BG104222A - Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists - Google Patents
Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonistsInfo
- Publication number
- BG104222A BG104222A BG104222A BG10422200A BG104222A BG 104222 A BG104222 A BG 104222A BG 104222 A BG104222 A BG 104222A BG 10422200 A BG10422200 A BG 10422200A BG 104222 A BG104222 A BG 104222A
- Authority
- BG
- Bulgaria
- Prior art keywords
- carboxylic acid
- receptor antagonists
- acid derivatives
- production
- novel carboxylic
- Prior art date
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title abstract 2
- 239000002308 endothelin receptor antagonist Substances 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19738578A DE19738578A1 (de) | 1997-09-04 | 1997-09-04 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
| DE1998111915 DE19811915A1 (de) | 1998-03-18 | 1998-03-18 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
| PCT/EP1998/005354 WO1999011629A1 (de) | 1997-09-04 | 1998-08-24 | Neue carbonsäurederivate, ihre herstellung und verwendung als gemischte eta/etb-endothelin-rezeptorantagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG104222A true BG104222A (en) | 2001-02-28 |
Family
ID=26039663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104222A BG104222A (en) | 1997-09-04 | 2000-03-06 | Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1009741A1 (xx) |
| JP (1) | JP2001514254A (xx) |
| KR (1) | KR20010023615A (xx) |
| CN (1) | CN1269792A (xx) |
| AR (1) | AR017052A1 (xx) |
| AU (1) | AU748610B2 (xx) |
| BG (1) | BG104222A (xx) |
| BR (1) | BR9811631A (xx) |
| CA (1) | CA2302350A1 (xx) |
| CO (1) | CO4970738A1 (xx) |
| HR (1) | HRP980484A2 (xx) |
| HU (1) | HUP0004935A3 (xx) |
| ID (1) | ID25620A (xx) |
| IL (1) | IL134276A0 (xx) |
| NO (1) | NO20001077D0 (xx) |
| NZ (1) | NZ502660A (xx) |
| PL (1) | PL338954A1 (xx) |
| SK (1) | SK1522000A3 (xx) |
| TR (1) | TR200000602T2 (xx) |
| TW (1) | TW546295B (xx) |
| WO (1) | WO1999011629A1 (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19924892A1 (de) * | 1999-06-01 | 2000-12-07 | Basf Ag | Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
| US20090263472A1 (en) * | 2006-05-29 | 2009-10-22 | Nicox S.A. | Endothelin receptor antagonist derivatives |
| RU2010140442A (ru) | 2008-03-05 | 2012-04-10 | Бёрингер Ингельхайм Интернациональ Гмбх (De) | Трициклические производные пиридина, лекарственные средства, содержащие такие соединения, их применение и способ их получения |
| JP5531097B2 (ja) * | 2009-07-10 | 2014-06-25 | カディラ・ヘルスケア・リミテッド | アンブリセンタンを調製するための改善された方法およびその新規な中間体 |
| MA34007B1 (fr) | 2010-02-19 | 2013-02-01 | Boehringer Ingelheim Int | Derives de pyridine tricycliques medicaments contenant ces composes leur utilisation et leur procede de preparation |
| JP5947382B2 (ja) | 2011-08-17 | 2016-07-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フロ[3,4−c]キノリン誘導体、このような化合物を含む薬物、それらの使用及びそれらの調製方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4411225A1 (de) * | 1994-03-31 | 1995-10-05 | Basf Ag | Verwendung von Carbonsäurederivaten als Arzneimittel |
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| US6136828A (en) * | 1996-02-01 | 2000-10-24 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| DE19614542A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19636046A1 (de) * | 1996-09-05 | 1998-03-12 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
-
1998
- 1998-08-24 WO PCT/EP1998/005354 patent/WO1999011629A1/de not_active Application Discontinuation
- 1998-08-24 CA CA002302350A patent/CA2302350A1/en not_active Abandoned
- 1998-08-24 SK SK152-2000A patent/SK1522000A3/sk unknown
- 1998-08-24 NZ NZ502660A patent/NZ502660A/en unknown
- 1998-08-24 HU HU0004935A patent/HUP0004935A3/hu unknown
- 1998-08-24 PL PL98338954A patent/PL338954A1/xx unknown
- 1998-08-24 BR BR9811631-2A patent/BR9811631A/pt not_active IP Right Cessation
- 1998-08-24 ID IDW20000386D patent/ID25620A/id unknown
- 1998-08-24 CN CN98808862A patent/CN1269792A/zh active Pending
- 1998-08-24 KR KR1020007002264A patent/KR20010023615A/ko not_active Withdrawn
- 1998-08-24 TR TR2000/00602T patent/TR200000602T2/xx unknown
- 1998-08-24 IL IL13427698A patent/IL134276A0/xx unknown
- 1998-08-24 AU AU95333/98A patent/AU748610B2/en not_active Ceased
- 1998-08-24 JP JP2000508669A patent/JP2001514254A/ja active Pending
- 1998-08-24 EP EP98948859A patent/EP1009741A1/de not_active Withdrawn
- 1998-09-02 HR HR19811915.1A patent/HRP980484A2/hr not_active Application Discontinuation
- 1998-09-03 CO CO98050561A patent/CO4970738A1/es unknown
- 1998-09-03 AR ARP980104402A patent/AR017052A1/es not_active Application Discontinuation
- 1998-09-03 TW TW087114595A patent/TW546295B/zh active
-
2000
- 2000-03-02 NO NO20001077A patent/NO20001077D0/no not_active Application Discontinuation
- 2000-03-06 BG BG104222A patent/BG104222A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU748610B2 (en) | 2002-06-06 |
| AR017052A1 (es) | 2001-08-22 |
| HUP0004935A2 (hu) | 2001-10-28 |
| CN1269792A (zh) | 2000-10-11 |
| BR9811631A (pt) | 2000-09-26 |
| NO20001077L (no) | 2000-03-02 |
| WO1999011629A1 (de) | 1999-03-11 |
| NO20001077D0 (no) | 2000-03-02 |
| TR200000602T2 (tr) | 2000-12-21 |
| JP2001514254A (ja) | 2001-09-11 |
| CO4970738A1 (es) | 2000-11-07 |
| ID25620A (id) | 2000-10-19 |
| IL134276A0 (en) | 2001-04-30 |
| SK1522000A3 (en) | 2000-08-14 |
| NZ502660A (en) | 2002-02-01 |
| AU9533398A (en) | 1999-03-22 |
| PL338954A1 (en) | 2000-12-04 |
| HRP980484A2 (en) | 1999-06-30 |
| CA2302350A1 (en) | 1999-03-11 |
| KR20010023615A (ko) | 2001-03-26 |
| HUP0004935A3 (en) | 2001-12-28 |
| EP1009741A1 (de) | 2000-06-21 |
| TW546295B (en) | 2003-08-11 |
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