CA2322764A1 - Antagonistes therapeutiques du recepteur de chemokine - Google Patents
Antagonistes therapeutiques du recepteur de chemokine Download PDFInfo
- Publication number
- CA2322764A1 CA2322764A1 CA002322764A CA2322764A CA2322764A1 CA 2322764 A1 CA2322764 A1 CA 2322764A1 CA 002322764 A CA002322764 A CA 002322764A CA 2322764 A CA2322764 A CA 2322764A CA 2322764 A1 CA2322764 A1 CA 2322764A1
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- CA
- Canada
- Prior art keywords
- cxcr4 antagonist
- sdf
- cells
- cxcr4
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne diverses utilisations thérapeutiques des antagonistes de CXCR4. Dans des réalisations diverses, des antagonistes de CXCR4 sont utilisés pour la fabrication de médicaments ou sont utilisés dans les traitements tels que la réduction de la production d'interféron gamma par les cellules T, le traitement d'une maladie auto-immune, le traitement de la sclérose multiple, le traitement du cancer, et l'inhibition de l'angiogénèse. La présente invention concerne aussi les procédés des traitements associés dans lesquels une dose d'un antagoniste de CXCR4 est administrée à l'aide d'une formulation d'usage pharmacologique. Cette invention concerne donc aussi des compositions thérapeutiques qui comprennent un antagoniste de CXCR4 et un excipient ou un support d'usage pharmacologique. Les antagonistes de CXCR4 de l'invention sont des composés de type peptide qui comprennent un fragment peptide sensiblement purifié, un fragment modifié, un analogue ou un sel de SDF-1 acceptable sur le plan pharmacologique.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002322764A CA2322764A1 (fr) | 1998-03-13 | 1999-03-12 | Antagonistes therapeutiques du recepteur de chemokine |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002226391A CA2226391A1 (fr) | 1998-03-13 | 1998-03-13 | Peptides n-terminaux du sdf-1 ayant des activites fonctionnelles facilitees par cxcr4 |
| CA2,245,224 | 1998-08-14 | ||
| CA2,226,391 | 1998-08-14 | ||
| CA002245224A CA2245224A1 (fr) | 1998-08-14 | 1998-08-14 | Antagonistes du recepteur de la chimiokine et chimiotherapie |
| PCT/CA1999/000221 WO1999047158A2 (fr) | 1998-03-13 | 1999-03-12 | Antagonistes therapeutiques du recepteur de chemokine |
| CA002322764A CA2322764A1 (fr) | 1998-03-13 | 1999-03-12 | Antagonistes therapeutiques du recepteur de chemokine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2322764A1 true CA2322764A1 (fr) | 1999-09-23 |
Family
ID=27170596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002322764A Abandoned CA2322764A1 (fr) | 1998-03-13 | 1999-03-12 | Antagonistes therapeutiques du recepteur de chemokine |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2322764A1 (fr) |
-
1999
- 1999-03-12 CA CA002322764A patent/CA2322764A1/fr not_active Abandoned
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |