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BR112023000065A2 - Sal e forma cristalina de composto de pirimidina e métodos de preparação para os mesmos - Google Patents

Sal e forma cristalina de composto de pirimidina e métodos de preparação para os mesmos

Info

Publication number
BR112023000065A2
BR112023000065A2 BR112023000065A BR112023000065A BR112023000065A2 BR 112023000065 A2 BR112023000065 A2 BR 112023000065A2 BR 112023000065 A BR112023000065 A BR 112023000065A BR 112023000065 A BR112023000065 A BR 112023000065A BR 112023000065 A2 BR112023000065 A2 BR 112023000065A2
Authority
BR
Brazil
Prior art keywords
salt
methods
crystalline form
preparation
pyrimidine compound
Prior art date
Application number
BR112023000065A
Other languages
English (en)
Inventor
Gong Zheng
Wang Jingyi
Li Hongming
Yi Shidong
Li Long
Wang Tianming
Chen Pingyun
Yang Chengxi
Wang Tao
Song Yaoyao
Zhou Jiangfeng
Liang Yufeng
Chen Zhonghui
Tian Qiang
Song Hongmei
XUE Tongtong
Original Assignee
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Kelun Biotech Biopharmaceutical Co Ltd filed Critical Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Publication of BR112023000065A2 publication Critical patent/BR112023000065A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SAL E FORMA CRISTALINA DE COMPOSTO DE PIRIMIDINA E MÉTODOS DE PREPARAÇÃO PARA OS MESMOS. São fornecidos um sal e uma forma cristalina de um composto de pirimidina e métodos de preparação para os mesmos. Especificamente, são fornecidos um sal e uma forma cristalina de um composto I, incluindo uma forma cristalina do sal, e métodos de preparação para os mesmos.
BR112023000065A 2020-07-28 2021-07-23 Sal e forma cristalina de composto de pirimidina e métodos de preparação para os mesmos BR112023000065A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010737039 2020-07-28
PCT/CN2021/108032 WO2022022398A1 (zh) 2020-07-28 2021-07-23 一种嘧啶类化合物的盐和晶型及其制备方法

Publications (1)

Publication Number Publication Date
BR112023000065A2 true BR112023000065A2 (pt) 2023-01-31

Family

ID=80037147

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023000065A BR112023000065A2 (pt) 2020-07-28 2021-07-23 Sal e forma cristalina de composto de pirimidina e métodos de preparação para os mesmos

Country Status (7)

Country Link
US (1) US20230295174A1 (pt)
EP (1) EP4190781A4 (pt)
JP (1) JP7688690B2 (pt)
KR (1) KR20230044358A (pt)
CN (1) CN115702154A (pt)
BR (1) BR112023000065A2 (pt)
WO (1) WO2022022398A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024240017A1 (zh) * 2023-05-19 2024-11-28 四川科伦博泰生物医药股份有限公司 杂环化合物治疗与ret基因改变相关疾病的用途和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2588220A1 (en) * 2004-12-23 2006-06-29 Pfizer Products Inc. Heteroaromatic derivatives useful as anticancer agents
US20080234267A1 (en) * 2007-03-20 2008-09-25 Karen Elizabeth Lackey Compounds and Methods of Treatment
ES2857081T3 (es) * 2015-07-16 2021-09-28 Array Biopharma Inc Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret
ES2948194T3 (es) * 2017-01-18 2023-09-01 Array Biopharma Inc Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET
WO2020114388A1 (zh) * 2018-12-06 2020-06-11 深圳市塔吉瑞生物医药有限公司 取代的吡唑并[1,5-a]吡啶化合物及包含该化合物的组合物及其用途
CN111285882B (zh) * 2018-12-07 2022-12-02 四川科伦博泰生物医药股份有限公司 稠环化合物、包含其的药物组合物及其制备方法和用途
KR20210131314A (ko) * 2019-02-19 2021-11-02 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 헤테로시클릴 화합물, 이를 포함하는 약제학적 조성물, 이의 제조 방법, 및 이의 용도
JP2024511389A (ja) * 2021-03-24 2024-03-13 スーチュアン・コールン－バイオテック・バイオファーマシューティカル・カンパニー・リミテッド キナーゼ薬剤耐性変異に関連する疾患を治療するための複素環式化合物の使用及び方法

Also Published As

Publication number Publication date
JP7688690B2 (ja) 2025-06-04
EP4190781A1 (en) 2023-06-07
JP2023535361A (ja) 2023-08-17
WO2022022398A1 (zh) 2022-02-03
EP4190781A4 (en) 2023-12-27
CN115702154A (zh) 2023-02-14
US20230295174A1 (en) 2023-09-21
KR20230044358A (ko) 2023-04-04

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