AU761274B2 - Pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens for treating gynecological disorders - Google Patents
Pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens for treating gynecological disorders Download PDFInfo
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- AU761274B2 AU761274B2 AU53570/00A AU5357000A AU761274B2 AU 761274 B2 AU761274 B2 AU 761274B2 AU 53570/00 A AU53570/00 A AU 53570/00A AU 5357000 A AU5357000 A AU 5357000A AU 761274 B2 AU761274 B2 AU 761274B2
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- lhrh
- raloxifen
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- 229940046836 anti-estrogen Drugs 0.000 title claims description 32
- 230000001833 anti-estrogenic effect Effects 0.000 title claims description 32
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 33
- 238000011282 treatment Methods 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- AUYLVPGDOVEOML-UHFFFAOYSA-N [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(piperidin-1-ylmethoxy)phenyl]methanone Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 AUYLVPGDOVEOML-UHFFFAOYSA-N 0.000 claims description 23
- 201000009273 Endometriosis Diseases 0.000 claims description 22
- 230000037396 body weight Effects 0.000 claims description 16
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 claims description 14
- 230000037182 bone density Effects 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 13
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- QRYFGTULTGLGHU-NBERXCRTSA-N iturelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CCCCNC(=O)C=1C=NC=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)CCCNC(=O)C1=CC=CN=C1 QRYFGTULTGLGHU-NBERXCRTSA-N 0.000 claims description 12
- 108010083551 iturelix Proteins 0.000 claims description 12
- 108700008462 cetrorelix Proteins 0.000 claims description 11
- SBNPWPIBESPSIF-MHWMIDJBSA-N cetrorelix Chemical compound C([C@@H](C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 SBNPWPIBESPSIF-MHWMIDJBSA-N 0.000 claims description 11
- 229960003230 cetrorelix Drugs 0.000 claims description 11
- 239000002474 gonadorelin antagonist Substances 0.000 claims description 11
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- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical group CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims description 9
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- 239000000556 agonist Substances 0.000 claims description 8
- 229940033942 zoladex Drugs 0.000 claims description 8
- WDYSQADGBBEGRQ-APSDYLPASA-N (2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-[(2r,3r,4r,5r,6s) Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WDYSQADGBBEGRQ-APSDYLPASA-N 0.000 claims description 7
- 108010037003 Buserelin Proteins 0.000 claims description 7
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 claims description 7
- 229960002719 buserelin Drugs 0.000 claims description 7
- 239000002434 gonadorelin derivative Substances 0.000 claims description 7
- 108010092834 ramorelix Proteins 0.000 claims description 7
- 229950000277 ramorelix Drugs 0.000 claims description 7
- 230000001627 detrimental effect Effects 0.000 claims description 6
- 206010013935 Dysmenorrhoea Diseases 0.000 claims description 5
- 230000002263 peptidergic effect Effects 0.000 claims description 5
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 3
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 claims description 3
- 102100024028 Progonadoliberin-1 Human genes 0.000 claims description 3
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
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- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 12
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- 238000009472 formulation Methods 0.000 description 5
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- 210000004291 uterus Anatomy 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 description 3
- 208000005171 Dysmenorrhea Diseases 0.000 description 3
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- 210000000988 bone and bone Anatomy 0.000 description 3
- 229950004203 droloxifene Drugs 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 208000007106 menorrhagia Diseases 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
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- 238000007918 intramuscular administration Methods 0.000 description 2
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- 229960003327 ormeloxifene Drugs 0.000 description 2
- XZEUAXYWNKYKPL-URLMMPGGSA-N ormeloxifene Chemical compound C1([C@@H]2[C@H](C3=CC=C(C=C3OC2(C)C)OC)C=2C=CC(OCCN3CCCC3)=CC=2)=CC=CC=C1 XZEUAXYWNKYKPL-URLMMPGGSA-N 0.000 description 2
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- -1 6-hydroxy-2-(4-hydroxyphenyl) piperidinoethoxy Chemical group 0.000 description 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
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- POZRVZJJTULAOH-LHZXLZLDSA-N danazol Chemical compound C1[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=CC2=C1C=NO2 POZRVZJJTULAOH-LHZXLZLDSA-N 0.000 description 1
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- VXYFNFAJVNPWCT-UHFFFAOYSA-N ethyl 2-(4-acetamidophenyl)-3-[[benzyl(methyl)amino]methyl]-7-[(2-methoxyphenyl)methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate Chemical compound C1=2SC(C=3C=CC(NC(C)=O)=CC=3)=C(CN(C)CC=3C=CC=CC=3)C=2C(=O)C(C(=O)OCC)=CN1CC1=CC=CC=C1OC VXYFNFAJVNPWCT-UHFFFAOYSA-N 0.000 description 1
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- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Our Ref:7522550 P/00/011 Regulation 3:2
AUSTRALIA
Patents Act 1990
ORIGINAL
COMPLETE SPECIFICATION STANDARD PATENT Applicant(s): Schering Aktiengesellschaft Mullerstrasse 178 D-13342 Berlin Germany DAVIES COLLISON CAVE Patent Trade Mark Attorneys Level 10, 10 Barrack Street SYDNEY NSW 2000 Address for Service: Invention Title: Pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens for treating gynecological disorders The following statement is a full description of this invention, including the best method of performing it known to me:- 5020 P \WPDOCS\CABSPECMj\iv (parnt 692470).doc-23/0D80 -1- ~This application is a divisional of parent application No. 15969/97.
S 20 The ensuing description is substantially identical to the description of the specification of the parent application. The "parent" description has been readopted to facilitate identification of the parent/divisional relationship. The scope of the invention of this divisional application is set forth in the claims of this specification.
PHARMACEUTICAL COMBINATION PREPARATION THAT CONSISTS OF LHRH-ANALOGUES AND ANTIESTROGENS FOR TREATING GYNECOLOGICAL DISORDERS The invention relates to a pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens with tissue-selective estrogenic action, as well as its use for treating gynecological disorders, especially for treating endometriosis and myomas.
Gynecological disorders or diseases diminish to a considerable extent the quality of life of women and in this connection frequently lead, in addition to sometimes intolerable pain, to infertility. One of the most frequent diseases of women of child-bearing age to 10%) is endometriosis. In association with this, severe pain during menstruation and low birthrate to sterility occur. Also myoma, a non-malignant tumor in the muscle tissue of the uterus, has a high incidence (in to 25% of women around 30 years of age). Myomas can cause abnormally heavy menstrual bleeding (hypermenorrhea), menses that may be accompanied by pain (dysmenorrhea), or intermenstrual bleeding (metrorrhagia and menorrhagia) and can also, depending on the situation, lead to limited fertility. In addition to these types of dysmenorrhea that are caused by endometriosis and myomas, dysmenorrheas that are functionally induced (by hormonal and vegetative disorders) also occur.
2 In the disease pictures that are described, gonal steroids (estrogens, gestagens), which are under the control of the hypothalamic-hypophyseal system, or growth factors (which also include cytokines) play a decisive role. These diseases or disorders are generally treated with hormones, such as LHRHanalogues (Lemay, A. et al., Fertil. Steril., 41, 863-871 (1984)). Some women experience side-effects with the latter, however. Thus, it is known that treatment with LHRH-agonists can lead to side-effects, such as, hypoestrogeneity (risk of osteoporosis) (Dawood, M. Y. et al, Fertil. Steril. 52, 21-25, S* (1989)), and danazol can result in androgenization symptoms (Dmowski, W. P. et al, Am. J. Obstet. Gynecol., 130, 41-48 (1978)).
To date, no established and validated long-term medicinal therapy exists for myomas. The current medicinal treatment is associated with considerable side-effects. Thus, the use of LHRH-agonists for more than six months results in a hypoestrogenic state in women (Matta, W. H. et al, Br. Med. 294, 1523-1525, (1987)) and is associated with a reduction in bone density, which increases the risk of osteoporosis (Dawood, M. Y.
Int. J. Gynecol. Obstet., 40, 29-42, (1993)). Other side-effects that are connected with estrogen deprivation (hot flashes) are also described by Dawood.
To avoid these side-effects, studies for treating gynecological disorders with LHRH-analogues and estrogens socalled Add-Back or HRT treatment schemes are known. It has not yet been possible, however, to find an estrogen dose that f 27- 3-03:20:34 612 93645173 14/ 31 PAWPDOCSCRS\SPEC17Sf2S0Ao-2 Mrch. 2003 -3completely prevents a reduction in bone density with LHRHagonist therapy (Howell, R. et al., Fertil. Steril. 64, 474- 481, (1995)), without simultaneously stimulating endometriosis or the endometrium, which can lead to endometrial hyperplasia and is associated with endometrial carcinomas.
It would therefore be desirable to provide a pharmaceutical combination preparation for treating gynaecological disorders, especially for treating endometriosis or myomas, with which a reduction in bone density is prevented and the drawbacks of previous hormone treatments are avoided.
The invention provides a method for ameliorating LHRH analogue-induced reduction in bone density in the treatment of gynaecological disorders comprising administering to a patient in need of such treatment one or more LHRH analogues and Raloxifen or a derivative thereof, wherein said one or more LHRH analogues and Raloxifen or a derivative thereof are administered sequentially or simultaneously.
The invention further provides a method of inhibiting LHRH analog-induced detrimental side effects due to the administration of an LHRH analog in the treatment of gynaecological disorders, wherein said detrimental side effects is reduction in bone density, comprising administering to a patient in need thereof on one more LHRH analogues and Raloxifen or a derivative thereof, wherein said one or more LHRH analogues and Raloxifen or a derivative thereof are administered sequentially or simultaneously.
Preferably, the Raloxifen derivative is the hydrochloride salt of Raloxifen.
The invention further provides a method of inhibiting LHRH analog-induced detrimental side effects due to the COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 27- 3-03:20:34 612 93645173 15/ 31 PA:WPDOCSISWECI\75225nMOc-2 MXdL. 200 -3aadministration of an LHRH analog to a patient in need thereof an effective amount of Raloxifen or the hydrochloride salt thereof.
The invention further provides a method for the treatment of a gynaecological disorder, which comprises .administering to a patient in need of such treatment, one or more LHRH analogues and Raloxifen or a derivative thereof, wherein said one or more LHRH analogues and Raloxifen or a derivative thereof are administered sequentially or simultaneously, and wherein LHRH analogue-induced bone density is ameliorated.
Preferably, the gynaecological diseases treated are endometriosis, myomas and/or dysmenorrhoea.
In a further aspect this invention provides use of an LHRH analogue and Raloxifen or a derivative thereof in the manufacture of a medicament for the treatment of a gynaecological disorder.
The LHRH-analogue is an LHRH-agonist or LHRH-antagonist.
Within the meaning of the invention, all LHRHantagonists and LHRH-agonists can .be used. Preferred LHRHanalogues are selected from the group of compounds leuprorelin, cetrorelix, antide, buserelin, ramorelix, zoladex, 2-(4acetyl-aminophenyl)-4,7-dihydro-7-(2-methoxybenzyl)-3-(Nmethyl-N-benzylaminomethyl)-4-oxothieno-[2,3-b]-pyridine-5carboxylic acid ethyl ester and 5-benzoyl-7-(2,6difluorobenzyl)-4, 7-dihydro-3-(N-methyl-Nbenzylaminomethyl)-2-(4-propionylamidophenyl)-4oxothieno[2,3-b]-pyridine.
COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 4 The active ingredients generally come in separate forms of administration or even in a common form of administration in the case of orally bio-available LHRH-antagonists.
The LHRH-analogues that are preferably used are known and are described in Patents US 4,005,063 (leuprorelin), EP-B1 0 299 402 (cetrorelix), GB 1 523 623 (buserelin), EP-A 0 451 791 (ramorelix), WO-A 89/01944 (antide), WO-A 92/20711 (Ac-D-Nal-D- CDa-D-Pal-Ser-Tyr-D-Cit-Leu-Lys(Mor)-Pro-D-Ala-NH 2 US 4,100,274 (zoladex) and WO-A 95/28405 2-(4-acetylaminophenyl)-4,7-dihydro- 7- (2-methoxybenzyl) (N-methyl-N-benzylaminomethyl) -4-oxothieno- [2,3-b]-pyridine-5-carboxylic acid ethyl ester.
They are produced and manufactured according to processes that are known in the art and, depending on the desired .application, come in oral or nasal form, as an injection, or as a long-term preparation that is to be used topically or Sintravaginally. According to the invention, the LHRH-analogues S can be administered as individual doses or as forms of deposits.
Depending on the form of administration, a dosage unit contains different amounts of active ingredient. Thus, with oral administration, 2 Ag-20 mg of LHRH-analogues per kg of body weight is usually administered. Administration can be done in solid or liquid form. For intravenous, subcutaneous, intramuscular, intranasal, or intravaginal applications, the amounts of the LHRH-analogues are 0.02 gg-2.5 mg per kg of body weight. For parenteral application, preferably an isotonic common-salt or dextrose solution is used, which optionally is set with a buffer to a pH of 5 to 9, preferably to the pH of the blood.
Leuprorelin is preferably used orally at a dosage of 2-100 Mg/kg of body weight (daily dosage); a tablet preferably contains 0.1 to 5.0 mg of leuprorelin. The dose for parenteral use is preferably between 0.02 and 1.0 gg/kg of body weight.
Cetrorelix is preferably used in the form of a physiologic common-salt solution with a quantity of active ingredient of between 0.1-2.5 mg/kg of body weight. DE 43 42 092 also S describes slow-release formulations of cetrorelix in DE 43 42 o* 092.
Buserelin is preferably administered at the following dosages: 0.02-1 Mg/kg of body weight (intravenous), 0.02-2 Mg/kg of body weight (subcutaneous), 0.02-10 Ag/kg of body weight (intramuscular), 0.1-50 g/kg of body weight (intranasal) and 10-200 Ag/kg of body weight (oral).
Also, as in the case of cetrorelix, slow-release formulations are possible. In the case of an implant, the latter contains 1-6 mg of cetrorelix.
Zoladex is preferably administered orally with a content of gg-20 mg/kg of body weight and parenterally with a content of 0.2 g-100 Mg/kg of body weight or with a slow-release system (WO-A 93/24150).
Antide is administered like cetrorelix in an amount of 0.1mg/kg of body weight.
2 7 3 0 3 2 0 3 4 27- 3-1203 2 9 3 64 5 173 1 6/ 3 1 6 The administration of ramorelix is preferably done in liposomal form.
Depot formulations for peptides (microparticles, implants) are described in, EP 0 505 966 and EP 0 315 875.
According to the invention, the second active ingredient comp~flent of the combination preparation is an antiestrogen with t issue- selective estrogenic actioj-..
Antiestrogenic substances are used in, i a tumor therapy.
Antiestrogens with tissue-selective estrogenic action in terms of the invention are defined as so-called SEIRM's (selective estrogen receptor modulators), which exert their partially agonistic estrogenic action in a tissue- or organ-selective itanner.
According to the invention, all antiestrogens with tissueselective estrogenic action can be used. Preferably those used are selected from the group of raloxifene, droloxifene, centchroman, or derivatives thereof. Especially preferred are antiestrogens of the raloxifene type.
