CN104740713A - Implantable biological energy insulin pump - Google Patents

Abstract

The invention provides an implantable bioenergy insulin pump, which includes a blood sugar monitoring part, an insulin injection pump, an infusion catheter, a control part, a signal transmitting part, an external communicator and a power generation part. The power generation part includes a power generation main body, a regulating terminal, an output electrode, an encapsulation layer and an electric energy storage part. Among them, the power generation main body is used to collect the mechanical energy generated when the aorta expands, and convert it into electrical energy. The main body of power generation is a multi-layer film structure, including a piezoelectric layer located in the center layer, and a first electrode layer and a second electrode layer located on both sides of the piezoelectric layer. The encapsulation layer covers the surfaces of the power generating body, the regulating terminal, the output electrodes and the electric energy storage unit. The adjustment ends are located at both ends of the power generation body and are used to adjust the length of the power generation body. The output electrodes are used to deliver electrical energy to the electrical energy storage. The implantable bioenergy insulin pump of the present invention does not need to replace batteries, and can be used for a lifetime after implantation once.

Description

Implantable bioenergy insulin pump

technical field

The invention relates to an implanted insulin pump, which belongs to the field of medical devices.

Background technique

Diabetes is a common and frequently-occurring disease in middle-aged and elderly patients. As a life-long disease, there is still a lack of radical treatment. In people with severe diabetes, intensive insulin therapy is usually required. Since intensive treatment requires 3 or more daily insulin injections, the risk of hypoglycemia and the possibility of weight gain are greatly increased.

Implantable insulin pumps developed or in clinical trials in recent years are conducive to continuous and stable blood sugar control and reduce diabetes-related complications. However, an implantable insulin pump, as an electronic device implanted in the body, requires a continuous power supply. However, the power supply time of existing micro-batteries is generally short, and once the energy of the batteries is exhausted after implantation, another operation is required to replace the batteries. This will not only cause physical pain and psychological fear and anxiety to patients, but also increase the financial burden on patients and their families.

Inside the human body, both the contraction of the heart and the flow of blood have steady and uninterrupted kinetic energy. If a small part of the kinetic energy can be harvested and converted into electrical energy, it is expected to become an ideal energy source for implantable insulin pumps. However, since the heart is the "engine" of the human body, improper collection of cardiac kinetic energy will inevitably affect the function of the heart and even cause heart damage. In addition, traditional electromagnetic induction generators based on Faraday's law are large in size and complex in structure, and are not suitable for implantation in vivo.

Contents of the invention

In order to solve the above problems, the present invention provides an implantable insulin pump that can be implanted in the body and indirectly uses the bioenergy of the heart to supply power, which is characterized in that it includes a blood glucose monitoring unit, an insulin injection pump, an infusion catheter, and a control unit for the injection pump. The control part for operation, the signal transmitting part, the external communicator for receiving signals, and the power generation part for providing electric energy. Wherein, the power generation part includes a power generation main body, an adjustment terminal, an output electrode, an electric energy storage unit, and an encapsulation layer. Wherein, the power generating body is used to surround the aorta, so as to collect the mechanical energy generated when the aorta expands, and convert it into electrical energy. The main body of power generation is a multi-layer film structure, including a piezoelectric material layer located in the central layer, and a first electrode layer and a second electrode layer located on both sides of the piezoelectric material layer. The adjustment ends are located at both ends of the power generation body and are used to adjust the length of the power generation body. The output electrodes are used to deliver electrical energy to the electrical energy storage unit. The electric energy storage unit is used for storing electric energy and supplying power for the blood sugar monitoring part, the control part, the insulin injection pump and the signal transmitting part. The encapsulation layer covers the surfaces of the power generation main body, the regulating terminal, the output electrodes and the electric energy storage unit.

In addition, the implantable bioenergy insulin pump of the present invention may also have the following features: wherein, the piezoelectric material layer contains nanoscale piezoelectric materials, and the nanoscale piezoelectric materials are piezoelectric crystals, piezoelectric ceramics, and organic piezoelectric polymers. any of the things.

In addition, the implantable bioenergy insulin pump of the present invention may also have the feature that the piezoelectric crystals, piezoelectric ceramics, and organic piezoelectric polymers may be single-layer or multi-layer structures of nanoscale piezoelectric materials.

In addition, the implantable bioenergy insulin pump of the present invention may also have such a feature: wherein, the electric energy storage part is a micro-rechargeable battery or a capacitor.

In addition, the implantable bioenergy insulin pump of the present invention may also have the following features: it further includes a rectification and filtering circuit connected between the electric energy storage unit and the output electrodes.

