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BG104302A - Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids - Google Patents

Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Info

Publication number
BG104302A
BG104302A BG104302A BG10430200A BG104302A BG 104302 A BG104302 A BG 104302A BG 104302 A BG104302 A BG 104302A BG 10430200 A BG10430200 A BG 10430200A BG 104302 A BG104302 A BG 104302A
Authority
BG
Bulgaria
Prior art keywords
phenyl
preparing substituted
cyanocyclohexanoic
acids
group
Prior art date
Application number
BG104302A
Other languages
Bulgarian (bg)
Inventor
Kevin Webb
Wilford Mendelson
Jianhao Chen
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of BG104302A publication Critical patent/BG104302A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a method of preparing a compound type where at least one of R' or R" is carboxyl group by treating a compound for formula with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and water. 12 claims
BG104302A 1997-10-10 2000-04-05 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids BG104302A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (1)

Publication Number Publication Date
BG104302A true BG104302A (en) 2001-08-31

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104302A BG104302A (en) 1997-10-10 2000-04-05 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Country Status (30)

Country Link
EP (1) EP1043930A4 (en)
JP (1) JP2001519363A (en)
KR (1) KR100560038B1 (en)
CN (1) CN1192025C (en)
AP (1) AP1335A (en)
AR (1) AR015952A1 (en)
AU (1) AU741832B2 (en)
BG (1) BG104302A (en)
BR (1) BR9814064A (en)
CA (1) CA2305614A1 (en)
DZ (1) DZ2619A1 (en)
EA (1) EA003609B1 (en)
HU (1) HUP0003905A3 (en)
ID (1) ID25536A (en)
IL (1) IL135434A (en)
MA (1) MA24670A1 (en)
MY (1) MY122105A (en)
NO (1) NO20001777L (en)
NZ (1) NZ503759A (en)
OA (1) OA11347A (en)
PE (1) PE121599A1 (en)
PL (1) PL191974B1 (en)
SA (1) SA99191000A (en)
SK (1) SK4902000A3 (en)
TR (1) TR200000945T2 (en)
TW (1) TW440557B (en)
UA (1) UA67753C2 (en)
UY (2) UY25201A1 (en)
WO (1) WO1999018793A1 (en)
ZA (1) ZA989228B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
WO2001043692A2 (en) * 1999-12-15 2001-06-21 Smithkline Beecham Corporation SALTS OF Cis-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1-CARBOXYLIC ACID
PT1250313E (en) * 2000-01-26 2007-01-31 Smithkline Beecham Corp Monohydrate of cis-lithium-cyano-4- 3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylate
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
WO2002060898A1 (en) 2001-01-31 2002-08-08 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
NZ526453A (en) 2001-01-31 2005-01-28 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
MXPA03006885A (en) 2001-01-31 2003-11-13 Pfizer Prod Inc Ether derivatives useful as inhibitors of pde4 isozymes.
CN102491959B (en) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 Preparation method of oxirane derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
FI944549L (en) * 1992-04-02 1994-11-30 Smithkline Beecham Corp Compounds useful in the treatment of allergic and inflammatory diseases
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
MY118813A (en) * 1997-02-12 2005-01-31 Smithkline Beecham Corp Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
NO20001777L (en) 2000-05-03
IL135434A (en) 2004-12-15
CA2305614A1 (en) 1999-04-22
MA24670A1 (en) 1999-07-01
ID25536A (en) 2000-10-12
EA200000406A1 (en) 2000-10-30
NO20001777D0 (en) 2000-04-06
KR100560038B1 (en) 2006-03-13
ZA989228B (en) 1999-04-12
AU9687498A (en) 1999-05-03
KR20010015709A (en) 2001-02-26
AR015952A1 (en) 2001-05-30
PL191974B1 (en) 2006-07-31
MY122105A (en) 2006-03-31
EP1043930A1 (en) 2000-10-18
AP2000001782A0 (en) 2000-06-30
UA67753C2 (en) 2004-07-15
WO1999018793A1 (en) 1999-04-22
PL339759A1 (en) 2001-01-02
CN1275052A (en) 2000-11-29
SK4902000A3 (en) 2000-11-07
DZ2619A1 (en) 2003-03-08
UY25201A1 (en) 2001-08-27
BR9814064A (en) 2000-09-26
SA99191000A (en) 2005-12-03
AU741832B2 (en) 2001-12-13
TR200000945T2 (en) 2000-10-23
EP1043930A4 (en) 2004-09-15
HUP0003905A3 (en) 2002-01-28
IL135434A0 (en) 2001-05-20
UY25524A1 (en) 2000-02-23
HUP0003905A2 (en) 2001-03-28
TW440557B (en) 2001-06-16
PE121599A1 (en) 2000-02-19
EA003609B1 (en) 2003-06-26
CN1192025C (en) 2005-03-09
NZ503759A (en) 2002-03-01
OA11347A (en) 2003-12-17
AP1335A (en) 2004-11-29
JP2001519363A (en) 2001-10-23

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