The above-mentioned antiestrogens; are known. Thus, e.g., raloxifene is a 6-hydroxy-2-(4-hydroxyphenyl) piperidinoethoxy) benzoyl Jbenzo (b Jthiophene., The active-i ngredient content of the antiestrogen that is used according to the invention is approximately 0.1 jig-10 mg of antiestrogen per k~g of body weight wiith daily administration,' depending on the form of administration. The antiestrogens can COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 be administered intravenously, subcutaneously, intramuscularly, orally, intranasally, or intravaginally. Slow-release formulations are also possible. The amount that is released daily is then also in the above-mentioned range.
The administration of the LHRH-analogue and the antiestrogen to patients can be done simultaneously and/or sequentially in time. Various treatment schemes are possible: 1. The LHRH-analogue is administered simultaneously with the tissue-selective antiestrogen over the same period.
Administration can be done daily, every 3 days, weekly, or once a month over a period of 1 to 6 months. Extended use is also readily possible. In the case of monthly use, a depot formulation is preferred.
2. The LHRH-analogue is first administered simultaneously with the tissue-selective antiestrogen over a specific period.
S. Relative to the time and frequency of administration (daily or at *.So longer intervals), the indications given above under 1. hold true. Then, the treatment itself is continued with the antiestrogen.
For administration time and frequency, the indications that are given under 1. also hold true.
3. The treatment with the LHRH-analogue is carried out over a specific period and completed. The tissue-selective antiestrogen is administered thereafter. The time and frequency of use can be selected for each component, as indicated under 1.
It was ntd-tata. treatment with the combination preparation according to the invention, srprisingly enough, prevents the previously observed LHRH-analogue-induced bone density rn'"ation and does not re-stimulate endometriosis, ~wThTh is inhibited in its growth, and also does not stimulate the growth of the normal endometrium in the uterus.
The pharmaceutical combination preparation according to the invention is especially suitable for long-term treatment of endometriosis or myomas and other steroid(sex)-hormone-dependent diseases since, on the one hand, the side-effects that normally occur under an LHRH-analogue (agonist or antagonist) treatment are avoided and, on the other hand, lost bone mass is again built up when the tissue-selective antiestrogen is administered after an LHRH-analogue treatment is completed). At the same time, the growth inhibition of endometriosis is maintained, without the endometrium in the uterus being stimulated.
Variant 1 has turned out to be especially preferred for long-term therapy.
The pharmaceutical combination preparation according to the invention is produced, for example, by virtue of the fact that the LHRH-analogues and the antiestrogens with tissue-selective estrogenic action are formulated separately from one another with the commonly used pharmaceutical vehicles, adjuvants, and/or additives, whereby the forms of administration of the individual active ingredients do not have to be identical. It is eminently possible, for one active ingredient of the combination preparation to be administered orally, while the other active ingredient is administered subcutaneously or nasally.
9 In the case of orally bio-available LHRH-analogues, both active ingredients (LHRH-analogues plus antiestrogens) can also be formulated together for oral administration. Separate oral forms of administration are also possible.
The subject matter of the invention is also the packaging unit, which in the case of peptidergic LHRH-analogues comprises at least three components. It contains two physically separately manufactured active ingredients, of which one active ingredient is an LHRH-analogue or a combination of LHRH-analogues, and the other active ingredient is an antiestrogen with tissue-selective estrogenic action. The third component is directions on the application of the forms of administration, which is simultaneous and/or sequential in time.
Another subject matter of the invention is the use of an LHRH-analogue or a combination of LHRH-analogues and an antiestrogen with tissue-selective estrogenic action for treating gynecological disorders, especially for treating endometriosis and myomas.
:Below, the invention is to be explained in more detail by the examples without, however, being limited to said examples.
27- 3-03:20:34 612 93645173 17/ 31 P WDOCSRSgSPECn7522SSOSAd-2 March, 2003 -9a- Other preferable aspects of the invention may include: Pharmaceutical combination preparation that contains two active ingredients, whereby one active ingredient is an LHRH-analogue or a combination of LHRH-analogues, and the other active ingredient is an antiestrogen with tissue-selective estrogenic action.
