BR9306551A - Derivados de peptídeo do tipo glucagona e de insulinotropina - Google Patents

Derivados de peptídeo do tipo glucagona e de insulinotropina

Info

Publication number: BR9306551A
Authority: BR; Brazil
Prior art keywords: insulinotropin; glucagon; peptide derivatives; peptide; derivatives
Prior art date: 1992-06-15

Application number

BR9306551A

Other languages

English (en)

Inventor

Glenn C Andrews

Gaston O Daumy

Eric R Larson

Michael L Francoeur

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-15

Filing date

1993-04-14

Publication date

1998-09-15

1993-04-14 Application filed by Pfizer filed Critical Pfizer

1998-09-15 Publication of BR9306551A publication Critical patent/BR9306551A/pt

Links

102000051325 Glucagon Human genes 0.000 title 1
108060003199 Glucagon Proteins 0.000 title 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1
229960004666 glucagon Drugs 0.000 title 1
GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

BR9306551A 1992-06-15 1993-04-14 Derivados de peptídeo do tipo glucagona e de insulinotropina BR9306551A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US89907392A	1992-06-15	1992-06-15
PCT/US1993/003388 WO1993025579A1 (en)	1992-06-15	1993-04-14	Glucagon-like peptide and insulinotropin derivatives

Publications (1)

Publication Number	Publication Date
BR9306551A true BR9306551A (pt)	1998-09-15

Family

ID=25410453

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9306551A BR9306551A (pt)	1992-06-15	1993-04-14	Derivados de peptídeo do tipo glucagona e de insulinotropina

Country Status (19)

