CN104001179B - To the abstersive cleaning products of vagina - Google Patents

Abstract

A vaginal cleansing product made by adding at least one cleaning agent to an expansion carrier, the expansion carrier includes a high expansion area and a low expansion area, and the high expansion area of the expansion carrier includes a cellulose Fiber, cotton and viscose fiber, the ratio of the three is 7:1:1, the low expansion area for preparing the expansion carrier includes a kind of cellulose fiber, cotton and viscose fiber, the ratio of the three is 4:3:1; The tail of the expansion carrier is provided with a pull wire; there are several keels (23) axially or radially along the surface of the expansion carrier; the cleaning agent is made of the following raw materials in parts by weight: liquid paraffin 30-60, Lanolin 10‑40, Olive Oil 10‑40, Carbomer 0.01‑10, Hyaluronic Acid 0.01‑10.

Description

Cleansing products that cleanse the vagina

This application is a divisional application of the parent application with the application number 2012104996277, the application date is November 29, 2012, and the invention title is "expandable carrier carrying effective components and its application".

technical field

The invention belongs to the hygienic field, in particular to an expansion carrier capable of carrying effective components.

Background technique

The new carrier with specific expansion properties is of great significance in the fields of food, medicine, cosmetics, disinfection products, health care products, health care products and medical devices, and can derive a large number of valuable products. For example, ordinary sterile tampons have a wide range of uses, and can be made into medical absorbent cotton commonly used in hospitals, disposable sanitary products, sanitary pads for women during menstruation, built-in tampons that can also be made into suppositories, etc.

However, in the fields of cosmetics, disinfection products, and medical devices, the requirements for each product are different, resulting in that most carriers with specific physical and chemical properties can only be used in a certain field and cannot be considered in all fields. At present, the expansion of ordinary absorbent cotton is irregular, and the material is single, so it is not flexible to choose a suitable product according to the specific application field.

Although the following patents have improved the physical properties and applications of absorbent cotton from different angles, such as Chinese patent CN02825892 discloses a special tampon for women's hygiene, Chinese patent CN88105466 discloses an expanded cellulose sponge, and Chinese patent CN200580022237 discloses an expanded For controlled intravaginal devices, Chinese patent CN200680014597 discloses a dual-mode absorbent sanitary napkin, and Chinese patent CN200880101828 discloses a tampon that can expand according to anthropometry. The problems of "carriers with specific swelling properties" such as narrow application fields, single material, and disordered expansion have not been completely resolved. It is of great significance to obtain new swelling carriers that can carry effective components.

Contents of the invention

The invention provides a new expansion carrier that can be used in multiple fields such as medicine, cosmetics, disinfection products, etc. The carrier can be made into medicines, cosmetics, disinfection products and other products according to different effective components carried by the carrier.

The swelling carrier carrying the effective components of the present invention can be swelled in an aqueous solution according to a predetermined swelling value, and the swelling carrier has a swelling value of 1-30 when saturated with water absorption, and the effective components can be immersed in the inside of the swelling carrier, or dissolved or dispersed in a Wrap in the mixture of swelling carriers. The swelling carrier is preferably applied vaginally, but should not limit the scope of the invention by having an application section.

The "carrying" in the present invention includes that the active ingredient can be directly or indirectly contacted with the swelling carrier.

"Active components" in the present invention refer to substances that can act on the human body and exert effects such as treatment, health care, disinfection, beauty treatment, and cleaning.

For cosmetics, active ingredients include but not limited to liquid paraffin, lanolin, olive oil, carbomer, hyaluronic acid, white mineral oil, petrolatum, lanolin, vegetable oil, etc., water-in-oil (W/O) type cleansing cream and lotions, oil-in-water (O/W) cleansing creams and lotions, surfactants.

Disinfection products include but are not limited to chlorhexidine acetate, chitosan, formic acid, acetic acid, benzoic acid, salicylic acid, ethanol, surfactants, halogens, etc.

For medicines including but not limited to all kinds of traditional Chinese medicine extracts and ornidazole, terconazole, mandelic acid, bismuth gallate, chlorhexidine acetate, zedoary oil, metronidazole, chloramphenicol, seabuckthorn seed oil, erythromycin , palmatine, progesterone, furazolidone, polycresol sulfonal, polycresol sulfonal, povidone iodine, carboprost methyl ester, Kangfuling, clindamycin phosphate, clotrimazole, matrine, Bifonazole, morphine sulfate, sulfasalazine, nudibranch, meocinzolidone, naproxen, diclofenac potassium, pyrantel pamoate, tegafur, tinidazole, ketoconazole, nitric acid Econazole, ibuprofen, clenbuterol hydrochloride, levamisole hydrochloride, ofloxacin, nystatin, tramadol hydrochloride, miconate nitrate, nonoxynol ether, prostaglandin E2, meloxicam, Mesalazine, ciclopirox olamine, carrageenate, dinoprostone, estriol, recombinant human interferon α2а suppository, butoconazole, fluconazole, fenticonazole, tioconazole, antifungal Clindamycin, itraconazole, clindamycin, tetracycline, erythromycin, doxycycline, lomefloxacin, norfloxacin, ciprofloxacin, azithromycin, cefltoxime.

