CN104535610A - Adjustable magnetic field generating device - Google Patents
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Abstract
一种可调式磁场发生装置，由绝缘外壳及设置在绝缘外壳内部的信号发生器、功率放大器、可调式磁热线圈、示波器、磁场测量仪、温度测量仪和带有冷凝管的样品池组成；可调式磁热线圈由两个相互独立的线圈及可调距离式骨架组成，固定槽固定在固定底座上，固定槽的两端设置有线圈距离调节杆，线圈通过固定夹与线圈距离调节杆连接，样品池放置于两线圈之间；信号发生器用于产生不同波形的信号，通过功率放大器的放大与调节，传输给线圈；磁场测量仪用于测定线圈产生的磁场强度；示波器用于测定施加在线圈上的信号；温度测量仪用于实时测量样品池中样品产生的磁热。该装置具有使用器件简单、精确性好、磁场强度大、可调控性好、适用性强等特点。
An adjustable magnetic field generating device is composed of an insulating shell and a signal generator arranged inside the insulating shell, a power amplifier, an adjustable magnetothermal coil, an oscilloscope, a magnetic field measuring instrument, a temperature measuring instrument, and a sample pool with a condenser tube; The adjustable magnetic heating coil is composed of two mutually independent coils and an adjustable distance skeleton. The fixing groove is fixed on the fixed base. The two ends of the fixing groove are provided with coil distance adjustment rods. The coil is connected to the coil distance adjustment rod through the fixing clip. , the sample cell is placed between the two coils; the signal generator is used to generate signals of different waveforms, which are amplified and adjusted by the power amplifier, and transmitted to the coil; the magnetic field measuring instrument is used to measure the magnetic field strength generated by the coil; The signal on the circle; the temperature measuring instrument is used to measure the magnetic heat generated by the sample in the sample cell in real time. The device has the characteristics of simple use of devices, good accuracy, high magnetic field strength, good controllability, strong applicability and the like.
Description
技术领域 technical field
本发明涉及一种磁热装置，具体涉及一种可调式磁场发生装置。 The invention relates to a magnetocaloric device, in particular to an adjustable magnetic field generating device.
背景技术 Background technique
磁热疗是将磁性药物载体输送至治疗区域或特定的目标组织或细胞后，在外加交变磁场的作用下，磁性微粒因磁损耗发热来控制载药系统的药物释放及释放动力学，提高药物的治疗效果及药物利用率。因为磁场可以穿透人体组织，对人体无影响，副作用小，因此，磁场被认为是增强药物在临床治疗中疗效的一种很有前途的工具。目前，并没有现成的可以控制药物磁释放的商品化磁热装置，实验研究中大部分也都是较为简单和粗糙的磁场装置，功能上仍不完善。因此，研发一种具备不同信号调节功能，温控系统，兼顾磁场强度检测，样品池尺寸可调节，施加样品的磁场强度可调可控的磁热磁场发生装置是十分必要的。 Magnetic hyperthermia is to deliver the magnetic drug carrier to the treatment area or specific target tissue or cells, under the action of an external alternating magnetic field, the magnetic particles generate heat due to magnetic loss to control the drug release and release kinetics of the drug-loading system, improving Drug efficacy and drug utilization. Because magnetic fields can penetrate human tissues, have no effect on the human body, and have little side effects, magnetic fields are considered to be a promising tool for enhancing the efficacy of drugs in clinical treatments. At present, there is no ready-made commercial magnetothermal device that can control the magnetic release of drugs, and most of the experimental researches are relatively simple and crude magnetic field devices, which are still not perfect in function. Therefore, it is very necessary to develop a magnetothermal magnetic field generator with different signal adjustment functions, temperature control system, magnetic field strength detection, adjustable sample cell size, and adjustable and controllable magnetic field strength applied to samples.
