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BRPI0306644B8 - método para produzir um peptídeo modificado - Google Patents

método para produzir um peptídeo modificado

Info

Publication number
BRPI0306644B8
BRPI0306644B8 BRPI0306644A BR0306644A BRPI0306644B8 BR PI0306644 B8 BRPI0306644 B8 BR PI0306644B8 BR PI0306644 A BRPI0306644 A BR PI0306644A BR 0306644 A BR0306644 A BR 0306644A BR PI0306644 B8 BRPI0306644 B8 BR PI0306644B8
Authority
BR
Brazil
Prior art keywords
peptide
producing
modified
amino acid
side chain
Prior art date
Application number
BRPI0306644A
Other languages
English (en)
Other versions
BR0306644A (pt
BRPI0306644B1 (pt
Inventor
Tomohiro Makino
Masaru Matsumoto
Yoshiharu Minamitake
Original Assignee
Asubio Pharma Co Ltd
Daiichi Sankyo Co Ltd
Daiichi Suntory Pharma Co Ltd
Daiichi Asubio Pharma Co Ltd
Kangawa Kenji
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asubio Pharma Co Ltd, Daiichi Sankyo Co Ltd, Daiichi Suntory Pharma Co Ltd, Daiichi Asubio Pharma Co Ltd, Kangawa Kenji filed Critical Asubio Pharma Co Ltd
Publication of BR0306644A publication Critical patent/BR0306644A/pt
Publication of BRPI0306644B1 publication Critical patent/BRPI0306644B1/pt
Publication of BRPI0306644B8 publication Critical patent/BRPI0306644B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"método para produzir um peptídeo modificado". a presente invenção refere-se a um método para produzir um peptídeo ou uma proteína nos quais uma cadeia lateral contém um resíduo de aminoácido modificado, o qual compreende produzir quimicamente um fragmento de peptídeo contendo um resíduo de aminoácido apresentando uma cadeia lateral modificada utilizando uma resina de clivagem em ácido fraco, produzir um fragmento de peptídeo não contendo resíduos de aminoácidos apresentando uma cadeia lateral modificada utilizando um método de recombinação genética ou/e um método enzimático, e condensar os dois tipos de fragmentos de peptídeo resultantes e, de acordo com a presente invenção, podem ser efetivamente obtidos um peptídeo ou uma proteína contendo modificações tais como acilação, glicosilação e fosforilação de alta qualidade.
BRPI0306644A 2002-04-11 2003-04-10 método para produzir um peptídeo modificado BRPI0306644B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002-109761 2002-04-11
JP2002109761 2002-04-11
PCT/JP2003/004590 WO2003084983A1 (fr) 2002-04-11 2003-04-10 Procede de production d'un peptide modifie

Publications (3)

Publication Number Publication Date
BR0306644A BR0306644A (pt) 2005-04-26
BRPI0306644B1 BRPI0306644B1 (pt) 2018-02-14
BRPI0306644B8 true BRPI0306644B8 (pt) 2021-05-25

Family

ID=28786604

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0306644A BRPI0306644B8 (pt) 2002-04-11 2003-04-10 método para produzir um peptídeo modificado

Country Status (10)

