BRPI0809873A2 - "composto, processo para a preparação do composto, método para o tratamento de uma desordem do sistema nervoso central, composição farmacêutica, uso do composto, método para testar antagonistas e antagonistas com seletividade para o receptor 5-th6 e método de tratamento" - Google Patents
"composto, processo para a preparação do composto, método para o tratamento de uma desordem do sistema nervoso central, composição farmacêutica, uso do composto, método para testar antagonistas e antagonistas com seletividade para o receptor 5-th6 e método de tratamento"Info
- Publication number
- BRPI0809873A2 BRPI0809873A2 BRPI0809873A BRPI0809873A BRPI0809873A2 BR PI0809873 A2 BRPI0809873 A2 BR PI0809873A2 BR PI0809873 A BRPI0809873 A BR PI0809873A BR PI0809873 A BRPI0809873 A BR PI0809873A BR PI0809873 A2 BRPI0809873 A2 BR PI0809873A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- antagonists
- treatment
- disorders
- pharmaceutically acceptable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 208000015114 central nervous system disease Diseases 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 2
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN940CH2007 | 2007-05-03 | ||
| PCT/IN2008/000247 WO2008136017A1 (en) | 2007-05-03 | 2008-04-15 | Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0809873A2 true BRPI0809873A2 (pt) | 2018-11-13 |
Family
ID=39743760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0809873A BRPI0809873A2 (pt) | 2007-05-03 | 2008-04-15 | "composto, processo para a preparação do composto, método para o tratamento de uma desordem do sistema nervoso central, composição farmacêutica, uso do composto, método para testar antagonistas e antagonistas com seletividade para o receptor 5-th6 e método de tratamento" |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8003670B2 (pt) |
| EP (1) | EP2155674B1 (pt) |
| JP (1) | JP5139512B2 (pt) |
| KR (1) | KR101162482B1 (pt) |
| CN (1) | CN101675032B (pt) |
| AT (1) | ATE513810T1 (pt) |
| AU (1) | AU2008246947B2 (pt) |
| BR (1) | BRPI0809873A2 (pt) |
| CA (1) | CA2683124C (pt) |
| CY (1) | CY1111836T1 (pt) |
| DK (1) | DK2155674T3 (pt) |
| EA (1) | EA016594B1 (pt) |
| ES (1) | ES2366496T3 (pt) |
| HR (1) | HRP20110530T1 (pt) |
| IL (1) | IL201491A (pt) |
| MX (1) | MX2009011461A (pt) |
| NZ (1) | NZ581580A (pt) |
| SI (1) | SI2155674T1 (pt) |
| WO (1) | WO2008136017A1 (pt) |
| ZA (1) | ZA200907015B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101338954B1 (ko) | 2012-02-13 | 2013-12-09 | 주식회사 평산 | 링 압연 공정을 이용한 비대칭 단면을 가지는 제품의 성형 장치 및 성형 방법 |
| KR101337003B1 (ko) | 2012-02-13 | 2013-12-04 | 주식회사 평산 | 링 압연 공법을 이용한 풍력 타워용 플랜지 제조방법 |
| CA2919147A1 (en) | 2013-07-25 | 2015-01-29 | Uniwersytet Jagiellonski | Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| EP3166924B1 (en) | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| WO2019180176A1 (en) | 2018-03-21 | 2019-09-26 | Spherium Biomed, S.L. | Composition for the treatment of schizophrenia and/or psychosis |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| CA2296033A1 (en) | 1997-07-11 | 1999-01-21 | Smithkline Beecham P.L.C. | Novel compounds |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| JP4597386B2 (ja) | 1999-04-21 | 2010-12-15 | エヌピーエス ファーマシューティカルス,インコーポレーテッド | 5−ht6親和性を有するピペリジン−インドール化合物 |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| NZ525592A (en) | 2000-11-02 | 2004-07-30 | Wyeth Corp | 1-Aryl- or 1-alkylsufonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
| BR0206595A (pt) | 2001-01-30 | 2004-07-13 | Lilly Co Eli | Composto, composição farmacêutica, e uso de um composto |
| KR100863622B1 (ko) | 2001-02-08 | 2008-10-15 | 메모리 파마슈티칼스 코포레이션 | 포스포디에스테라제 4 억제제로서의 트리플루오로메틸푸린 |
| WO2002098857A1 (en) | 2001-06-07 | 2002-12-12 | F. Hoffmann-La Roche Ag | New indole derivatives with 5-ht6 receptor affinity |
| US20040242589A1 (en) | 2001-08-07 | 2004-12-02 | Bromidge Steven Mark | 3-arylsulfonyl-7-piperzinyl-indoles-benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
