CA2249654C - Benzoxazines permettant d'accroitre la reponse synaptique - Google Patents
Benzoxazines permettant d'accroitre la reponse synaptique Download PDFInfo
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- CA2249654C CA2249654C CA002249654A CA2249654A CA2249654C CA 2249654 C CA2249654 C CA 2249654C CA 002249654 A CA002249654 A CA 002249654A CA 2249654 A CA2249654 A CA 2249654A CA 2249654 C CA2249654 C CA 2249654C
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Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés représentés par la formule générale (I) et permettant d'accroître les réponses synaptiques liées à la médiation par les récepteurs AMPA. Dans cette formule générale (I), ou bien R<1> et R<2> appartiennent indépendamment l'un de l'autre au groupe des H et R<4>O sous la réserve que l'un au moins de R<1> et R<2> est R<4>O, R<4>O appartenant au groupe des H, alkyle, et alkyle à substitution halo, ou bien R<1> et R<2> forment ensemble un radical bivalent unique appartenant au groupe des radicaux représentés par les formules spécifiques (II), (III), (IV), (V), (VI), et (VII). Ces composés conviennent au traitement de sujets souffrant de défaillances de l'activité nerveuse ou intellectuelle, par suite d'un nombre insuffisant ou d'une faiblesse des synapses excitateurs, ou d'un nombre insuffisant de récepteurs AMPA. Ces composés, qui conviennent également au traitement de sujets non atteints, chez lesquels on cherche une meilleure efficacité des fonctions sensori-motrices et cognitives mettant en oeuvre des réseaux cérébraux utilisant des récepteurs AMPA, ou chez lesquels on essaie d'améliorer les fonctions mnésiques, conviennent par ailleurs au traitement de la schizophrénie et permettent une amélioration du codage par la mémoire.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/624,335 | 1996-04-03 | ||
| US08/624,335 US5736543A (en) | 1996-04-03 | 1996-04-03 | Benzoxazines for enhancing synaptic response |
| PCT/US1997/005184 WO1997036907A1 (fr) | 1996-04-03 | 1997-03-28 | Benzoxazines permettant d'accroitre la reponse synaptique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2249654A1 CA2249654A1 (fr) | 1997-10-09 |
| CA2249654C true CA2249654C (fr) | 2006-10-03 |
Family
ID=37101804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002249654A Expired - Fee Related CA2249654C (fr) | 1996-04-03 | 1997-03-28 | Benzoxazines permettant d'accroitre la reponse synaptique |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2249654C (fr) |
-
1997
- 1997-03-28 CA CA002249654A patent/CA2249654C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2249654A1 (fr) | 1997-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130328 |