CN104490386B - The changing method of a kind of multi-channel electrode array and system - Google Patents

Abstract

The present invention provides a multi-channel electrode array switching method and system, the method comprising: a control unit sends a detection signal to a second multi-channel analog switch; the second multi-channel analog switch switches to Connected with the detection device; the detection device measures the impedance value of the electrode array when the first multi-channel analog switch is in the current channel; the detection device sends the impedance value to the control unit; the The control unit switches the first multi-channel analog switch according to the impedance value. The invention realizes fully automatic multi-channel microelectrode modification and measurement and automatic switching between channels, realizes the preparation of microelectrode arrays under unattended conditions, accelerates the preparation process of nerve electrodes, and is suitable for commercial nerve microelectrodes Array production.

Description

A switching method and system for a multi-channel electrode array

technical field

The present invention relates to the technical field of electrophysiology, in particular to the electrophysiological nerve microelectrode array technology, and specifically to a multi-channel electrode array switching method and system.

Background technique

At present, at least one tenth of the world's population is suffering from neuropsychiatric diseases, and the treatment burden of epilepsy, schizophrenia, depression, drug addiction, Alzheimer's disease and other neuropsychiatric diseases accounts for all 13% of diseases, more than cardiovascular disease and cancer. And with the acceleration of the pace of life and the aging of the population structure, the number of patients is still increasing. The increasing incidence of neuropsychiatric diseases worldwide not only imposes a heavy burden on patients and society, but also poses unprecedented challenges to the treatment and research of these diseases. At the same time, due to the contradiction between the complexity of the brain and the existing research and treatment techniques, people's in-depth research on neuropsychiatric diseases is seriously restricted.

In order to comprehensively and in-depth study the remodeling and repair mechanism of neural circuits and improve the diagnosis and treatment of neuropsychiatric diseases, it is urgent to study the connection between specific behaviors and neuronal coding in specific brain regions in animal models of waking activity. Electrophysiological technology is one of the important technical means to achieve this goal. By implanting electrodes in specific brain regions of model animals, electrophysiological signals under different stimulation conditions can be recorded, and the connection between the specific behavior of model animals and the discharge pattern of electrophysiological signals can be studied.

In order to improve the spatial resolution of electrodes, obtain more coded information of nerve cells, and record more electrical activities of nerve cells, microelectrode arrays are currently used for electrophysiological recording. The number of channels of the microelectrode array usually reaches more than 64 channels, or even thousands of channels. Therefore, the modification and detection process of multi-channel electrode arrays is very tedious. However, there is currently no channel switching system dedicated to the modification and detection of neural electrodes, which can only be switched manually. This not only consumes a lot of manpower for repetitive work, but also requires technical personnel with certain professional knowledge to judge and record the measurement results, which is prone to errors, and is very likely to damage the electrode due to improper parameter control or improper operation.

Therefore, how to develop a complete multi-channel electrode array automatic switching mechanism to solve the problem of switching between multiple instruments and multiple channels in the preparation and detection process of the neural microelectrode array currently used for electrophysiological research is an urgent problem to be solved in this field. technical challenge.

Contents of the invention

In order to solve the problem of switching between multiple instruments and multiple channels in the preparation and detection process of neural microelectrode arrays used in electrophysiological research in the prior art, the present invention provides a switching method and system for multi-channel electrode arrays. unit to control the first multi-channel analog switch and the second multi-channel analog switch, and combined with the detection device and electroplating device, it realizes fully automatic multi-channel micro-electrode modification and measurement and automatic switching between channels, realizing unattended The preparation of the microelectrode array under the condition accelerates the preparation process of the neural electrode and is suitable for the production of the commercial neural microelectrode array.

One of the objects of the present invention is to provide a multi-channel electrode array switching method, the method comprising: the control unit sends a detection signal to the second multi-channel analog switch; the second multi-channel analog switch according to the The detection signal is switched to be connected to the detection device; the detection device measures the impedance value of the electrode array when the first multi-channel analog switch is in the current channel; the detection device sends the impedance value to the control unit ; The control unit switches the first multi-channel analog switch according to the impedance value.

In a preferred embodiment of the present invention, the switching of the first multi-channel analog switch by the control unit according to the impedance value includes: the control unit acquires a preset first impedance threshold and a second impedance threshold , and the first impedance threshold is less than the second impedance threshold; the control unit judges whether the impedance value is less than the first impedance threshold or whether the impedance value is greater than the first impedance threshold Two impedance thresholds; when the judgment is yes, the control unit outputs a negative feedback signal; the control unit switches the first multi-channel analog switch to the next channel according to the negative feedback signal; The control unit records the channel information of the electrode array.

In a preferred embodiment of the present invention, the switching of the first multi-channel analog switch by the control unit according to the impedance value includes: the control unit acquires a preset first impedance threshold and a second impedance threshold , and the first impedance threshold is less than the second impedance threshold; the control unit judges whether the impedance value is greater than the first impedance threshold and less than the second impedance threshold; when judging When yes, the control unit sends an electroplating signal to the second multi-channel analog switch; the second multi-channel analog switch is switched to connect with the electroplating device according to the electroplating signal; the electroplating The device performs electroplating on the electrode array; after the electroplating, the second multi-channel analog switch is switched to be connected to the detection device; the detection device measures when the first multi-channel analog switch is in the current channel , the impedance value of the electrode array after electroplating; the detection device sends the impedance value of the electrode array after electroplating to the control unit; the control unit switches according to the impedance value of the electrode array after electroplating The first multi-channel analog switch.

In a preferred embodiment of the present invention, the switching of the first multi-channel analog switch by the control unit according to the impedance value of the electrode array after electroplating includes: the control unit judges that the electrode array after electroplating is Whether the impedance value of the array is less than the first impedance threshold; when it is judged to be yes, the control unit outputs a positive feedback signal; the control unit switches the first multi-channel according to the positive feedback signal The analog switch goes to the next channel.

In a preferred embodiment of the present invention, the switching of the first multi-channel analog switch by the control unit according to the impedance value of the electrode array after electroplating includes: the control unit judges that the electrode array after electroplating is Whether the impedance value of the array is greater than the first impedance threshold; when it is judged to be yes, the control unit obtains the preset electroplating threshold; the control unit sends the electroplating threshold to the second multi-channel analog switch. signal; the second multi-channel analog switch is switched to be connected to the electroplating device according to the electroplating signal; the electroplating device performs electroplating threshold secondary electroplating on the electrode array; when the electroplating threshold secondary electroplating is completed, The second multi-channel analog switch is switched to be connected to the detection device; the detection device measures the impedance value of the electrode array after the first multi-channel analog switch is in the current channel and the electroplating threshold is completed; The detection device sends the impedance value of the electrode array after the electroplating threshold to the control unit; the control unit switches the first multiple Channel analog switch.

In a preferred embodiment of the present invention, the switching of the first multi-channel analog switch by the control unit according to the electroplating threshold and the impedance value of the electrode array after the end of electroplating includes: the control unit judges that the electroplating Threshold Whether the impedance value of the electrode array is greater than the first impedance threshold after the electroplating is completed; when it is judged to be yes, the control unit outputs a negative feedback signal; the control unit switches the The first multi-channel analog switch described above proceeds to the next channel.

In a preferred embodiment of the present invention, the switching of the first multi-channel analog switch by the control unit according to the impedance value of the electrode array after electroplating includes: the control unit judges that the electrode array after electroplating is Whether the impedance value of the array is greater than the first impedance threshold; when it is judged to be yes, the control unit obtains the preset electroplating threshold; the control unit sends the electroplating threshold to the second multi-channel analog switch. signal; the second multi-channel analog switch is switched to be connected to the electroplating device according to the electroplating signal; the electroplating device performs n times electroplating on the electrode array, and the n is a positive integer and less than The electroplating threshold; after n times of electroplating, the second multi-channel analog switch is switched to be connected to the detection device; the detection device measures when the first multi-channel analog switch is in the current channel, The impedance value of the electrode array after n times of electroplating; the detection device sends the impedance value of the electrode array after n times of electroplating to the described control unit; The impedance value of the array switches the first multi-channel analog switch.

In a preferred embodiment of the present invention, the switching of the first multi-channel analog switch by the control unit according to the impedance value of the electrode array after the n times of electroplating includes: the control unit judges that the n times Whether the impedance value of the electrode array after electroplating is greater than the first impedance threshold; when it is judged to be yes, the control unit outputs a zero feedback signal; the control unit switches the The first multi-channel analog switch re-enters the current channel.

In a preferred embodiment of the present invention, the method further includes: the control unit sending the channel information of the electrode array to a recording unit; the recording unit storing the channel information of the electrode array.

In a preferred embodiment of the present invention, the method further includes: the recording unit outputs the channel information of the electrode array to the display unit through the third multi-channel analog switch; the display unit displays the electrode array Channel information for the array.

One of the objectives of the present invention is to provide a multi-channel electrode array switching system, the system includes: a detection device, an electroplating device, the system also includes a control unit; connected to the control unit The first multi-channel analog switch, the second multi-channel analog switch; the electrode array connected to the first multi-channel analog switch through the electrode interface; wherein, the control unit includes: a detection signal sending unit for sending The second multi-channel analog switch sends a detection signal; the second multi-channel analog switch includes: a first connection unit, configured to switch to connect with the detection device according to the detection signal; The detection device includes: a first measuring unit, used to measure the impedance value of the electrode array when the first multi-channel analog switch is in the current channel; a first sending unit, used to send the impedance value to the The control unit; the control unit also includes: a first switching unit, configured to switch the first multi-channel analog switch according to the impedance value.

In a preferred embodiment of the present invention, the first switching unit includes: an impedance threshold acquisition unit, configured to acquire a preset first impedance threshold and a second impedance threshold, and the first impedance threshold is smaller than the said second impedance threshold; a first judging unit for judging whether said impedance value is less than said first impedance threshold or whether said impedance value is greater than said second impedance threshold; first feedback signal output The unit is used to output a negative feedback signal when the first judging unit judges yes; the first channel switching unit is used to switch the first multi-channel analog switch to the next channel according to the negative feedback signal. A channel: a channel information recording unit, configured to record channel information of the electrode array.

In a preferred embodiment of the present invention, the first switching unit further includes: a second judging unit, configured to judge whether the impedance value is greater than the first impedance threshold and smaller than the second impedance threshold The first electroplating signal sending unit is used to send an electroplating signal to the second multi-channel analog switch when the second judging unit judges yes; the second multi-channel analog switch further includes: Two connection units, for switching to connect with the electroplating device according to the electroplating signal; the electroplating device includes: a first electroplating unit, for electroplating the electrode array; a first detection signal sending unit, It is used to send a detection signal to the second multi-channel analog switch after the electroplating is completed; the first connection unit in the second multi-channel analog switch is used to switch to the detection device according to the detection signal connected; the detection device also includes: a second measuring unit for measuring the impedance value of the electrode array after the electroplating ends when the first multi-channel analog switch is in the current channel; the second sending unit is used for electroplating After the end of the electroplating, the impedance value of the electrode array is sent to the control unit; the control unit also includes: a second switching unit, which is used to switch the first multi-channel simulation according to the impedance value of the electrode array after the electroplating. switch.

In a preferred embodiment of the present invention, the second switching unit includes: a third judging unit, configured to judge whether the impedance value of the electrode array after electroplating is less than the first impedance threshold; the second feedback The signal output unit is used to output a positive feedback signal when the third judging unit judges yes; the second channel switching unit is used to switch the first multi-channel analog switch according to the positive feedback signal to enter to the next channel.

In a preferred embodiment of the present invention, the second switching unit includes: a fourth judging unit for judging whether the impedance value of the electrode array after the electroplating is greater than the first impedance threshold; A unit, configured to acquire a preset electroplating threshold when the fourth judging unit judges yes; a second electroplating signal sending unit, configured to send an electroplating signal to the second multi-channel analog switch; the The second connection unit in the second multi-channel analog switch is used to switch to connect with the electroplating device according to the electroplating signal; the electroplating device includes: a second electroplating unit for the electrode array Perform electroplating threshold secondary electroplating; the second detection signal sending unit is used to send a detection signal to the second multi-channel analog switch after the electroplating threshold secondary electroplating is completed; the first connection unit in the second multi-channel analog switch, It is used to switch to connect with the detection device according to the detection signal; the detection device measurement also includes: a third measurement unit, used to measure the first multi-channel analog switch in the current channel, electroplating The impedance value of the electrode array after the threshold secondary electroplating is completed; the third sending unit is used to send the impedance value of the electrode array after the electroplating threshold secondary electroplating is completed to the control unit; the control unit also includes: a third switching unit is used for switching the first multi-channel analog switch according to the electroplating threshold and the impedance value of the electrode array after the electroplating is completed.

In a preferred embodiment of the present invention, the third switching unit includes: a fifth judging unit, configured to judge whether the impedance value of the electrode array after the electroplating threshold is greater than the first impedance threshold; A third feedback signal output unit, configured to output a negative feedback signal when the fifth judging unit judges yes; a third channel switching unit, configured to switch the first multi-channel according to the negative feedback signal The analog switch goes to the next channel.

In a preferred embodiment of the present invention, the electroplating device further includes: a third electroplating unit, configured to perform n times of electroplating on the electrode array, where n is a positive integer and less than the electroplating threshold; The third detection signal sending unit is used to send a detection signal to the second multi-channel analog switch after n times of electroplating; the first connection unit in the second multi-channel analog switch is used to detect according to the The signal is switched to be connected with the detection device; the measurement of the detection device also includes: a fourth measurement unit, which is used to measure the impedance value of the electrode array after n times of electroplating when the first multi-channel analog switch is in the current channel The fourth sending unit is used to send the impedance value of the electrode array after n times of electroplating to the control unit; the control unit also includes: a fourth switching unit, which is used to transmit the impedance value of the electrode array according to the n times of electroplating. The impedance value of the rear electrode array switches the first multi-channel analog switch.

In a preferred embodiment of the present invention, the fourth switching unit includes: a sixth judging unit, configured to judge whether the impedance value of the electrode array after the n times of electroplating is greater than the first impedance threshold; The four-feedback signal output unit is used to output a zero feedback signal when the sixth judging unit judges yes; the fourth channel switching unit is used to switch the first multi-channel analog according to the zero feedback signal Switch to re-enter the current channel.

In a preferred embodiment of the present invention, the system further includes: a recording unit, configured to store channel information of the electrode array sent by the control unit.