Country	Link
EP (2)	EP0646128A1 (pt)
JP (1)	JP2575298B2 (pt)
KR (1)	KR0154880B1 (pt)
CN (1)	CN1057098C (pt)
AU (1)	AU671117B2 (pt)
BR (1)	BR9306551A (pt)
CA (1)	CA2138161C (pt)
CZ (1)	CZ315594A3 (pt)
FI (1)	FI932722A7 (pt)
HR (1)	HRP930993A2 (pt)
HU (2)	HUT64367A (pt)
IL (1)	IL105928A0 (pt)
MX (1)	MX9303554A (pt)
NO (1)	NO944853D0 (pt)
PL (1)	PL176007B1 (pt)
RU (1)	RU2128663C1 (pt)
SK (1)	SK155694A3 (pt)
WO (1)	WO1993025579A1 (pt)
YU (1)	YU41493A (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6849708B1 (en)	1986-05-05	2005-02-01	The General Hospital Corporation	Insulinotropic hormone and uses thereof
US7138486B2 (en)	1986-05-05	2006-11-21	The General Hospital Corporation	Insulinotropic hormone derivatives and uses thereof
US5614492A (en) *	1986-05-05	1997-03-25	The General Hospital Corporation	Insulinotropic hormone GLP-1 (7-36) and uses thereof
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6284727B1 (en)	1993-04-07	2001-09-04	Scios, Inc.	Prolonged delivery of peptides
US5705483A (en)	1993-12-09	1998-01-06	Eli Lilly And Company	Glucagon-like insulinotropic peptides, compositions and methods
GB9409496D0 (en)	1994-05-12	1994-06-29	London Health Ass	Method for improving glycaemic control in diabetes
US5574008A (en) *	1994-08-30	1996-11-12	Eli Lilly And Company	Biologically active fragments of glucagon-like insulinotropic peptide
US5512549A (en) *	1994-10-18	1996-04-30	Eli Lilly And Company	Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
AU4415796A (en) *	1994-12-07	1996-06-26	Bionebraska, Inc.	Production of c-terminal amidated peptides from recombinant protein constructs
US5834428A (en)	1995-04-14	1998-11-10	1149336 Ontario Inc.	Glucagon-like peptide-2 and its therapeutic use
US5990077A (en) *	1995-04-14	1999-11-23	1149336 Ontario Inc.	Glucagon-like peptide-2 and its therapeutic use
US6184201B1 (en)	1995-04-14	2001-02-06	Nps Allelix Corp.	Intestinotrophic glucagon-like peptide-2 analogs
US5747453A (en) *	1995-06-06	1998-05-05	Alza Corporation	Method for increasing the electrotransport flux of polypeptides
US6333189B1 (en)	1996-06-06	2001-12-25	Alza Corporation	Method of making an electrotransport device
US6956026B2 (en)	1997-01-07	2005-10-18	Amylin Pharmaceuticals, Inc.	Use of exendins for the reduction of food intake
US6006753A (en) *	1996-08-30	1999-12-28	Eli Lilly And Company	Use of GLP-1 or analogs to abolish catabolic changes after surgery
UA65549C2 (uk)	1996-11-05	2004-04-15	Елі Ліллі Енд Компані	Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
CA2283834A1 (en) *	1997-03-31	1998-10-08	James Arthur Hoffmann	Glucagon-like peptide-1 analogs
US7157555B1 (en)	1997-08-08	2007-01-02	Amylin Pharmaceuticals, Inc.	Exendin agonist compounds
BR9815670A (pt)	1997-11-14	2000-10-17	Amylin Pharmaceuticals Inc	Compostos agonistas de exendina
US7223725B1 (en)	1997-11-14	2007-05-29	Amylin Pharmaceuticals, Inc.	Exendin agonist compounds
US6380357B2 (en) *	1997-12-16	2002-04-30	Eli Lilly And Company	Glucagon-like peptide-1 crystals
FR2777283B1 (fr) *	1998-04-10	2000-11-24	Adir	Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2339326A1 (en)	1998-08-10	2000-02-24	Josephine Egan	Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof
DK1137666T5 (da) *	1998-12-07	2009-10-05	Univ Tulane	GLP-1-analoger
CZ294029B6 (cs) *	1998-12-07	2004-09-15	Societe De Conseils De Recherches Et D'application	Analog GLP-1, jeho použití a farmaceutický prostředek jej obsahující
WO2000069911A1 (en)	1999-05-17	2000-11-23	Conjuchem, Inc.	Long lasting insulinotropic peptides
US6514500B1 (en)	1999-10-15	2003-02-04	Conjuchem, Inc.	Long lasting synthetic glucagon like peptide {GLP-!}
AU2001274809A1 (en)	2000-04-12	2001-10-30	Human Genome Sciences, Inc.	Albumin fusion proteins
US7090869B2 (en)	2000-12-01	2006-08-15	Takeda Pharmaceutical Company Limited	Method for producing preparation containing bioactive substance
EP1351984A2 (en)	2000-12-13	2003-10-15	Eli Lilly And Company	Amidated glucagon-like peptide-1
JP2005514337A (ja) *	2001-10-18	2005-05-19	ブリストル−マイヤーズ　スクイブ　カンパニー	ヒトグルカゴン様ペプチド−１模倣体、並びに糖尿病および関連疾患の処置におけるその使用
EP2990417A1 (en)	2001-12-21	2016-03-02	Human Genome Sciences, Inc.	Albumin insulin fusion protein
PL209734B1 (pl)	2002-02-20	2011-10-31	Emisphere Tech Inc	Preparat farmaceutyczny zawierający związek GLP-1 i czynnik dostarczający oraz jego zastosowanie
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
US20060286129A1 (en)	2003-12-19	2006-12-21	Emisphere Technologies, Inc.	Oral GLP-1 formulations
JP2007537149A (ja) *	2004-01-08	2007-12-20	セラテクノロジーズインコーポレイテッド	長時間作用性のグルカゴン様ペプチド−１類似体
WO2005103087A1 (en)	2004-04-23	2005-11-03	Conjuchem Biotechnologies Inc.	Method for the purification of albumin conjugates
WO2007053946A1 (en)	2005-11-09	2007-05-18	Conjuchem Biotechnologies Inc.	Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
US8178495B2 (en)	2008-06-27	2012-05-15	Duke University	Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
JP2013532172A (ja)	2010-07-09	2013-08-15	ダナファーバーキャンサーインスティテュートインコーポレイテッド	安定化したインスリン分泌促進ペプチド及び使用方法
US20150157619A1 (en)	2012-07-10	2015-06-11	Takeda Pharmaceutical Company Limited	Pharmaceutical preparation for injection
HRP20211768T1 (hr)	2015-05-22	2022-02-18	The Board Of Trustees Of The Leland Stanford Junior University	Liječenje postbarijatrijske hipoglikemije s antagonistima glp-1
US20190290772A1 (en) *	2016-06-02	2019-09-26	Indiana University Research And Technology Corporation	Glucagon-like peptide-1-t3 conjugates
BR112019010236A2 (pt)	2016-11-21	2019-08-20	Eiger Biopharmaceuticals Inc	formulações tamponadas de exendina (9-39)
MX2019010651A (es) *	2017-03-08	2020-01-13	Intarcia Therapeutics Inc	Aparato y métodos para administración de un compuesto nauseogénico desde un dispositivo de administración de fármacos.
RS65380B1 (sr)	2017-08-24	2024-04-30	Novo Nordisk As	Glp-1 kompozicije i njihova upotreba
CN115135305B (zh)	2020-02-18	2025-09-12	诺和诺德股份有限公司	药物制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE193541T1 (de) *	1989-03-20	2000-06-15	Gen Hospital Corp	Insulinotropes hormon
CA2073856C (en) *	1990-01-24	2002-12-03	Douglas I. Buckley	Glp-1 analogs useful for diabetes treatment
ATE138102T1 (de) *	1991-02-19	1996-06-15	Takeda Chemical Industries Ltd	Verfahren zur herstellung von cysteinfreien peptiden
DK36492D0 (da) *	1992-03-19	1992-03-19	Novo Nordisk As	Praeparat
DK36392D0 (da) *	1992-03-19	1992-03-19	Novo Nordisk As	Anvendelse af kemisk forbindelse
DK39892D0 (da) *	1992-03-25	1992-03-25	Bernard Thorens	Peptid

