BR102018004862A2 - composto, forma cristalina, composição farmacêutica, e, métodos para inibir ask1 e para tratar uma condição - Google Patents

composto, forma cristalina, composição farmacêutica, e, métodos para inibir ask1 e para tratar uma condição Download PDF

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Publication number: BR102018004862A2
Authority: BR; Brazil
Prior art keywords: compound; pyridin; fluoropropan; triazol; distinguished
Prior art date: 2017-03-14

Application number

BR102018004862A

Other languages

English (en)

Portuguese (pt)

Inventor

Notte Gregory

Lynne Alleva Jennifer

Farand Julie

Elodie DEMPAH Kassibla

Original Assignee

Gilead Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-03-14

Filing date

2018-03-12

Publication date

2019-01-02

2018-03-12 Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc

2019-01-02 Publication of BR102018004862A2 publication Critical patent/BR102018004862A2/pt

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BR102018004862A 2017-03-14 2018-03-12 composto, forma cristalina, composição farmacêutica, e, métodos para inibir ask1 e para tratar uma condição BR102018004862A2 (pt)

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AR (1)	AR111178A1 (fr)
BR (1)	BR102018004862A2 (fr)
JO (1)	JOP20180017A1 (fr)
TW (1)	TW201840551A (fr)
UY (1)	UY37631A (fr)
WO (1)	WO2018169742A1 (fr)

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TWI625121B (zh)	2009-07-13	2018-06-01	基利科學股份有限公司	調節細胞凋亡信號之激酶的抑制劑
JP7377718B2 (ja)	2017-05-12	2023-11-10	エナンタファーマシューティカルズインコーポレイテッド	アポトーシスシグナル調節キナーゼ１阻害剤およびその使用方法
WO2019046186A1 (fr)	2017-08-28	2019-03-07	Enanta Pharmaceuticals, Inc.	Inhibiteurs de la kinase 1 régulant le signal apoptotique contenant des tétrazoles et méthodes d'utilisation de ceux-ci
US10683289B2 (en)	2018-05-02	2020-06-16	Enanta Pharmaceuticals, Inc.	Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
IL278368B2 (en)	2018-05-02	2024-06-01	Enanta Pharm Inc	Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods for its use
CN110818683B (zh) *	2018-08-10	2023-04-14	中国科学院上海药物研究所	2-吡啶取代脲结构小分子化合物及其合成和应用
WO2020041417A1 (fr)	2018-08-22	2020-02-27	Enanta Pharmaceuticals, Inc.	Inhibiteurs de la kinase 1 régulant le signal d'apoptose contenant un cycloalkyle et leurs procédés d'utilisation
WO2020106707A1 (fr)	2018-11-19	2020-05-28	Enanta Pharmaceuticals, Inc.	Inhibiteurs de la kinase 1 régulant le signal d'apoptose et leurs méthodes d'utilisation
US11466033B2 (en)	2019-03-25	2022-10-11	Enanta Pharmaceuticals, Inc.	Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
AU2021282582A1 (en) *	2020-06-04	2023-02-02	Curasen Therapeutics, Inc.	Forms and compositions of a beta adrenergic agonist
WO2023125904A1 (fr) *	2021-12-30	2023-07-06	苏州晶云药物科技股份有限公司	Forme cristalline d'un composé d'acide azacyclobutyl nicotinique et son procédé de préparation
CN117503932B (zh) *	2022-07-30	2024-09-24	中国医学科学院阜外医院	Jun抑制剂在制备用于治疗射血分数保留的心衰的药物中的用途
CN117054652B (zh) *	2023-08-04	2024-05-17	南京医科大学	一种用于辅助检测心肌肥厚的生物标志物及其应用
CN118252938B (zh) *	2024-01-24	2025-02-11	中国医学科学院阜外医院	抑制或敲除Jun基因表达的试剂用于治疗射血分数保留的心衰的用途

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TWI625121B (zh)	2009-07-13	2018-06-01	基利科學股份有限公司	調節細胞凋亡信號之激酶的抑制劑
EP2545964A1 (fr)	2011-07-13	2013-01-16	Phenex Pharmaceuticals AG	Nouveaux composés se liant au fxr (nr1 h4) et modulant son activité
UY34573A (es)	2012-01-27	2013-06-28	Gilead Sciences Inc	Inhibidor de la quinasa que regula la señal de la apoptosis
WO2015187499A1 (fr)	2014-06-03	2015-12-10	Gilead Sciences, Inc.	Utilisation d'un inhibiteur d'ask1, éventuellement associé à un inhibiteur de loxl2, pour le traitement d'une maladie du foie
TW201618781A (zh)	2014-08-13	2016-06-01	吉李德科學股份有限公司	治療肺高血壓之方法
MA41252A (fr) *	2014-12-23	2017-10-31	Gilead Sciences Inc	Formes solides d'un inhibiteur d'ask 1

2017
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2018
- 2018-03-07 WO PCT/US2018/021334 patent/WO2018169742A1/fr not_active Ceased
- 2018-03-12 BR BR102018004862A patent/BR102018004862A2/pt not_active Application Discontinuation
- 2018-03-13 TW TW107108465A patent/TW201840551A/zh unknown
- 2018-03-14 AR ARP180100585A patent/AR111178A1/es unknown
- 2018-03-14 UY UY0001037631A patent/UY37631A/es not_active Application Discontinuation

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UY37631A (es)	2018-09-28
JOP20180017A1 (ar)	2019-01-30
AR111178A1 (es)	2019-06-12
WO2018169742A1 (fr)	2018-09-20
TW201840551A (zh)	2018-11-16

Publication	Publication Date	Title
BR102018004862A2 (pt)	2019-01-02	composto, forma cristalina, composição farmacêutica, e, métodos para inibir ask1 e para tratar uma condição
US10946004B2 (en)	2021-03-16	Solid forms of an ASK1 inhibitor
JP6086633B2 (ja)	2017-03-01	アポトーシスシグナル調節キナーゼとしての置換されたピリジン−２−カルボキサミド化合物
JP5770950B2 (ja)	2015-08-26	アポトーシスシグナル調節キナーゼ阻害剤
JP5745721B2 (ja)	2015-07-08	アポトーシスシグナル調節キナーゼ阻害剤
JP2019077719A (ja)	2019-05-23	アポトーシスシグナル調節キナーゼ阻害剤
HK1246277B (en)	2023-10-20	Solid forms of an ask1 inhibitor
HK1238633A1 (en)	2018-05-04	Solid forms of an ask1 inhibitor

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2021-09-14	B11Y	Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired