|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
EP0739981A1
(en)
*
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
EP0894135B1
(en)
|
1996-04-04 |
2004-08-11 |
Unilever Plc |
Multivalent and multispecific antigen-binding protein
|
|
US6136311A
(en)
|
1996-05-06 |
2000-10-24 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of cancer
|
|
CA2288992C
(en)
|
1997-04-30 |
2012-06-12 |
Enzon, Inc. |
Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
|
|
US6333396B1
(en)
|
1998-10-20 |
2001-12-25 |
Enzon, Inc. |
Method for targeted delivery of nucleic acids
|
|
EP1002861A1
(en)
*
|
1998-10-26 |
2000-05-24 |
Unilever Plc |
Antigen-binding proteins comprising a linker which confers restricted conformational flexibility
|
|
CN1332797A
(zh)
|
1998-12-11 |
2002-01-23 |
荷兰联合利华有限公司 |
漂白酶和含有它们的洗涤剂组合物
|
|
ES2528794T3
(es)
|
2000-04-11 |
2015-02-12 |
Genentech, Inc. |
Anticuerpos multivalentes y usos de los mismos
|
|
US20030204618A1
(en)
*
|
2001-04-27 |
2003-10-30 |
Foster Michael S. |
Using virtual identifiers to process received data routed through a network
|
|
CA2447851C
(en)
*
|
2001-06-28 |
2012-08-28 |
Domantis Limited |
Dual-specific ligand and its use
|
|
GB0115841D0
(en)
*
|
2001-06-28 |
2001-08-22 |
Medical Res Council |
Ligand
|
|
JP4443923B2
(ja)
*
|
2001-10-15 |
2010-03-31 |
イミューノメディクス、インコーポレイテッド |
親和性向上剤
|
|
MXPA04006327A
(es)
*
|
2001-12-26 |
2005-07-13 |
Ibc Pharmaceuticals |
Metodos para generar agentes multivalentes, multiespecificos de dominios vh y vl.
|
|
EP2075256A2
(en)
|
2002-01-14 |
2009-07-01 |
William Herman |
Multispecific binding molecules
|
|
EP2135879A3
(en)
*
|
2002-06-28 |
2010-06-23 |
Domantis Limited |
Ligand
|
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
US9701754B1
(en)
|
2002-10-23 |
2017-07-11 |
City Of Hope |
Covalent disulfide-linked diabodies and uses thereof
|
|
EP1578801A2
(en)
*
|
2002-12-27 |
2005-09-28 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
AU2004232928A1
(en)
*
|
2003-04-22 |
2004-11-04 |
Ibc Pharmaceuticals |
Polyvalent protein complex
|
|
WO2005026325A2
(en)
*
|
2003-09-10 |
2005-03-24 |
Surromed, Inc, |
Bivalent targeting of cell surfaces
|
|
ES2484340T3
(es)
|
2003-12-05 |
2014-08-11 |
Multimmune Gmbh |
Anticuerpos anti hsp70 terapéuticos y diagnósticos
|
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
JP2012228248A
(ja)
*
|
2005-08-19 |
2012-11-22 |
Abbott Lab |
二重可変ドメイン免疫グロブリン及びその使用
|
|
US20090215992A1
(en)
*
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
|
SG2014010029A
(en)
*
|
2005-08-19 |
2014-08-28 |
Abbott Lab |
Dual variable domain immunoglobin and uses thereof
|
|
MX2008005405A
(es)
*
|
2005-10-28 |
2008-09-11 |
Florida Internat University Bo |
Anticuerpos quimericos equinos: humanos.
|
|
EA200801170A1
(ru)
*
|
2005-12-01 |
2008-12-30 |
Домантис Лимитед |
Форматы неконкурентного доменного антитела, которые связываются с рецептором интерлейкина 1 первого типа
|
|
EP2674440B1
(en)
|
2005-12-16 |
2019-07-03 |
IBC Pharmaceuticals, Inc. |
Multivalent immunoglobulin-based bioactive assemblies
|
|
EP1996716B1
(en)
|
2006-03-20 |
2011-05-11 |
The Regents of the University of California |
Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
|
|
TW200900420A
(en)
|
2007-02-02 |
2009-01-01 |
Amgen Inc |
Hepcidin, hepcidin antagonists and methods of use
|
|
KR20100040840A
(ko)
|
2007-06-06 |
2010-04-21 |
도만티스 리미티드 |
폴리펩티드,항체 가변 도메인 및 길항제
|
|
CA2698343C
(en)
|
2007-09-04 |
2018-06-12 |
The Regents Of The University Of California |
High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection
|
|
EP2050764A1
(en)
*
|
2007-10-15 |
2009-04-22 |
sanofi-aventis |
Novel polyvalent bispecific antibody format and uses thereof
|
|
CN104072613A
(zh)
*
|
2007-11-13 |
2014-10-01 |
Evec股份有限公司 |
与hGM-CSF结合的单克隆抗体及包含它的药物组合物
|
|
CA2709354C
(en)
|
2007-12-21 |
2014-06-17 |
Amgen Inc. |
Anti-amyloid antibodies and uses thereof
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
AU2009205706B2
(en)
|
2008-01-15 |
2015-03-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Markers of acute myeloid leukemia stem cells
|
|
EP2803675A3
(en)
|
2008-01-25 |
2014-12-24 |
Amgen, Inc |
Ferroportin antibodies and methods of use
|
|
BRPI0910482A2
(pt)
*
|
2008-04-29 |
2019-09-24 |
Abbott Lab |
imunoglobinas de domínio variável duplo e usos das mesmas
|
|
US9315577B2
(en)
|
2008-05-01 |
2016-04-19 |
Amgen Inc. |
Anti-hepcidin antibodies and methods of use
|
|
RU2010153578A
(ru)
|
2008-06-03 |
2012-07-20 |
Эбботт Лэборетриз (Us) |
Иммуноглобулины с двойными вариабельными доменами и их применение
|
|
MX2010013239A
(es)
|
2008-06-03 |
2011-02-24 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
NZ603698A
(en)
*
|
2008-07-08 |
2014-03-28 |
Abbvie Inc |
Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
|
|
WO2010096486A1
(en)
|
2009-02-17 |
2010-08-26 |
Cornell Research Foundation, Inc. |
Methods and kits for diagnosis of cancer and prediction of therapeutic value
|
|
CA2755133A1
(en)
|
2009-03-20 |
2010-09-23 |
Amgen Inc. |
Selective and potent peptide inhibitors of kv1.3
|
|
MX2011010159A
(es)
|
2009-04-02 |
2011-10-17 |
Roche Glycart Ag |
Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla.
|
|
WO2010115589A1
(en)
|
2009-04-07 |
2010-10-14 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
EP2451479B1
(en)
*
|
2009-07-06 |
2015-04-01 |
F.Hoffmann-La Roche Ag |
Bi-specific digoxigenin binding antibodies
|
|
AU2010289527C1
(en)
*
|
2009-09-01 |
2014-10-30 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
US20120283415A1
(en)
*
|
2009-09-10 |
2012-11-08 |
Ucb Pharma S.A. |
Multivalent Antibodies
|
|
EP4134095A1
(en)
|
2009-09-15 |
2023-02-15 |
The Board of Trustees of the Leland Stanford Junior University |
Synergistic anti-cd47 therapy for hematologic cancers
|
|
AU2010296018B2
(en)
|
2009-09-16 |
2016-05-05 |
Genentech, Inc. |
Coiled coil and/or tether containing protein complexes and uses thereof
|
|
MX2012004415A
(es)
|
2009-10-15 |
2012-05-08 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
ES2702053T3
(es)
*
|
2009-11-02 |
2019-02-27 |
Univ Washington |
Composiciones terapéuticas de nucleasas y métodos
|
|
AR079114A1
(es)
|
2009-11-20 |
2011-12-28 |
Amgen Inc |
Proteinas de enlace de antigenos anti-orai1 y usos de las mismas
|
|
MX354143B
(es)
|
2009-12-02 |
2018-02-14 |
Imaginab Inc |
Minicuerpos j591 y diacuerpos-cys para apuntar con especificidad de objetivo a un antígeno de membrana específico para próstata de humano (psma) y métodos para su uso.
|
|
CN102770456B
(zh)
*
|
2009-12-04 |
2018-04-06 |
弗·哈夫曼-拉罗切有限公司 |
多特异性抗体、抗体类似物、组合物和方法
|
|
TR201903279T4
(tr)
*
|
2010-03-25 |
2019-03-21 |
Ucb Biopharma Sprl |
Disülfür stabilize edilmiş DVD-IG molekülleri.
|
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
|
EP3252072A3
(en)
|
2010-08-03 |
2018-03-14 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
CN103068846B9
(zh)
|
2010-08-24 |
2016-09-28 |
弗·哈夫曼-拉罗切有限公司 |
包含二硫键稳定性Fv片段的双特异性抗体
|
|
CN103260639A
(zh)
|
2010-08-26 |
2013-08-21 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
KR20130110169A
(ko)
|
2010-09-22 |
2013-10-08 |
암젠 인크 |
담체 면역글로뷸린 및 이것의 용도
|
|
CN102168058B
(zh)
*
|
2010-11-30 |
2013-01-16 |
湖南师范大学 |
一种抗肿瘤靶向工程菌和菌剂及其制备方法
|
|
WO2012085111A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
BR112013019975A2
(pt)
|
2011-02-28 |
2017-08-01 |
Hoffmann La Roche |
proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira"
|
|
RU2013141078A
(ru)
|
2011-02-28 |
2015-04-10 |
Ф. Хоффманн-Ля Рош Аг |
Одновалентные антигенсвязывающие белки
|
|
US20130344074A1
(en)
|
2011-03-16 |
2013-12-26 |
Sanofi |
Uses of a dual v region antibody-like protein
|
|
MX366923B
(es)
*
|
2011-03-28 |
2019-07-31 |
Sanofi Sa |
Proteínas de unión de tipo anticuerpo con región variable dual que tienen orientación de la región de unión con entrecruzamiento.
|
|
TWI838039B
(zh)
|
2011-03-28 |
2024-04-01 |
法商賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
WO2012149197A2
(en)
|
2011-04-27 |
2012-11-01 |
Abbott Laboratories |
Methods for controlling the galactosylation profile of recombinantly-expressed proteins
|
|
DK2704737T3
(en)
|
2011-04-29 |
2018-04-23 |
Univ Washington |
THERAPEUTIC NUCLEASE COMPOSITIONS AND PROCEDURES
|
|
UY34317A
(es)
|
2011-09-12 |
2013-02-28 |
Genzyme Corp |
Anticuerpo antireceptor de célula T (alfa)/ß
|
|
EP2797955A2
(en)
|
2011-12-30 |
2014-11-05 |
AbbVie Inc. |
Dual variable domain immunoglobulins against il-13 and/or il-17
|
|
JP6486686B2
(ja)
|
2012-02-10 |
2019-03-20 |
ジェネンテック, インコーポレイテッド |
単鎖抗体及び他のヘテロ多量体
|
|
US9150645B2
(en)
|
2012-04-20 |
2015-10-06 |
Abbvie, Inc. |
Cell culture methods to reduce acidic species
|
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
US9212227B2
(en)
|
2012-04-30 |
2015-12-15 |
Janssen Biotech, Inc. |
ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions
|
|
CN110256567B
(zh)
|
2012-06-27 |
2023-04-25 |
弗·哈夫曼-拉罗切有限公司 |
用于选择并产生含有至少两种不同结合实体的定制靶向实体的方法及其用途
|
|
JP6309002B2
(ja)
|
2012-06-27 |
2018-04-11 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
標的に特異的に結合する少なくとも1つの結合実体を含む抗体Fc領域結合体を作製するための方法およびその使用
|
|
US9512214B2
(en)
|
2012-09-02 |
2016-12-06 |
Abbvie, Inc. |
Methods to control protein heterogeneity
|
|
PL2895513T3
(pl)
|
2012-09-12 |
2018-11-30 |
Genzyme Corporation |
FC zawierające polipeptydy o zmienionej glikozylacji i zmniejszonej funkcji efektorowej
|
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
TW202014439A
(zh)
|
2012-11-01 |
2020-04-16 |
美商艾伯維有限公司 |
抗-vegf/dll4雙重可變區域免疫球蛋白及其用途
|
|
US20140377269A1
(en)
*
|
2012-12-19 |
2014-12-25 |
Adimab, Llc |
Multivalent antibody analogs, and methods of their preparation and use
|
|
MX370679B
(es)
|
2013-03-11 |
2019-12-19 |
Genzyme Corp |
Polipéptidos de unión hiperglicosilados.
|
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
WO2014151878A2
(en)
|
2013-03-14 |
2014-09-25 |
Abbvie Inc. |
Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
|
|
MX366124B
(es)
|
2013-03-15 |
2019-06-27 |
Janssen Biotech Inc |
Anticuerpos antagonistas del interferón alfa y omega.
|
|
WO2014144280A2
(en)
|
2013-03-15 |
2014-09-18 |
Abbvie Inc. |
DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17
|
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
EP3052640A2
(en)
|
2013-10-04 |
2016-08-10 |
AbbVie Inc. |
Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
|
|
EP3055329B1
(en)
|
2013-10-11 |
2018-06-13 |
F. Hoffmann-La Roche AG |
Multispecific domain exchanged common variable light chain antibodies
|
|
US9181337B2
(en)
|
2013-10-18 |
2015-11-10 |
Abbvie, Inc. |
Modulated lysine variant species compositions and methods for producing and using the same
|
|
US9085618B2
(en)
|
2013-10-18 |
2015-07-21 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same
|
|
US10988745B2
(en)
|
2013-10-31 |
2021-04-27 |
Resolve Therapeutics, Llc |
Therapeutic nuclease-albumin fusions and methods
|
|
ES2884255T3
(es)
|
2013-11-06 |
2021-12-10 |
Janssen Biotech Inc |
Anticuerpos anti-CCL17
|
|
US20150139988A1
(en)
|
2013-11-15 |
2015-05-21 |
Abbvie, Inc. |
Glycoengineered binding protein compositions
|
|
PL3553087T3
(pl)
|
2014-01-08 |
2025-04-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Terapia celowana nowotworu złośliwego płuc
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
DK3116909T3
(da)
|
2014-03-14 |
2020-01-20 |
Novartis Ag |
Antistofmolekyler til lag-3 og anvendelser deraf
|
|
EP3119423B1
(en)
|
2014-03-15 |
2022-12-14 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
|
SG11201607198WA
(en)
|
2014-03-19 |
2016-09-29 |
Genzyme Corp |
Site-specific glycoengineering of targeting moieties
|
|
CA2949998A1
(en)
|
2014-05-28 |
2015-12-03 |
Agenus Inc. |
Anti-gitr antibodies and methods of use thereof
|
|
TWI713453B
(zh)
|
2014-06-23 |
2020-12-21 |
美商健生生物科技公司 |
干擾素α及ω抗體拮抗劑
|
|
TWI745962B
(zh)
|
2014-06-27 |
2021-11-11 |
法商賽諾菲公司 |
測定投予至人類個體之包括雙-v-區類抗體蛋白或其片段的劑量是否在人類個體中與il-4或il-13特異性結合之方法
|
|
EP3160513B1
(en)
|
2014-06-30 |
2020-02-12 |
Glykos Finland Oy |
Saccharide derivative of a toxic payload and antibody conjugates thereof
|
|
MX2016017393A
(es)
|
2014-07-01 |
2017-09-05 |
Pfizer |
Diacuerpos heterodimericos biespecificos y sus usos.
|
|
WO2016014553A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
CN106687483B
(zh)
|
2014-07-21 |
2020-12-04 |
诺华股份有限公司 |
使用人源化抗-bcma嵌合抗原受体治疗癌症
|
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
TWI719942B
(zh)
|
2014-07-21 |
2021-03-01 |
瑞士商諾華公司 |
使用cd33嵌合抗原受體治療癌症
|
|
WO2016019300A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Subset-optimized chimeric antigen receptor-containing t-cells
|
|
US9815901B2
(en)
|
2014-08-19 |
2017-11-14 |
Novartis Ag |
Treatment of cancer using a CD123 chimeric antigen receptor
|
|
EP3180359A1
(en)
|
2014-08-14 |
2017-06-21 |
Novartis AG |
Treatment of cancer using gfr alpha-4 chimeric antigen receptor
|
|
EP3967709A1
(en)
|
2014-09-17 |
2022-03-16 |
Novartis AG |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
|
CA2964123C
(en)
|
2014-10-09 |
2023-09-05 |
Genzyme Corporation |
Glycoengineered antibody drug conjugates
|
|
KR102513870B1
(ko)
|
2014-10-14 |
2023-03-23 |
노파르티스 아게 |
Pd-l1에 대한 항체 분자 및 그의 용도
|
|
US20180334490A1
(en)
|
2014-12-03 |
2018-11-22 |
Qilong H. Wu |
Methods for b cell preconditioning in car therapy
|
|
ES2764111T3
(es)
|
2014-12-03 |
2020-06-02 |
Hoffmann La Roche |
Anticuerpos multiespecíficos
|
|
EP3029137B1
(en)
|
2014-12-06 |
2019-01-02 |
GEMoaB Monoclonals GmbH |
Genetic modified pluri- or multipotent stem cells and uses thereof
|
|
WO2016094273A1
(en)
|
2014-12-08 |
2016-06-16 |
Dana-Farber Cancer Institute, Inc. |
Methods for upregulating immune responses using combinations of anti-rgmb and anti-pd-1 agents
|
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
|
CA2972048C
(en)
|
2014-12-22 |
2023-03-07 |
The Rockefeller University |
Anti-mertk agonistic antibodies and uses thereof
|
|
WO2016149368A1
(en)
|
2015-03-17 |
2016-09-22 |
Memorial Sloan Kettering Cancer Center |
Anti-muc16 antibodies and uses thereof
|
|
RU2021121771A
(ru)
|
2015-04-08 |
2022-01-12 |
Новартис Аг |
Cd20 терапия, cd22 терапия и комбинированная терапия клетками, экспрессирующими химерный антигенный рецептор (car) к cd19
|
|
US12128069B2
(en)
|
2015-04-23 |
2024-10-29 |
The Trustees Of The University Of Pennsylvania |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
BR112017025564B8
(pt)
|
2015-05-29 |
2022-01-04 |
Agenus Inc |
Anticorpos anti-ctla-4 e métodos de uso dos mesmos
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
|
CN108025051B
(zh)
|
2015-07-29 |
2021-12-24 |
诺华股份有限公司 |
包含抗pd-1抗体分子的联合疗法
|
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
|
DK3317301T3
(da)
|
2015-07-29 |
2021-06-28 |
Immutep Sas |
Kombinationsterapier omfattende antistofmolekyler mod lag-3
|
|
MX2018001522A
(es)
|
2015-08-05 |
2018-03-15 |
Janssen Biotech Inc |
Anticuerpos anti-cd154 y metodos de uso de estos.
|
|
SG10201913625XA
(en)
|
2015-08-07 |
2020-03-30 |
Imaginab Inc |
Antigen binding constructs to target molecules
|
|
EP3344656A1
(en)
|
2015-09-01 |
2018-07-11 |
Agenus Inc. |
Anti-pd-1 antibodies and methods of use thereof
|
|
EP3156417A1
(en)
*
|
2015-10-13 |
2017-04-19 |
Affimed GmbH |
Multivalent fv antibodies
|
|
EP3362074B1
(en)
|
2015-10-16 |
2023-08-09 |
President and Fellows of Harvard College |
Regulatory t cell pd-1 modulation for regulating t cell effector immune responses
|
|
US20180355043A1
(en)
|
2015-12-17 |
2018-12-13 |
Janssen Biotech, Inc. |
Antibodies Specifically Binding HLA-DR and Their Uses
|
|
JP2019503349A
(ja)
|
2015-12-17 |
2019-02-07 |
ノバルティス アーゲー |
Pd−1に対する抗体分子およびその使用
|
|
CA3007421A1
(en)
|
2015-12-17 |
2017-06-22 |
Novartis Ag |
Combination of c-met inhibitor with antibody molecule to pd-1 and uses thereof
|
|
EP3405492B1
(en)
|
2016-01-21 |
2020-10-21 |
Novartis AG |
Multispecific molecules targeting cll-1
|
|
US20200281973A1
(en)
|
2016-03-04 |
2020-09-10 |
Novartis Ag |
Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
|
|
CN110753755B
(zh)
|
2016-03-21 |
2023-12-29 |
丹娜法伯癌症研究院 |
T细胞耗竭状态特异性基因表达调节子及其用途
|
|
US11549099B2
(en)
|
2016-03-23 |
2023-01-10 |
Novartis Ag |
Cell secreted minibodies and uses thereof
|
|
JP7497955B6
(ja)
|
2016-04-15 |
2024-07-01 |
ノバルティス アーゲー |
選択的タンパク質発現のための組成物および方法
|
|
MX389710B
(es)
|
2016-05-27 |
2025-03-20 |
Agenus Inc |
Anticuerpos anti proteina inmunoglobulina de linfocitos t y dominio de mucina 3 (tim-3) y métodos para usarlos.
|
|
US20210177896A1
(en)
|
2016-06-02 |
2021-06-17 |
Novartis Ag |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
CA3029627A1
(en)
|
2016-07-01 |
2018-01-04 |
Resolve Therapeutics, Llc |
Optimized binuclease fusions and methods
|
|
CN109689685A
(zh)
|
2016-07-08 |
2019-04-26 |
斯塔滕生物技术有限公司 |
抗apoc3抗体及其使用方法
|
|
CN110461315B
(zh)
|
2016-07-15 |
2025-05-02 |
诺华股份有限公司 |
使用与激酶抑制剂组合的嵌合抗原受体治疗和预防细胞因子释放综合征
|
|
BR112019001570A2
(pt)
|
2016-07-28 |
2019-07-09 |
Novartis Ag |
terapias de combinação de receptores de antígeno quiméricos e inibidores de pd-1
|
|
CA3032581A1
(en)
|
2016-08-01 |
2018-02-08 |
Novartis Ag |
Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
|
|
MY200337A
(en)
|
2016-10-07 |
2023-12-20 |
Novartis Ag |
Nucleic acid molecules encoding chimeric antigen receptors comprising a cd20 binding domain
|
|
CN110023337B
(zh)
|
2016-10-11 |
2024-01-05 |
艾吉纳斯公司 |
抗lag-3抗体及其使用方法
|
|
AU2017353939B2
(en)
|
2016-11-07 |
2025-01-30 |
Neuracle Science Co., Ltd. |
Anti-family with sequence similarity 19, member A5 antibodies and method of use thereof
|
|
KR20230037664A
(ko)
|
2016-12-07 |
2023-03-16 |
아게누스 인코포레이티드 |
항-ctla-4 항체 및 이의 사용 방법
|
|
EP4043485A1
(en)
|
2017-01-26 |
2022-08-17 |
Novartis AG |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
|
WO2018147960A1
(en)
|
2017-02-08 |
2018-08-16 |
Imaginab, Inc. |
Extension sequences for diabodies
|
|
US10626169B2
(en)
|
2017-02-17 |
2020-04-21 |
Sanofi |
Multispecific binding molecules having specificity to dystroglycan and laminin-2
|
|
JP7304288B2
(ja)
|
2017-02-17 |
2023-07-06 |
サノフイ |
ジストログリカンおよびラミニン2に対する特異性を有する多特異性結合性分子
|
|
WO2018160731A1
(en)
|
2017-02-28 |
2018-09-07 |
Novartis Ag |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
|
KR20190133198A
(ko)
|
2017-03-27 |
2019-12-02 |
셀진 코포레이션 |
면역원성의 감소를 위한 방법 및 조성물
|
|
BR112019017241A2
(pt)
|
2017-04-13 |
2020-04-14 |
Agenus Inc |
anticorpos anti-cd137 e métodos de uso dos mesmos
|
|
AU2018255938A1
(en)
|
2017-04-21 |
2019-10-31 |
Staten Biotechnology B.V. |
Anti-ApoC3 antibodies and methods of use thereof
|
|
WO2018201056A1
(en)
|
2017-04-28 |
2018-11-01 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
US20200179511A1
(en)
|
2017-04-28 |
2020-06-11 |
Novartis Ag |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
MA50957A
(fr)
|
2017-05-01 |
2020-10-14 |
Agenus Inc |
Anticorps anti-tigit et leurs méthodes d'utilisation
|
|
KR20200021087A
(ko)
|
2017-06-22 |
2020-02-27 |
노파르티스 아게 |
Cd73에 대한 항체 분자 및 이의 용도
|
|
MX2019015738A
(es)
|
2017-06-27 |
2020-02-20 |
Novartis Ag |
Regimen de dosificacion para anticuerpos anti-tim-3 y usos de los mismos.
|
|
WO2019005756A1
(en)
|
2017-06-28 |
2019-01-03 |
The Rockefeller University |
CONJUGATES AGONIST ANTIBODY ANTI-MERTK-MEDICINE
|
|
EP3652209A2
(en)
|
2017-07-11 |
2020-05-20 |
Compass Therapeutics LLC |
Agonist antibodies that bind human cd137 and uses thereof
|
|
US20200172617A1
(en)
|
2017-07-20 |
2020-06-04 |
Novartis Ag |
Dosage regimens of anti-lag-3 antibodies and uses thereof
|
|
CA3073537A1
(en)
|
2017-08-22 |
2019-02-28 |
Sanabio, Llc |
Soluble interferon receptors and uses thereof
|
|
MX2020004512A
(es)
|
2017-10-31 |
2020-08-13 |
|
Anticuerpos anti apolipoproteina c-iii (anti-apoc3) y metodos de uso de los mismos.