In addition, the implantable bioenergy insulin pump of the present invention may also have the feature that the adjustment end is fixed by any one of surgical thread suture, titanium clamp clip or adhesive bonding.

In addition, the implantable bioenergy insulin pump of the present invention may also have the following features: one end of the adjustment end is a single row of teeth, the tip of the teeth is smooth and faces the outside of the power generating body, and the other end of the adjustment end is a locking tooth. One side of the card slot has tooth grooves matched with the card teeth, and the other side is a plane, and the card teeth are engaged with the card slots.

In addition, the implantable bioenergy insulin pump of the present invention may also have the following feature: wherein, the encapsulation layer uses a flexible polymer insulation material with good biocompatibility as the encapsulation material.

In addition, the implantable bioenergy insulin pump of the present invention may also have the following feature: the pressure of the power generation part on the aorta is less than 140mmHg.

Invention function and effect

The implantable bioenergy insulin pump of the present invention collects the energy generated when the aorta expands by implanting the nanoscale piezoelectric material and converts it into electrical energy as its energy source. Therefore, as long as the heart is beating, the present invention can use the patient's own biological energy to provide electric energy, eliminating the need to use batteries as power sources, and solving the problem of replacing batteries through surgery after the battery energy is exhausted.

Since the present invention uses nanoscale piezoelectric materials as the main body of power generation, it can not only effectively convert bioenergy in the body into electric energy, but also has a small volume and is more suitable for implantation in the body.

Since the present invention adopts a soft annular structure to wrap around the outer wall of the aorta, and can quantitatively control the pressure of the system on the aorta, it can efficiently and fully collect the mechanical energy generated when the aorta expands without causing any damage to the aorta. Cardiac function is significantly affected.

In addition, since the present invention is packaged with a flexible polymer insulating material with good biocompatibility, it can not only isolate the power generation body from the internal environment, but also effectively transmit the pressure generated by the deformation of the aortic wall to the piezoelectric material.

In addition, the tension of the power generation body around the aorta can be adjusted by using the adjustment ends at both ends of the power generation body, so that the deformation degree of the piezoelectric material and the output power can be adjusted. And because the adjustment end does not contain piezoelectric materials and electrode layers, the structure of the power generation body will not be damaged when it is fixed with surgical sutures or titanium clips.

Moreover, since the power generating body of the present invention is located outside the aorta and does not come into direct contact with blood, there is no risk of thrombus formation and stroke (myocardial infarction or cerebral infarction).

Description of drawings

FIG. 1 is a schematic diagram of an implantable bioenergy insulin pump according to Embodiment 1 of the present invention;

Fig. 2 is a schematic diagram of a power generating body according to Embodiment 1 of the present invention;

Fig. 3 is a cross-sectional view of the internal structure of the power generation main body of Embodiment 1 of the present invention;

Fig. 4 is a partial enlarged view of the region A of the main body of power generation in Fig. 3;

Fig. 5 is a cross-sectional view of the power generation body installed on the aorta in Embodiment 1 of the present invention;

Fig. 6 is a schematic diagram of the adjusting end in the fourth embodiment of the present invention having a locking tooth structure; and

Fig. 7 is a schematic circuit diagram of the present invention.

Detailed ways

The following describes the specific implementation of the implantable bioenergy insulin pump of the present invention according to the accompanying drawings,

<Example 1>

Fig. 1 is a schematic diagram of an implantable bioenergy insulin pump according to Embodiment 1 of the present invention. As shown in FIG. 1 , the implantable bioenergy insulin pump 100 includes a control unit 19, a signal transmitting unit 16, a syringe pump 15, an infusion catheter 151, a blood glucose monitoring unit 20, and a power generation unit 200. The power generation unit 200 includes a power generation body 11, A rectification filter circuit 12 , an output electrode 14 and an electric energy storage unit 13 .

The power generating body 11 is an elastic annular structure, which can surround the aorta 18. The power generating body 11 has a piezoelectric material inside, which can generate electric energy by utilizing the deformation of the aorta. The output electrode 14 of the power generation main body 11 is connected with a rectification filter circuit 12, so that the electric energy output by the power generation main body 11 becomes stable. The electric energy storage unit 13 is connected behind the rectifying and filtering circuit 12 to store electric energy and provide power for the blood glucose monitoring part 20 , the control part 19 , the signal transmitting part 16 and the injection pump 15 of the bioenergy insulin pump 100 .