The "predetermined expansion value" of the present invention is to achieve the purpose of presetting the expansion value of the expansion carrier through the selection and proportioning of materials for preparing the expansion carrier. The pre-set expansion value can make the active ingredient fully contact with the vaginal epithelium and mucous membrane wall, and realize selective contact. For example, a better material and proportion with a predetermined expansion value is as follows: the preparation of the first expansion carrier includes at least one kind of soluble fiber and one kind of natural fiber and one kind of synthetic fiber, and the ratio of the three is 4-7:1 - 3:1, most preferably 5.5:2:1. Surprisingly, the swelling carrier can swell to a predetermined value in an aqueous solution with a pH value of 3.0-8.0.

In order to better adapt to the physiological structure of the vagina, the expansion values of different parts of the expansion carrier are different. It is also possible for different parts of the swelling carrier to have the same swelling value but different swelling sequences.

The surface of the expansion carrier carrying effective components of the present invention is provided with a keel along the axial or radial direction. In the axial direction, it is preferable that the expansion sequence of the front and rear ends of the expansion carrier is different but the expansion value after expansion is the same, and it is optimal that the outer end (drawing end) of the expansion carrier expands first. In the radial direction, it is preferred that all parts of the expansion carrier expand at the same time. After expansion, the expansion value of the keel part is greater than that of other parts. It is optimal that the expansion value of the keel at the outer end (drawing end) of the expansion carrier is the largest, forming a multi-layer leak-proof.

The "entry end" of the present invention refers to the end that first enters the vagina; the "pull-out end" of the present invention refers to the end that is connected with the drawstring when pulled out from the vagina.

When the expansion values are different, it is preferred that the high expansion area of the preparation expansion carrier comprises a cellulose fiber and a natural fiber and a synthetic fiber in a ratio of 7:1:1, and the low expansion area of the preparation expansion support Consists of one cellulose fiber and one natural and one synthetic fiber in a ratio of 4:3:1. The above-mentioned high-expansion regions and low-expansion regions can be arranged in various ways such as intervals and adjacent ones.

The measurement method of "expansion value when saturated with water absorption" in different directions is the same. The following is only an example of the determination method of radial expansion value: refer to the method of melting time limit measurement in the second appendix of the Chinese Pharmacopoeia 2010 edition, take 3 expansion carriers, and After standing at room temperature for 1 hour, measure the diameter D1 of the tail respectively; place the 3 expandable carriers on the lower round plates of the 3 metal frames respectively, put them into their respective sleeves, and fix them with hooks. Immerse the above devices vertically into containers filled with not less than 4L of water at 37.0°C±0.5°C, the upper end of which should be 90mm below the water surface, install a rotator in the container, and turn the device over in the solution every 10 minutes once. After 60 minutes, when it was taken out from the melting time limiter, the diameter D2 of the tail after expansion of the expansion carrier was measured immediately, and the calculation formula for the radial expansion value (S ₁ ) was:

S ₁ =D2/D1

Among them, S ₁ is the mean value of the measurement results of 3 expandable supports.

The expansion value of the preferred expansion carrier of the present invention is 1-10, and a pull wire is provided at its tail. The backguy can adopt multiple materials such as aseptic string, PVC, PE, nylon, cloth, etc.

The preferred size of the expansion carrier carrying the effective components of the present invention in most fields is 3.0-15.0 mm in diameter, 1.0-4.0 g in weight tolerance, 10.0-60.0 mm in length, and 50 mm in length of the pull wire. A better expansion carrier has a diameter of 10.0-11.0 mm, a weight and tolerance of 2.10-2.40 g, a length of 43.0-46.0 mm, and a length of the pull wire ≥ 100 mm.

The expansion carrier of the present invention is selected from cotton, fiber, resin, polyurethane sponge, cellulose fiber, paper, non-woven fabric, polymer water-absorbing material, foam material, superabsorbent, hydrogel; cellulose fiber includes wood pulp , cotton, rayon, viscose, Lyocell; fibers include synthetic fibers or natural fibers, synthetic fibers include polyolefin, polyester, polyamide, rayon, superabsorbent fibers, acrylic fibers, viscose fibers , regenerated cellulose fibers; natural fibers including wool, cotton, flax, hemp, jute, ramie and wood pulp.

Another preferred solution provided by the present invention is that the outer periphery of the expansion carrier carrying the effective components is wrapped with a protective layer, and the protective layer can limit the expansion range of the expansion carrier. For example, a sterile tampon is used as an expansion carrier for carrying active components, and a non-woven fabric is used as a protective layer.

A better solution is also provided that the expansion carrier carrying the effective components of the present invention is provided with a built-in expansion carrier, and after the expansion carrier plays an expansion role, the built-in expansion carrier re-expands, preferably, there are two built-in expansion carriers or 2 or more. When there are multiple built-in expansion carriers, one built-in expansion carrier can be placed in another built-in expansion carrier, or multiple built-in expansion carriers can be placed side by side into the same or built-in expansion carrier.

The weight ratio of the preferred effective component and expansion carrier of the present invention is 0.1:50～50:1, when containing built-in expansion carrier, the weight ratio of active component and expansion carrier and built-in expansion carrier and is 0.1:50～50 : 1.

The application of the active ingredient-carrying swelling carrier of the present invention is exemplified below.

One is the application as a disinfection product. The disinfection product can be an antibacterial maintenance agent, and the effective components include at least one active ingredient that has a cleaning effect on the vaginal environment and at least one polymer auxiliary material. The active ingredients include but are not limited to chlorhexidine acetate and chitosan, and the polymer excipients are seaweed polysaccharide and liquid paraffin. Preferably, the parts by weight of chlorhexidine acetate and chitosan are 100%.

The second is the application as a cosmetic. The cosmetic is a cleaning product that is made by adding at least one cleaning agent to the expansion carrier and has a cleaning effect on the vagina. Cleaning products may also include boosters made of pharmaceutical grade polyethylene or polypropylene.

The color of the booster is uniform, without obvious color difference, the surface is smooth and smooth, without deformation, obvious scratches, blisters and oil stains.

The preferred cleaning agent is made of the following raw materials in parts by weight: 30-60 liquid paraffin, 10-40 lanolin, 10-40 olive oil, 0.01-10 carbomer, and 0.01-10 hyaluronic acid.

The optimal cleaning agent consists of 44 parts by weight of liquid paraffin, 27 parts of lanolin, 28 parts of olive oil, 0.5 part of carbomer and 0.5 part of hyaluronic acid.

The beneficial effect of the expansion carrier carrying the active component of the present invention is that its unique physical properties such as expansion according to a predetermined expansion value, expansion under a specific pH value, and timed expansion allow it to be used as a variety of pharmaceuticals, cosmetics, disinfection products, etc. A new expansion carrier for field use. And a large number of tests prove that all have good performance when being applied to different fields, such as when doing disinfection products as described in Example 1, the stock solution acts for 3-5 minutes, and the bacteriostatic rate to Escherichia coli, Staphylococcus aureus, Candida albicans is equal to Between 50% and 90%.

Description of drawings

Fig. 1, the schematic diagram of the structure of the expansion carrier carrying the effective components of Example 1 of the present invention;

Fig. 2, the schematic diagram of the structure of the expansion carrier carrying the effective component of the embodiment 2 of the present invention;

Fig. 3, the schematic diagram of the structure of the expansion carrier in Example 3 of the present invention before expansion;

Fig. 4. Schematic diagram of the structure of the expanded carrier in Example 3 of the present invention after expansion;

Fig. 5, the front view of booster of the present invention;

Fig. 6 is a disassembled schematic diagram of the booster of the present invention.

detailed description

Embodiment 1 antibacterial curing agent

As shown in Figure 1, the expansion carrier 11 of the present invention carrying effective components is a body 12 made of cellulose fiber, jute and viscose fiber according to 5.5:2:1, and the cellulose fiber is Shanghai Luoyang Provided by New Material Technology Co., Ltd. Several keels 13 are arranged on the surface of the body 12 along the axial direction, and the pulling end expands first, and the expansion value of the pulling end and the entering end are the same. One end of the expansion carrier has a cotton rope 14 .

The active components carried by the swelling carrier are chlorhexidine acetate, chitosan, seaweed polysaccharide and liquid paraffin in a weight ratio of 100:100.

The stock solution carried by the bacteriostatic maintenance agent acts on the vagina for 3-5 minutes, and the bacteriostatic rate to Escherichia coli, Staphylococcus aureus and Candida albicans is all 50%-90%.

Example 2 Cleaning Products

As shown in FIG. 2 , in the expansion carrier 21 carrying effective components of the present invention, several keels 23 are arranged on the surface of the body 22 along the neck direction. The keel 23 is a high-expansion zone, and the rest are low-expansion zones. The high-expansion area for preparing the expansion carrier includes cellulose fiber, cotton and viscose fiber, and the ratio of the three is 7:1:1, and the low-expansion area for preparing the expansion carrier includes cellulose fiber, cotton and viscose fiber, and the ratio of the three is 4:3:1. The cellulose fiber was provided by Shanghai Luoyang New Material Technology Co., Ltd. The pulling end and the entering end expand at the same time, but with different expansion values.

The active ingredients carried by the swelling carrier in this embodiment are 44 liquid paraffin, 27 lanolin, 28 olive oil, 0.5 carbomer, and 0.5 hyaluronic acid.

Embodiment 3 limited expansion carrier

As shown in Figure 3, the expansion carrier 31 carrying the active ingredient of the present invention is in a pre-expanded state, including three non-woven fabrics 33 wrapped around the outer periphery of the sterile tampon 32 carrying the active ingredient, combined with the expansion shown in Figure 4 After the state, it shows that the non-woven fabric can limit the expansion range of the sterile tampon.

Example 4

It is basically the same as Example 1, except that the material is a sterile tampon. The optimal expansion carrier has a diameter of 10.0 mm, a weight and tolerance of 2.20 g, a length of 43.0 mm, and a length of the pull wire of 150 mm.

Example 5

It is basically the same as Example 2, except that the material is a sterile tampon. The optimal expansion carrier has a diameter of 11.0 mm, a weight deviation of 2.40 g, a length of 46.0 mm, and a pull wire length of 200 mm.

Example 6

The propeller 61 as shown in Figure 5 and 6 includes a propeller main body 63 and a pull rod 62 that can be pushed and pulled in the propeller main body 63. Tube 65 is connected.

The above-mentioned embodiments are only descriptions of preferred implementations of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, those skilled in the art may make various modifications to the technical solutions of the present invention. and improvements, all should fall within the scope of protection determined by the claims of the present invention.

Claims (10)

1. it is a kind of by expandable carrier add that at least one cleaning agent is made to the abstersive cleaning products of vagina, its feature It is, the expandable carrier includes highly expanded area and low bulk area, preparing the highly expanded region of the expandable carrier includes one kind Cellulose fibre, cotton and viscose rayon, proportions are 7:1:1, preparing the low bulk region of the expandable carrier includes one kind Cellulose fibre, cotton and viscose rayon, proportions are 4:3:1；The cleaning agent is made up of the raw material of following weight： Atoleine 30-60, lanolin 10-40, olive oil 10-40, card pool nurse 0.01-10, hyaluronic acid 0.01-10；The expansion The afterbody of carrier is provided with bracing wire；Axially or radially there are some keel (13), the cellulose fiber along the surface of the expandable carrier Tie up and provided for Shanghai Royang Innovative Material Technologies Co., Ltd..

2. cleaning products as claimed in claim 1, it is characterised in that the cleaning agent is made up of the raw material of following parts by weight： Atoleine 44, lanolin 27, olive oil 28, card pool nurse 0.5, hyaluronic acid 0.5.

3. cleaning products as claimed in claim 1, it is characterised in that the different parts swell value of the expandable carrier is different 's.

4. cleaning products as claimed in claim 3, it is characterised in that the swell value of the keel is more than the expandable carrier Other positions.

5. cleaning products as claimed in claim 1, it is characterised in that a diameter of 3.0-15.0mm of the expandable carrier, again Measure the ㎜ of deviation 1.0-4.0g, length 10.0-60.0 ㎜, bracing wire length >=50.

6. cleaning products as claimed in claim 1, it is characterised in that the periphery of the expandable carrier is enclosed with overcoat, institute The expansion amplitude of expandable carrier can be limited by stating overcoat.

7. cleaning products as claimed in claim 6, it is characterised in that the expandable carrier is sliver, the overcoat is nothing Spin cloth.

8. cleaning products as claimed in claim 1, it is characterised in that the inside of the expandable carrier sets built-in expansion to carry Body, after the expandable carrier plays expansion, built-in expandable carrier reflation.

9. cleaning products as claimed in claim 8, it is characterised in that the built-in expandable carrier is 2 or more than 2.

10. cleaning products as claimed in claim 5, it is characterised in that a diameter of 10.0-11.0mm of the expandable carrier, The ㎜ of deviation of weight 2.10-2.40g, length 43.0-46.0 ㎜, bracing wire length >=100.