CA2580853C - Plaque a micromotifs avec des micropalettes pour analyse biochimique adressable - Google Patents

Plaque a micromotifs avec des micropalettes pour analyse biochimique adressable Download PDF

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Publication number: CA2580853C
Authority: CA; Canada
Prior art keywords: plate; pallet; pallets; sites; samples
Prior art date: 2004-10-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2580853A

Other languages

English (en)

Other versions

CA2580853A1 (fr

Inventor

Mark Bachman

Guann-Pyng Li

Nancy Allbritton

Christopher Sims

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of California San Diego UCSD

Original Assignee

University of California San Diego UCSD

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-04

Filing date

2005-10-04

Publication date

2014-04-29

2005-10-04 Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD

2006-04-20 Publication of CA2580853A1 publication Critical patent/CA2580853A1/fr

2014-04-29 Application granted granted Critical

2014-04-29 Publication of CA2580853C publication Critical patent/CA2580853C/fr

2025-10-04 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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Classifications

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- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Analytical Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Clinical Laboratory Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Immunology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Automatic Analysis And Handling Materials Therefor (AREA)

CA2580853A 2004-10-04 2005-10-04 Plaque a micromotifs avec des micropalettes pour analyse biochimique adressable Expired - Fee Related CA2580853C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US61588204P	2004-10-04	2004-10-04
US60/615,882		2004-10-04
PCT/US2005/035860 WO2006041938A2 (fr)	2004-10-04	2005-10-04	Plaque a micromotifs avec des micropalettes pour analyse biochimique adressable

Publications (2)

Publication Number	Publication Date
CA2580853A1 CA2580853A1 (fr)	2006-04-20
CA2580853C true CA2580853C (fr)	2014-04-29

Family

ID=36148879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2580853A Expired - Fee Related CA2580853C (fr)	2004-10-04	2005-10-04	Plaque a micromotifs avec des micropalettes pour analyse biochimique adressable

Country Status (10)

Country	Link
EP (1)	EP1799864A4 (fr)
JP (1)	JP4887298B2 (fr)
KR (1)	KR20070062578A (fr)
CN (1)	CN101035910A (fr)
AU (1)	AU2005294377B2 (fr)
CA (1)	CA2580853C (fr)
IL (1)	IL182039A0 (fr)
MX (1)	MX2007004068A (fr)
RU (1)	RU2007116801A (fr)
WO (1)	WO2006041938A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7951580B2 (en)	2004-04-21	2011-05-31	The Regents Of The University Of California	Automated, programmable, high throughput, multiplexed assay system for cellular and biological assays
US7695954B2 (en)	2004-10-04	2010-04-13	The Regents Of The University Of California	Micropatterned plate with micro-pallets for addressable biochemical analysis
CA2648778A1 (fr)	2006-04-10	2007-10-18	The Regents Of The University Of California	Procede de culture de cellules sur des palettes amovibles pour expansionet analyse cellulaire subsequente
TW200810834A (en) *	2006-04-28	2008-03-01	Univ California	Method of manufacture of a plate of releasable elements and its assembly into a cassette
WO2009015361A1 (fr)	2007-07-25	2009-01-29	The Regents Of The University Of California	Utilisation de résine époxy epon photosensibilisée 1002f pour des applications de mems et biomems
US9487745B2 (en)	2007-07-27	2016-11-08	The Regents Of The University Of California	Micro-patterned plate composed of an array of releasable elements surrounded with solid or gel walls
KR101179553B1 (ko)	2008-12-22	2012-09-05	한국전자통신연구원	세포 배양 컴파트먼트 유닛 및 이를 포함하는 어레이
CN102943027B (zh) *	2012-11-22	2014-11-26	清华大学	一种正压型高通量单细胞图形化装置
KR101595159B1 (ko) *	2012-12-07	2016-02-18	서울대학교산학협력단	마이크로어레이 기판 상의 생화학 분자들의 분리방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997029354A1 (fr) *	1996-02-05	1997-08-14	Bayer Aktiengesellschaft	Procede et dispositif pour trier et recuperer des objets biologiques deposes sur un support plat, tels que des cellules biologiques ou des organites cellulaires, des coupes histologiques, des particules de chromosomes etc., au moyen de faisceaux laser
US6875620B1 (en) *	1996-10-31	2005-04-05	Agilent Technologies, Inc.	Tiling process for constructing a chemical array
JP3432173B2 (ja) *	1999-05-12	2003-08-04	アロカ株式会社	生物組織の処理装置
US6770441B2 (en) *	2000-02-10	2004-08-03	Illumina, Inc.	Array compositions and methods of making same
JP2004537712A (ja)	2000-10-18	2004-12-16	バーチャル・アレイズ・インコーポレーテッド	多重細胞分析システム
JP4755368B2 (ja) *	2001-07-24	2011-08-24	株式会社セルシード	高密度細胞アレイ用基板、製造法、及びその利用方法
US7142987B2 (en)	2001-11-07	2006-11-28	Genvault Corporation	Apparatus, system, and method of archival and retrieval of samples
US6632660B2 (en) *	2002-01-04	2003-10-14	Applera Corporation	Petal-array support for use with microplates
JP4167431B2 (ja) *	2002-02-26	2008-10-15	株式会社Ｄｎａチップ研究所	生化学的検査用の検査基板
US7399643B2 (en) *	2002-09-12	2008-07-15	Cyvera Corporation	Method and apparatus for aligning microbeads in order to interrogate the same

2005
- 2005-10-04 KR KR1020077009234A patent/KR20070062578A/ko not_active Ceased
- 2005-10-04 RU RU2007116801/13A patent/RU2007116801A/ru not_active Application Discontinuation
- 2005-10-04 WO PCT/US2005/035860 patent/WO2006041938A2/fr active Application Filing
- 2005-10-04 CN CNA2005800336952A patent/CN101035910A/zh active Pending
- 2005-10-04 AU AU2005294377A patent/AU2005294377B2/en not_active Ceased
- 2005-10-04 MX MX2007004068A patent/MX2007004068A/es unknown
- 2005-10-04 CA CA2580853A patent/CA2580853C/fr not_active Expired - Fee Related
- 2005-10-04 JP JP2007534910A patent/JP4887298B2/ja not_active Expired - Fee Related
- 2005-10-04 EP EP05802866A patent/EP1799864A4/fr not_active Ceased
2007
- 2007-03-20 IL IL182039A patent/IL182039A0/en unknown

Also Published As

Publication number	Publication date
WO2006041938A3 (fr)	2007-04-12
CN101035910A (zh)	2007-09-12
AU2005294377A1 (en)	2006-04-20
JP2008516199A (ja)	2008-05-15
JP4887298B2 (ja)	2012-02-29
AU2005294377B2 (en)	2011-12-01
RU2007116801A (ru)	2008-11-10
IL182039A0 (en)	2007-07-24
KR20070062578A (ko)	2007-06-15
WO2006041938A2 (fr)	2006-04-20
EP1799864A4 (fr)	2009-06-03
CA2580853A1 (fr)	2006-04-20
EP1799864A2 (fr)	2007-06-27
MX2007004068A (es)	2007-06-04

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