Fig. 2 is a schematic diagram of a power generating body according to Embodiment 1 of the present invention. As shown in FIG. 2 , the initial state of the power generating body 11 is an open loop shape, and there is an adjustment end 23 at both ends of the ring structure, and the two adjustment ends need to be connected together when installed on the outer wall of the aorta. The outer surfaces of the generating body 11 and the regulating end 23 are covered with an encapsulation layer 22 . The power generating body has two output electrodes 14 for outputting the electric energy generated by the power generating body 11 .

Fig. 3 is a sectional view of the internal structure of the power generating body of the embodiment of the present invention. As shown in Fig. 3, the interior of the power generating body 11 is a multi-layer thin film structure, including a nanoscale piezoelectric material 111 located in the central layer of the main body, and piezoelectric The first electrode layer 112 and the second electrode layer 113 on both sides of the electrical material. The encapsulation layer 22 is made of biocompatible flexible polymer insulating material, covers the surface of the power generation body 11 and the output electrode 14 , and extends to the outside of the power generation body 11 to form an adjustment terminal 23 on each side.

Fig. 4 is a partial enlarged view of the region A of the power generation body in Fig. 3 . As shown in Figure 4, the nano-scale piezoelectric material 111 located in the central layer of the power generation body 11, the first electrode layer 112 and the second electrode layer 113 are made of thin-layer materials with high conductivity such as gold or silver, and are compatible with the nano-scale piezoelectric material. Electrical material 111 is connected.

The power generating body 11 is a curved ring structure in a natural state, and its thin film structure has good elasticity, so it can wrap around the aorta softly.

When implanted in the body, the power generating body 11 can be implanted around the aorta and surround the aorta by surgical methods. Then, by adjusting the adjusting end 23, the power generating body 11 is in close contact with the outer wall of the aorta, so as to collect the energy generated by the deformation of the aorta.

Excessive compression of the aorta may increase the workload of the heart 17, so a pressure sensor can be temporarily placed between the power generation body 11 and the wall of the aorta to measure the pressure of the power generation body 11 on the aorta to avoid adverse effects on the heart .

Since the inside of the adjustment end 23 does not contain piezoelectric material layers and electrode layers, when the two sides of the adjustment end 23 are closed with surgical sutures or titanium clips, no damage will be caused to the power generation body 11 .

Fig. 5 is a cross-sectional view of the generator main body installed on the aorta in the embodiment of the present invention. The working process of the implantable bioenergy insulin pump of the present invention will be described below with reference to FIG. 1 and FIG. 5 .

As shown in FIG. 1 and FIG. 5 , the power generating body 11 surrounds the aorta 18 . When the heart 17 contracts, the impact of the blood flow causes the aorta 18 to expand. As shown in FIG. The two ends form a potential difference and generate a current, and the current is conducted to the output electrode 14 through the first electrode layer 112 and the second electrode layer 113, and then enters the electric energy storage unit 13 after passing through the rectification and filtering circuit 12, and the electric energy storage unit 13 is a miniature rechargeable battery . The electric energy storage unit 13 then supplies electric energy to the blood glucose monitoring part 20 , the control part 19 , the signal transmitting part 16 and the injection pump 15 of the implantable bioenergy insulin pump. When the blood glucose sensor senses that the blood glucose level in the body is higher than the threshold, the control unit 19 will control the injection pump 15 to infuse an appropriate amount of insulin into the blood through the infusion catheter 151. The working status is output to the external communicator 152.

Fig. 7 is a schematic circuit diagram of an embodiment of the implantable bioenergy insulin pump of the present invention. As shown in Fig. 7, the power generation main body 11 is connected with the rectification and filtering circuit 12, and the electric energy generated by the power generation main body 11 passes through the rectification and filtering circuit 12 and is converted to the electric energy. The storage unit 13 is charged, and the electric energy storage unit 13 is used to supply power to electrical appliances, namely the blood glucose monitoring unit, the control unit, the signal transmitting unit and the injection pump in this embodiment.

<Example 2>

In this embodiment, the shape of the blood glucose monitoring part, the control part, the signal transmitting part, the injection pump, the power generation body and the setting of the adjustment end of the implantable bioenergy insulin pump are the same as in the first embodiment, the difference is that in this embodiment , the piezoelectric material layer of the power generation body adopts nanoscale piezoelectric ceramic materials.

Another difference is that in this embodiment, the adjustment end 23 is fixed by a titanium clip. While being fixed, use a miniature pressure sensor to detect the pressure of the generator body on the outer wall of the aorta, and slowly tighten the teeth until the pressure reaches 120-140mmHg.

