CA2282827A1 - Procedes pour soulager les douleurs neuropathiques - Google Patents
Procedes pour soulager les douleurs neuropathiques Download PDFInfo
- Publication number
- CA2282827A1 CA2282827A1 CA002282827A CA2282827A CA2282827A1 CA 2282827 A1 CA2282827 A1 CA 2282827A1 CA 002282827 A CA002282827 A CA 002282827A CA 2282827 A CA2282827 A CA 2282827A CA 2282827 A1 CA2282827 A1 CA 2282827A1
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- amino acid
- prosaposin
- receptor agonist
- neuropathic pain
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- 102000020233 phosphotransferase Human genes 0.000 description 1
- DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
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- 229920003023 plastic Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000030716 positive regulation of phosphorylation Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
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- 230000002062 proliferating effect Effects 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 1
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- 238000012216 screening Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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- 150000003410 sphingosines Chemical class 0.000 description 1
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- 230000007838 tissue remodeling Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 229940108519 trasylol Drugs 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-HOSYLAQJSA-K trioxido(oxo)-$l^{5}-phosphane Chemical compound [O-][32P]([O-])([O-])=O NBIIXXVUZAFLBC-HOSYLAQJSA-K 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Cette invention se rapporte à un procédé permettant de soulager les douleurs neuropathiques chez un sujet, en administrant à ce sujet un agoniste de récepteur de prosaposine en quantité propre à soulager ses douleurs neuropathiques. Cette invention se rapporte également à un procédé permettant d'empêcher l'apparition de douleurs neuropathiques chez un sujet, en lui administrant un agoniste de récepteur de prosaposine en quantité propre à alléger ses douleurs neurophatiques. Cette invention se rapporte également à des agonistes de récepteurs de prosaposine et à l'utilisation de ces agonistes pour stimuler la croissance des neurites, pour empêcher la mort des cellules neurales, pour promouvoir la myélination et pour empêcher la démyélination neurale. Cette invention présente en outre un procédé pour inhiber la neuropathie sensorielle ou la maladie des motoneurones, par mise en contact des cellules neuronales avec une composition contenant une quantité inhibitrice efficace d'agoniste de récepteur de prosaposine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/US97/04143 | 1997-03-05 | ||
| PCT/US1997/004143 WO1997032895A1 (fr) | 1996-03-05 | 1997-03-05 | Methodes de soulagement de la douleur nevropathique a l'aide de peptides derives de prosaposine |
| PCT/US1997/016062 WO1998039357A1 (fr) | 1997-03-05 | 1997-09-11 | Procedes pour soulager les douleurs neuropathiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2282827A1 true CA2282827A1 (fr) | 1998-09-11 |
Family
ID=85773700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002282827A Abandoned CA2282827A1 (fr) | 1997-03-05 | 1997-09-11 | Procedes pour soulager les douleurs neuropathiques |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0979238A4 (fr) |
| CA (1) | CA2282827A1 (fr) |
| WO (1) | WO1998039357A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6271196B1 (en) * | 1996-03-05 | 2001-08-07 | Regents Of The University Of Ca | Methods of alleviating neuropathic pain using prosaposin-derived peptides |
| JP2001512228A (ja) * | 1997-07-17 | 2001-08-21 | ミエロスコーポレーション | プロサポシンレセプターアッセイ法 |
| IL147093A0 (en) * | 1999-06-16 | 2002-08-14 | Myelos Corp | Retro-inverso peptides derived from interleukin-3 |
| US7135461B1 (en) * | 2000-06-16 | 2006-11-14 | Myelos Corporation | Retro-inverso peptides derived from interleukin-6 |
| IL147094A0 (en) * | 1999-06-16 | 2002-08-14 | Myelos Corp | Retro-inverso peptides derived from interleukin-6 |
| US7115571B1 (en) * | 2000-06-16 | 2006-10-03 | Myelos Corporation | Retro-inverso peptides derived from interleukin-3 |
| US7109168B1 (en) | 2000-06-16 | 2006-09-19 | Myelos Corporation | Retro-inverso peptides derived from leukemia inhibitory factor |
| JP2003502341A (ja) * | 1999-06-16 | 2003-01-21 | マイアロス コーポレイション | 白血病阻害因子に由来するレトロ−インベルソなペプチド |
| GB9914480D0 (en) | 1999-06-21 | 1999-08-18 | Univ Dundee | Use of peptides |
| US8060209B2 (en) | 2008-01-25 | 2011-11-15 | Boston Scientific Neuromodulation Corporation | Methods and systems of treating ischemia pain in visceral organs |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE108459T1 (de) * | 1986-04-22 | 1994-07-15 | Salk Inst For Biological Studi | Antagonisten des fibroblasten-wachstumsfaktors. |
| US5571787A (en) * | 1993-07-30 | 1996-11-05 | Myelos Corporation | Prosaposin as a neurotrophic factor |
| US5700909A (en) * | 1993-07-30 | 1997-12-23 | The Regents Of The University Of California | Prosaposin and cytokine-derived peptides |
| US6271196B1 (en) * | 1996-03-05 | 2001-08-07 | Regents Of The University Of Ca | Methods of alleviating neuropathic pain using prosaposin-derived peptides |
| AU7795698A (en) * | 1997-03-24 | 1998-10-20 | Myelos Corporation | Synthetic saposin c-derived neurotrophic peptides |
-
1997
- 1997-09-11 CA CA002282827A patent/CA2282827A1/fr not_active Abandoned
- 1997-09-11 EP EP97941027A patent/EP0979238A4/fr not_active Withdrawn
- 1997-09-11 WO PCT/US1997/016062 patent/WO1998039357A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP0979238A1 (fr) | 2000-02-16 |
| EP0979238A4 (fr) | 2000-08-23 |
| WO1998039357A1 (fr) | 1998-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |