CN104984385B - A kind of pre- stick of water soluble medical - Google Patents
A kind of pre- stick of water soluble medical Download PDFInfo
- Publication number
- CN104984385B CN104984385B CN201510436651.XA CN201510436651A CN104984385B CN 104984385 B CN104984385 B CN 104984385B CN 201510436651 A CN201510436651 A CN 201510436651A CN 104984385 B CN104984385 B CN 104984385B
- Authority
- CN
- China
- Prior art keywords
- parts
- stick
- water
- polyglycereol
- rosin ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000002994 raw material Substances 0.000 claims abstract description 20
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims abstract description 19
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims abstract description 19
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000002148 esters Chemical class 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 28
- 239000005844 Thymol Substances 0.000 claims description 14
- 230000000844 anti-bacterial effect Effects 0.000 claims description 14
- 229960000790 thymol Drugs 0.000 claims description 14
- 239000003899 bactericide agent Substances 0.000 claims description 13
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 6
- 208000014674 injury Diseases 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 5
- 239000007864 aqueous solution Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 239000003125 aqueous solvent Substances 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000005507 spraying Methods 0.000 abstract description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000246358 Thymus Species 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The present invention provide it is a kind of be applied to injury gained in sports, surprisingly pull to wait and wrap up dressing, a kind of pre- stick of water soluble medical.The effect of water-soluble pre- stick is sprayed on the pars affecta skin of patient, quickly forms a kind of ventilative thin layer mucous membrane, is easy to bandage during wrapping not slipped with skin close adhesion, it is not loose be easy to remove.A kind of pre- stick of water soluble medical is by aqueous solvent（A）Constituted with polyglycereol rosin ester two parts.A agent raw material is the aqueous solution containing a small amount of medicinal alcohol；B agent is polyglycereol rosin ester thick liquid.Have the advantage that：Water-soluble pre- stick using the spraying of nuisanceless carbon dioxide propellant, can rapid film formation, it is easy to use, it is pollution-free to bad border.
Description
Technical field
The present invention relates to a kind of natural water-soluble pre- stick, specifically a kind of affected part for being sprayed at patient, favorably
In skin and bandage organic adhesion and be easy to what is removed, the material of referred to as a kind of pre- stick of water soluble medical.
Background technology
At present, at home, outside for the fixation of trauma skin surface bandage water-soluble pre- stick is undiscovered and remembers
Carry.The raw material based on polyglycereol rosin ester, the pre- stick of water-soluble bandage of exploitation will be opened for water-soluble pre- stick
Open up a new field.Due to the pre- stick water as solvent of this research project, the raw material based on natural glycerin modified rosin ester,
Auxiliary is antioxygen bactericide in the thymol extracted from the plants such as thyme, imparts natural, safe, the non-stimulated spy of pre- stick
Property.Because raw material is based on cheap and high security, thus it succeed in developing will for injury gained in sports, unexpected unexpected damage such as pull
New contribution is made in the fixation of bandage during the treatment of wound, meanwhile, the application of water-soluble pre- stick creates good warp for enterprise
Benefit of helping and social benefit.
The content of the invention
Pulled it is an object of the invention to provide one kind for human muscle, when injury gained in sports is treated, bandage is fixed necessary
A kind of water-soluble pre- stick.
The purpose of the present invention realizes that the pre- stick of water soluble medical is by the raw material of following weight proportion in the following manner
It is made, 70-90 parts of deionized water, 5-10 parts of medicinal alcohol, 2-6 parts of polyglycereol rosin ester, thymol bactericide 0.05-0.20
Part, preparation method is as follows：Individual raw material is added in reactor by proportioning, stirring is opened, is heated to 75 DEG C -- 90 DEG C, heating stirring
Homogeneous half an hour, it is finished product to be cooled to room temperature packaging.
The pre- stick of described water soluble medical, is to be prepared from the following raw materials in parts by weight, 75-85 parts of deionized water, doctor
With 6-9 parts of alcohol, 3-5 parts of polyglycereol rosin ester, 0.08-0.18 parts of thymol bactericide.
The pre- stick of described water soluble medical, is to be prepared from the following raw materials in parts by weight, 80 parts of deionized water, medical wine
Smart 7 parts, 4 parts of polyglycereol rosin ester, 0.15 part of thymol bactericide.
The excellent effect of the present invention is as follows：
Because polyglycerol rosin has certain emulsibility in itself, and contain multiple hydroxyls in molecule（—OH）And ether
Chain（-O-）Group, it is water-soluble good, can be mixed to the aqueous solution of uniformity in any proportion with water.Polyglycereol
The sticky feature group contained in rosin ester molecule, can be with the hydroxyl on gauze and skin（-0H）With amino (- NH2) formation
Faint hydrogen bond and realize bonding.Because pre- stick is that moisture on the aqueous solution, skin is easily locked without volatile, so not
Length is stopped by gauze to be all easy to remove.
Raw material aqueous solvent in formula, medical glycerine, polyglycereol rosin ester are natural, inexpensive, and raw material is easy to get.
Preservative in formula is thymol, is the thymol solution extracted from natural thyme, frequently as external application
One kind of bactericide, with medical value.With very strong bactericidal action and very strong acaricidal action, effect is rapid reliable.
Make solvent with alcohol water blend, wrap up pre-bonding when being treated applied to patient's local damage, pre- stick being had in itself
Some bioaffinities, it is nontoxic to skin, non-stimulated and with certain protective effect.
Pre- stick function admirable, it is easy to use, after spraying can effectively, a thin layer of glue is promptly formed on skin
Film, and the wrapping and adhesion of bandage are realized, thus it is pre- anti-slip and loose, and be easy to release and change.
The chemical stability of water-soluble pre- stick is good, and heat-resisting, cold tolerance is good, and physical property is good, there is enough glue
Property, no volume contraction, rheology is small, is non-thermal, electric conductor.
Embodiment
Embodiment 1：
The pre- stick of water soluble medical is to be prepared from the following raw materials in parts by weight, 90 parts of deionized water, 10 parts of medicinal alcohol,
6 parts of polyglycereol rosin ester, 0.20 part of thymol bactericide：
Preparation method is as follows：Individual raw material is added in reactor by proportioning, stirring is opened, 75 DEG C -90 DEG C, heating are heated to
Homogeneous half an hour is stirred, it is finished product to be cooled to room temperature packaging.
Embodiment 2
The pre- stick of water soluble medical is to be prepared from the following raw materials in parts by weight, 70 parts of deionized water, 5 parts of medicinal alcohol,
2 parts of polyglycereol rosin ester, 0.05 part of thymol bactericide.
Preparation method is same as Example 1.
Embodiment 3
The pre- stick of described water soluble medical, is to be prepared from the following raw materials in parts by weight, 75 parts of deionized water, medical wine
Smart 6 parts, 3 parts of polyglycereol rosin ester, 0.08 part of thymol bactericide.
Preparation method is same as Example 1.
Embodiment 4
The pre- stick of described water soluble medical, is to be prepared from the following raw materials in parts by weight, 85 parts of deionized water, medical wine
Smart 9 parts, 5 parts of polyglycereol rosin ester, 0.18 part of thymol bactericide.
Preparation method is same as Example 1.
Embodiment 5
The pre- stick of described water soluble medical, is to be prepared from the following raw materials in parts by weight, 80 parts of deionized water, medical wine
Smart 7 parts, 4 parts of polyglycereol rosin ester, 0.15 part of thymol bactericide.
Preparation method is same as Example 1.
This water soluble medical pre-bonding agent producing process is relatively simple, and the key of technical process is polyglycereol rosin ester in water
Dissolving.
Embodiment 6
The pre- stick of water soluble medical is sprayed on pars affecta skin when using, then wrapped up using bandage, bandage i.e. with
Skin is brought into close contact, and is difficult to slip, convenient to be applicable, with safety, it is natural, efficiently, biological property is good the characteristics of.The pre- stick
Succeed in developing, and the application in wound auxiliary treatment rehabilitation, it will the security of increase wound wrapping and the pre- stick of reduction
Cost, the physiotherapy and rehabilitation for injury gained in sports and accident trauma is made new contribution, at the same create good economic benefit and
Social benefit.