1993
- 1993-04-14 CA CA002138161A patent/CA2138161C/en not_active Expired - Lifetime
- 1993-04-14 PL PL93306766A patent/PL176007B1/pl unknown
- 1993-04-14 EP EP93909505A patent/EP0646128A1/en not_active Ceased
- 1993-04-14 WO PCT/US1993/003388 patent/WO1993025579A1/en not_active Application Discontinuation
- 1993-04-14 KR KR1019940704555A patent/KR0154880B1/ko not_active Expired - Lifetime
- 1993-04-14 AU AU40275/93A patent/AU671117B2/en not_active Expired
- 1993-04-14 JP JP6501448A patent/JP2575298B2/ja not_active Expired - Lifetime
- 1993-04-14 CZ CZ943155A patent/CZ315594A3/cs unknown
- 1993-04-14 SK SK1556-94A patent/SK155694A3/sk unknown
- 1993-04-14 BR BR9306551A patent/BR9306551A/pt not_active Application Discontinuation
- 1993-04-14 RU RU94046251A patent/RU2128663C1/ru active
- 1993-04-14 EP EP99110184A patent/EP0969016A2/en not_active Withdrawn
- 1993-06-07 IL IL105928A patent/IL105928A0/xx not_active IP Right Cessation
- 1993-06-14 FI FI932722A patent/FI932722A7/fi unknown
- 1993-06-14 YU YU41493A patent/YU41493A/sh unknown
- 1993-06-14 CN CN93108718A patent/CN1057098C/zh not_active Expired - Fee Related
- 1993-06-14 HU HU9301739A patent/HUT64367A/hu unknown
- 1993-06-15 MX MX9303554A patent/MX9303554A/es active IP Right Grant
- 1993-06-24 HR HR07/899,073A patent/HRP930993A2/xx not_active Application Discontinuation
1994
- 1994-12-14 NO NO944853A patent/NO944853D0/no not_active Application Discontinuation
1995
- 1995-06-28 HU HU95P/P00479P patent/HU211498A9/hu unknown