Combination preparation according to characterised in that the LHRH-analogue is an LHRH-agonist or an LHRH-antagonist.
Combination preparation according to or wherein the LHRH-analogue is selected from the group of compounds leuprorelin, cetrorelix, buserelin, antide, Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Lys(Mor)-D-Ala-
NH
2 ramorelix, zoladex, or derivatives thereof.
Combination preparation according to one of to wherein the LHRH-analogue or the combination of the LHRH-analogues is/are orally bio-available.
Combination preparation according to one of to wherein the LHRH-analogue is a non-peptidergic LHRHagonist or LHRH-antagonist.
Combination preparation according to one of to wherein the antiestrogen is selected from the group of compounds raloxifene, droloxifene, centchroman or derivatives thereof.
Combination preparation according to one of to wherein the antiestrogen is of the raloxifene type.
Combination preparation according to one of to wherein the two active ingredients are present in separate forms of administration.
Combination preparation according to one of to wherein the two active ingredients are present in common forms of administration.
COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 27- 3-03:20:34 612 93645173 18/ 31 ?PWPDOCSRSSPECW75225.dMc-2 MUdr200M -9b- Process for the production of a pharmaceutical combination preparation, wherein an LHRH-analogue or a combination of LHRH-analogues and an antiestrogen with tissue-selective action are formulated together or separately with commonly used pharmaceutical vehicles, adjuvants and/or additives.
Process according to wherein the LHRH-analogue or the combination of LHRH-analogues and the antiestrogen with tissue-selective estrogenic action are formulated separately from one another.
Process according to wherein the LHRH-analogues or the combination of LHRH-analogues and the antiestrogen with tissue-selective estrogenic action are formulated together.
Use of an LHRH-analogue or a combination of LHRHanalogues and an antiestrogen with tissue-selective estrogenic action for treating gynaecological disorders, especially for treating endometriosis and myomas.
Use according to wherein LHRH-analogues and antiestrogens are used simultaneously and/or sequentially in time.
Packaging unit that contains two physically separately manufactured active ingredients, of which one active ingredient is an LHRH-analogue or a combination of LHRH-analogues and the other active ingredient is an antiestrogen with tissue-selective estrogenic action and that contains as a third component instructions on the application of the forms of administration that are simultaneous and/or sequential in time.
COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 Embodiments Example 1 Influence of LHRH-Administration and Raloxifene Administration on Experimentally Induced Endometriosis in Rats 1.1 Comparison of the Administration in Each Case of an Active Ingredient Component by Itself with the Simultaneous Administration of Active Ingredients (Combination Preparation) Method: Endometrium pieces were transplanted into various areas of the abdominal cavities of 60 animals.
Four weeks later, the development of endometriosis (cystic endometriosis foci) was checked.
The animals were then treated over 4 weeks with the LHRHantagonists antide (0.5 mg/animal every 3 days and raloxifene (3 mg/animal per day in each case alone or in a combination of the two compounds. At the end, the size of the endometriosis focus before the start of treatment was compared with the values after 4 weeks of treatment.
The combination of LHRH-antagonist plus raloxifene resulted in complete regression of endometriosis without a significant reduction in bone mass. At the same time, no estrogenic effects on the uterus (no stimulation of the endometrium) were shown.
By comparison, treatment with the LHRH-antagonist by itself led to complete regression of the endometriosis focus, but at the same time also to a drop in the endogenic estrogen levels, which 11 correspond to an ovariectomy. It resulted in a clear reduction of bone density or an increase in the osteoclast activity.
Administration of raloxifene resulted in only partial regression of endometriosis.
1.2 LHRH-Antagonist Antide and Raloxifen for Administration That Is Simultaneous and Sequential in Time For the first 2 weeks, 60 animals received the LHRHantagonist antide and raloxifene in parallel, and for the following 2 weeks they received raloxifene alone. The dosages were selected as under 1.1.
