CN104678115B - Multi-pass agent detection devices in integrated quantitative sampling reagent adding device detector - Google Patents

Abstract

The invention discloses a multi-optical path reagent detection device for an integrated quantitative sampling and reagent adding device detector, which includes a detection and receiving circuit board, a bracket for placing the integrated quantitative sampling and reagent adding device, and a bracket for driving the bracket around the shaft. Swing driving device, two-dimensional code scanner, emitting light source, lens channel matching the emitting light source and photoelectric converter D1; the driving device includes a mixing motor; the number of emitting light sources is greater than or equal to 2; emitting light source, driving device and the lens channel are set on the frame; the output shaft of the mixing motor is fixedly connected to the bracket, and there are trunnions on both sides of the bracket, and the trunnion is connected with the output shaft of the mixing motor; the bracket is located between the emitting light source and the lens channel During this period, the light from the emitting light source is transmitted to the input end of the photoelectric converter D1 through the lens channel, and the output end of the photoelectric converter D1 is connected to the input end of the corresponding detection and receiving circuit board. The invention has the advantages of convenient use, accurate detection, and the ability to realize multi-light path detection in a body.

Description

Multi-light path reagent detection device in the integrated quantitative sampling and reagent device detector

technical field

The invention relates to a multi-optical path detection reagent device, in particular to a multi-optical path reagent detection device in an integrated quantitative sampling and reagent addition device detector.

Background technique

At this stage, the testing of reagents mostly stays at the stage where a single machine completes a single type of test, and one machine cannot be used for multiple purposes, such as absorbance detection, scattering turbidimetric detection, immunofluorescence detection, etc. Each detection requires a different type of detection When testing the sampling reagent, the testing personnel need to place the integrated quantitative sampling and reagent adding device equipped with the sampling reagent in the corresponding testing instrument, which is very inconvenient to use and carry, time-consuming and labor-intensive; at the same time, the placed There is no verification mechanism for sampling reagents. If the testing personnel misplace the detector, it will not only cause inaccurate test results and waste of sampling reagents, but more seriously, it may cause irreversible loss of important sampling reagents. Currently on the market, for the device containing sampling reagents described in the patent titled "An Integrated Quantitative Sampling and Reagent Device" (its patent number is: 201010539091.8), it has not been able to achieve multiple types of internal reagents. Different optical paths are selected and detected, which brings great inconvenience to the use. In actual operation, each time for different reagents, the detector needs to be replaced, which greatly reduces the efficiency of test detection. At this stage, it is often necessary to repeat many times. Step operation, which also increases the probability of reagent deterioration or contamination.

Contents of the invention

The technical problem to be solved by the present invention is to provide a multi-optical path reagent detection device used in an integrated quantitative sampling and reagent detection device, which is convenient to use, accurate in detection, and multi-purpose.

The present invention adopts following technical scheme:

The multi-light path reagent detection device in the integrated quantitative sampling and reagent adding device detector includes a detection and receiving circuit board, a bracket for placing the integrated quantitative sampling and reagent adding device, a driving device for driving the bracket to swing around the axis, A two-dimensional code scanner, an emitting light source, a lens channel matched with the emitting light source, and a photoelectric converter D1; the driving device includes a mixing motor; the number of the emitting light source is greater than or equal to 2, and the number of the lens channel The number is the same as that of the emitting light source; the emitting light source, the driving device and the lens channel are all arranged on the frame;

The output shaft of the mixing motor is fixedly connected to the bracket, and trunnions are arranged on both sides of the bracket, and the trunnions are connected with the output shaft of the mixing motor; The light direction of the light source is consistent; the bracket is located between the emitting light source and the lens channel, and the light of the emitting light source is transmitted to the input end of the photoelectric converter D1 through the lens channel, and the output end of the photoelectric converter D1 is connected to the corresponding detection The input end of the receiving circuit board; the integrated quantitative sampling and reagent adding device is provided with a two-dimensional code for uniquely identifying the tested agent, and the two-dimensional code scanner is connected with the integrated quantitative sampling and reagent adding device on the two-dimensional code position Corresponding.

A lens is arranged in front of the scanning lens of the two-dimensional code scanner. The model of the two-dimensional code scanner can be Keyence two-dimensional code reader R-610.

The emitting light source is a full-wavelength light source and/or a laser tube, the detection and receiving circuit board corresponding to the full-wavelength light source is a grating receiving sensor, and the detection and receiving circuit board corresponding to the laser tube is an adjustable gain light intensity signal receiving amplifier circuit ;

The adjustable gain light intensity signal receiving amplifying circuit includes an operational amplifier chip IC1, a digital potentiometer chip IC2, feedback resistors R1~R2, and capacitors C1~C6; the photoelectric converter D1 is connected to pin 2 of the operational amplifier chip IC1 and between the ground; the resistor R1 and the capacitor C3 are connected in parallel between pin 2 of the operational amplifier chip IC1 and pin 6 of the digital potentiometer chip IC2; the capacitors C1 and C2 are connected in parallel and connected to pin 4 of the operational amplifier chip IC Between the pin and the ground; the 6 pins and 7 pins of the operational amplifier chip IC1 are respectively connected to the 7 pins of the digital potentiometer chip IC2 and the power supply VDD; the parallel connection of the capacitors C4 and C5 is connected to the 7 pins of the operational amplifier chip IC1 and the ground; the capacitor C6 is connected in parallel between the 8 pins of the digital potentiometer chip IC2 and the ground, and the 8 pins of the digital potentiometer chip IC2 are connected to the power supply VCC; the 5 pins of the digital potentiometer chip IC2 are connected through a resistor R2 is grounded; pins 1, 2, and 3 of the digital potentiometer chip IC2 are respectively connected to MCU control pins; the model of the operational amplifier chip IC1 is OTA121, and the model of the digital potentiometer chip IC2 is MCT41050.

Further, the full-wavelength light source may be a light bulb.

When there are three lens channels, one of which needs to correspond to a laser tube, and the other two need to correspond to a full-wavelength light source, the emission light source is a laser tube and a full-wavelength light source, and the two lens channels share a full-wavelength light source, wherein all The wavelength light source is placed in the lampshade, and the light is guided to the luminous place through the optical fiber connected to the lampshade.

As a further improvement of the present invention, it also includes a magnet for determining that the bracket is swinging in place. The magnet is installed on the bracket. The detector is installed at the position where the swing is in place, and the position where the swing is in place is the position corresponding to each emitting light source on the arc track of the bracket swinging.

The magnetic sensor used to identify the position of the magnet is a Hall sensor.

As a further improvement of the present invention, the frame is a height-adjustable bracket.

The bracket is an upper and lower unsealed tubular cavity with vertical openings on the side, and a light-transmitting hole passing through the cavity is provided on the tubular cavity; the position of the light-transmitting hole is related to the emission light source and the lens channel on the same horizontal line, and the direction of the light transmission hole corresponds to the light emitted from the light source.

The beneficial effects of the present invention are:

The invention is reasonable in structure, easy to use, and can realize multi-purpose of one machine. The motor drives the bracket to rotate to the corresponding position and aligns with the corresponding lens channel. Since different sampling reagents in the integrated quantitative sampling and reagent addition device need to adopt different optical paths for detection, The invention can realize the automatic detection of different sampling reagents in the same body without replacing the instrument.

According to the information on the QR code label on the integrated quantitative sampling and reagent device scanned by the QR code scanner, the required detection type can be judged, and the detection type can be automatically rotated and matched to the corresponding lens channel to complete the detection, and according to the information in the QR code The information adopts different judgment methods for the signal of the receiving circuit board through detection, and integrates the multi-light path reagent detection, which reduces the cost, improves the efficiency, saves the time of the detection personnel and patients, and avoids human errors at the same time. The two-dimensional code information classifies and processes the test results of patients to facilitate follow-up work.

In addition, a lens is arranged in front of the scanning lens of the two-dimensional code scanner, and the focal length of the two-dimensional code scanner can be adjusted according to needs, which is convenient to use, and shortens the distance between the two-dimensional code scanner and the sampler, which is conducive to reducing the overall The size of the device improves the overall integration.

The bracket is provided with a magnet for identifying the swing position, which is beneficial to accurate positioning and improves the accuracy of the rotation of the bracket.

The bracket is designed as an upper and lower unsealed tubular cavity with a vertical opening on the side, which is helpful for the subsequent design of the device to move up and down along the strip-shaped vertical opening, and to support the sampler in the bracket to the designated position. It is practical and easy to use.

The device is provided with a frame for fixing the emission light source, the driving device and the lens channel, which has a shock-absorbing effect on the equipment installed on it, and the height of the above-mentioned frame is adjustable, which is convenient for calibrating the height of each component.

Description of drawings

Fig. 1 is a structural schematic diagram of the present invention.

Fig. 2 is a schematic diagram of the structure of the present invention after removing the driving device.

Fig. 3 is a schematic diagram of the positional relationship between the emitting light source and the lens channel in the present invention.

Fig. 4 is a schematic structural diagram of the bracket in the present invention.

Fig. 5 is a schematic circuit diagram of an embodiment of a detection and receiving circuit board in the present invention.

Figure 6 is a schematic diagram of the overall structure of the integrated quantitative sampling and reagent adding device detector.

Fig. 7 is a structural schematic diagram of the mixing structure of the present invention.

Fig. 8 is a schematic structural view of the fixing plate of the present invention.

Fig. 9 is a schematic structural diagram of the fixing plate positioning assembly of the present invention.

Fig. 10 is a schematic diagram of the interlocking relationship between the notch and the protrusion in the present invention.

Fig. 11 is a schematic diagram of the connection relationship between the pressing rack and the horizontal carriage of the present invention.

Fig. 12 is a schematic structural view of the hatch panel of the present invention.

Fig. 13 is a schematic diagram of the state of the bracket swinging to a certain station in the present invention.

Among them, 1 lens, 2 mixing motor, 3 output shaft, 4 emitting light source, 5 lens channel, 6 detection and receiving circuit board, 7 two-dimensional code scanner, 8 light transmission hole, 9 frame, 10 trunnion, 11 vertical Straight opening, 12 integrated quantitative sampling and reagent adding device, 13 magnet, 14 air supply pipe, 15 heating plate, 16 detector shell, 17 driving motor, 18 driving gear, 19 optical fiber, 20 full-wavelength light source, 21 lampshade, 22 Grating receiving sensor, 23 trigger switch, 1-3 display, 1-5 fixing hole, 1-6 splash-proof groove, 2-1 pressing rack, 2-4 guide rod, 2-6 spare guide rail, 2-7 level Carriage, 2-8 guide rail, 2-9 down-pressing linkage gear, 2-10 down-pressing driven gear, 2-11 notch, 2-13 guide rail, 2-15 missing tooth, 2-16 protrusion , 2-17 positioning card, 2-18 pressure plate, 2-19 meshing teeth, 2-21 slave drive gear, 2-22 stepped hole, 3-2 bracket, 3-3 clamping reed, 3-4 support frame , 3-8 fixed plate, 3-9 positioning boss, 3-10 positioning card slot, 3-11 lifting rack frame, 3-12 lifting rack, 3-13 positioning hook, 3-15 limit protrusion , 3-18 ridge-shaped protrusion, 3-21 out of missing teeth, 4-1 hatch, 4-2 hatch panel, 4-3 hatch post, 4-4 hatch slot, 4-5 end baffle, 5-2 pressure flap, 5-3 return spring, 5-4 driven gear, 5-5 vertical slide rail, 5-9 tray, 9-3 guide arc plate.

Detailed ways

The present invention will be further described in detail below in conjunction with accompanying drawings 1 to 13 and specific embodiments.

The bracket 3-2 in this embodiment can be used in conjunction with the device described in the Chinese patent titled "An Integrated Quantitative Sampling and Reagent Device" (patent number: 201010539091.8).

The multi-light path reagent detection device in the integrated quantitative sampling and reagent adding device detector includes a detection receiving circuit board 6, a bracket 3-2 for placing the integrated quantitative sampling and reagent adding device 12, a driving device, and a two-dimensional code scanning device 7, emitting light source 4, lens channel 5 and photoelectric converter D1 matched with emitting light source 4; the driving device includes a mixing motor 2; The number of 5 is the same as the number of emitting light sources 4; the output shaft 3 of the mixing motor 2 is fixedly connected to the bracket 3-2, and the direction of the output shaft 3 of the mixing motor 2 is consistent with the light direction of the emitting light source 4 ; The bracket 3-2 is located between the emitting light source 4 and the lens passage 5, the light of the emitting light source 4 passes through the lens passage 5 to the input end of the photoelectric converter D1, and the output terminal of the photoelectric converter D1 is connected to Corresponding to the input end of the detection receiving circuit board 6; the integrated quantitative sampling and reagent adding device 12 is affixed with a two-dimensional code for uniquely identifying the liquid to be tested, and the two-dimensional code scanner 7 is connected with the integrated quantitative sampling and adding reagent device 12 corresponds to the position of the two-dimensional code.

As shown in Figure 4, the bracket 3-2 is an upper and lower unsealed tubular cavity with strip-shaped vertical openings 11 on the side, and a light-transmitting hole 8 passing through the cavity is provided on the tubular cavity. The position of the light-transmitting hole 8 is on the same horizontal line as the emitting light source 4 and the lens channel 5 , and the direction of the light-transmitting hole 8 corresponds to the light emitted by the emitting light source 4 .

A lens is arranged in front of the scanning lens of the two-dimensional code scanner 7 .

The emitting light source 4 is a full-wavelength light source 20 and/or a laser tube, the detection and receiving circuit board 6 corresponding to the full-wavelength light source 20 is a grating receiving sensor 22, and the detection and receiving circuit board 6 corresponding to the laser tube is an adjustable gain Light intensity signal receiving amplifier circuit;

The detecting and receiving circuit board 6 is an adjustable gain light intensity signal receiving and amplifying circuit, which is a prior art.

As shown in Figure 5, the adjustable gain light intensity signal receiving amplifying circuit includes an operational amplifier chip IC1, a digital potentiometer chip IC2, feedback resistors R1~R2, capacitors C1~C6; the photoelectric converter D1 is connected to the operational amplifier between pin 2 of the chip IC1 and ground; the resistor R1 and capacitor C3 are connected in parallel between pin 2 of the operational amplifier chip IC1 and pin 6 of the digital potentiometer chip IC2; the capacitors C1 and C2 are connected in parallel and then connected to Between pin 4 of the operational amplifier chip IC1 and the ground; pin 6 and pin 7 of the operational amplifier chip IC1 are respectively connected to pin 7 of the digital potentiometer chip IC2 and the power supply VDD; the capacitors C4 and C5 are connected in parallel and connected to the operating Between the pin 7 of the amplifier chip IC1 and the ground; the capacitor C6 is connected in parallel between the pin 8 of the digital potentiometer chip IC2 and the ground, and the pin 8 of the digital potentiometer chip IC2 is connected to the power supply VCC; the digital potentiometer chip The 5 pins of IC2 are grounded through the resistor R2; the 1, 2, and 3 pins of the digital potentiometer chip IC2 are respectively connected to the MCU control pins; the model of the operational amplifier chip IC1 is OTA121, and the model of the digital potentiometer chip IC2 is MCT41050.

Further, the full-wavelength light source 20 may be a light bulb.

As a further improvement of the present invention, it also includes a magnet 13 for determining that the bracket 3-2 is swinging into place, and the magnet 13 is installed on the bracket 3-2, and a magnetic sensor for identifying the position of the magnet 13 is installed at the swinging position , the magnetic sensor used to identify the position of the magnet 13 is a Hall sensor.

As a further improvement of the present invention, the frame 9 includes an emission light source bracket for fixing the emission light source 4 , a driving device bracket for fixing the driving device and/or a lens channel bracket for fixing the lens channel 5 . All three can be installed or installed selectively, mainly to adjust the optical path in a straight line.

As a further improvement of the present invention, the frame 9 is a height-adjustable bracket.

As shown in Figure 3, when there are three lens channels 5, one of which needs to correspond to a laser tube, and the other two need to correspond to a full-wavelength light source 20, the emitting light source 4 is a laser tube and a full-wavelength light source 20, two The lens channel 5 shares a full-wavelength light source 20, wherein the full-wavelength light source 20 is placed in the lampshade 21, and the light is guided to the light emitting place through the optical fiber 19 connected to the lampshade 21. As shown in Figures 1 to 3 and Figure 13, the output shaft 3 of the mixing motor 2 drives the bracket 3-2 to rotate to the position of the corresponding lens channel 5. In this embodiment, three emitting light sources 4 and corresponding Three lens channels 5, the three lens channels 5 are absorbance detection channel, scattering turbidimetric channel and immunofluorescence channel; The first lens is received by the photoelectric converter D1; the immunofluorescence channel, after the light is filtered by the filter, is received by the photoelectric converter D1. The detecting and receiving circuit board 6 is an adjustable gain light intensity signal receiving and amplifying circuit; the detecting and receiving circuit board 6 can make a current amplifying circuit or an integral amplifying circuit or other corresponding ones with similar functions according to the difference of the corresponding emitting light source 4 The circuit belongs to the circuit commonly used by those skilled in the art, and will not be described in detail here.

In this embodiment, the absorbance detection channel and the scattering turbidimetric channel are all connected to the current amplification circuit through the photoelectric converter D1, as shown in Figure 5, the current amplification circuit is an adjustable gain light intensity signal receiving amplification circuit, That is, it includes an operational amplifier chip IC1, a digital potentiometer chip IC2, feedback resistors R1~R2, and capacitors C1~C6; the photoelectric converter D1 is connected between pin 2 of the operational amplifier chip IC1 and the ground; the resistor R1 and the capacitor C3 is connected in parallel between the 2 pins of the operational amplifier chip IC1 and the 6 pins of the digital potentiometer chip IC2; the capacitors C1 and C2 are connected in parallel between the 4 pins of the operational amplifier chip IC1 and the ground; the operational amplifier The 6 pins and 7 pins of the chip IC1 correspond to the 7 pins of the digital potentiometer chip IC2 and the power supply VDD; the capacitors C4 and C5 are connected in parallel and then connected between the 7 pins of the operational amplifier chip IC1 and the ground; the capacitor C6 is connected in parallel Between pin 8 of the digital potentiometer chip IC2 and the ground, pin 8 of the digital potentiometer chip IC2 is connected to the power supply VCC; pin 5 of the digital potentiometer chip IC2 is grounded through a resistor R2; the digital potentiometer chip IC2 The pins 1, 2, and 3 are respectively connected to the MCU control pins; the model of the operational amplifier chip IC1 is OTA121, and the model of the digital potentiometer chip IC2 is MCT41050. The immunofluorescence channel is then connected to an integral amplifier circuit through a photoelectric converter D1, and the integral amplifier circuit has been published in the patent No. ZL200820077266.6.

Working process of the present invention is as follows:

First, put the integrated quantitative sampling and reagent adding device 12 equipped with sampling reagents into the bracket 3-2, and according to the different test agents contained in the integrated quantitative sampling and reagent adding device 12, artificially control the driving motor 17 to rotate, Thereby, the integrated quantitative sampling and reagent adding device 12 in the bracket 3-2 is driven to swing to the corresponding lens channel 5, and the corresponding optical signal receiving and detecting device is selected. In this embodiment, the absorbance detection channel and the scattering turbidity channel are selected. It is still an immunofluorescence channel. After the channel is determined, the mixing motor 2 is automatically started, and the output shaft 3 of the mixing motor 2 rotates to drive the bracket 3-2 to rotate at a certain angle, so that the emission light source 4 is aligned with the light transmission on the bracket 3-2. Holes 8 are equipped with magnetic sensors at each emission light source 4 or on the opposite side. When sensing that the magnet 13 on the bracket 3-2 is in place, since each lens channel 5 has a corresponding emission light source 4, it will The emission light that will start the emission light source 4 penetrates the sampling reagent in the integrated quantitative sampling and reagent addition device 12, the light passes through the sampling reagent and the corresponding lens channel 5 coaxially, and the received light intensity signal is converted by the photoelectric converter D1 Generate an electrical signal, send the electrical signal to the detection and receiving circuit board 6, generate a corresponding current according to the magnitude of the light intensity signal, and the current is amplified by the amplifier circuit composed of operational amplifier chips IC1, R1, C3, and digital potentiometer chips IC2, R2 And converted into a voltage signal and output through the 6 pins of IC1, the digital potentiometer chip IC2 is an adjustable digital potentiometer, which acts in the feedback circuit of the amplifying circuit, and adjusts the tap position of the digital potentiometer chip IC2 through the MCU control signal. The magnification of the circuit is used to achieve the function of adjusting the gain, and the detection result is obtained after processing. The working process is simple and convenient, and the accuracy is high.

When a two-dimensional code label is attached to the integrated quantitative sampling and reagent device 12 of the device, a two-dimensional code scanner 7 needs to be set in the device, and the two-dimensional code scanner 7 is aligned with the two-dimensional code label. After the two-dimensional code scanner 7 scans, it reads the information, and determines the type of lens channel 5 to be selected accordingly, and the follow-up process is the same as above.

The detector is also provided with a temperature control device. The temperature control device includes a heat dissipation block and a heat dissipation fan arranged on the heat dissipation block, a heating sheet 15 and a temperature sensor. The heat dissipation fan is arranged on one side of the heat dissipation block. The sheet 15 is in contact with the heat dissipation block, and the temperature sensor is arranged on the heat dissipation block or in the housing of the detector. An air supply pipe 14 is also arranged on the heat dissipation block, and the air supply pipe 14 is sleeved on the heat dissipation block.

As shown in Figures 1 to 13, the working process of the overall detector is as follows:

First of all, it is used for the start-up detection of the detector of the integrated quantitative sampling and reagent device 12:

After the detector is powered on, the temperature sensor works to obtain the real-time temperature in the cabin. When the temperature is equal to or higher than the preset minimum setting detection standard temperature, the temperature control device enters the standby state; when the temperature is lower than the preset minimum setting When detecting the standard temperature, the temperature control device works, and the heating sheet 15 works after power-on to increase the temperature inside the detector housing 16. When the temperature is equal to or higher than the preset maximum value, the heating sheet 15 stops working; the temperature sensor ensures that the detector The internal temperature of the casing 16 is not lower than a preset temperature range.

A detection device with an integrated quantitative sampling and reagent device 12 is designed to detect whether the integrated quantitative sampling and reagent device 12 is placed in the bracket 3-2. The integrated quantitative sampling and reagent adding device 12 will give an alarm prompt, and start to prepare for the follow-up mixing and detection process; when there is no signal from the integrated quantitative sampling and reagent adding device 12, the detector enters the standby state. The detection device may be a trigger switch 23 or other sensors, such as an infrared sensor switch or a proximity switch.

When it is necessary to detect the reagent in the integrated quantitative sampling and reagent device 12, the driving motor 17 in the body starts, and the driving gear 18 drives the pressing down from the driving gear 2-10 and from the driving gear 2-21, and from the driving gear 2-10. Drive the downward pressure linkage gear 2-9 to push the horizontal carriage 2-7 away from the drive gear 18 through the protrusion 2-16, and the hatch post 4-3 at the top of the horizontal carriage 2-7 passes through the hatch slot 4- 4. Push aside the hatch panel 4-2 at the upper end of the machine body, open the hatch 4-1 above the detector casing 16, and at the same time, lift the lifting rack 3-12 meshed with it from the driving gear 2-21, and lift The rack rack 3-11 rises to the predetermined position thereupon, and now the tray 5-9 of the reagent in the integrated quantitative sampling and reagent device 12 rises to the highest position; this time the detector waits for the integrated quantitative sampling and reagent adding device 12 in place.

The second is to read the reagent tube information:

The operator puts the integrated quantitative sampling and reagent adding device 12 to be tested through the hatch 4-1, and a guide arc plate 9-3 is arranged at the lower part of the detector housing 16 facing the hatch 4-1. Under the guidance of the guide arc plate 9-3, the integrated quantitative sampling and reagent adding device 12 is inserted into the above-mentioned bracket 3-2, and an information code is printed on the integrated quantitative sampling and reagent adding device 12, and the information code and The information reading device is facing, and when the integrated quantitative sampling and reagent device 12 is in place, the detection device senses it, and then judges that the integrated quantitative sampling and reagent device 12 is in place, and the two-dimensional code scanner 7 reads the integrated The information code on the quantitative sampling and adding reagent device 12 judges the angle that the mixing motor 2 should rotate and the emission light source 4 that should be enabled according to the information on the information code, that is, judges the type of reagent to be selected according to the type information of the reagent to be detected represented on the information code. Which kind of emitting light source 4 corresponds to the rotation of the frame 3-2, that is, which kind of detection optical path is selected.

The information code on the integrated quantitative sampling and reagent adding device 12 can be a barcode or a two-dimensional code, and the corresponding information reading device is a barcode reading device or a two-dimensional code scanner 7 .

Next is the fixing of the integrated quantitative sampling plus reagent device 12:

After the information has been read, the drive motor 17 starts to reversely rotate to drive the drive gear 18 to move, and the drive gear 18 drives the lower pressure from the drive gear 2-10 and the action from the drive gear 2-21, and the lower pressure connection from the drive gear 2-10. Driven gear 2-9, and by being arranged on the projection 2-16 that presses down interlocking gear 2-9 and presses down driven gear 2-10, inserts the notch 2- on the horizontal part of horizontal carriage 2-7 In this way in 11, the horizontal carriage 2-7 is moved close to the drive gear 18, and the top of the horizontal carriage 2-7 is provided with a hatch post 4-3, and the hatch post 4-3 passes through the hatch slot 4 -4 Turn back the hatch panel 4-2 that is used to cover the hatch 4-1 at the upper end of the body, close the hatch 4-1 above the body to form a dark environment inside the detector, and set it on the upper end of the horizontal carriage 2-7 The pressing plate 2-18 also moves to directly above the integrated quantitative sampling and reagent device 12 thereupon; the horizontal carriage 2-7 is close to the slave drive gear 2-21, and at the same time, the downward pressure fixed on the horizontal carriage 2-7 The tooth bar 2-1 presses down the driven gear 2-10 and presses down the interlocking gear 2-9 to approach, and the meshing teeth 2-19 on the pressed tooth bar 2-1 are respectively connected with the driven gear 2-10 and the down gear 2-10. Press linkage gear 2-9 to engage;

At the same time, the driving gear 2-21 also rotates in the opposite direction, and the elevating rack 3-12 meshed with it descends, which drives the elevating rack 3-11 to descend, lifting the integrated quantitative sampling and reagent device 12. The tray 5-9 also descends, so the integrated quantitative sampling and reagent adding device 12 falls with the tray 5-9 by its own gravity under the constraint of the bracket 3-2, and the integrated quantitative sampling and reagent adding device 12 enters the bracket 3-2 as a whole. Inside, when the flange of the integrated quantitative sampling and reagent adding device 12 conflicts with the clamping reed 3-3, the integrated quantitative sampling and reagent adding device 12 no longer descends with the tray 5-9, and the bracket 3-2 is lifting The chute on one side of the rack frame 3-11 corresponds to the position of the limit protrusion 3-15 on the elevating rack frame 3-11. In order to ensure that the positions of the chute and the limit protrusion 3-15 match properly, this The ridge type hook head 3-20 of the positioning hook 3-13 of the lifting rack rack 3-11 is stuck in the positioning slot 3-10 of the positioning boss 3-9 on the fixed plate 3-8. The bracket 3-2 can swing left and right along the stop protrusion 3-15 when the mixing motor 2 drives the chute, and the working position at this moment is the mixing position. In the mixing position, the mixing motor 2 drives the bracket 3-2 to swing left and right, and the arc-shaped chute slides along the arc-shaped limiting protrusion 3-15, and the limiting protrusion 3-15 can be set intermittently.

At this time, the trajectory of the left and right swings of the bracket 3-2 corresponds to the radian of the limit protrusion 3-15 on the elevating rack rack 3-11. The radians of 3-15 are suitable, and at this time, the ridge-shaped hook head 3-20 of the positioning hook 3-13 of the lifting rack frame 3-11 is clamped on the fixed plate 3-8 on the positioning boss 3-9. In the positioning slot 3-10, the bracket 10 at this time can swing left and right along the arc of the limit protrusion 3-15 under the drive of the mixing motor 3-1, and the working position at this time is the mixing position.

In the mixing position, the mixing motor 3-1 drives the bracket 10 to swing left and right, and the bracket 10 slides along the arc-shaped limiting protrusion 3-15, and the limiting protrusion 3-15 can be set intermittently.

The motor 2 for mixing continues to rotate in the opposite direction to drive the drive gear 18 to move, and the drive gear 2-21 is separated from the lifting rack 3-12, the lifting rack 3-11 moves down, and the limit protrusion 3-15 follows Move down and misplace the chute, and the discontinuous limit projections 3-15 are stuck on both sides of the card holder 3-2 to fix the bracket 3-2; the working position at this time is the pressing position.

Although the driving gear 2-21 is separated from the elevating rack 3-12, the elevating rack 3-11 will be pressed in the lowest position by the pressing flap 5-2 at the top of the driving gear 2-21. The pressing gear rack 2-1 meshed with the pressing gear 2-9 and the pressing driven gear 2-10 will drive the pressing plate 2-18 to move down, and press the flange of the integrated quantitative sampling and reagent adding device 12 into the locking position Reed 3-3, fixed integrated quantitative sampling and reagent adding device 12.

In the pressed position, the bracket 3-2 and the integrated quantitative sampling and reagent device 12 are fixed, the pressure plate 2-18 exerts pressure on the integrated quantitative sampling and reagent device 15, and the clamping reed 3- 3 is used to prevent the integrated quantitative sampling and reagent adding device 15 from being dislocated when it is under pressure.

The driven gear 5-4 and/or the driven gear 2-21 is provided with a pressing flap 5-2, and one end of the pressing flap 5-2 corresponds to the top end of the elevating rack 3-12. When the pressure flap 5-2 is arranged on the driven gear 5-4, the middle part of the pressure flap 5-2 is hinged with the driven gear 5-4, and the other end is connected to the driven gear 5-4 through the return spring 5-3. connect. The same is true when the pressing flap 5-2 is arranged on the slave driving gear 2-21. Because the pressure flap 5-2 makes the pressure plate 2-18 press down under the drive of the drive gear 16, the driven gear 2-21 and the lifting rack 3-12 engaged at this time will hinder the pressure plate 2-18 from pressing down, so the pressure plate 2-18 is pressed down. When the driven gear 2-21 and the elevating rack 3-12 must be disengaged, the elevating rack 3-11 after disengagement is not restricted, so the pressure flap 5-2 is set to press the free elevating rack 3-11 all the time. placed at the bottom.

The symmetrically arranged driven gear 5-4 and the driven gear 2-21 can be fixedly connected through a connecting rod, thereby increasing the stability of the driven gear 5-4.

Then there is the mixing process:

After the integrated quantitative sampling and reagent adding device 12 is stuck in place, the drive motor 17 is started to return the body to the mixing position, and the mixing motor 2 is started to make the bracket 3-2 swing left and right, and the integrated quantitative sampling and reagent adding device 12 is carried out. For the first mixing, the reagent and the collected blood sample are mixed evenly. After the first mixing time (number of times) reaches the set time (number of times), the drive motor 17 is started to return the body to the pressing position, and the pressing plate 2-18 Press the integrated quantitative sampling and adding reagent device 12 twice to pierce the film of the liquid storage bag storing the detection agent, so that a small amount of air enters the liquid storage bag. At this time, the detection liquid does not overflow, and the driving motor 17 starts to make the body return to the mixing chamber After the second mixing time (number of times) reaches the set time (number of times), the drive motor 17 is started to return the body to the pressing position, and the pressing plate 2-18 is mixed for the third time. Press the reagent tube to squeeze out all the detection reagents, and the body returns to the mixing position again for the third mixing. The third mixing time (times) reaches the set time (times) and the mixing ends. Horizontal carriage 2-7 moves back and forth repeatedly when pressing down operation repeatedly, and this moment, hatch post 4-3 slides freely in hatch draw-in groove 4-4, and hatch panel 4-2 is unaffected.

A further improvement is that, in the following process of fixing and mixing the integrated quantitative sampling and reagent device 12, a radial magnetizing magnet is fixedly arranged on one end of the rotating shaft of the drive gear 2-21, and a magnet is arranged on the frame 9. There is a magnetic sensor corresponding to the radial magnetization magnet, and the stop of the driving motor 17 is controlled by the information of the magnetic sensor.

Or improve to, the swing end of described bracket 3-2 is equipped with magnet 13, the magnetic sensor that is used to identify the position of magnet 13 is installed in the position of swinging, and each magnetic sensor that is used to identify the position of magnet 13 is installed in the position of swinging, The place where the swing is in place is each corresponding emitting light source 4 along the arc track of the swing of the bracket 3-2. Stop at the place where the magnetic sensor is installed so that when the bracket 3-2 swings to the position on the magnetic sensor induction, a signal is given to the mixing motor 2 to stop rotating and lock the position, ensuring that the bracket 3-2 The light transmission hole 8 on the 2 is aligned with the emission light source 4, and the other side of the light transmission hole 8 is aligned with the corresponding lens channel 5, forming a smooth optical path and preparing for optical path detection.

The fixed plate 3-8 is provided with a positioning boss 3-9, and the positioning boss 3-9 is placed in the relief groove of the lifting rack frame 3-11, and the two sides of the positioning boss 3-9 A positioning card slot 3-10 is provided, and a positioning hook 3-13 compatible with the positioning card slot 3-10 is provided on the two side walls of the said give way slot, and the said positioning card slot 3-10 is located on two opposite sides. Between 3-18 adjacent ridge-shaped protrusions.

The horizontal carriage 2-7 is a door-shaped structure, and a pressing rack 2-1 is arranged on the horizontal carriage 2-7; the pressing rack 2-1 is a frame structure, and Its upper part is provided with pressing plate 2-18, and described pressing rack frame 2-1 one side is provided with meshing tooth 2-19, and its other side is provided with guide rail 2-13 for guiding; One side of 2-7 is provided with a convex edge matched with the guide rail 2-13, so that the pressing rack 2-1 can move up and down along the horizontal carriage 2-7 by means of the guide rail 2-13, The bottom of described horizontal carriage 2-7 is frame 9.

Next is the detection process:

After the mixing is completed, the integrated quantitative sampling and reagent adding device 12 returns to the vertical position before mixing. At this time, the emission light source 4 of the light detection emits the detection light, passes through the reagent to be detected and reaches the detection receiving circuit board 6, and the detection receiving circuit Board 6 converts the optical information into electrical signals and transmits them back to the signal processing circuit. The signal processing circuit transmits the analysis results to the control unit. modules and printers.

Finally, the driving motor 17 is reversely rotated, the body hatch 4-1 is opened, and the integrated quantitative sampling and reagent addition device 12 is returned to the out-of-cabin position. Lift to the highest position, the instrument gives a prompt of the end of the test, the operator takes away the integrated quantitative sampling and reagent device 12, the control unit detects that there is no integrated quantitative sampling and reagent device 12 in the instrument, and the instrument returns to the standby state.

The present invention is only to protect the automatic identification multi-light path reagent detection device, and other descriptions are to reflect its working mode and process, which do not belong to the protection content of the present invention.

The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be described in the foregoing embodiments Modifications are made to the technical solutions, or equivalent replacements are made to some of the technical features; these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. the multi-pass agent detection devices in integrated quantitative sampling reagent adding device detector, it is characterised in that：It includes For placing integrated quantitative sampling reagent adding device（12）Bracket（3-2）, for driving bracket（3-2）Around axis vertical oscillation Driving device, transmitting light source（4）With with launch light source（4）The optical signal receiving detection device to match；The transmitting light source （4）Quantity be greater than or equal to 2, the transmitting light source（4）With corresponding optical signal receiving detection device respectively positioned at described Bracket（3-2）The both sides of swinging plane, the driving device drive bracket（3-2）Vertical oscillation selects corresponding optical signal to receive Detection device；The bracket（3-2）For upper and lower open-ended tubular housing；The integrated quantitative samples reagent adding device（12） On post Quick Response Code for unique mark fluid to be measured.

2. the multi-pass reagent detection dress in integrated quantitative sampling reagent adding device detector according to claim 1 Put, it is characterised in that：It further includes dimensional code scanner（7）, the integrated quantitative sampling reagent adding device（12）It is equipped with The Quick Response Code of reagent, the dimensional code scanner are tested for unique mark（7）Reagent adding device is sampled with integrated quantitative （12）Upper two dimension code position is corresponding.

3. the multi-pass reagent detection in integrated quantitative sampling reagent adding device detector according to claim 1 or 2 Device, it is characterised in that：The optical signal receiving detection device includes photoelectric converter D1 and detection circuit board for receiving（6）, institute State transmitting light source（4）Lens passage is equipped between photoelectric converter D1（5）, the transmitting light source（4）Light successively through one Body formula quantitative sampling reagent adding device（12）In reagent, lens passage（5）Reach the input terminal of photoelectric converter D1, the light The corresponding detection circuit board for receiving of output termination of electric transducer D1（6）Input terminal.

4. the multi-pass reagent detection in integrated quantitative sampling reagent adding device detector according to claim 1 or 2 Device, it is characterised in that：The driving device includes mixing motor（2）；The mixing motor（2）Output shaft（3）It is fixed to connect Connect the bracket（3-2）, the mixing motor（2）Output shaft（3）Direction and transmitting light source（4）Radiation direction it is consistent；Institute State bracket（3-2）Positioned at transmitting light source（4）Between corresponding optical signal receiving detection device.

5. the multi-pass reagent detection dress in integrated quantitative sampling reagent adding device detector according to claim 3 Put, it is characterised in that：The detection circuit board for receiving（6）Amplifying circuit is received for adjustable gain light intensity signal.

6. the multi-pass reagent detection dress in integrated quantitative sampling reagent adding device detector according to claim 5 Put, it is characterised in that：The adjustable gain light intensity signal, which receives amplifying circuit, includes operation amplifier chip IC 1, digital regulation resistance Chip IC 2, feedback resistance R1 ~ R2, capacitance C1 ~ C6；The photoelectric converter D1 is connected on 2 feet and ground of operation amplifier chip IC 1 Between；Resistance R1 and capacitance the C3 parallel connections are followed by 6 feet of 2 feet and digital regulation resistance chip IC 2 in operation amplifier chip IC 1 Between；The capacitance C1 and C2 parallel connections are followed by between 4 feet and ground of operation amplifier chip IC 1；The operation amplifier chip IC 1 6 feet and 7 feet corresponding 7 feet and power vd D for connecing digital regulation resistance chip IC 2 respectively；The capacitance C4 and C5 parallel connections are followed by Between 7 feet and ground of operation amplifier chip IC 1；The capacitance C6 is connected in parallel between 8 feet of digital regulation resistance chip IC 2 and ground, 8 feet of the digital regulation resistance chip IC 2 meet power supply VCC；5 feet of the digital regulation resistance chip IC 2 are grounded through resistance R2；Institute 1,2,3 feet for stating digital regulation resistance chip IC 2 connect MCU control feet respectively；The model of the operation amplifier chip IC 1 OTA121, the model MCT41050 of the digital regulation resistance chip IC 2.

7. the multi-pass reagent detection in integrated quantitative sampling reagent adding device detector according to claim 1 or 2 Device, it is characterised in that：It is further included for determining bracket（3-2）Swing magnet in place（13）, the magnet（13）Installation In bracket（3-2）On, for identifying magnet（13）Each magnetic inductor of position is installed on swing and locates in place, and the swing is in place Locate as along bracket（3-2）Corresponding each transmitting light source on the arc track of swing（4）Place.

8. the multi-pass reagent detection dress in integrated quantitative sampling reagent adding device detector according to claim 7 Put, it is characterised in that：For identifying the magnet（13）The magnetic inductor of position is Hall sensor.

9. the multi-pass reagent detection in integrated quantitative sampling reagent adding device detector according to claim 1 or 2 Device, it is characterised in that：The bracket（3-2）Vertical opening is equipped with for side（11）Tubular housing, on the tubular housing Loophole equipped with perforation cavity（8）；The loophole（8）Position with transmitting light source（4）It is corresponding.

10. the multi-pass reagent detection dress in integrated quantitative sampling reagent adding device detector according to claim 2 Put, it is characterised in that：The dimensional code scanner（7）Scanning lens before be provided with lens（1）.