In a preferred embodiment of the present invention, the system further includes: a third multi-channel analog switch connected to the recording unit; a display unit connected to the third multi-channel analog switch for displaying Channel information of the electrode array.

The beneficial effect of the present invention is that it provides a multi-channel electrode array switching method and system, the first multi-channel analog switch and the second multi-channel analog switch are controlled by the control unit, combined with the detection device and the electroplating device, the realization of Fully automatic multi-channel microelectrode modification and measurement and automatic switching between channels realizes the preparation of microelectrode arrays under unattended conditions, accelerates the preparation process of neural electrodes, and is suitable for the production of commercial neural microelectrode arrays. The invention solves the problem of switching between multiple instruments and multiple channels in the preparation and detection process of the neural microelectrode array used for electrophysiological research in the prior art.

In order to make the above and other objects, features and advantages of the present invention more comprehensible, preferred embodiments will be described in detail below together with the accompanying drawings.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

FIG. 1 is a flow chart of Embodiment 1 of a method for switching a multi-channel electrode array provided by an embodiment of the present invention;

FIG. 2 is a flow chart of Embodiment 2 of a method for switching a multi-channel electrode array provided by an embodiment of the present invention;

FIG. 3 is a flow chart of Embodiment 3 of a method for switching a multi-channel electrode array provided by an embodiment of the present invention;

FIG. 4 is a specific flow chart of the first embodiment of step S105 in FIG. 1;

FIG. 5 is a specific flow chart of the second embodiment of step S105 in FIG. 1;

FIG. 6 is a specific flow chart of the first embodiment of step S509 in FIG. 5;

FIG. 7 is a specific flow chart of the second embodiment of step S509 in FIG. 5;

FIG. 8 is a specific flowchart of step S709 in FIG. 7;

FIG. 9 is a specific flow chart of the third embodiment of step S509 in FIG. 5;

FIG. 10 is a specific flowchart of step S909 in FIG. 9;

Fig. 11 is a structural block diagram of Embodiment 1 of a multi-channel electrode array switching system provided by an embodiment of the present invention;

Fig. 12 is a structural block diagram of Embodiment 2 of a multi-channel electrode array switching system provided by an embodiment of the present invention;

Fig. 13 is a structural block diagram of Embodiment 3 of a multi-channel electrode array switching system provided by an embodiment of the present invention;

FIG. 14 is a structural block diagram of Embodiment 4 of a switching system for a multi-channel electrode array provided by an embodiment of the present invention;

Fig. 15 is a structural block diagram of Embodiment 5 of a switching system for a multi-channel electrode array provided by an embodiment of the present invention;

Fig. 16 is a structural block diagram of Embodiment 6 of a multi-channel electrode array switching system provided by an embodiment of the present invention;

Fig. 17 is a structural block diagram of Embodiment 7 of a multi-channel electrode array switching system provided by an embodiment of the present invention;

Fig. 18 is a structural block diagram of Embodiment 8 of a switching system for a multi-channel electrode array provided by an embodiment of the present invention;

Fig. 19 is a structural block diagram of Embodiment 9 of a multi-channel electrode array switching system provided by an embodiment of the present invention;

Fig. 20 is a structural block diagram of Embodiment 10 of a multi-channel electrode array switching system provided by an embodiment of the present invention;

Fig. 21 is a schematic diagram of a multi-channel electrode array automatic switching scheme in a specific embodiment provided by the present invention.

detailed description

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

In order to improve the spatial resolution of electrodes and record the electrical activities of more nerve cells, microelectrode arrays are currently used for electrophysiological recording. The number of channels of the microelectrode array usually reaches more than 64 channels, or even thousands of channels. Therefore, the modification and detection process of multi-channel electrode arrays is very tedious. However, there is currently no channel switching device dedicated to the modification and detection of neural electrodes, so switching can only be done manually. This not only consumes a lot of manpower for repetitive work, but also requires technical personnel with certain professional knowledge to judge and record the measurement results, which is prone to errors, and is very likely to damage the electrode due to improper parameter control or improper operation.

In view of the deficiencies of the above-mentioned solutions, the purpose of the present invention is to provide a switching method and system for multi-channel electrode arrays, to solve the problems between multiple instruments and multi-channels in the preparation and detection process of neural microelectrode arrays currently used for electrophysiological research. Toggle question. This system is especially suitable for the preparation and detection of microelectrode arrays with more than 64 channels, which can accelerate the preparation process of nerve electrodes. By combining with electrode plating devices and detection devices, commercialized nerve microelectrode arrays can be realized under unattended conditions. modification and detection.

Fig. 1 is a specific flowchart of Embodiment 1 of a method for switching a multi-channel electrode array proposed by the present invention. It can be seen from Fig. 1 that in Embodiment 1, the method includes:

S101: The control unit sends a detection signal to the second multi-channel analog switch.

S102: The second multi-channel analog switch is switched to connect with the detection device according to the detection signal.

S103: The detection device measures the impedance value of the electrode array when the first multi-channel analog switch is in the current channel.

S104: The detection device sends the impedance value to the control unit.

S105: The control unit switches the first multi-channel analog switch according to the impedance value.

Fig. 2 is a specific flow chart of Embodiment 2 of a method for switching a multi-channel electrode array proposed by the present invention. It can be seen from Fig. 2 that in Embodiment 2, the method includes:

S201: The control unit sends a detection signal to the second multi-channel analog switch.

S202: The second multi-channel analog switch is switched to connect with the detection device according to the detection signal.

S203: The detection device measures the impedance value of the electrode array when the first multi-channel analog switch is in the current channel.

S204: The detection device sends the impedance value to the control unit.

S205: The control unit switches the first multi-channel analog switch according to the impedance value.

S206: The control unit sends the channel information of the electrode array to the recording unit.

S207: The recording unit stores channel information of the electrode array.

Fig. 3 is a specific flowchart of Embodiment 3 of a method for switching a multi-channel electrode array proposed by the present invention. It can be seen from Fig. 3 that in Embodiment 3, the method includes:

S301: The control unit sends a detection signal to the second multi-channel analog switch.

S302: The second multi-channel analog switch is switched to connect with the detection device according to the detection signal.

S303: The detection device measures the impedance value of the electrode array when the first multi-channel analog switch is in the current channel.

S304: The detection device sends the impedance value to the control unit.

S305: The control unit switches the first multi-channel analog switch according to the impedance value.

S306: The control unit sends the channel information of the electrode array to the recording unit.

S307: The recording unit stores channel information of the electrode array.

S308: The recording unit outputs the channel information of the electrode array to the display unit through the third multi-channel analog switch;

S309: The display unit displays channel information of the electrode array.

In a specific implementation manner, the third multi-channel analog switch directly enters the next channel after being exposed to the output signal.

The display unit is composed of LED lights equal to the number of electrode interface channels; when positive feedback is received, the LED lights of the same channel are on; when negative feedback is received, the LED lights of the same channel are off.

FIG. 4 is a specific flow chart of the first embodiment of step S105 in FIG. 1. As can be seen from FIG. 4, this step includes:

S401: The control unit acquires a preset first impedance threshold and a second impedance threshold, and the first impedance threshold is smaller than the second impedance threshold. In a specific embodiment, the preset first impedance threshold is, for example, 500 kΩ, and the preset second impedance threshold is, for example, 3000 kΩ.

S402: The control unit judges whether the impedance value is smaller than the first impedance threshold or whether the impedance value is larger than the second impedance threshold.

S403: When the judgment is yes, the control unit outputs a negative feedback signal.

S404: The control unit switches the first multi-channel analog switch to the next channel according to the negative feedback signal.

S405: The control unit records channel information of the electrode array.

In a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, first switch the first multi-channel analog switch to the current channel, such as channel 1, and simultaneously The channel analog switch is switched to channel 1 (that is, connected to the detection device) and the impedance measurement is started. When the impedance value of the electrode array is less than 500kΩ or greater than 3000kΩ when the electrode array is not electroplated, the feedback of the impedance measurement result is negative, that is, a negative feedback signal is output. The control unit controls the first multi-channel analog switch by receiving the feedback signal. When the feedback signal is defined as negative, output negative feedback to the recording unit, directly record channel information and control the first multi-channel analog switch to enter the next channel.

FIG. 5 is a specific flow chart of the second embodiment of step S105 in FIG. 1. As can be seen from FIG. 5, this step specifically includes:

S501: The control unit acquires a preset first impedance threshold and a second impedance threshold, and the first impedance threshold is smaller than the second impedance threshold.

In a specific embodiment, the preset first impedance threshold is, for example, 500 kΩ, and the preset second impedance threshold is, for example, 3000 kΩ.

S502: The control unit judges whether the impedance value is greater than the first impedance threshold and smaller than the second impedance threshold.

S503: When the judgment is yes, the control unit sends an electroplating signal to the second multi-channel analog switch;

S504: The second multi-channel analog switch is switched to connect with the electroplating device according to the electroplating signal;

S505: The electroplating device performs electroplating on the electrode array;

S506: After the electroplating is finished, the second multi-channel analog switch is switched to be connected to the detection device;

S507: The detection device measures the impedance value of the electrode array after the electroplating is completed when the first multi-channel analog switch is in the current channel;

S508: the detection device sends the impedance value of the electrode array after electroplating to the control unit;

S509: The control unit switches the first multi-channel analog switch according to the impedance value of the electrode array after electroplating.

In a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, first switch the first multi-channel analog switch to the current channel, such as channel 1, and simultaneously The channel analog switch is switched to channel 1 (that is, connected to the detection device) and the impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement.

FIG. 6 is a specific flow chart of the first implementation of step S509 in FIG. 5. It can be seen from FIG. 6 that this step specifically includes:

S601: The control unit judges whether the impedance value of the electrode array after electroplating is less than the first impedance threshold.

S602: When the judgment is yes, the control unit outputs a positive feedback signal;

S603: The control unit switches the first multi-channel analog switch to the next channel according to the positive feedback signal.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is less than 500kΩ, switch the first multi-channel analog switch to the next channel. That is, when the impedance value of the electrode array after electroplating is less than 500kΩ, the output signal is defined as positive, that is, a positive feedback signal is output. The control unit controls the first multi-channel analog switch by receiving the feedback signal, and when the feedback signal is defined as positive, the output is positively fed back to the recording unit, and controls the first multi-channel analog switch to enter the next channel.

FIG. 7 is a specific flow chart of the second embodiment of step S509 in FIG. 5. As can be seen from FIG. 7, this step includes:

S701: The control unit judges whether the impedance value of the electrode array after electroplating is greater than the first impedance threshold.

S702: When the determination is yes, the control unit acquires a preset electroplating threshold. In a specific embodiment, the plating threshold is, for example, 5.

S703: the control unit sends an electroplating signal to the second multi-channel analog switch;

S704: The second multi-channel analog switch is switched to connect with the electroplating device according to the electroplating signal.

S705: The electroplating device performs electroplating threshold electroplating on the electrode array;

S706: After the electroplating threshold is finished, the second multi-channel analog switch is switched to be connected to the detection device;

S707: The detection device measures the impedance value of the electrode array after the electroplating threshold second electroplating is completed when the first multi-channel analog switch is in the current channel;

S708: the detection device sends the impedance value of the electrode array after the electroplating threshold to the control unit;

S709: The control unit switches the first multi-channel analog switch according to the electroplating threshold and the impedance value of the electrode array after electroplating is completed.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After the electroplating is repeated for a threshold number of times (such as 5 times), the detection device measures the impedance value at this time. The control unit switches the first multi-channel analog switch according to the impedance value at this time.

Fig. 8 is the specific flowchart of step S709 in Fig. 7, as can be seen from Fig. 8, this step specifically comprises:

S801: The control unit judges whether the impedance value of the electrode array after the electroplating threshold is greater than the first impedance threshold;

S802: When the judgment is yes, the control unit outputs a negative feedback signal;

S803: The control unit switches the first multi-channel analog switch to the next channel according to the negative feedback signal.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After the electroplating is repeated for a threshold number of times (such as 5 times), the detection device measures the impedance value at this time. When the impedance value at this time is greater than 500kΩ, directly record the channel information and switch the first multi-channel analog switch to the next channel. At this time, when the impedance value of the electrode array is still greater than 500kΩ after 5 cycles after electroplating, the output signal is defined as negative, that is, a negative feedback signal is output. The control unit controls the first multi-channel analog switch by receiving the feedback signal. When the feedback signal is defined as negative, the output is negatively fed back to the recording unit, and controls the first multi-channel analog switch to enter the next channel.

FIG. 9 is a specific flow chart of the third implementation of step S509 in FIG. 5. It can be seen from FIG. 9 that this step specifically includes:

S901: The control unit determines whether the impedance value of the electrode array after the electroplating is greater than the first impedance threshold;

S902: when the judgment is yes, the control unit acquires a preset electroplating threshold;

S903: the control unit sends an electroplating signal to the second multi-channel analog switch;

S904: The second multi-channel analog switch is switched to connect with the electroplating device according to the electroplating signal;

S905: The electroplating device performs n times of electroplating on the electrode array, where n is a positive integer and less than the electroplating threshold;

S906: After the n times of electroplating are completed, the second multi-channel analog switch is switched to be connected to the detection device;

S907: The detection device measures the impedance value of the electrode array after n times of electroplating when the first multi-channel analog switch is in the current channel;

S908: the detection device sends the impedance value of the electrode array after n times of electroplating to the control unit;

S909: The control unit switches the first multi-channel analog switch according to the impedance value of the electrode array after the n times of electroplating.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After repeating n times of electroplating (such as 1, 2, 3, 4 times), the detection device measures the impedance value at this time.

Fig. 10 is a specific flowchart of step S909 in Fig. 9, as can be seen from Fig. 10, this step specifically includes:

S1001: The control unit judges whether the impedance value of the electrode array after the n times of electroplating is greater than the first impedance threshold;

S1002: When the judgment is yes, the control unit outputs a zero feedback signal;

S1003: The control unit switches the first multi-channel analog switch to re-enter the current channel according to the zero feedback signal.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After repeated electroplating threshold times (such as 1, 2, 3, 4 times), the detection device measures the impedance value at this time. When the impedance value at this time is greater than 500kΩ, the output signal is defined as zero, that is, a zero feedback signal is output. When the feedback signal is defined as zero, the control unit controls the first multi-channel analog switch to re-enter the original channel.

