporation Methods of analyzing multi-channel profiles
US7962291B2 (en) 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
US8105777B1 (en) 2008-02-13 2012-01-31 Nederlands Kanker Instituut Methods for diagnosis and/or prognosis of colon cancer
WO2016018960A1 (fr) 2014-07-30 2016-02-04 President And Fellows Of Harvard College Systèmes et méthodes permettant de déterminer des acides nucléiques
WO2018218150A1 (fr) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systèmes et méthodes de criblage à base d'image à haut débit
WO2019219757A1 (fr) * 2018-05-15 2019-11-21 Albert-Ludwig-Universität Freiburg Transformateur de microréseau
CN114592039A (zh) * 2022-03-24 2022-06-07 广州鸿溪见杉科技有限公司 检测核酸片段剪接情况的高通量基因芯片及其制备方法

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5217889A (en) * 1990-10-19 1993-06-08 Roninson Igor B Methods and applications for efficient genetic suppressor elements
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
US5262311A (en) * 1992-03-11 1993-11-16 Dana-Farber Cancer Institute, Inc. Methods to clone polyA mRNA
US5556749A (en) 1992-11-12 1996-09-17 Hitachi Chemical Research Center, Inc. Oligoprobe designstation: a computerized method for designing optimal DNA probes
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5856103A (en) 1994-10-07 1999-01-05 Board Of Regents The University Of Texas Method for selectively ranking sequences for antisense targeting
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US5723320A (en) 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
US6156502A (en) 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
US5817461A (en) 1996-01-03 1998-10-06 Hamilton Civic Hospitals Research Development Inc. Methods and compositions for diagnosis of hyperhomocysteinemia
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US20030165931A1 (en) 1998-03-11 2003-09-04 Bruno Tocque Qualitative differential screening
FR2775984B1 (fr) 1998-03-11 2006-09-15 Bioscreen Therapeutics Sa Criblage differentiel qualitatif
US6881571B1 (en) 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US6165709A (en) 1997-02-28 2000-12-26 Fred Hutchinson Cancer Research Center Methods for drug target screening
US6028189A (en) 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
US6384210B1 (en) 1997-03-20 2002-05-07 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
EP2275574B1 (fr) 1997-08-15 2015-06-03 Gene Logic Inc. Codage d'haplotypes de séquence du gène BRCA2 humain
AU9127898A (en) 1997-09-02 1999-03-22 Isis Pharmaceuticals, Inc. Compositions and methods for the identification and quantitation of deletion sequence oligonucleotides in synthetic oligonucleotide preparations
US6492109B1 (en) 1997-09-23 2002-12-10 Gene Logic, Inc. Susceptibility mutation 6495delGC of BRCA2
US6051379A (en) 1997-09-23 2000-04-18 Oncormed, Inc. Cancer susceptibility mutations of BRCA2
AU1099699A (en) 1997-10-15 1999-05-03 President And Fellows Of Harvard College Cell regulatory genes, encoded products, and uses related thereto
JP2001521754A (ja) 1997-10-30 2001-11-13 コールド スプリング ハーバー ラボラトリー Ｄｎａ識別のためのプローブアレイ及びプローブアレイの使用方法
AU755032B2 (en) 1997-12-12 2002-11-28 Regents Of The University Of California, The Methods for defining cell types
AU1726199A (en) 1997-12-31 1999-07-19 Chiron Corporation Metastatic cancer regulated gene
CA2224475A1 (fr) 1998-02-25 1999-08-25 University Of British Columbia Collecteur des facteurs de transcription et d'interaction de proteine
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
EP1084271A2 (fr) 1998-05-07 2001-03-21 Axys Pharmaceuticals, Inc. Genotypage du gene de l'udp-glucuronosyltransferase 1 humain (ugt1)
GB9809764D0 (en) 1998-05-07 1998-07-08 Isis Innovation MMP-9 Gene polymorphisms
US5965352A (en) 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
US6324479B1 (en) 1998-05-08 2001-11-27 Rosetta Impharmatics, Inc. Methods of determining protein activity levels using gene expression profiles
US6448003B1 (en) 1998-06-10 2002-09-10 Dna Sciences Laboratories, Inc. Genotyping the human phenol sulfotransferbase 2 gene STP2
US6132969A (en) 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models
US6218122B1 (en) 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
ATE343645T1 (de) 1998-07-21 2006-11-15 Univ Rutgers Verbinden einer gensequenz mit einer genfunktion mittels dreidimensionaler (3d) proteinstrukturbestimmung
EP1141282A2 (fr) 1998-08-07 2001-10-10 Axys Pharmaceuticals, Inc. Genes humains transporteurs d'anions atnov
US6146830A (en) 1998-09-23 2000-11-14 Rosetta Inpharmatics, Inc. Method for determining the presence of a number of primary targets of a drug
US6203987B1 (en) 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
US6950752B1 (en) 1998-10-27 2005-09-27 Rosetta Inpharmatics Llc Methods for removing artifact from biological profiles
US6258536B1 (en) 1998-12-01 2001-07-10 Jonathan Oliner Expression monitoring of downstream genes in the BRCA1 pathway
CA2354322A1 (fr) 1998-12-09 2000-06-15 Massachusetts Institute Of Technology Procedes se rapportant a l'identification de mutations ponctuelles dans un genome
US6245518B1 (en) 1998-12-11 2001-06-12 Hyseq, Inc. Polynucleotide arrays and methods of making and using the same
US6801859B1 (en) 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6222093B1 (en) 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
AU3583200A (en) 1999-01-25 2000-08-07 Combimatrix Corporation A method for selecting oligonucleotides having low cross hybridization
GB9902971D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Assay
GB9902970D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Novel matrix
AU3875200A (en) 1999-03-11 2000-09-28 Orion Genomics, Llc Genome chips and optical transcript mapping
EP1165838B1 (fr) 1999-03-19 2006-10-11 Cornell Research Foundation, Inc. Reaction en chaine de la polymerase couplee, digestion de l'endonuclease de restriction, et procede de reaction de detection par ligase
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6355431B1 (en) * 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
WO2000065088A2 (fr) 1999-04-26 2000-11-02 Amersham Pharmacia Biotech Ab Amorces servant a l'identification, le typage ou la classification d'acides nucleiques
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
US20010053849A1 (en) 1999-06-16 2001-12-20 Mary Jeanne Kreek Plural biological sample arrays, and preparation and uses thereof
AU5495600A (en) 1999-06-17 2001-01-09 Fred Hutchinson Cancer Research Center Oligonucleotide arrays for high resolution hla typing
EP1192448B1 (fr) 1999-07-05 2006-09-27 Novartis AG Procede servant a l'utiliser une platine de detection
CA2378665A1 (fr) 1999-07-09 2001-01-18 Andre R. Miserez Polymorphismes dans l'adn de proteines de fixation a un element regulateur de sterol
US6271002B1 (en) 1999-10-04 2001-08-07 Rosetta Inpharmatics, Inc. RNA amplification method
GB2373500B (en) 2000-02-04 2004-12-15 Aeomica Inc Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
WO2001081632A1 (fr) 2000-04-25 2001-11-01 Affymetrix, Inc. Technique de surveillance de l'expression de genes alternativement episses
US6713257B2 (en) * 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays

Also Published As

Publication number Publication date
EP1349957A2 (fr) 2003-10-08
WO2002016650A2 (fr) 2002-02-28
WO2002016650A3 (fr) 2003-08-07
CA2420525A1 (fr) 2002-02-28
US7807447B1 (en) 2010-10-05

Similar Documents

Publication Publication Date Title
AU2001258771A1 (en) -secretase inhibitors
AU2778801A (en) Antisense compositions and methods
AUPQ419099A0 (en) Novel compositions and methods
AU2001280604A1 (en) Compositions comprising icariside i and anhydroicaritin and methods for making the same
AU2001280599A1 (en) Compounds and methods
AU2001293189A1 (en) Compositions and methods for regulating apoptosis
AU2001293297A1 (en) Phyisological profiling
AU2001253418A1 (en) Compounds and methods
AU2001286750A1 (en) Compositions and methods for exon profiling
AU2001271720A1 (en) Methods and compositions for determining gene function
AU1530001A (en) Inhibitor compositions
AUPQ875700A0 (en) Combination compositions
AU2001243394A1 (en) Compounds and methods
AU2001241098A1 (en) Composition
AU2370201A (en) Program profiling
AUPQ872300A0 (en) Compounds and methods
AU2001237546A1 (en) Methods for characterizing polymorphisms
AU2001278951A1 (en) Compounds and methods
AU2001266648A1 (en) Kits and methods for optimizing the efficacy of chondroprotective compositions
AU2001275201A1 (en) Acne-treating composition
AU2001235764A1 (en) Compositions
AU2001287852A1 (en) Composition
AU2001251111A1 (en) Lubricant and flushing compositions
AU2002235277A1 (en) Compounds and methods
AU2001287732A1 (en) Copolycarbonate-based composition