| JP2005528587A (ja) | 2002-02-01 | 2005-09-22 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 新規ヒト5−ht6受容体に関連する疾患のための診断用および治療用物質 |
| JP2005522432A (ja) | 2002-02-05 | 2005-07-28 | グラクソ グループ リミテッド | ニューロン成長の促進方法 |
| ES2386828T3 (es) | 2002-03-27 | 2012-08-31 | Glaxo Group Limited | Derivados de quinolina y su uso como ligandos 5-HT6 |
| BRPI0315958B8 (pt) * | 2002-11-28 | 2021-05-25 | Suven Life Sciences Ltd | composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto |
| WO2004048331A1 (en) | 2002-11-28 | 2004-06-10 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| US7875605B2 (en) | 2002-11-28 | 2011-01-25 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| DE60312226T2 (de) | 2002-12-18 | 2007-11-15 | Suven Life Sciences Ltd. | Tetrazyklische 3-substituierte indole mit serotoninrezeptoraffinität |
| BR0215986A (pt) * | 2002-12-20 | 2005-11-01 | Cancer Rec Tech Ltd | Composto, composição, uso de composto, e, método para o tratamento de uma condição proliferativa, para o tratamento de câncer e de uma condição mediada pela tioredoxina/tioredoxina reductase, para inibir a tioredoxina/tioredoxina reductase em uma célula, in vitro ou in vivo e, para regular e inibir a proliferação celular |
| ES2222828B1 (es) | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| WO2006038594A1 (ja) * | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | N型カルシウムチャネル阻害薬 |
| CA2618636C (en) * | 2005-08-12 | 2011-01-18 | Suven Life Sciences Limited | Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands |
-
2008
- 2008-04-15 CN CN2008800144405A patent/CN101675032B/zh not_active Expired - Fee Related
- 2008-04-15 AT AT08763731T patent/ATE513810T1/de active
- 2008-04-15 DK DK08763731.0T patent/DK2155674T3/da active
- 2008-04-15 SI SI200830379T patent/SI2155674T1/sl unknown
- 2008-04-15 WO PCT/IN2008/000247 patent/WO2008136017A1/en active Application Filing
- 2008-04-15 MX MX2009011461A patent/MX2009011461A/es active IP Right Grant
- 2008-04-15 KR KR1020097025160A patent/KR101162482B1/ko not_active Expired - Fee Related
- 2008-04-15 BR BRPI0809873A patent/BRPI0809873A2/pt not_active IP Right Cessation
- 2008-04-15 EP EP08763731A patent/EP2155674B1/en active Active
- 2008-04-15 HR HR20110530T patent/HRP20110530T1/hr unknown
- 2008-04-15 EA EA200971017A patent/EA016594B1/ru not_active IP Right Cessation
- 2008-04-15 JP JP2010505014A patent/JP5139512B2/ja not_active Expired - Fee Related
- 2008-04-15 NZ NZ581580A patent/NZ581580A/en not_active IP Right Cessation
- 2008-04-15 AU AU2008246947A patent/AU2008246947B2/en not_active Ceased
- 2008-04-15 CA CA2683124A patent/CA2683124C/en not_active Expired - Fee Related
- 2008-04-15 US US12/598,616 patent/US8003670B2/en not_active Expired - Fee Related
- 2008-04-15 ES ES08763731T patent/ES2366496T3/es active Active
-
2009
- 2009-10-08 ZA ZA200907015A patent/ZA200907015B/xx unknown
- 2009-10-13 IL IL201491A patent/IL201491A/en active IP Right Grant
-
2011
- 2011-09-14 CY CY20111100881T patent/CY1111836T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101675032A (zh) | 2010-03-17 |
| EA200971017A1 (ru) | 2010-04-30 |
| JP2010526057A (ja) | 2010-07-29 |
| ES2366496T3 (es) | 2011-10-20 |
| CY1111836T1 (el) | 2015-10-07 |
| US20100087484A1 (en) | 2010-04-08 |
| HK1138264A1 (en) | 2010-08-20 |
| KR20100007954A (ko) | 2010-01-22 |
| IL201491A0 (en) | 2010-05-31 |
| HRP20110530T1 (hr) | 2011-09-30 |
| EP2155674B1 (en) | 2011-06-22 |
| EA016594B1 (ru) | 2012-06-29 |
| CA2683124C (en) | 2012-09-25 |
| KR101162482B1 (ko) | 2012-07-03 |
| ZA200907015B (en) | 2010-07-28 |
| JP5139512B2 (ja) | 2013-02-06 |
| NZ581580A (en) | 2011-03-31 |
| AU2008246947B2 (en) | 2011-03-31 |
| WO2008136017A1 (en) | 2008-11-13 |
| AU2008246947A1 (en) | 2008-11-13 |
| IL201491A (en) | 2015-04-30 |
| DK2155674T3 (da) | 2011-09-26 |
| ATE513810T1 (de) | 2011-07-15 |
| CN101675032B (zh) | 2012-10-31 |
| CA2683124A1 (en) | 2008-11-13 |
| US8003670B2 (en) | 2011-08-23 |
| SI2155674T1 (sl) | 2011-10-28 |
| MX2009011461A (es) | 2009-11-10 |
| EP2155674A1 (en) | 2010-02-24 |
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