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AU6455896A - Novel factor viii:c polypeptide analogs with altered metal-binding properties - Google Patents

Novel factor viii:c polypeptide analogs with altered metal-binding properties

Info

Publication number
AU6455896A
AU6455896A AU64558/96A AU6455896A AU6455896A AU 6455896 A AU6455896 A AU 6455896A AU 64558/96 A AU64558/96 A AU 64558/96A AU 6455896 A AU6455896 A AU 6455896A AU 6455896 A AU6455896 A AU 6455896A
Authority
AU
Australia
Prior art keywords
factor viii
binding properties
polypeptide analogs
novel factor
altered metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU64558/96A
Inventor
Fred E. Cohen
David T. Hung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of AU6455896A publication Critical patent/AU6455896A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU64558/96A 1995-07-11 1996-07-09 Novel factor viii:c polypeptide analogs with altered metal-binding properties Abandoned AU6455896A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87195P 1995-07-11 1995-07-11
US000871 1995-07-11
PCT/US1996/011438 WO1997003193A1 (en) 1995-07-11 1996-07-09 Novel factor viii:c polypeptide analogs with altered metal-binding properties

Publications (1)

Publication Number Publication Date
AU6455896A true AU6455896A (en) 1997-02-10

Family

ID=21693379

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64558/96A Abandoned AU6455896A (en) 1995-07-11 1996-07-09 Novel factor viii:c polypeptide analogs with altered metal-binding properties

Country Status (2)

Country Link
AU (1) AU6455896A (en)
WO (1) WO1997003193A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
EP2206785A1 (en) 1998-12-31 2010-07-14 Novartis Vaccines and Diagnostics, Inc. Improved expression of HIV polypeptides and production of virus-like particles
PT1750733E (en) 2004-05-03 2014-02-14 Baxter Healthcare Sa Method of administering porcine b-domainless fviii
EP1598367A1 (en) * 2004-05-18 2005-11-23 ZLB Behring GmbH Modified coagulation factors with enhanced stability and their derivatives
EP1816201A1 (en) 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
AU2007338298B2 (en) 2006-12-22 2013-02-07 Csl Behring Gmbh Modified coagulation factors with prolonged in vivo half-life
PL2291523T3 (en) 2008-06-24 2015-05-29 Csl Behring Gmbh Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life
MX351220B (en) 2010-11-05 2017-10-05 Baxalta GmbH A new variant of antihemophilic factor viii having increased specific activity.
PL2814502T3 (en) 2012-02-15 2018-02-28 Csl Behring Gmbh Von willebrand factor variants having improved factor viii binding affinity
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
EP3164150B1 (en) 2014-07-02 2020-11-04 CSL Behring Lengnau AG Modified von willebrand factor
US11155601B2 (en) 2015-03-06 2021-10-26 CSL Behring Lengnau AG Modified von Willebrand factor having improved half-life
CA2986626A1 (en) 2015-05-22 2016-12-01 Csl Behring Recombinant Facility Ag Truncated von willebrand factor polypeptides for treating hemophilia
CN107810194B (en) 2015-05-22 2021-10-08 康诺贝林伦瑙有限公司 Method for preparing modified von willebrand factor
BR112018013861A2 (en) 2016-01-07 2018-12-18 Csl Behring Recombinant Facility Ag polypeptide, complex, pharmaceutical composition, methods for treating a blood clotting disorder, for producing a polypeptide and dimer of a polypeptide, for increasing factor viii half life and for increasing dimerization of said polypeptide, use of a polypeptide, kit pharmaceutical, plasmid or vector, and host cell
CA3008448A1 (en) 2016-01-07 2017-07-13 Csl Behring Recombinant Facility Ag Mutated von willebrand factor
CA3043250A1 (en) 2016-11-11 2018-05-17 CSL Behring Lengnau AG Truncated von willebrand factor polypeptides for treating hemophilia
KR20190073576A (en) 2016-11-11 2019-06-26 체에스엘 베링 렝나우 아게 A cut von Willebrand factor polypeptide for extravascular administration in the treatment or prevention of blood clotting disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE465222C5 (en) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab A recombinant human factor VIII derivative and process for its preparation

Also Published As

Publication number Publication date
WO1997003193A1 (en) 1997-01-30

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