It is the known technology of those skilled in the art in addition to the technical characteristic described in specification.
Claims (3)
1. a kind of pre- stick of water soluble medical, it is characterised in that be to be prepared from the following raw materials in parts by weight, deionized water 70-90
Part, 5-10 parts of medicinal alcohol, 2-6 parts of polyglycereol rosin ester, 0.05-0.20 parts of thymol bactericide, preparation method is as follows：Will be each
Raw material is added in reactor by proportioning, is opened stirring, is heated to 75 DEG C -- 90 DEG C, heating stirring homogeneous half an hour, it is cooled to room
Thermometer bulb dress is finished product.
2. the pre- stick of water soluble medical according to claim 1, it is characterised in that be by the raw material system of following weight proportion
Into 75-85 parts of deionized water, 6-9 parts of medicinal alcohol, 3-5 parts of polyglycereol rosin ester, 0.08-0.18 parts of thymol bactericide.
3. the pre- stick of water soluble medical according to claim 1, it is characterised in that be by the raw material system of following weight proportion
Into 80 parts of deionized water, 7 parts of medicinal alcohol, 4 parts of polyglycereol rosin ester, 0.15 part of thymol bactericide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510436651.XA CN104984385B (en) | 2015-07-23 | 2015-07-23 | A kind of pre- stick of water soluble medical |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510436651.XA CN104984385B (en) | 2015-07-23 | 2015-07-23 | A kind of pre- stick of water soluble medical |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104984385A CN104984385A (en) | 2015-10-21 |
| CN104984385B true CN104984385B (en) | 2017-08-29 |
Family
ID=54296357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510436651.XA Expired - Fee Related CN104984385B (en) | 2015-07-23 | 2015-07-23 | A kind of pre- stick of water soluble medical |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104984385B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441168A (en) * | 2017-09-27 | 2017-12-08 | 山东维赫生物科技有限公司 | Compound peppermint is unsting hydrogel plaster |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2073758A (en) * | 1978-10-30 | 1981-10-21 | Kendall & Co | Pressure-sensitive adhesives |
| CN1308537A (en) * | 1998-07-10 | 2001-08-15 | 久光制药株式会社 | Steroid-containing cataplasms and process for producing the same |
| CN1946429A (en) * | 2004-04-28 | 2007-04-11 | 久光制药株式会社 | patch |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2481301A (en) * | 1999-07-19 | 2001-02-05 | Coloplast A/S | A carbon dioxide generating device |
-
2015
- 2015-07-23 CN CN201510436651.XA patent/CN104984385B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2073758A (en) * | 1978-10-30 | 1981-10-21 | Kendall & Co | Pressure-sensitive adhesives |
| CN1308537A (en) * | 1998-07-10 | 2001-08-15 | 久光制药株式会社 | Steroid-containing cataplasms and process for producing the same |
| CN1946429A (en) * | 2004-04-28 | 2007-04-11 | 久光制药株式会社 | patch |
Non-Patent Citations (1)
| Title |
|---|
| "马来松香聚甘油酯的合成及性能研究";王百军等;《日用化学工业》;20030430;第33卷(第2期);84-86 * |
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| Publication number | Publication date |
|---|---|
| CN104984385A (en) | 2015-10-21 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Shi Shaojun Inventor after: Cui Shanshan Inventor after: Xing Yuping Inventor after: Wang Xingqi Inventor before: Cui Shanshan Inventor before: Xing Yuping Inventor before: Wang Xingqi |
|
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221116 Address after: 276000 southwest of the intersection of Xiangyu road and Xiamen Road, Zhimadun street, Linyi Economic Development Zone, Shandong Province Patentee after: Shandong Weishi Pharmaceutical Co.,Ltd. Address before: 276017 Floor 2, Block D, Innovation Building, Keji Avenue, High tech Zone, Linyi City, Shandong Province Patentee before: SHANDONG VIANOR BIOTECH CO.,LTD. |
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| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170829 |
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| CF01 | Termination of patent right due to non-payment of annual fee |