As a result, as with the simultaneous administration of the active ingredients, complete regression of the endometriosis was also noted without a significant reduction in bone mass. At the same time, no estrogenic effects on the uterus were shown.
1.3 Administration of the Combination Preparation That Is Sequential in Time Over 2 weeks, 60 animals received the LHRH-antagonist antide. After LHRH administration was completed, raloxifene was then administered for 2 weeks.
This sequential treatment also resulted in 100% regression of the endometriosis without a reduction in bone density.
27- 3-03:20:34 612 93645173 19/ 31 P:\WPDOCWE~RSPEC~752250 do-2 Mu'h. 1003 -12- Example 2 Analogously to Example 1, treatment with LHRHantagonist Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Lys(Mor)- Pro-D-Ala-NH 2 and droloxifene was carried out on 40 animals.
The same results were achieved as under Example 1.
The reference to any prior art in this specification is not, and should not be taken as an acknowledgment or any form of suggestion that that prior art forms part of the common general knowledge in Australia.
COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28
Claims (1)
- 27- 3-03:20:34 612 93645173 20/ 31 rMWPDOCSMIWRPECa752M.d-c2 Mabr. -13- The claims defining the invention are as follows: 1. A method for ameliorating LHRH analogue-induced reduction in bone density in the treatment of gynaecological disorders comprising administering to a patient in need of such treatment one or more LHRH analogues and Raloxifen or a derivative thereof, wherein said one or more LHRH analogues and Raloxifen or -a derivative thereof are administered sequentially or simultaneously. 2. A method according to claim 1 wherein said LHRH analogue is Leuprorelin, Cetrorelix, Buserelin, Antide, Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Lys(Mor)-Pro-D- Ala-NH 2 Ramorelix, Zoladex or combinations thereof. 3. A method according to claim 1, wherein Raloxifen is administered after administration of said LHRH analogue. 4. A method according to claim 1, wherein said LHRH analogue is Leuprorelin, Cetrorelix, Antide, Ac-D-Nal- D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Lys(Mor)-Pro-D-Ala-NH 2 Ramorelix, or Zoladex. A method according to claim 4, wherein said LHRH analogue is Antide. 6. A method according to claim 4, wherein said LHRH analogue is Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu- Lys(Mor)-Pro-D-Ala-NH 2 COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 27- 3-03:20:34 612 93645173 21/ 31 P.WPDOCSiRS\PECMKA7S2I5XO. M-r. 1003 -14- 7. A method according to claim 1, wherein said LHRH analogue is an LHRH agonist. 8. A method according to claim 1, wherein said LHRH analogue is Leuprorelin, Cetrorelix, Buserelin, Antide, Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Lys(Mor)-Pro-D- Ala-NH 2 Ramorelix, or Zoladex. 9. A method according to claim 1, wherein said one or more LHRH analogues is orally bioavailable. A method according to claim 1, wherein said one or more LHRH analogues is a non-peptidergic LHRH agonist or non-peptidergic LHRH antagonist. 11. A method according to claim 1, wherein said LHRH analogue is LHRH antagonist. 12. A method according to claim 1, wherein said LHRH analogue is administered in the amount of 2 gg-20 mg per kilogram of body weight and Raloxifen is administered in an amount of 0.1 Ag-10 mg per kilogram of body weight. 13. A method according to claim 1, wherein said LHRH analogue is peptidergic. 14. A method of inhibiting LHRH analog-induced detrimental side effects due to the administration of an LHRH analog in the treatment of gynaecological disorders, wherein said detrimental side effects is reduction in bone density, comprising administering to a patient in COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 27- 3-03:20:34 612 93645173 22/ 31 P~WP MOCSR SSPECS1250. dok-I Mar~h. 200 need thereof one or more LHRH analogues and Raloxifen or a derivative thereof, wherein said one or more LHRH analogues and Raloxifen or a derivative thereof are administered sequentially or simultaneously. A method according to claim 14, wherein said patient is a woman. 16. A method according to claim 15, wherein said anti- estrogen is administered orally. 