<Example Three>

In this embodiment, the blood glucose monitoring part, control part, signal transmitting part, syringe pump, and the shape of the power generation body and the setting of the adjustment end of the bioenergy insulin pump are the same as in the first embodiment, the difference is that in this embodiment, the power generation body The piezoelectric material layer is made of piezoelectric polymer, and the adjustment end is fixed by adhesive bonding. While being fixed, use a miniature pressure sensor to detect the pressure of the generator body on the outer wall of the aorta, and slowly tighten the teeth until the pressure reaches 120-140mmHg.

<Example 4>

In this embodiment, the shape of the blood glucose monitoring part, control part, signal transmitting part, syringe pump, power generation main body and the setting of the adjustment end of the bioenergy insulin pump are the same as in the first embodiment, the difference lies in this embodiment, as shown in Fig. As shown in 6, one end of the adjustment end 61 is a single row of locking teeth, and the tip of the tooth is smooth and faces the outside of the main body of the generator, so as to prevent the tip of the tooth from damaging human tissues such as the heart or the aorta. The other end of the adjustment end 61 is a card slot, and one side of the card slot has a tooth groove matching with the card teeth, and the other side is a plane. When fixing the generating part on the outer wall of the aorta, slowly insert the locking teeth into the slot, and at the same time use the micro pressure sensor to detect the pressure of the generating body on the outer wall of the aorta, and slowly tighten the locking teeth until the pressure reaches 120-140mmHg.

Of course, the implantable bioenergy insulin pump of the present invention is not limited to the designs described in the above embodiments, and its piezoelectric material layer, electrode layer and packaging layer can be made of various existing suitable materials.

Claims (9)

1. An implantable bioenergy insulin pump, characterized in that it comprises: Blood Glucose Monitoring Department; Insulin injection pump; An infusion catheter connected to a syringe pump; a control unit that controls the operation of the syringe pump; Signal transmission department; an external communicator for receiving signals; and a power generation unit for supplying power to the blood glucose monitoring unit, the injection pump, the control unit and the signal transmitting unit, Wherein, the power generation part includes a power generation main body, an adjustment terminal, an output electrode, an electric energy storage unit and an encapsulation layer, The power generating body is used to surround the aorta to collect the mechanical energy generated when the aorta expands and convert it into electrical energy, The power generating body is a multi-layer film structure, including a piezoelectric material layer located in the central layer, and a first electrode layer and a second electrode layer respectively located on both sides of the piezoelectric material layer, The adjustment end is located at both ends of the power generation body, and is used to adjust the length of the power generation body, The output electrodes are used to deliver electrical energy to the electrical energy storage unit, The electric energy storage unit is used to store electric energy and supply power to the blood glucose monitoring part, the injection pump, the signal transmitting part and the control part, The encapsulation layer covers the power generating body, the regulating terminal, the output electrode and the surface of the electric energy storage unit. 2. The implantable bioenergy insulin pump according to claim 1, characterized in that: Wherein, the piezoelectric material layer contains a nanoscale piezoelectric material, and the nanoscale piezoelectric material is any one of piezoelectric crystals, piezoelectric ceramics and organic piezoelectric polymers. 3. The implantable bioenergy insulin pump according to claim 2, characterized in that: Wherein, the piezoelectric crystals, piezoelectric ceramics, and organic piezoelectric polymers may be single-layer or multi-layer structures of nanoscale piezoelectric materials. 4. The implantable bioenergy insulin pump according to claim 1, characterized in that: Wherein, the electric energy storage part is a micro-rechargeable battery or a capacitor. 5. The implantable bioenergy insulin pump according to claim 1, further comprising: The rectification and filtering circuit is connected between the electric energy storage unit and the output electrode. 6. The implantable bioenergy insulin pump according to claim 1, characterized in that: Wherein, the fixing method of the adjustment end uses any one of surgical sutures, titanium clips and bonding. 7. The implantable bioenergy insulin pump according to claim 1, characterized in that: Wherein, one end of the adjusting end is a single row of locking teeth, the tip of the locking teeth is smooth and faces the outside of the power generation body, the other end of the adjusting end is a locking groove, and the inner side of the locking groove has a groove corresponding to the locking teeth. The other side of the matching tooth groove is a plane, and the locking teeth are engaged with the locking grooves. 8. The implantable bioenergy insulin pump according to claim 1, characterized in that: Wherein, the encapsulation layer uses a flexible polymer insulation material with good biocompatibility as the encapsulation material. 9. The implantable bioenergy insulin pump according to claim 1, characterized in that: The pressure of the generating part on the aorta is less than 140mmHg.