As mentioned above, the present invention provides a multi-channel electrode array switching method, which can realize full-motion multi-channel microelectrode modification and measurement, and automatic switching between channels. The preparation of the microelectrode array under unattended conditions is realized, the preparation process of the neural electrode is accelerated, and it is suitable for the production of commercial neural microelectrode arrays.

The patent of the present invention intends to use an automatic switching system for multi-channel electrode arrays to solve the problem of switching between multiple instruments and multiple channels in the process of preparation and detection of neural micro-electrode arrays currently used for electrophysiological research. This system is especially suitable for the preparation and detection of microelectrode arrays with more than 64 channels, can accelerate the preparation process of nerve electrodes, and can realize the modification and detection of commercial nerve microelectrode arrays under unattended conditions.

Fig. 11 is a structural block diagram of Embodiment 1 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 11 that in Embodiment 1, the system includes a detection device 108 and an electroplating device 107, Also includes: a control unit 100; a first multi-channel analog switch 101 and a second multi-channel analog switch 109 connected to the control unit; electrodes connected to the first multi-channel analog switch through an electrode interface 102 array 103 .

Wherein, the control unit 100 includes:

The detection signal sending unit 11 is configured to send a detection signal to the second multi-channel analog switch.

The second multi-channel analog switch 109 includes: a first connection unit 91, configured to switch to connect with the detection device according to the detection signal.

The detection device 108 includes:

The first measurement unit 81 is configured to measure the impedance value of the electrode array when the first multi-channel analog switch is in the current channel.

The first sending unit 82 is configured to send the impedance value to the control unit.

The control unit further includes: a first switching unit 12, configured to switch the first multi-channel analog switch according to the impedance value.

Fig. 12 is a structural block diagram of Embodiment 2 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 12 that in Embodiment 2, the system further includes:

The recording unit 104 is configured to store channel information of the electrode array sent by the control unit.

Fig. 13 is a structural block diagram of Embodiment 3 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 13 that in Embodiment 3, the system further includes:

The third multi-channel analog switch 105 is connected to the recording unit;

The display unit 106 connected to the third multi-channel analog switch is configured to display channel information of the electrode array.

In a specific implementation manner, the third multi-channel analog switch directly enters the next channel after being exposed to the output signal.

The display unit is composed of LED lights equal to the number of electrode interface channels; when positive feedback is received, the LED lights of the same channel are on; when negative feedback is received, the LED lights of the same channel are off.

The multi-channel electrode array switching system provided by the present invention includes a control unit 100, a first multi-channel analog switch 101 connected to the control unit, a second multi-channel analog switch 109, and the first multi-channel analog switch 109 through the electrode interface 102. An electrode array 103 connected to a multi-channel analog switch, an electrode interface 102 , a recording unit 104 , a third multi-channel analog switch, and a display unit 106 .

Wherein, the control unit 100 is used to control the first multi-channel analog switch and the second multi-channel analog switch 109, and transmit the channel information of the electrode array 103 to the recording unit 104; the first multi-channel analog switch 101 is connected to the electrode interface 102, and uses For the switching of the electrode interface 102 channels; the electrode interface 102 is connected to the electrode array 103 for conducting with the electrode array 103; the second multi-channel analog switch 109 is connected to the electroplating device 107 and the detection device 108 for the electroplating device 107 and the detection device Switching between 108; the detection device 108 is connected to the control unit 100, and the impedance detection signal is fed back to the control unit 100; the recording unit 104 is used for storing electrode channel information, and the result is output to the display unit 106 through the multi-channel analog switch C105; The third multi-channel analog switch 105 is used for switching channels of the display unit 106, and the display unit 106 is used for displaying information of electrode channels.

The second multi-channel analog switch 109 includes two channels, which are respectively connected to the electroplating device 107 and the measuring device 108 . The control unit 100 is connected with the second multi-channel analog switch 109 for switching the second multi-channel analog switch 109 in the electroplating device 107 and the measuring device 108 .

The detection device 108 is connected to the control unit 100 for feeding back the impedance measurement result of the electrode array 103 at 1 kHz to the control unit 100 .

Impedance measurement feedback is one of positive, negative or zero. Among them, when the impedance value of the electrode is greater than 500kΩ and less than 3000kΩ when it is not electroplated, or the impedance value of the electrode is less than 500kΩ after electroplating, the output signal is defined as positive; when the impedance value of the electrode is less than 500kΩ or greater than 3000kΩ when it is not electroplated, or the electrode is in When the impedance value is greater than 500kΩ after 5 cycles of electroplating, the output signal is defined as negative; when the electrode has less than 5 electroplating cycles, if the impedance value is greater than 500kΩ, the output signal is defined as zero.

The control unit 100 controls the first multi-channel analog switch 101 by receiving the feedback signal; when the feedback signal is defined as positive, the output is positively fed back to the recording unit 104, and controls the first multi-channel analog switch 101 to enter the next channel; when the feedback When the signal is defined as negative, output negative feedback to the recording unit 104, and control the first multi-channel analog switch 101 to enter the next channel; when the feedback signal is defined as zero, control the first multi-channel analog switch 101 to re-enter the original channel.

The control unit simultaneously controls the first multi-channel analog switch 101 and the second multi-channel analog switch 109, and when the control unit controls the first multi-channel analog switch 101 to enter a new channel or re-enter the old channel, the control unit 100 simultaneously controls the second multi-channel analog switch 109. Channel analog switch 109 is reset to channel 1. In the second multi-channel analog switch 109 , channel 1 is connected to the detection device 108 , and channel 2 is connected to the electroplating device 107 . When the electrode detection is completed, the control unit 100 receives the measurement signal and controls the second multi-channel analog switch 109 to switch to channel 2, and switch back to channel 1 within a specified time.

The feedback signal can be triggered manually or through the detection device 108 .

Fig. 14 is a structural block diagram of Embodiment 4 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 14 that the first switching unit 12 includes:

The impedance threshold acquisition unit 121 is configured to acquire a preset first impedance threshold and a second impedance threshold, and the first impedance threshold is smaller than the second impedance threshold. In a specific embodiment, the preset first impedance threshold is, for example, 500 kΩ, and the preset second impedance threshold is, for example, 3000 kΩ.

The first judging unit 122 is configured to judge whether the impedance value is smaller than the first impedance threshold or whether the impedance value is larger than the second impedance threshold.

The first feedback signal output unit 123 is configured to output a negative feedback signal when the first judgment unit judges yes.

The first channel switching unit 124 is configured to switch the first multi-channel analog switch to the next channel according to the negative feedback signal.

The channel information recording unit 125 is configured to record the channel information of the electrode array.

In a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, first switch the first multi-channel analog switch to the current channel, such as channel 1, and simultaneously The channel analog switch is switched to channel 1 (that is, connected to the detection device) and the impedance measurement is started. When the impedance value of the electrode array is less than 500kΩ or greater than 3000kΩ when the electrode array is not electroplated, the feedback of the impedance measurement result is negative, that is, a negative feedback signal is output. The control unit controls the first multi-channel analog switch by receiving the feedback signal. When the feedback signal is defined as negative, output negative feedback to the recording unit, directly record channel information and control the first multi-channel analog switch to enter the next channel.

Fig. 15 is a structural block diagram of Embodiment 5 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 15 that the first switching unit 12 further includes:

The second judging unit 126 is configured to judge whether the impedance value is greater than the first impedance threshold and smaller than the second impedance threshold.

The first electroplating signal sending unit 127 is configured to send an electroplating signal to the second multi-channel analog switch by the control unit when the second judging unit judges yes;

The second multi-channel analog switch 109 also includes: a second connection unit 92, which is used to switch to connect with the electroplating device according to the electroplating signal;

The electroplating device 107 includes: a first electroplating unit 71 for electroplating the electrode array;

The first detection signal sending unit 72 is configured to send a detection signal to the second multi-channel analog switch after the electroplating is finished;

The first connection unit 91 in the second multi-channel analog switch is used to switch to connect with the detection device according to the detection signal;

The detection device 108 also includes: a second measurement unit 83, which is used to measure the impedance value of the electrode array after the electroplating is completed when the first multi-channel analog switch is in the current channel;

The second sending unit 84 is used to send the impedance value of the electrode array after electroplating to the control unit;

The control unit 100 further includes: a second switching unit 13, configured to switch the first multi-channel analog switch according to the impedance value of the electrode array after the electroplating is completed.

In a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, first switch the first multi-channel analog switch to the current channel, such as channel 1, and simultaneously The channel analog switch is switched to channel 1 (that is, connected to the detection device) and the impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement.

Fig. 16 is a structural block diagram of Embodiment 6 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 16 that the second switching unit 13 includes:

The third judging unit 131 is configured to judge whether the impedance value of the electrode array after electroplating is less than the first impedance threshold.

The second feedback signal output unit 132 is configured to output a positive feedback signal to the control unit when the third judging unit judges yes;

The second channel switching unit 133 is used for the control unit to switch the first multi-channel analog switch to the next channel according to the positive feedback signal.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is less than 500kΩ, switch the first multi-channel analog switch to the next channel. That is, when the impedance value of the electrode array after electroplating is less than 500kΩ, the output signal is defined as positive, that is, a positive feedback signal is output. The control unit controls the first multi-channel analog switch by receiving the feedback signal, and when the feedback signal is defined as positive, the output is positively fed back to the recording unit, and controls the first multi-channel analog switch to enter the next channel.

Fig. 17 is a structural block diagram of Embodiment 7 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 17 that the second switching unit 13 includes:

The fourth judging unit 134 is configured to judge whether the impedance value of the electrode array after electroplating is greater than the first impedance threshold.

The electroplating threshold acquisition unit 135 is configured to, when the fourth judging unit judges yes, the control unit acquires a preset electroplating threshold. In a specific embodiment, the plating threshold is, for example, 5.

A second electroplating signal sending unit 136, configured to send an electroplating signal to the second multi-channel analog switch;

The second connection unit 92 in the second multi-channel analog switch 109 is used to switch to connect with the electroplating device according to the electroplating signal.

The electroplating device 107 includes: a second electroplating unit 73, which is used to perform electroplating threshold secondary electroplating on the electrode array;

The second detection signal sending unit 74 is used to send a detection signal to the second multi-channel analog switch after the electroplating threshold is completed;

The first connection unit 91 in the second multi-channel analog switch is used to switch to connect with the detection device according to the detection signal;

The detection device measurement 108 also includes: a third measurement unit 85, which is used to measure the impedance value of the electrode array after the first multi-channel analog switch is in the current channel and the electroplating threshold is completed;

The third sending unit 86 is used to send the impedance value of the electrode array after the electroplating threshold second electroplating to the control unit;

The control unit further includes: a third switching unit 14, configured to switch the first multi-channel analog switch according to the electroplating threshold and the impedance value of the electrode array after the electroplating is completed.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After the electroplating is repeated for a threshold number of times (such as 5 times), the detection device measures the impedance value at this time. The control unit switches the first multi-channel analog switch according to the impedance value at this time.

Fig. 18 is a structural block diagram of Embodiment 8 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 18 that the third switching unit 14 includes:

The fifth judging unit 141 is used to judge whether the impedance value of the electrode array after the electroplating threshold is greater than the first impedance threshold;

The third feedback signal output unit 142 is configured to output a negative feedback signal to the control unit when the fifth judgment unit judges yes;

The third channel switching unit 143 is configured to switch the first multi-channel analog switch to the next channel according to the negative feedback signal.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After the electroplating is repeated for a threshold number of times (such as 5 times), the detection device measures the impedance value at this time. When the impedance value at this time is greater than 500kΩ, directly record the channel information and switch the first multi-channel analog switch to the next channel. At this time, when the impedance value of the electrode array is still greater than 500kΩ after 5 cycles after electroplating, the output signal is defined as negative, that is, a negative feedback signal is output. The control unit controls the first multi-channel analog switch by receiving the feedback signal. When the feedback signal is defined as negative, the output is negatively fed back to the recording unit, and controls the first multi-channel analog switch to enter the next channel.

Fig. 19 is a structural block diagram of Embodiment 9 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 19 that:

The electroplating device 107 further includes: a third electroplating unit 75, configured to perform n times of electroplating on the electrode array, where n is a positive integer and less than the electroplating threshold;

The third detection signal sending unit 76 is configured to send a detection signal to the second multi-channel analog switch after n times of electroplating;

The first connection unit 91 in the second multi-channel analog switch is used to switch to connect with the detection device according to the detection signal;

The detection device 108 also includes: a fourth measurement unit 87, which is used to measure the impedance value of the electrode array after n times of electroplating when the first multi-channel analog switch is in the current channel;

The fourth sending unit 88 is used to send the impedance value of the electrode array after n times of electroplating to the control unit;

The control unit further includes: a fourth switching unit 15, configured to switch the first multi-channel analog switch according to the impedance value of the electrode array after the n times of electroplating.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After repeating n times of electroplating (such as 1, 2, 3, 4 times), the detection device measures the impedance value at this time.

Fig. 20 is a structural block diagram of Embodiment 10 of a multi-channel electrode array switching system provided by an embodiment of the present invention. It can be seen from Fig. 20 that the fourth switching unit 15 includes:

A sixth judging unit 151, configured to judge whether the impedance value of the electrode array after the n times of electroplating is greater than the first impedance threshold;

The fourth feedback signal output unit 152 is configured to, when the sixth judgment unit judges yes, the control unit outputs a zero feedback signal;

The fourth channel switching unit 153 is configured to switch the first multi-channel analog switch to re-enter the current channel according to the zero feedback signal.

That is, in a specific embodiment of the present invention, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to the current channel, such as channel 1, while the Two multi-channel analog switches are switched to channel 1 (that is, connected to the detection device) and impedance measurement is started. When the impedance value of the electrode array is greater than 500kΩ and less than 3000kΩ when the electrode array is not electroplated, switch the second multi-channel analog switch to channel 2 (that is, connect to the electroplating device) and start electroplating, and automatically jump after electroplating (such as after 5 seconds) Back to channel 2 (that is, connected to the detection device) for impedance measurement. When the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to the channel (that is, connect to the electroplating device) for re-plating. After repeated electroplating threshold times (such as 1, 2, 3, 4 times), the detection device measures the impedance value at this time. When the impedance value at this time is greater than 500kΩ, the output signal is defined as zero, that is, a zero feedback signal is output. When the feedback signal is defined as zero, the control unit controls the first multi-channel analog switch to re-enter the original channel.

As mentioned above, the switching system of a multi-channel electrode array provided by the present invention, through the control unit to control the first multi-channel analog switch, the second multi-channel analog switch, combined with the detection device and the electroplating device, can realize the The preparation of the microelectrode array under human-attended conditions accelerates the preparation process of neural electrodes, and is suitable for the production of commercial neural microelectrode arrays. In the specific implementation process, the electrode channel can be manually adjusted according to actual needs, or only one of the electrode preparation and electrode measurement functions can be used.

The technical solution of the present invention will be described in detail below in conjunction with specific embodiments. Fig. 21 is a schematic diagram of a multi-channel electrode array automatic switching scheme in a specific embodiment provided by the present invention. As can be seen from Figure 21, in this specific embodiment, the electrode array is connected to the first multi-channel analog switch through the electrode interface. In the actual operation process, the first multi-channel analog switch is first switched to channel 1, while the second multi-channel The analog switch is also switched to the channel (ie connected to the detection device) and the impedance measurement is started. When the impedance value of the electrode array is less than 500kΩ or greater than 3000kΩ when the electrode array is not electroplated, directly record the channel information and switch the first multi-channel analog switch to the next channel; when the electrode array is not electroplated When the impedance value is greater than 500kΩ and less than 3000kΩ, switch the second Two multi-channel analog switches to channel 2 (that is, connected to the electroplating device) and start electroplating, and automatically jump back to channel 1 (that is, connected to the detection device) after 5 seconds for impedance measurement. When the measured impedance value is less than 500kΩ, switch the first multi-channel analog switch to the next channel; when the measured impedance value is greater than 500kΩ, switch the second multi-channel analog switch to channel 2 (that is, be connected to the electroplating device) for re-plating; When the impedance value is greater than 500kΩ after repeated electroplating 5 times, directly record the channel information and switch the first multi-channel analog switch to the next channel.

To sum up, the present invention proposes a multi-channel electrode array switching method and system, which controls the first multi-channel analog switch and the second multi-channel analog switch through the control unit, and combines the detection device and the electroplating device to realize Fully automatic multi-channel microelectrode modification and measurement and automatic switching between channels realizes the preparation of microelectrode arrays under unattended conditions, accelerates the preparation process of neural electrodes, and is suitable for the production of commercial neural microelectrode arrays. The invention solves the problem of switching between multiple instruments and multiple channels in the preparation and detection process of the neural microelectrode array used for electrophysiological research in the prior art.

Those of ordinary skill in the art can understand that all or part of the processes in the methods of the above embodiments can be implemented through computer programs to instruct related hardware to complete, and the programs can be stored in general computer-readable storage media. During execution, it may include the processes of the embodiments of the above-mentioned methods. Wherein, the storage medium may be a magnetic disk, an optical disk, a read-only memory (Read-Only Memory, ROM) or a random access memory (Random Access Memory, RAM) and the like.

Those skilled in the art can also understand that whether various functions listed in the embodiments of the present invention are implemented by hardware or software depends on specific applications and design requirements of the entire system. Those skilled in the art may use various methods to implement the described functions for each specific application, but such implementation should not be understood as exceeding the protection scope of the embodiments of the present invention.

In the present invention, specific examples have been applied to explain the principles and implementation methods of the present invention. The description of the above examples is only used to help understand the method of the present invention and its core idea; meanwhile, for those of ordinary skill in the art, according to this The idea of the invention will have changes in the specific implementation and scope of application. To sum up, the contents of this specification should not be construed as limiting the present invention.

Claims (20)

1. a switching method of multi-channel electrode array, it is characterized in that, described method comprises: The control unit sends a detection signal to the second multi-channel analog switch; The second multi-channel analog switch is switched to connect with the detection device according to the detection signal; The detection device measures the impedance value of the electrode array when the first multi-channel analog switch is in the current channel; The detection device sends the impedance value to the control unit; The control unit switches the first multi-channel analog switch according to the impedance value. 2. The method according to claim 1, wherein said control unit switching said first multi-channel analog switch according to said impedance value comprises: The control unit acquires a preset first impedance threshold and a second impedance threshold, and the first impedance threshold is smaller than the second impedance threshold; The control unit judges whether the impedance value is less than the first impedance threshold or whether the impedance value is greater than the second impedance threshold; When the judgment is yes, the control unit outputs a negative feedback signal; The control unit switches the first multi-channel analog switch to the next channel according to the negative feedback signal; The control unit records channel information of the electrode array. 3. The method according to claim 1, wherein said control unit switching said first multi-channel analog switch according to said impedance value comprises: The control unit acquires a preset first impedance threshold and a second impedance threshold, and the first impedance threshold is smaller than the second impedance threshold; The control unit judges whether the impedance value is greater than the first impedance threshold and smaller than the second impedance threshold; When the judgment is yes, the control unit sends an electroplating signal to the second multi-channel analog switch; The second multi-channel analog switch is switched to connect with the electroplating device according to the electroplating signal; The electroplating device electroplates the electrode array; After the electroplating is finished, the second multi-channel analog switch is switched to be connected to the detection device; The detection device measures the impedance value of the electrode array after the electroplating is completed when the first multi-channel analog switch is in the current channel; The detection device sends the impedance value of the electrode array after electroplating to the control unit; The control unit switches the first multi-channel analog switch according to the impedance value of the electrode array after electroplating. 4. The method according to claim 3, wherein the control unit switching the first multi-channel analog switch according to the impedance value of the electrode array after the electroplating ends comprises: The control unit judges whether the impedance value of the electrode array after the electroplating is less than the first impedance threshold; When the judgment is yes, the control unit outputs a positive feedback signal; The control unit switches the first multi-channel analog switch to the next channel according to the positive feedback signal. 5. The method according to claim 3, wherein the control unit switching the first multi-channel analog switch according to the impedance value of the electrode array after the electroplating ends comprises: The control unit determines whether the impedance value of the electrode array after the electroplating is greater than the first impedance threshold; When the judgment is yes, the control unit acquires a preset electroplating threshold; The control unit sends an electroplating signal to the second multi-channel analog switch; The second multi-channel analog switch is switched to connect with the electroplating device according to the electroplating signal; The electroplating device performs electroplating threshold electroplating on the electrode array; When the electroplating threshold is finished, the second multi-channel analog switch is switched to be connected to the detection device; The detection device measures the impedance value of the electrode array when the first multi-channel analog switch is in the current channel and after the electroplating threshold is completed; The detection device sends the impedance value of the electrode array to the control unit after the electroplating threshold second electroplating is completed; The control unit switches the first multi-channel analog switch according to the electroplating threshold and the impedance value of the electrode array after electroplating. 6. The method according to claim 5, wherein the control unit switching the first multi-channel analog switch according to the impedance value of the electrode array after the electroplating threshold is completed after the electroplating threshold comprises: The control unit judges whether the impedance value of the electrode array after the electroplating threshold is greater than the first impedance threshold after the end of electroplating; When the judgment is yes, the control unit outputs a negative feedback signal; The control unit switches the first multi-channel analog switch to the next channel according to the negative feedback signal. 7. The method according to claim 3, wherein the control unit switching the first multi-channel analog switch according to the impedance value of the electrode array after the electroplating ends comprises: The control unit judges whether the impedance value of the electrode array after the electroplating is greater than the first impedance threshold; When the judgment is yes, the control unit acquires a preset electroplating threshold; The control unit sends an electroplating signal to the second multi-channel analog switch; The second multi-channel analog switch is switched to connect with the electroplating device according to the electroplating signal; The electroplating device performs n times of electroplating on the electrode array, where n is a positive integer and less than the electroplating threshold; After n times of electroplating, the second multi-channel analog switch is switched to be connected to the detection device; The detection device measures the impedance value of the electrode array after n times of electroplating when the first multi-channel analog switch is in the current channel; The detection device sends the impedance value of the electrode array after n times of electroplating to the control unit; The control unit switches the first multi-channel analog switch according to the impedance value of the electrode array after the n times of electroplating. 8. The method according to claim 7, wherein the control unit switching the first multi-channel analog switch according to the impedance value of the electrode array after the n times of electroplating includes: The control unit judges whether the impedance value of the electrode array after the n times of electroplating is greater than the first impedance threshold; When the judgment is yes, the control unit outputs a zero feedback signal; The control unit switches the first multi-channel analog switch to re-enter the current channel according to the zero feedback signal. 9. method according to claim 1 or 2, is characterized in that, described method also comprises: The control unit sends the channel information of the electrode array to the recording unit; The recording unit stores channel information of the electrode array. 10. method according to claim 9, is characterized in that, described method also comprises: The recording unit outputs the channel information of the electrode array to the display unit through the third multi-channel analog switch; The display unit displays channel information of the electrode array. 11. A switching system for a multi-channel electrode array, characterized in that the system includes a detection device and an electroplating device, and the system also includes: control unit; A first multi-channel analog switch and a second multi-channel analog switch connected to the control unit; An electrode array connected to the first multi-channel analog switch through an electrode interface; Wherein, the control unit includes: A detection signal sending unit, configured to send a detection signal to the second multi-channel analog switch; The second multi-channel analog switch includes: a first connection unit, configured to switch to connect with the detection device according to the detection signal; Described detection device comprises: a first measurement unit, configured to measure the impedance value of the electrode array when the first multi-channel analog switch is in the current channel; a first sending unit, configured to send the impedance value to the control unit; The control unit further includes: a first switching unit, configured to switch the first multi-channel analog switch according to the impedance value. 12. The system according to claim 11, wherein the first switching unit comprises: An impedance threshold acquisition unit, configured to acquire a preset first impedance threshold and a second impedance threshold, and the first impedance threshold is smaller than the second impedance threshold; A first judging unit, configured to judge whether the impedance value is smaller than the first impedance threshold or whether the impedance value is larger than the second impedance threshold; a first feedback signal output unit, configured to output a negative feedback signal when the first judgment unit judges yes; A first channel switching unit, configured to switch the first multi-channel analog switch to the next channel according to the negative feedback signal; The channel information recording unit is used to record the channel information of the electrode array. 13. The system of claim 12, wherein: The first switching unit also includes: A second judging unit, configured to judge whether the impedance value is greater than the first impedance threshold and smaller than the second impedance threshold; The first electroplating signal sending unit is configured to send an electroplating signal to the second multi-channel analog switch when the second judging unit judges yes; The second multi-channel analog switch further includes: a second connection unit, configured to switch to connect with the electroplating device according to the electroplating signal; The electroplating device includes: a first electroplating unit for electroplating the electrode array; The first detection signal sending unit is configured to send a detection signal to the second multi-channel analog switch after the electroplating is completed; The first connection unit in the second multi-channel analog switch is used to switch to connect with the detection device according to the detection signal; The detection device further includes: a second measurement unit, used to measure the impedance value of the electrode array after the electroplating is completed when the first multi-channel analog switch is in the current channel; The second sending unit is used to send the impedance value of the electrode array after electroplating to the control unit; The control unit further includes: a second switching unit, configured to switch the first multi-channel analog switch according to the impedance value of the electrode array after the electroplating is completed. 14. The system according to claim 13, wherein the second switching unit comprises: The third judging unit is used to judge whether the impedance value of the electrode array after the electroplating is less than the first impedance threshold; The second feedback signal output unit is configured to output a positive feedback signal when the third judging unit judges yes; The second channel switching unit is configured to switch the first multi-channel analog switch to the next channel according to the positive feedback signal. 15. The system of claim 13, wherein: The second switching unit includes: The fourth judging unit is used to judge whether the impedance value of the electrode array after the electroplating is greater than the first impedance threshold; An electroplating threshold acquisition unit, configured to acquire a preset electroplating threshold when the fourth judging unit judges yes; A second electroplating signal sending unit, configured to send an electroplating signal to the second multi-channel analog switch; The second connection unit in the second multi-channel analog switch is used to switch to connect with the electroplating device according to the electroplating signal; The electroplating device includes: a second electroplating unit, which is used to perform plating threshold secondary electroplating on the electrode array; The second detection signal sending unit is used to send a detection signal to the second multi-channel analog switch after the electroplating threshold second electroplating is completed; The first connection unit in the second multi-channel analog switch is used to switch to connect with the detection device according to the detection signal; The measurement of the detection device also includes: a third measurement unit, used to measure the impedance value of the electrode array after the electroplating threshold second electroplating is completed when the first multi-channel analog switch is in the current channel; The third sending unit is used to send the impedance value of the electrode array to the control unit after the electroplating threshold second electroplating is completed; The control unit further includes: a third switching unit, configured to switch the first multi-channel analog switch according to the electroplating threshold and the impedance value of the electrode array after electroplating. 16. The system according to claim 15, wherein the third switching unit comprises: The fifth judging unit is used to judge whether the impedance value of the electrode array after the electroplating threshold is greater than the first impedance threshold; A third feedback signal output unit, configured to output a negative feedback signal when the fifth judgment unit judges yes; The third channel switching unit is configured to switch the first multi-channel analog switch to the next channel according to the negative feedback signal. 17. The system of claim 15, wherein: The electroplating device further includes: a third electroplating unit, configured to perform n times of electroplating on the electrode array, where n is a positive integer and less than the electroplating threshold; A third detection signal sending unit, configured to send a detection signal to the second multi-channel analog switch after n times of electroplating; The first connection unit in the second multi-channel analog switch is used to switch to connect with the detection device according to the detection signal; The measurement of the detection device also includes: a fourth measurement unit, which is used to measure the impedance value of the electrode array after n times of electroplating when the first multi-channel analog switch is in the current channel; The fourth sending unit is used to send the impedance value of the electrode array after n times of electroplating to the control unit; The control unit further includes: a fourth switching unit, configured to switch the first multi-channel analog switch according to the impedance value of the electrode array after the n times of electroplating. 18. The system according to claim 17, wherein the fourth switching unit comprises: The sixth judging unit is used to judge whether the impedance value of the electrode array after the n times of electroplating is greater than the first impedance threshold; The fourth feedback signal output unit is configured to output a zero feedback signal when the sixth judgment unit judges yes; The fourth channel switching unit is configured to switch the first multi-channel analog switch to re-enter the current channel according to the zero feedback signal. 19. The system according to claim 11 or 12, wherein the system further comprises: a recording unit, configured to store the channel information of the electrode array sent by the control unit. 20. The system according to claim 19, further comprising: The third multi-channel analog switch is connected to the recording unit; A display unit connected to the third multi-channel analog switch, configured to display channel information of the electrode array.