17. A method according to claim 14, wherein said LHRH analog is Leuprorelin, Buserelin or Zoladex. 18. A method according to claim 1 or claim 14, wherein said Raloxifen derivative is the hydrochloride salt of Raloxifen. 19. A method according to claim 1 or 14, wherein the gynaecological disorder is endometriosis, myomas and/or dysmenorrhoea. A method for the treatment of a gynaecological disorder, which comprises administering to a patient in need of such treatment, one or more LHRH analogues and Raloxifen or a derivative thereof, wherein said one or more LHRH analogues and Raloxifen or a derivative thereof are administered sequentially or simultaneously, and wherein LHRH analogue-induced bone density is ameliorated. COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28 27- 3-03:20:34 612 93645173 23/ 31 P\AWFOCCSCR0 8PECn75225SO.4c-28 M*h. 2003 -16- 21. A method according to claim 20 which is a method for the treatment of endometriosis, myomas and/or dysmenorrhoea. 22. Use of an LHRH analogue and Raloxifen or a derivative thereof in the manufacture of a medicament for the treatment of a gynaecological disorder. 23. Use according to claim 22, wherein said LHRH-analogues Raloxifen or a derivative thereof are formulated together or separately, with one or more pharmaceutically acceptable vehicles, adjuvants and/or additives. 24. Methods for ameliorating LHRH analogue-induced reduction in bone density or detrimental side effects, substantially as hereinbefore described with reference to the Examples. DATED this 28th day of March, 2003 SCHERING AKTIENGESELLSCHAFT By its Patent Attorneys DAVIES COLLISON CAVE COMS ID No: SMBI-00199664 Received by IP Australia: Time 10:19 Date 2003-03-28
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU53570/00A AU761274B2 (en) | 1996-01-29 | 2000-08-23 | Pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens for treating gynecological disorders |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19604231 | 1996-01-29 | ||
| AU15969/97A AU1596997A (en) | 1996-01-29 | 1997-01-29 | Combined pharmaceutical preparation containing 1HRH-analogous subs tances and anti-estrogens for treating gynaecological disorders |
| AU53570/00A AU761274B2 (en) | 1996-01-29 | 2000-08-23 | Pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens for treating gynecological disorders |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU15969/97A Division AU1596997A (en) | 1996-01-29 | 1997-01-29 | Combined pharmaceutical preparation containing 1HRH-analogous subs tances and anti-estrogens for treating gynaecological disorders |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003203977A Division AU2003203977A1 (en) | 1996-01-29 | 2003-03-28 | Pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens for treating gynecological disorders |
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| Publication Number | Publication Date |
|---|---|
| AU5357000A AU5357000A (en) | 2000-10-26 |
| AU761274B2 true AU761274B2 (en) | 2003-05-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU53570/00A Ceased AU761274B2 (en) | 1996-01-29 | 2000-08-23 | Pharmaceutical combination preparation that consists of LHRH-analogues and antiestrogens for treating gynecological disorders |
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| AU (1) | AU761274B2 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0584952A1 (en) * | 1992-07-28 | 1994-03-02 | Eli Lilly And Company | Improvements in or relating to benzothiophenes |
| EP0635270A1 (en) * | 1993-07-22 | 1995-01-25 | Eli Lilly And Company | Parathyroid hormone and raloxifene for increasing bone mass |
-
2000
- 2000-08-23 AU AU53570/00A patent/AU761274B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0584952A1 (en) * | 1992-07-28 | 1994-03-02 | Eli Lilly And Company | Improvements in or relating to benzothiophenes |
| EP0635270A1 (en) * | 1993-07-22 | 1995-01-25 | Eli Lilly And Company | Parathyroid hormone and raloxifene for increasing bone mass |
Non-Patent Citations (1)
| Title |
|---|
| ROBERTSON J ET AL (1989) HORM. RES. 32/SUPPL PP206-208 * |
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| AU5357000A (en) | 2000-10-26 |
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