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BR0313961A - Processos e intermediários para preparar triazolo-piridinas - Google Patents

Processos e intermediários para preparar triazolo-piridinas

Info

Publication number
BR0313961A
BR0313961A BR0313961-1A BR0313961A BR0313961A BR 0313961 A BR0313961 A BR 0313961A BR 0313961 A BR0313961 A BR 0313961A BR 0313961 A BR0313961 A BR 0313961A
Authority
BR
Brazil
Prior art keywords
hydrogen
pyridines
intermediates
processes
alkyl
Prior art date
Application number
BR0313961-1A
Other languages
English (en)
Inventor
Richard Allen Buzon
Michael James Castaldi
Zhengong Bryan Li
David Harold Brown Ripin
Yong Tao
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0313961A publication Critical patent/BR0313961A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSOS E INTERMEDIáRIOS PARA PREPARAR TRIAZOLO-PIRIDINAS". A presente invenção refere-se com um novo processo de preparar triazolo-piridinas de fórmula I em que R^ 1^ é selecionado do grupo composto por hidrogênio, (C~ 1~-C~ 6~)alquila ou outros substituintes adequados; R^ 3^ é selecionado do grupo composto por hidrogênio, (C~ 1~-C~ 6~)alquila ou outros substituintes adequados; s é um número inteiro de 0-5; R^ 4^ é hidrogênio ou um substituinte adequado; e com intermediários para a sua preparação. Os compostos preparados de acordo com os métodos da presente invenção são inibidores potentes das cinases MAP, preferencialmente da cinase p38. Aqueles são úteis no tratamento de inflamação, osteoartrite, artrite reumatóide, câncer, reperfusão ou isquemia no acidente vascular cerebral ou ataque cardíaco, doenças auto-imunes e outras perturbações.
BR0313961-1A 2002-08-30 2003-08-18 Processos e intermediários para preparar triazolo-piridinas BR0313961A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40708502P 2002-08-30 2002-08-30
PCT/IB2003/003669 WO2004020438A2 (en) 2002-08-30 2003-08-18 Novel processes and intermediates for preparing triazolo-pyridines

Publications (1)

Publication Number Publication Date
BR0313961A true BR0313961A (pt) 2005-07-19

Family

ID=31978416

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313961-1A BR0313961A (pt) 2002-08-30 2003-08-18 Processos e intermediários para preparar triazolo-piridinas

Country Status (10)

Country Link
US (1) US20040053959A1 (pt)
EP (1) EP1537107A2 (pt)
JP (1) JP2006508914A (pt)
AR (1) AR041192A1 (pt)
AU (1) AU2003253188A1 (pt)
BR (1) BR0313961A (pt)
CA (1) CA2496812A1 (pt)
MX (1) MXPA05002123A (pt)
TW (1) TW200413367A (pt)
WO (1) WO2004020438A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE334131T1 (de) * 2003-02-14 2006-08-15 Pfizer Prod Inc Triazolopyridine als entzündungshemmende verbindungen
EP1781655A2 (en) * 2004-08-18 2007-05-09 Pharmacia & Upjohn Company LLC Triazolopyridine compounds useful for the treatment of inflammation
US7579360B2 (en) * 2005-06-09 2009-08-25 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
US7572807B2 (en) * 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2057164A1 (en) 2006-08-07 2009-05-13 Incyte Corporation Triazolotriazines as kinase inhibitors
ES2301380B1 (es) 2006-08-09 2009-06-08 Laboratorios Almirall S.A. Nuevos derivados de 1,7-naftiridina.
EA026126B1 (ru) 2006-11-22 2017-03-31 Инсайт Холдингс Корпорейшн Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US8119658B2 (en) * 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
EP2300455B1 (en) 2008-05-21 2017-07-19 Incyte Holdings Corporation Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
EA025304B1 (ru) 2010-02-03 2016-12-30 Инсайт Холдингс Корпорейшн ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИНЫ В КАЧЕСТВЕ c-Met ИНГИБИТОРОВ
ES2691650T3 (es) 2011-09-15 2018-11-28 Novartis Ag 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como inhibidores de tirosina quinasa c-Met
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
LT3691620T (lt) 2017-10-05 2022-09-26 Fulcrum Therapeutics, Inc. P38 kinazės inhibitoriai, sumažinantys dux4 ir pasrovinių genų raišką, skirti fshd gydymui
TW202419442A (zh) * 2022-09-09 2024-05-16 美商富曼西公司 用於合成（３－氯－２－吡啶基）肼之新方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69433501T2 (de) * 1993-11-08 2004-11-04 Smithkline Beecham Corp. Oxazole zur behandlung von zytokinvermittelten erkrankungen
IL125223A0 (en) * 1996-01-11 1999-03-12 Smithkline Beecham Corp Novel substituted imidazole compounds
US6207687B1 (en) * 1998-07-31 2001-03-27 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
WO2000040243A1 (en) * 1999-01-08 2000-07-13 Smithkline Beecham Corporation Novel compounds
CO5170501A1 (es) * 1999-04-14 2002-06-27 Novartis Ag AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
MXPA03008144A (es) * 2001-03-09 2003-12-12 Pfizer Prod Inc Nuevos compuestos antiinflamatorios de triazolopiridinas.

Also Published As

Publication number Publication date
TW200413367A (en) 2004-08-01
CA2496812A1 (en) 2004-03-11
MXPA05002123A (es) 2005-06-06
AU2003253188A1 (en) 2004-03-19
WO2004020438A2 (en) 2004-03-11
US20040053959A1 (en) 2004-03-18
JP2006508914A (ja) 2006-03-16
AR041192A1 (es) 2005-05-04
WO2004020438A3 (en) 2004-07-22
AU2003253188A8 (en) 2004-03-19
EP1537107A2 (en) 2005-06-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A,5A,6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2069 DE 31/08/2010.