CA2367045A1 - Traitement de certains cancers associes a un gain de poids - Google Patents
Traitement de certains cancers associes a un gain de poids Download PDFInfo
- Publication number
- CA2367045A1 CA2367045A1 CA002367045A CA2367045A CA2367045A1 CA 2367045 A1 CA2367045 A1 CA 2367045A1 CA 002367045 A CA002367045 A CA 002367045A CA 2367045 A CA2367045 A CA 2367045A CA 2367045 A1 CA2367045 A1 CA 2367045A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- chlorophenyl
- cyclobutyl
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 14
- 230000004584 weight gain Effects 0.000 title description 5
- 235000019786 weight gain Nutrition 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 70
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 9
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- 208000026310 Breast neoplasm Diseases 0.000 claims abstract description 6
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- 206010014759 Endometrial neoplasm Diseases 0.000 claims abstract description 6
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims abstract description 6
- 208000008589 Obesity Diseases 0.000 claims abstract description 6
- UWAOJIWUVCMBAZ-UHFFFAOYSA-N [1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-dimethylazanium;chloride Chemical compound Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UWAOJIWUVCMBAZ-UHFFFAOYSA-N 0.000 claims abstract description 6
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- 238000000034 method Methods 0.000 claims description 24
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 13
- WQSACWZKKZPCHN-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N)CC(C)C)CCC1 WQSACWZKKZPCHN-UHFFFAOYSA-N 0.000 claims description 5
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 5
- KFNNPQDSPLWLCX-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethylbutan-1-amine;hydron;chloride;hydrate Chemical compound O.Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 KFNNPQDSPLWLCX-UHFFFAOYSA-N 0.000 claims description 4
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- 208000010201 Exanthema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne un composé représenté par la formule (I) ou un sel de ce composé acceptable du point de vue pharmaceutique, R¿1? et R¿2? représentant indépendamment H ou un méthyle (par exemple un hydrochlorure d'amine <u>N</u>,<u>N</u>-diméthyl-1-[1-(4-chlorophényl)cyclobutyl]-3-méthylbutyle éventuellement sous la forme de son monohydrate). Ce composé s'utilise dans le traitement de cancers associés à l'obésité, y compris le cancer du côlon, le cancer du sein, le cancer de l'endomètre et le cancer de la vésicule biliaire.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12525099P | 1999-03-19 | 1999-03-19 | |
| US60/125,250 | 1999-03-19 | ||
| PCT/US2000/007361 WO2000056323A1 (fr) | 1999-03-19 | 2000-03-17 | Traitement de certains cancers associes a un gain de poids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2367045A1 true CA2367045A1 (fr) | 2000-09-28 |
Family
ID=22418838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002367045A Abandoned CA2367045A1 (fr) | 1999-03-19 | 2000-03-17 | Traitement de certains cancers associes a un gain de poids |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1171106A1 (fr) |
| JP (1) | JP2002539255A (fr) |
| KR (1) | KR20010113765A (fr) |
| CN (1) | CN1399545A (fr) |
| AU (1) | AU3632000A (fr) |
| BG (1) | BG105998A (fr) |
| BR (1) | BR0009161A (fr) |
| CA (1) | CA2367045A1 (fr) |
| CZ (1) | CZ20013281A3 (fr) |
| HU (1) | HUP0200497A2 (fr) |
| IL (1) | IL145239A0 (fr) |
| MX (1) | MXPA01009470A (fr) |
| NO (1) | NO20014478L (fr) |
| NZ (1) | NZ514012A (fr) |
| PL (1) | PL351958A1 (fr) |
| SK (1) | SK13372001A3 (fr) |
| TR (1) | TR200102692T2 (fr) |
| WO (1) | WO2000056323A1 (fr) |
| ZA (1) | ZA200107687B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004096202A1 (fr) * | 2003-04-28 | 2004-11-11 | Cipla Limited | Formulation pharmaceutique contenant un agent anti-obesite et un acidulant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8531071D0 (en) * | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| US5459164A (en) * | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
-
2000
- 2000-03-17 HU HU0200497A patent/HUP0200497A2/hu unknown
- 2000-03-17 AU AU36320/00A patent/AU3632000A/en not_active Abandoned
- 2000-03-17 CZ CZ20013281A patent/CZ20013281A3/cs unknown
- 2000-03-17 KR KR1020017011855A patent/KR20010113765A/ko not_active Withdrawn
- 2000-03-17 JP JP2000606228A patent/JP2002539255A/ja not_active Withdrawn
- 2000-03-17 PL PL00351958A patent/PL351958A1/xx not_active Application Discontinuation
- 2000-03-17 SK SK1337-2001A patent/SK13372001A3/sk unknown
- 2000-03-17 IL IL14523900A patent/IL145239A0/xx unknown
- 2000-03-17 WO PCT/US2000/007361 patent/WO2000056323A1/fr not_active Application Discontinuation
- 2000-03-17 EP EP00915015A patent/EP1171106A1/fr not_active Withdrawn
- 2000-03-17 TR TR2001/02692T patent/TR200102692T2/xx unknown
- 2000-03-17 CA CA002367045A patent/CA2367045A1/fr not_active Abandoned
- 2000-03-17 CN CN00807533A patent/CN1399545A/zh active Pending
- 2000-03-17 NZ NZ514012A patent/NZ514012A/xx not_active Application Discontinuation
- 2000-03-17 MX MXPA01009470A patent/MXPA01009470A/es unknown
- 2000-03-17 BR BR0009161-8A patent/BR0009161A/pt not_active Application Discontinuation
-
2001
- 2001-09-14 NO NO20014478A patent/NO20014478L/no unknown
- 2001-09-18 ZA ZA200107687A patent/ZA200107687B/en unknown
- 2001-10-10 BG BG105998A patent/BG105998A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL351958A1 (en) | 2003-07-14 |
| CZ20013281A3 (cs) | 2002-07-17 |
| NZ514012A (en) | 2001-09-28 |
| SK13372001A3 (sk) | 2002-07-02 |
| IL145239A0 (en) | 2002-06-30 |
| HUP0200497A2 (en) | 2002-08-28 |
| TR200102692T2 (tr) | 2002-03-21 |
| MXPA01009470A (es) | 2004-03-19 |
| NO20014478D0 (no) | 2001-09-14 |
| AU3632000A (en) | 2000-10-09 |
| BR0009161A (pt) | 2002-01-22 |
| WO2000056323A1 (fr) | 2000-09-28 |
| KR20010113765A (ko) | 2001-12-28 |
| EP1171106A1 (fr) | 2002-01-16 |
| CN1399545A (zh) | 2003-02-26 |
| NO20014478L (no) | 2001-10-29 |
| ZA200107687B (en) | 2002-12-18 |
| BG105998A (en) | 2002-06-28 |
| JP2002539255A (ja) | 2002-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |