CN104436176A - Novel biological antibacterial spray for upper respiratory infection and pneumonia - Google Patents

Abstract

The invention relates to a novel biological antibacterial spray based on upper respiratory tract infection and pneumonia, which is characterized in that it is composed of tea tree oil, chitosan, lactic acid, lysozyme, ultrafine tea powder and optional pharmaceutical Carriers that can be used for injection are mixed and prepared according to a specific process. The present invention is based on a novel biological antibacterial spray composed of natural biological antibacterial agents for upper respiratory tract infection and pneumonia. Its production prescription and process are simple, low in cost, and does not contain any other additives. Commonly used bacteria, including drug-resistant bacteria (such as methicillin-resistant Staphylococcus aureus), have the effect of killing quickly, and have good absorption, no stimulation, no toxic side effects, and are not easy to cause drug resistance.

Description

A new biological antibacterial spray based on upper respiratory tract infection and pneumonia

technical field

The invention relates to a novel biological antibacterial spray for upper respiratory tract infection and pneumonia, in particular to a natural antibacterial drug spray containing tea tree oil and chitosan for treating upper respiratory tract infection and pneumonia.

Background technique

Upper respiratory tract infection refers to infection of the respiratory tract above the throat, including rhinitis, sinusitis, pharyngitis, tonsillitis, etc. Viruses or bacteria that already exist or are invaded by the outside world grow and reproduce rapidly, leading to infection.

Pneumonia is one of the most common infectious diseases, mainly caused by bacteria (pneumococcus, Staphylococcus aureus, etc.), viruses (coronavirus, adenovirus, etc.), fungi (Candida albicans, Aspergillus, etc.), atypical pathogens (such as Legionella, mycoplasma, etc.) infection or physical and chemical factors (radiation, gastric acid inhalation, etc.). Pneumonia often refers to pneumonia caused by bacterial infection.

Before the application of antibiotics, bacterial pneumonia was a great threat to the health of children and the elderly. The emergence and development of antibiotics once significantly reduced the mortality rate of pneumonia. However, in recent years, due to the emergence of drug-resistant bacteria, the overall mortality rate of pneumonia has not decreased, and has even increased. Therefore, it is urgent to find safe and efficient new antibacterial drugs.

The invention is composed of natural biological antibacterial substances such as tea tree oil, chitosan, biological enzymes and superfine tea powder, has good killing effect on common clinical bacteria, including drug-resistant bacteria, and is not easy to cause drug resistance itself.

Pulmonary drug delivery through the respiratory tract by spray can directly reach the lesion, the specific surface area of lung absorption is large, the route of drug entering the blood circulation is shortened, the absorption is fast, and the first-pass effect of the liver can be avoided, and the damage to protein drugs can be avoided. Compared with other drug delivery methods, it has the characteristics of rapidity and high efficiency.

The purpose of the present invention is to overcome the shortcoming and deficiency of existing treatment method, develop a kind of novel antibacterial spray that is used for upper respiratory tract infection and pneumonia treatment.

Contents of the invention

The purpose of the present invention is to provide a new type of antibacterial spray based on upper respiratory tract infection and pneumonia, to overcome the shortcomings of existing treatment methods, and to achieve rapid, safe and efficient sterilization without using any chemical drugs and antibiotics .

Technical scheme of the present invention:

The new antibacterial spray mainly composed of tea tree oil and chitosan based on upper respiratory tract infection and pneumonia involved in the present invention is realized through the following technical scheme:

The content of each component of biological antibacterial spray:

(a) Tea tree oil: 0.2% ~ 5.85%

(b) Chitosan: 0.1% ~ 2%

(c) Lactic acid: 0.05% ~ 1.2%

(d) Superfine tea powder: 0.4% ~ 2%

(e) Biological enzyme: 0.1% ~ 0.3%

(f) Water: 88.65% ~ 99.15%

The preparation method of biological antibacterial drug spray is as follows:

a. tea tree oil is prepared into tea tree oil nano liposome according to the method described in Chinese patent CN1957924A;

b. Add a certain amount of water to a certain amount of chitosan, stir to make the chitosan fully wet, slowly add a certain amount of lactic acid, stir and mix to obtain solution A;

c. Dissolve a certain amount of lysozyme in a certain amount of water to prepare solution B;

d. Mix and stir the tea tree oil nanoliposome, solution A and solution B to obtain a uniform mixture C;

e. Finally, add a certain amount of ultra-fine tea powder to the mixed solution C, stir and mix evenly and pack in containers to obtain the pharmaceutical preparation of the present invention.

The present invention is based on: tea tree oil is the volatile essential oil that several kinds of plant branches and leaves of Melaleuca genus extract. It inhibits the production of inflammatory mediators by activating monocytes, changes the permeability of microbial membranes and inhibits pathogenic bacteria and molds. It is a powerful and non-toxic natural fungicide. Because tea tree oil stimulates the skin and mucous membranes when the concentration is high, and even causes allergic reactions, the tea tree oil in the present invention is a nano-liposome, which not only reduces the adverse drug reaction, is easily absorbed by the body, but also makes the drug slow, continuous, Controlled release, prolonging drug action time, improving drug utilization.

Chitosan, lactic acid and biological enzymes are used as raw materials to achieve the synergistic sterilization purpose of chitosan, chitosan degradation products and lysozyme through the chitosan combined degradation process.

The chitosan used is a refined deacetylation product of chitin, and the degree of deacetylation is greater than 95%.

Lactic acid has good biocompatibility, is less irritating, and has a certain bactericidal effect. The main purpose of adding here is to dissolve chitosan.

Lysozyme is a bactericidal substance commonly found in various tissues and secretions of humans and animals, as well as some plants and microorganisms. It mainly destroys the glycine-peptide bond (GLY-GLY) of peptidoglycan in the cell wall of pathogenic bacteria. Sterilization, it is difficult for bacteria to develop drug resistance.

The particle size of ultrafine tea powder is between 1 and 100 microns, which is ultrafine green tea powder. The ultrafine tea powder contains tea polyphenols, which have a good killing effect on drug-resistant bacteria, and because of the small particle size, it is easy to Evenly suspended in liquid medium, easy to be absorbed by human body.

The novel biological antibacterial medicine adopts the form of spray, does not need throwing agent as power, has no pollution, simple production prescription and process, low cost, and has the advantages of positioning, quick effect and convenient use.

When the new type of biological antibacterial drug spray is inhaled by the human respiratory tract, it can quickly kill common clinical pathogenic bacteria that cause upper respiratory tract infection and pneumonia, and it is also effective against common drug-resistant bacteria, such as: drug-resistant Streptococcus pneumoniae, A. Oxicillin Staphylococcus aureus, etc. also have a rapid killing effect, which solves the problem of drug-resistant strains due to the clinical use of antibiotics.

Detailed ways

The specific implementation of the present invention is illustrated by the following examples, but the protection scope of the present invention is not limited thereto.

Examples 1-6

Prepare novel antimicrobial drug spray according to the following ratio:

Example:

The antibacterial agent spray of above-mentioned embodiment is all greater than 90% to Streptococcus pneumoniae, Staphylococcus aureus, MRSA, Pseudomonas aeruginosa and Candida albicans.

Claims (6)

1., based on the new bio antibacterial spray of upper respiratory tract infection and pneumonia, it is characterized in that, the degree of biological antibiotic medicine each component is:

(a) tea tree oil: 0.2% ~ 5.85%

(b) chitosan: 0.1% ~ 2%

(c) lactic acid: 0.05% ~ 1.2%

(d) ultra-fine tea powder: 0.4% ~ 2%

(e) enzyme: 0.1% ~ 0.3%

(f) water: 88.65% ~ 99.15%.

2., as claimed in claim 1 based on the new bio antibacterial spray of upper respiratory tract infection and pneumonia, it is characterized in that the deacetylation of described chitosan is greater than 95%.

3., as claimed in claim 1 based on the new bio antibacterial spray of upper respiratory tract infection and pneumonia, it is characterized in that the particle size range of described ultra-fine tea powder is 1 ~ 100 micron.

4., as claimed in claim 1 based on the new bio antibacterial spray of upper respiratory tract infection and pneumonia, it is characterized in that described enzyme is the compound enzyme of one or more of lysozyme, staphylococcus lysozyme or papain.

5., as claimed in claim 1 based on the new bio antibacterial spray of upper respiratory tract infection and pneumonia, it is characterized in that described water is sterilized water for injection.

6., as claimed in claim 1 based on the new bio antibacterial spray of upper respiratory tract infection and pneumonia, its preparation method comprises the following steps:

A tea tree oil is prepared into nano liposome of tea plant oil by method described in Chinese patent CN1957924A by ();

B () adds a certain amount of water in a certain amount of chitosan, stir after making the abundant moistening of chitosan, slowly add a certain amount of lactic acid, stirring and evenly mixing obtained solution A;

C a certain amount of lysozyme is dissolved in a certain amount of water by (), obtained solution B;

D nano liposome of tea plant oil, solution A and solution B mix and blend are uniformly mixed liquid C by ();

Add a certain amount of ultra-fine tea powder in (e) the most backward mixed liquor C, stirring and evenly mixing subpackage in a reservoir, i.e. obtained pharmaceutical preparation of the present invention.