发明内容 Contents of the invention
为了解决现有磁热装置的空白及功能不完善的问题，本发明提供了一种可调式磁场发生装置，该装置线圈间距离可调、直流/交变磁场可调、产生磁场强度可调，具有使用器件简单、精确性好、磁场强度大、可调控性好、适用性强等特点，在教学，科研及医药领域有较广的应用前景和价值。 In order to solve the problems of blank and imperfect functions of existing magnetothermal devices, the present invention provides an adjustable magnetic field generating device, the distance between the coils of the device is adjustable, the DC/alternating magnetic field is adjustable, and the intensity of the generated magnetic field is adjustable. It has the characteristics of simple use of devices, good accuracy, high magnetic field strength, good controllability, and strong applicability. It has broad application prospects and values in the fields of teaching, scientific research, and medicine.
本发明的目的是通过以下技术方案实现的： The purpose of the present invention is achieved through the following technical solutions:
一种可调式磁场发生装置，由绝缘外壳及设置在绝缘外壳内部的信号发生器、功率放大器、可调式磁热线圈、示波器、磁场测量仪、温度测量仪和带有冷凝管的样品池组成，其中： An adjustable magnetic field generating device is composed of an insulating shell and a signal generator arranged inside the insulating shell, a power amplifier, an adjustable magnetothermal coil, an oscilloscope, a magnetic field measuring instrument, a temperature measuring instrument and a sample pool with a condensing tube. in:
所述可调式磁热线圈由两个相互独立的线圈及可调距离式骨架组成，其中：可调距离式骨架由线圈距离调节杆、固定槽、固定夹和固定底座组成，固定槽固定在固定底座上，固定槽的两端设置有线圈距离调节杆，线圈通过固定夹与线圈距离调节杆连接； The adjustable magnetic heating coil is composed of two mutually independent coils and an adjustable distance skeleton, wherein: the adjustable distance skeleton is composed of a coil distance adjustment rod, a fixing groove, a fixing clip and a fixing base, and the fixing groove is fixed on the fixed On the base, coil distance adjustment rods are arranged at both ends of the fixing groove, and the coil is connected with the coil distance adjustment rod through a fixing clip;
所述样品池放置于两线圈之间； The sample cell is placed between the two coils;
所述信号发生器用于产生不同波形的信号，通过功率放大器的放大与调节，传输给线圈； The signal generator is used to generate signals of different waveforms, which are amplified and adjusted by the power amplifier and transmitted to the coil;
所述磁场测量仪用于测定线圈产生的磁场强度； The magnetic field measuring instrument is used to measure the magnetic field intensity produced by the coil;
所述示波器与线圈连接，用于测定施加在线圈上的信号； The oscilloscope is connected to the coil for measuring the signal applied to the coil;
所述温度测量仪用于实时测量样品池中样品产生的磁热。 The temperature measuring instrument is used for real-time measurement of the magnetic heat generated by the sample in the sample pool.
与现有技术相比，本发明具有如下优点： Compared with prior art, the present invention has following advantage:
一、本发明作为用于磁性药物载体的药物控制释放的可调式磁场装置的设计，采用铁磁非晶为缠绕线圈的磁芯部分，提高了同等条件下磁场区域的强度及空间磁场的均匀度。 1. The design of the present invention as an adjustable magnetic field device for drug controlled release of magnetic drug carriers adopts ferromagnetic amorphous as the magnetic core part of the winding coil, which improves the intensity of the magnetic field area and the uniformity of the spatial magnetic field under the same conditions .
二、该可调式磁场装置通过线圈中间设置间隙，并设有固定底座和可滑动调节杆的方式，使调整样品池的间距更为方便，可满足不同研究对象对样品池间隙的具体需求。 2. The adjustable magnetic field device sets a gap in the middle of the coil, and is equipped with a fixed base and a slidable adjustment rod, which makes it more convenient to adjust the distance between the sample cells and can meet the specific needs of different research objects for the gap between the sample cells.
三、该可调试磁场装置设置有信号发生装置功能，可以实现加载到线圈上的不同波形信号的输出功能。 3. The adjustable magnetic field device is provided with the function of a signal generating device, which can realize the output function of different waveform signals loaded on the coil.
四、该可调试磁场装置设置有功率放大功能，可以实现比较小的输出电流即可产生比较大的磁场幅值(磁感应强度)变化。 4. The adjustable magnetic field device is equipped with a power amplification function, which can generate a relatively large change in the magnetic field amplitude (magnetic induction intensity) with a relatively small output current.
五、该可调试磁场装置设置有磁场强度测量仪，可以实现产生的磁场实时监控功能。 5. The adjustable magnetic field device is equipped with a magnetic field strength measuring instrument, which can realize the real-time monitoring function of the generated magnetic field.
六、该可调试磁场装置设置有温度测量仪，可以实现样品处产生的磁热实时监测与控制功能。 6. The adjustable magnetic field device is equipped with a temperature measuring instrument, which can realize the real-time monitoring and control function of the magnetic heat generated at the sample.
附图说明：Description of drawings:
图1为可调式磁场发生装置的连接框图； Fig. 1 is a connection block diagram of an adjustable magnetic field generating device;
图2为可调线圈装置的俯视图； Figure 2 is a top view of the adjustable coil device;
图3为可调线圈装置的侧视图； Fig. 3 is a side view of the adjustable coil device;
图4为铁磁非晶与线圈距离调节杆的连接剖面图； Fig. 4 is the cross-sectional view of the connection between the ferromagnetic amorphous and the coil distance adjusting rod;
图5为固定槽与线圈距离调节杆的连接剖面图； Fig. 5 is a connection sectional view of the fixed groove and the coil distance adjusting rod;
图中：1-信号发生装置，2-功率放大器，3-可调式磁热线圈，4-示波器，5-磁场测量仪，6-温度测量仪，7-冷凝管，8-样品池，9-磁感应探头，10-热感性探头，11-绝缘外壳，12-铁磁非晶，13-线圈，14-线圈距离调节杆，15-固定槽，16-固定夹，17-固定底座。 In the figure: 1-signal generating device, 2-power amplifier, 3-adjustable magnetothermal coil, 4-oscilloscope, 5-magnetic field measuring instrument, 6-temperature measuring instrument, 7-condensing tube, 8-sample cell, 9- Magnetic induction probe, 10-thermal sensitivity probe, 11-insulating shell, 12-ferromagnetic amorphous, 13-coil, 14-coil distance adjustment rod, 15-fixing groove, 16-fixing clip, 17-fixing base.
具体实施方式 Detailed ways
下面结合附图对本发明的技术方案作进一步的说明，但并不局限于此，凡是对本发明技术方案进行修改或者等同替换，而不脱离本发明技术方案的精神和范围，均应涵盖在本发明的保护范围中。 The technical solution of the present invention will be further described below in conjunction with the accompanying drawings, but it is not limited thereto. Any modification or equivalent replacement of the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention should be covered by the present invention. within the scope of protection.
如图1-5所示，本发明提供的可调式磁场发生装置由绝缘外壳11及设置在绝缘外壳11内部的信号发生器1、功率放大器2、可调式磁热线圈3、示波器4、磁场测量仪5、温度测量仪6和带有冷凝管7的样品池8组成。 As shown in Figures 1-5, the adjustable magnetic field generating device provided by the present invention consists of an insulating casing 11 and a signal generator 1, a power amplifier 2, an adjustable magnetic thermal coil 3, an oscilloscope 4, and a magnetic field measurement device arranged inside the insulating casing 11. instrument 5, a temperature measuring instrument 6 and a sample pool 8 with a condenser tube 7.
所述的可调式磁热线圈3由两个相互独立的磁芯为铁磁非晶12的线圈13及可调距离式骨架组成，可调距离式骨架由线圈距离调节杆14、固定槽15、固定夹16和固定底座17组成，固定槽15固定在固定底座17上，固定槽15的两端设置有线圈距离调节杆14，线圈13通过固定夹16与线圈距离调节杆14连接，可根据不同尺寸的样品池8来调节线圈13间的距离。其中磁芯为横截面为方形结构，缠绕线圈13的导线铜质导线。 Described adjustable magnetocaloric coil 3 is made up of coil 13 and adjustable distance formula skeleton that two mutually independent magnetic cores are ferromagnetic amorphous 12, and adjustable distance formula skeleton is made up of coil distance adjusting rod 14, fixed groove 15, The fixed clip 16 and the fixed base 17 are composed, the fixed groove 15 is fixed on the fixed base 17, the two ends of the fixed groove 15 are provided with the coil distance adjustment rod 14, the coil 13 is connected with the coil distance adjustment rod 14 through the fixed clip 16, and can be adjusted according to different The size of the sample cell 8 to adjust the distance between the coils 13 . Wherein the magnetic core is a square structure with a cross section, and the wires of the coil 13 are wound with copper wires.
所述信号发生器1用于产生不同波形的信号，通过功率放大器2的放大与调节，传输给线圈13。线圈13产生的磁场强度可通过磁场测量仪5直接测定，输出的信号则可以通过示波器4进行检测。线圈间的样品放置处产生的磁场可通过功率放大器2调节施加在线圈13的电流，电压大小以及调节线圈间隙的距离来实现磁场装置的磁场强度控制。 The signal generator 1 is used to generate signals of different waveforms, which are amplified and adjusted by the power amplifier 2 and transmitted to the coil 13 . The magnetic field intensity generated by the coil 13 can be directly measured by the magnetic field measuring instrument 5 , and the output signal can be detected by the oscilloscope 4 . The magnetic field generated at the place where the sample is placed between the coils can be adjusted by the power amplifier 2 to the current applied to the coil 13, the magnitude of the voltage and the distance between the coils to realize the control of the magnetic field intensity of the magnetic field device.
本发明所述可调式磁场发生装置的工作原理是:首先利用铜质导线缠绕在铁磁非晶12上形成可产生磁场的线圈13材料2个，线圈13的缠绕方向是一致的。装置中的信号发生器1为电流及频率信号源，由信号发生器1发出的信号，经过功率放大器2，将输出的信号进行放大与调节输送给缠绕的线圈13，两个线圈13的间隙处即可产生一定的磁场，其强度可以用磁场测量仪5的磁感应探头9进行测量。此时施加在线圈13上的信号可以通过连接的示波器4进行检测。两个线圈13间隙处为样品池8位置，当在样品池8中放置一定可产生磁热的样品时，样品产生的磁热可用温度测量仪6的热感性探头10来实时测量。可根据具体的实验需要，整个流程中可以分别采用信号发生器1发出的波形，电压及频率，功率放大器2适当放大与调节输出的信号以及通过可调式线圈3间的距离来调节实验所需的磁场强度及磁热的频率需要。实验过程的磁场强度及温度又可以通过磁场测量仪5及温度测定仪6进行精确控制，本装置可全面满足磁热效应的相关研究和应用。 The working principle of the adjustable magnetic field generating device of the present invention is as follows: first, copper wires are used to wind the ferromagnetic amorphous 12 to form 2 coils 13 materials capable of generating a magnetic field, and the winding directions of the coils 13 are consistent. The signal generator 1 in the device is the current and frequency signal source. The signal sent by the signal generator 1 passes through the power amplifier 2, and the output signal is amplified and adjusted to the wound coil 13. The gap between the two coils 13 A certain magnetic field can be generated, and its strength can be measured with the magnetic induction probe 9 of the magnetic field measuring instrument 5 . The signal applied to the coil 13 at this time can be detected by the connected oscilloscope 4 . The gap between the two coils 13 is the position of the sample cell 8. When a sample capable of generating magnetic heat is placed in the sample cell 8, the magnetic heat generated by the sample can be measured in real time by the thermosensitive probe 10 of the temperature measuring instrument 6. According to the specific experimental needs, the waveform, voltage and frequency sent by the signal generator 1 can be used in the whole process, the power amplifier 2 can properly amplify and adjust the output signal, and the distance between the adjustable coils 3 can be used to adjust the distance required for the experiment. Magnetic field strength and frequency of magneto-caloric need. The magnetic field strength and temperature during the experiment can be precisely controlled by the magnetic field measuring instrument 5 and the temperature measuring instrument 6. This device can fully meet the related research and application of the magnetocaloric effect.
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| CN110837068A (en) * | 2019-11-25 | 2020-02-25 | 中北大学 | A device that maintains a constant and uniform magnetic field locally and precisely adjusts the direction strength |
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