|
|
US11718679B2
(en)
|
2017-10-31 |
2023-08-08 |
Compass Therapeutics Llc |
CD137 antibodies and PD-1 antagonists and uses thereof
|
|
BR112020008888A2
(pt)
|
2017-11-16 |
2020-10-20 |
Novartis Ag |
terapias de combinação
|
|
EP3713961A2
(en)
|
2017-11-20 |
2020-09-30 |
Compass Therapeutics LLC |
Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
|
|
US12247060B2
(en)
|
2018-01-09 |
2025-03-11 |
Marengo Therapeutics, Inc. |
Calreticulin binding constructs and engineered T cells for the treatment of diseases
|
|
MX2020007882A
(es)
|
2018-01-26 |
2020-12-03 |
Genzyme Corp |
Variantes fc con unión mejorada a fcrn y semivida prolongada.
|
|
CA3090249A1
(en)
|
2018-01-31 |
2019-08-08 |
Novartis Ag |
Combination therapy using a chimeric antigen receptor
|
|
CA3089988A1
(en)
|
2018-02-01 |
2019-08-08 |
Memorial Sloan Kettering Cancer Center |
Antibodies to galectin-3 and methods of use thereof
|
|
EP3765517A1
(en)
|
2018-03-14 |
2021-01-20 |
Elstar Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
US20210147547A1
(en)
|
2018-04-13 |
2021-05-20 |
Novartis Ag |
Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
|
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
|
JP7530638B2
(ja)
|
2018-05-10 |
2024-08-08 |
ニューラクル サイエンス カンパニー リミテッド |
配列類似性19、メンバーa5抗体を有する抗ファミリー及びその使用方法
|
|
WO2019226658A1
(en)
|
2018-05-21 |
2019-11-28 |
Compass Therapeutics Llc |
Multispecific antigen-binding compositions and methods of use
|
|
AU2019272575A1
(en)
|
2018-05-21 |
2020-12-10 |
Compass Therapeutics Llc |
Compositions and methods for enhancing the killing of target cells by NK cells
|
|
WO2019227003A1
(en)
|
2018-05-25 |
2019-11-28 |
Novartis Ag |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
SG11202011830SA
(en)
|
2018-06-13 |
2020-12-30 |
Novartis Ag |
Bcma chimeric antigen receptors and uses thereof
|
|
CN112654394B
(zh)
|
2018-06-19 |
2025-07-11 |
阿塔盖有限责任公司 |
针对补体成分5的抗体分子和其用途
|
|
WO2020003210A1
(en)
|
2018-06-29 |
2020-01-02 |
Kangwon National University University-Industry Cooperation Foundation |
Anti-l1cam antibodies and uses thereof
|
|
WO2020010250A2
(en)
|
2018-07-03 |
2020-01-09 |
Elstar Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
WO2020021465A1
(en)
|
2018-07-25 |
2020-01-30 |
Advanced Accelerator Applications (Italy) S.R.L. |
Method of treatment of neuroendocrine tumors
|
|
MA53811A
(fr)
|
2018-10-03 |
2022-03-16 |
Staten Biotechnology B V |
Anticorps spécifiques à l'apoc3 humaine et du cynomolgus et procédés pour leur utilisation
|
|
TW202430572A
(zh)
|
2018-11-13 |
2024-08-01 |
美商坎伯斯治療有限責任公司 |
對抗檢查點分子之多特異性結合構築體及其用途
|
|
KR20210106437A
(ko)
|
2018-12-20 |
2021-08-30 |
노파르티스 아게 |
3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물
|
|
AU2019400980A1
(en)
|
2018-12-20 |
2021-06-24 |
Novartis Ag |
Pharmaceutical combinations
|
|
KR20210107721A
(ko)
*
|
2018-12-21 |
2021-09-01 |
23앤드미 인코포레이티드 |
항-il-36 항체 및 이의 사용 방법
|
|
SG11202106525TA
(en)
|
2018-12-24 |
2021-07-29 |
Sanofi Sa |
Multispecific binding proteins with mutant fab domains
|
|
ES2982474T3
(es)
|
2019-02-15 |
2024-10-16 |
Novartis Ag |
Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos
|
|
CA3124935A1
(en)
|
2019-02-15 |
2020-08-20 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
US10871640B2
(en)
|
2019-02-15 |
2020-12-22 |
Perkinelmer Cellular Technologies Germany Gmbh |
Methods and systems for automated imaging of three-dimensional objects
|
|
SG11202109061YA
(en)
|
2019-02-21 |
2021-09-29 |
Marengo Therapeutics Inc |