Also Published As

Publication number	Publication date
CZ315594A3 (en)	1995-07-12
MX9303554A (es)	1994-06-30
EP0646128A1 (en)	1995-04-05
IL105928A0 (en)	1993-10-20
HU211498A9 (en)	1995-11-28
CN1085913A (zh)	1994-04-27
FI932722A0 (fi)	1993-06-14
SK155694A3 (en)	1995-05-10
HRP930993A2 (en)	1996-12-31
JP2575298B2 (ja)	1997-01-22
NO944853L (no)	1994-12-14
AU671117B2 (en)	1996-08-15
JPH07504679A (ja)	1995-05-25
CA2138161C (en)	2003-10-21
CN1057098C (zh)	2000-10-04
CA2138161A1 (en)	1993-12-23
NO944853D0 (no)	1994-12-14
RU2128663C1 (ru)	1999-04-10
EP0969016A2 (en)	2000-01-05
AU4027593A (en)	1994-01-04
PL176007B1 (pl)	1999-03-31
KR0154880B1 (ko)	1998-10-15
RU94046251A (ru)	1996-10-27
FI932722L (fi)	1993-12-16
HU9301739D0 (en)	1993-09-28
YU41493A (sh)	1996-10-18
FI932722A7 (fi)	1993-12-16
WO1993025579A1 (en)	1993-12-23
HUT64367A (en)	1993-12-28
KR950701937A (ko)	1995-05-17

Publication	Publication Date	Title
BR9306551A (pt)	1998-09-15	Derivados de peptídeo do tipo glucagona e de insulinotropina
ITMI920408A1 (it)	1993-08-25	Derivati benzopiranici e benzotiopiranici
BR1100824A (pt)	1999-08-31	Composto e composição farmacêutica
FI941398A7 (fi)	1994-03-25	Modifioituja peptidijohdannaisia
ATA75293A (de)	1997-11-15	Indolderivate
IT1266582B1 (it)	1997-01-09	Derivati (di)azacicloesanici e diazacicloeptanici
DE69223266D1 (de)	1998-01-08	Peptidderivate und deren Verwendung
ITMI931471A1 (it)	1995-01-07	Sci
FI934004A7 (fi)	1994-03-16	7-isoindolinyylikinoloni- ja naftyridonijohdannaiset
DE69330497D1 (de)	2001-08-30	Chinazolin-derivate
NO944838D0 (no)	1994-12-14	Arabinogalaktanderivater og anvendelser derav
FI20010214A7 (fi)	2001-02-05	Asyyliaminoindolijohdannaisia
FI945416L (fi)	1994-11-17	Dolastatiinijohdannaisia
DE59308714D1 (de)	1998-07-30	Cyclobutan-benzol-derivate
FI20002460L (fi)	2000-11-09	4-difenyylimetyylipiperidiinijohdannaisia
FI933201L (fi)	1994-01-17	Vaerme- och kylvals
NO922934D0 (no)	1992-07-23	Cykloheksan- og tetrahydropyranderivater
DE69313890D1 (de)	1997-10-23	5-Aminoflavon-Derivate
FI933019L (fi)	1994-01-02	Bensotiazepin- och bensoxatzepinderivat
FI1031U1 (fi)	1993-11-19	En troakar
ITMI921571A1 (it)	1993-12-26	Azaciclo e azabiciclo alchiliden idrossilamine
FI920456A7 (fi)	1992-08-06	MSH-peptidijohdannaisia
BR9205281A (pt)	1993-07-27	Pentapeptideos imuno-reguladores e neuro-reguladores
ITMI920631A0 (it)	1992-03-18	Derivati mercato acetamidici
ITRM920060A1 (it)	1992-04-27	Xenocollagene e derivati

Legal Events

Date	Code	Title	Description
1999-06-22	EG	Technical examination (opinion): publication of technical examination (opinion)
1999-08-17	PC	Transfer	Free format text: SCIOS INC. (US)
1999-11-16	FC	Decision: refusal
2001-03-06	TE	Change of address
2001-04-24	CKFC	Appeal: appeal against refusal
2018-03-27	B15K	Others concerning applications: alteration of classification	Ipc: C07K 14/605 (2006.01), A61K 38/00 (2006.0