Country Link
US (1) US7138489B2 (pt)
EP (1) EP1493747B1 (pt)
KR (1) KR101036524B1 (pt)
CN (1) CN100491395C (pt)
AU (1) AU2003236080B8 (pt)
BR (1) BRPI0306644B8 (pt)
CA (1) CA2472235C (pt)
ES (1) ES2400703T3 (pt)
IL (2) IL162780A0 (pt)
WO (1) WO2003084983A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7357947B2 (en) * 2001-09-10 2008-04-15 Biomet, Inc. Bone graft material incorporating demineralized bone matrix and lipids
AU2003235401B2 (en) * 2002-05-21 2008-09-25 Daiichi Sankyo Company, Limited Medicinal compositions containing ghrelin
CA2496687A1 (en) * 2002-09-18 2004-04-01 Centre Hospitalier De L'universite De Montreal (Chum) Ghrh analogues
US7939629B2 (en) 2004-10-19 2011-05-10 Lonza Ag Method for solid phase peptide synthesis
US20070042501A1 (en) * 2005-08-20 2007-02-22 Institute Of Nuclear Energy Research A novel technology for the purity assay of TRODAT-1 raw material
US7763707B2 (en) * 2006-03-13 2010-07-27 Liat Mintz Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation
IN2015DN04172A (pt) 2012-10-24 2015-10-16 Daiichi Sankyo Companyltd
HK1219477A1 (zh) 2013-03-21 2017-04-07 Sanofi-Aventis Deutschland Gmbh 合成含有乙内酰脲的肽产物
EP2976325B1 (en) 2013-03-21 2017-03-01 Sanofi-Aventis Deutschland GmbH Synthesis of cyclic imide containing peptide products
CA2978216A1 (en) * 2014-03-04 2015-09-11 Motus Therapeutics, Inc. Process for the liquid phase synthesis of h-inp-(d)bal-(d)trp-phe-apc-nh2, and pharmaceutically acceptable salts thereof
WO2016165621A1 (zh) * 2015-04-14 2016-10-20 成都先导药物开发有限公司 一种固相合成dna编码化合物库的方法
CN114401981B (zh) * 2019-06-18 2024-11-08 北京费森尤斯卡比医药有限公司 胰高血糖素制造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118473A0 (en) 1995-06-02 1996-09-12 Suntory Ltd Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof
CA2198968C (en) 1996-03-04 2010-02-09 Toyofumi Masuda Process for production of secretory kex2 derivatives
CA2198966C (en) 1996-03-04 2011-06-21 Yuji Suzuki Method for cleaving chimeric protein using processing enzyme
IL132030A (en) 1998-01-30 2009-06-15 Asubio Pharma Co Ltd Process for producing peptide with the use of accessory peptide
JP4471501B2 (ja) * 1999-03-04 2010-06-02 アスビオファーマ株式会社 ＯｍｐＴプロテアーゼによる切断を制御する方法
ES2154590B1 (es) * 1999-05-20 2001-11-01 Lipotec Sa Procedimiento de sintesis de peptidos en fase solida
DE60043361D1 (de) * 1999-07-23 2009-12-31 Kenji Kangawa Neue Peptide
DE60111733T2 (de) * 2000-04-12 2006-05-18 Amersham Health As Integrinbindende peptidderivate

Also Published As

Publication number Publication date
BR0306644A (pt) 2005-04-26
AU2003236080B2 (en) 2009-06-11
BRPI0306644B1 (pt) 2018-02-14
CN100491395C (zh) 2009-05-27
CA2472235C (en) 2012-05-22
US7138489B2 (en) 2006-11-21
EP1493747A1 (en) 2005-01-05
IL162780A (en) 2013-10-31
US20050131208A1 (en) 2005-06-16
IL162780A0 (en) 2005-11-20
CA2472235A1 (en) 2003-10-16
ES2400703T3 (es) 2013-04-11
AU2003236080A1 (en) 2003-10-20
AU2003236080B8 (en) 2009-07-02
KR20050012717A (ko) 2005-02-02
KR101036524B1 (ko) 2011-05-24
EP1493747B1 (en) 2012-12-19
CN1612891A (zh) 2005-05-04
WO2003084983A1 (fr) 2003-10-16
EP1493747A4 (en) 2007-11-28

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: KANGAWA, KENJI (JP) , DAIICHI ASUBIO PHARMA CO., L

Free format text: ALTERADO DE: DAIICHI SUNTORY PHARMA CO., LTD.

B25I Requirement for requested change of headquarter

Owner name: KANGAWA, KENJI (JP) , DAIICHI ASUBIO PHARMA CO., L

Free format text: A FIM DE ATENDER A SOLICITACAO CONSTANTE NA PETICAO NO 020050141056/RJ DE 05/12/2005, QUEIRA APRESENTAR A GUIA DE RECOLHIMENTO REFERENTE A ESTE ATO.

B25G Requested change of headquarter approved

Owner name: KANGAWA, KENJI (JP) , DAIICHI ASUBIO PHARMA CO., L

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020050141056/RJ DE 05/12/2005.

B25D Requested change of name of applicant approved

Owner name: KANGAWA, KENJI (JP) , ASUBIO PHARMA CO., LTD. (JP)

Free format text: ALTERADO DE: DAIICHI ASUBIO PHARMA CO., LTD.

B25A Requested transfer of rights approved

Owner name: KANGAWA, KENJI (JP) , DAIICHI SANKYO COMPANY, LIMI

Free format text: TRANSFERIDO POR INCORPORACAO DE : ASUBIO PHARMA CO., LTD.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/04/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

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