Multifunctional molecules that bind to t cell related cancer cells and uses thereof
|
|
AU2020224681A1
(en)
|
2019-02-21 |
2021-09-16 |
Marengo Therapeutics, Inc. |
Antibody molecules that bind to NKp30 and uses thereof
|
|
WO2020172553A1
(en)
|
2019-02-22 |
2020-08-27 |
Novartis Ag |
Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors
|
|
JP7668534B2
(ja)
|
2019-02-26 |
2025-04-25 |
インスピアーナ, インコーポレイテッド |
高親和性抗mertk抗体およびその使用
|
|
US20220185876A1
(en)
|
2019-03-29 |
2022-06-16 |
Atarga, Llc |
Anti fgf23 antibody
|
|
JP7575401B2
(ja)
|
2019-04-03 |
2024-10-29 |
ジェンザイム・コーポレーション |
断片化が低減した抗アルファベータtcr結合ポリペプチド
|
|
CN113891729A
(zh)
|
2019-05-24 |
2022-01-04 |
赛诺菲 |
治疗系统性硬化症的方法
|
|
CN115175932A
(zh)
|
2019-07-16 |
2022-10-11 |
赛诺菲 |
用于治疗阿尔茨海默病的中和抗β淀粉样蛋白抗体
|
|
CA3148764A1
(en)
|
2019-07-25 |
2021-01-28 |
Genzyme Corporation |
Methods of treating antibody-mediated disorders with fcrn antagonists
|
|
EP4021486A1
(en)
|
2019-08-30 |
2022-07-06 |
Agenus Inc. |
Anti-cd96 antibodies and methods of use thereof
|
|
MX2022004769A
(es)
|
2019-10-21 |
2022-05-16 |
Novartis Ag |
Inhibidores de tim-3 y sus usos.
|
|
AU2020370086A1
(en)
|
2019-10-21 |
2022-05-19 |
Novartis Ag |
Combination therapies with venetoclax and TIM-3 inhibitors
|
|
KR20220105664A
(ko)
|
2019-11-26 |
2022-07-27 |
노파르티스 아게 |
Bcma 및 cd19에 결합하는 키메라 항원 수용체 및 이의 용도
|
|
MX2022007761A
(es)
|
2019-12-20 |
2022-07-21 |
Novartis Ag |
Usos de anticuerpos anti-tgf? e inhibidores de punto de control para el tratamiento de enfermedades proliferativas.
|
|
EP4090762A1
(en)
|
2020-01-17 |
2022-11-23 |
Becton, Dickinson and Company |
Methods and compositions for single cell secretomics
|
|
AU2021207348A1
(en)
|
2020-01-17 |
2022-08-11 |
Novartis Ag |
Combination comprising a TIM-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia
|
|
WO2021173995A2
(en)
|
2020-02-27 |
2021-09-02 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
AR121462A1
(es)
|
2020-02-28 |
2022-06-08 |
Genzyme Corp |
Polipéptidos de unión modificados para conjugación optimizada con drogas
|
|
CA3182346A1
(en)
|
2020-06-23 |
2021-12-30 |
Novartis Ag |
Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
TW202216761A
(zh)
|
2020-07-16 |
2022-05-01 |
瑞士商諾華公司 |
抗β細胞素抗體、其片段及多特異性結合分子
|
|
WO2022026592A2
(en)
|
2020-07-28 |
2022-02-03 |
Celltas Bio, Inc. |
Antibody molecules to coronavirus and uses thereof
|
|
WO2022029573A1
(en)
|
2020-08-03 |
2022-02-10 |
Novartis Ag |
Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
WO2022040345A1
(en)
|
2020-08-18 |
2022-02-24 |
Cephalon, Inc. |
Anti-par-2 antibodies and methods of use thereof
|
|
WO2022043557A1
(en)
|
2020-08-31 |
2022-03-03 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
WO2022043558A1
(en)
|
2020-08-31 |
2022-03-03 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
CN116472288A
(zh)
|
2020-11-06 |
2023-07-21 |
诺华股份有限公司 |
抗体Fc变体
|
|
MX2023005609A
(es)
|
2020-11-13 |
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|
|
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|
|
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|
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|
|
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|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
|
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|
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|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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