CN105013072B - Band medicine delayed release device for uterus - Google Patents
Band medicine delayed release device for uterus Download PDFInfo
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- CN105013072B CN105013072B CN201510443480.3A CN201510443480A CN105013072B CN 105013072 B CN105013072 B CN 105013072B CN 201510443480 A CN201510443480 A CN 201510443480A CN 105013072 B CN105013072 B CN 105013072B
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- mesh bag
- uterus
- holder
- delayed release
- release device
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Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of band medicine delayed release device and method for implantation for uterus, described device includes holder, mesh bag and gelinite；The holder is in integrally sleeve-shaped, and surrounding side wall is formed with through-hole；The gelinite is made of gel rubber material and drug；The side of the mesh bag forms micropore, and the inside of the mesh bag forms accommodating cavity；In a state of use, mesh bag is in the inside of holder, and gel rubber material expansion struts mesh bag, and drug is externally discharged through micropore and the through-hole.The method for implantation is the holder to be first sent into intrauterine, then the mesh bag is sent into holder, finally injects the gelinite inside mesh bag.The present invention forms advantageous reliable outer support by " adaptive ability " of holder, " compliance " feature of gel rubber material water swelling forms mesh bag appropriate inner support, the two collective effect can form reliable, suitable inside support inside uterus, realize long-term, the reliable sustained-release administration carried out inside uterus.
Description
Technical field
The present invention relates to the technical fields of the Design for Medical Device of uterine disease treatment more particularly to a kind of for uterus
Band medicine delayed release device and method for implantation.
Background technology
Inflammation of uterus is common gynecological disease, and great puzzlement is brought to female patient.Inflammation of uterus is treated at present
Scheme has：Oral medicine and vaginal plugging.
The advantages of oral medicine is convenient to take, and disadvantage is the patient for having part to need accurate administration indication but because oral
And it is forced to circulate drug without targeting, specific aim and the big heavy discount of therapeutic effect through whole body.
The advantages of vaginal plugging, is easy to use and has opposite targeting, the disadvantage is that causing due to not having support after filling
It just absorbs within one day to two days or outflow is external, the patient for partly needing long-term sustained release to be administered needs weekly medicine-feeding for several times, and effect is not
It is good and very inconvenient.
The applicant has found there is following patent application in the prior art by patent retrieval.
Chinese Patent No. 200410050861.7 discloses a kind of Novel pessulum, may be implemented in vagina holding medicine
The method for treating cervicitis, but long-term sustained-release administration effect cannot be reached.
Chinese patent CN102860895B discloses a kind of pessary with slow release stent, the technical solution adopted is that passing through
The inside of ring pessary be equipped with can slow releasing pharmaceutical holder, which is isolated with the external world by microporous barrier, the microporous barrier
It is upper to form several micropores, pass through for particle, vagina administration can be played the role of.But the problem is that, this micropore administration
Mode is relatively more limited, the drug being only limitted between 0.1nm-10nm, and the too small easy blocking of micro-pore diameter, is unfavorable for interior foreign object
The metabolism of matter is circulated；The implantation of pessary can also cause patient a degree of secondary damage.
Chinese patent CN2936292Y discloses a kind of intrauterine administration device with sustained-release and controlled release drug form, uses
Scheme be by being placed with the hollow reticulate body of drug inside setting one, being placed into intrauterine and carry out sustained-release administration.The device
Volume it is larger, in implantation process be easy that patient is caused to damage, and its internal drug placed is easy to be fallen by port,
Ontology adaptive ability is poor, can not provide intrauterine wall suitable support force.
Therefore, the applicant is dedicated to developing a kind of band medicine delayed release device and method for implantation for uterus, in intrauterine
Portion forms reliable, suitable inside support, realizes long-term, the reliable sustained-release administration carried out inside uterus.
Invention content
The purpose of the present invention exactly proposes a kind of band medicine delayed release device and method for implantation for uterus, inside uterus
Reliable, suitable inside support is formed, realizes long-term, the reliable sustained-release administration carried out inside uterus.
The present invention is in order to solve the above technical problems, provide a kind of band medicine delayed release device for uterus comprising holder,
Mesh bag and gelinite.
The holder is in integrally sleeve-shaped, and surrounding side wall is formed with several through-holes.
The gelinite is mainly made of the drug of the gel rubber material of fluid-absorbing expansion and treatment uterine disease.
The side of the mesh bag is formed with several micropores, and the inside of the mesh bag is formed with for housing the gelinite
Accommodating cavity.
In a state of use, the mesh bag is in the inside of the holder, and the gel rubber material is in the accommodating cavity interior suction
It receives moisture expansion and struts the mesh bag, the drug is externally discharged through the micropore and the holder.
The present invention forms outer support by holder, and gel rubber material water swelling forms inner support, the common shape of the two to mesh bag
It is supported at reliable and suitable inside, excellent toughness and rigidity is collectively formed, therefore resist the adaptive ability of ambient pressure more
By force.Meanwhile and realize that gelinite in a state of use absorbs water to form the self-expanding of mesh bag, this self-expanding can be according to suffered
The ambient pressure arrived so that device is conducive to be formed with inside uterus conformally against the geometry of irregular tissue wall
Larger support contact surface, 360 degree of comprehensive administrations play sterilization thoroughly, while the micropore on mesh bag being avoided to be blocked, and are convenient for
Drug in gelinite is spread by the way that the micropore on mesh bag is lasting to mesh bag surrounding, and realization is long-term, reliably carries out intrauterine
The sustained-release administration in portion.
And due to having good biomechanical property after gel rubber material water swelling, device and intrauterine can be promoted
Portion space automatic adaptation, will not cause device to form excessive isolation, and excess pressure will not be caused to intrauterine wall, is effectively kept away
Pain and sense of discomfort are generated after having exempted from expansion.
Preferably, the gel rubber material is one or both of gel sponge material and injecting fluid gel rubber material.
Preferably, the drug is one or both of anodyne, antiphlogistic and biological agent or three kinds.
Preferably, the mesh bag internal preset has sponge material layer.
Preferably, the mesh bag is composed of or integrally formed two lateral plates or more lateral plates, pass through the surrounding of the lateral plate
Edge is interconnected and fixed, and inside forms the accommodating cavity for housing the gelinite, is offered respectively on the lateral plate multiple
The micropore.
The mesh bag of the present invention, which is further designed to the inside that two sides are composed, has the gasket form of accommodating cavity, makes
Implantation that is convenient and easily facilitating mesh bag.
Preferably, the mesh bag is made of degradable high polymer material.
Preferably, the degradable high polymer material includes one or more in following material：Polycaprolactone, poly- second
Lactide, poly(hydrobutyl ester), plastic starch material, polyether-ether-ketone, zein, polylactic acid, polydioxanone, lactic acid/hydroxyl
Acetic acid copolymer, collagen and methylcellulose.
The present invention further use degradable high polymer material make mesh bag, mainly utilize degradable material the characteristics of,
Timeliness of degrading synchronizes, and it is free to avoid the occurrence of bulk/hard material.
Preferably, the holder includes connecting rod and the elastic support ring that ring diameter size can be changed under external force.It is multiple
At tubular, the connecting rod is connected on two adjacent elastic support rings axial alignment the elastic support ring successively,
The elastic support ring and the connecting rod constitute the holder of the variable sleeve-shaped of inner space size.
Holder is further arranged to have certain Elastomeric interior portion spatially-variable form by the present invention, may be implemented to plant in holder
Changed before entering and by the ring diameter of elastic support ring after implantation and realized, is implanted into smaller state, reduces damage, while being implanted into
After can be by suitably extending, preferably to coordinate the self-expanding of mesh bag in use, and support with the good of uterus inner wall
It leans on.
Preferably, the elastic support ring is formed by connecting by one in sinusoidal wave shape or corrugated elastic strip head and the tail, have
Preferable spatial radial changing capability.
Preferably, the elastic support ring is connected by multiple elastic circular rings and is formed by connecting from beginning to end, there can be radial direction simultaneously
With axial spatial variations ability.
The present invention is met the elastic support ring by different structure and realizes elastically-deformable purpose, naturally it is also possible to straight
It connects using elastic material or realizes this purpose in conjunction with elastic material.
Preferably, the holder is made by nondegradable high molecular material or degradation material.
Preferably, the degradation material uses different polymer or copolymer.
To adapt to the otherness demand of the treatment cycle of different sufferers.And degradation material, it is therefore an objective to avoid to be implanted into
The device take out again, can with the absorption of drug, can finally generate water and carbon dioxide pass through uterus channel be discharged body
Outside, without any side effects to human body.
The present invention also proposes a kind of method for implantation with medicine delayed release device, described to be used for son with medicine delayed release device for above-mentioned
The band medicine delayed release device in palace, implantation process include the following steps：
The holder is sent into intrauterine by step 1；
Step 2, the inside that the mesh bag is sent into the holder；
Step 3 injects the gelinite inside the mesh bag.
Method for implantation proposed by the present invention with medicine delayed release device is different from conventional device entirety method for implantation, but skilful
It is wonderful to be implanted into be divided into holder, mesh bag and gelinite two parts with medicine delayed release device respectively, it is ultimately formed in patient's body
The band medicine delayed release device of assembled state, and play effectiveness, implantation process is more convenient, and small with wound, easy to operate, implantation
The more preferable advantage of success rate.
Preferably, the step 1 is specific as follows：
Step 1.1, under the auxiliary of hysteroscope, use seal wire from uterus vaginal approach first so that seal wire reaches uterus
The stent-expansion device for being preinstalled with the holder is implanted into intrauterine by position along seal wire；
Step 1.2 extracts the interior bar of the stent-expansion device out, the outer tube of the stent-expansion device and is set in described
Holder indwelling on outer tube is in intrauterine.
Step 1.3, under the monitoring of hysteroscope, the holder is slowly expanded by the stent-expansion device, until reaching
Stop after scheduled size.
After the present invention is implanted into uterus under compression, it can slowly be expanded until reaching set by stent-expansion device
Stop expansion after pressure, therefore can fit closely, come into full contact with inflammation affected part inside uterus so that drug effect absorbs more preferably.
Preferably, in the step 1.3, it is that upper bottom edge is long that the stent-expansion is cross section by the stent-expansion device
Trapezoidal sleeve-shaped in bottom can preferably adapt to uterus inner case.
Preferably, the step 2 is specially to be sent under the auxiliary of hysteroscope through conduit after being folded the mesh bag
To the inside of the holder, the conduit is then withdrawn from, the mesh bag expansion restores its unfolded preceding state.
Preferably, the step 3 specially modulates the gelinite in advance, by external pressure devices by the gel
Body injects in the sponge material layer of the mesh bag internal preset, and gradual imbibition body (can within the border in corpus uteri pendular ring for the gelinite
Can also be injecting fluid to be internal moisture) expansion struts mesh bag, and the drug in the gelinite passes through the mesh bag
Upper micropore continues slow dispersal events to outside.
Preferably, the method for implantation of the present invention further includes step 3：Toward mesh bag internal injection liquid so that gelinite is quick
It absorbs the injecting fluid and realizes self-expanding.
In conclusion the present invention is for the band medicine delayed release device and method for implantation in uterus, to include following point or several points have
Beneficial effect：
1, band medicine delayed release device of the invention can realize that long-term sustained release is administered, and be particularly suitable for meeting intrauterine long-term
Continuous medication demand.
2, " adaptive ability " for passing through holder with medicine delayed release device of the present invention forms advantageous reliable outer support, gel
" compliance " feature of material water swelling forms mesh bag appropriate inner support, the two collective effect can inside uterus shape
It is supported at reliable, suitable inside, realizes long-term, the reliable sustained-release administration carried out inside uterus.
3, of the invention to be not easy to plug with the micropore on medicine delayed release device, do not interfere with the metabolism circulation of inside and outside substance.
4, band medicine delayed release device of the invention in use, has good, suitable biomechanical property, being capable of shape
At the isolation of appropriateness, and inside and outside mass exchange and metabolism are formed, prevents substance rotten and harmful substance accumulation.
5, the present invention can avoid patient that from need to treating the pain that inflammation of uterus periodically puts medicine, of the invention for uterus
Band medicine delayed release device realizes the cooperation with existing stent-expansion device by sleeve-shaped holder, is conveniently implanted into intrauterine, simultaneously
By the variation of compressive state and expansion state, in conjunction with the self-expanding of the biological adaptivity of mesh bag so that device is conformally
Against the geometry of irregular tissue wall, is conducive to and forms larger support contact surface inside uterus, 360 degrees omnidirection is given
Medicine plays that sterilization is thorough, while avoiding that the micropore on mesh bag is blocked, drug is fallen, and passes through mesh bag convenient for the drug in gelinite
On micropore it is lasting spread to mesh bag surrounding, realize long-term, the reliable sustained-release administration carried out inside uterus.
6, the configuration of the present invention is simple, implantation is convenient, applied widely.
7, implantation can realize that minimally invasive implantation, holder can be sent into intrauterine, then expand by holder under compression
Prop slowly struts, and reaches minimum to the wound of patient, further decreases the injury to patient.
8, using Biodegradable material, without second operation, row takes out again, and wound is small, has reduced or remitted sufferer pain, and make
With conveniently.
Description of the drawings
Invention is further described in detail with reference to the accompanying drawings and detailed description：
Fig. 1 is the dimensional structure diagram with medicine delayed release device that specific embodiment is used for uterus.
Fig. 2 is the cross section structure schematic diagram for the mesh bag that specific embodiment is built-in with gelinite.
Fig. 3 is the dimensional structure diagram of specific embodiment mesh bag.
Fig. 4 is the structural schematic diagram of a lateral plate of specific embodiment mesh bag.
Fig. 5 is the planar development schematic diagram of specific embodiment holder.
Fig. 6 is the cross-sectional structure schematic diagram of specific embodiment holder in an expanded state.
Fig. 7 is the planar development schematic diagram of holder in other embodiment.
Drawing reference numeral explanation：
Holder 1, mesh bag 2, gelinite 3, through-hole 4, micropore 5, lateral plate 6, connecting rod 7, elastic support ring 8.
Specific implementation mode
As shown in Figure 1, present embodiment discloses a kind of band medicine delayed release devices for uterus comprising holder 1, mesh bag 2
With gelinite 3.
It is in sleeve-shaped that the holder 1 of the present embodiment is whole as shown in Figure 1, and surrounding side wall is formed with multiple through-holes 4, through-hole 4
Concrete shape can be changeable, as long as disclosure satisfy that internal drug disengages and limits internal mesh bag and falls.
The gelinite 3 of the present embodiment is mainly by the medicine group of the gel rubber material and treatment uterine disease of fluid-absorbing expansion
At.
Illustratively, the gel rubber material of the present embodiment selects injecting fluid gel rubber material, the choice of drug antiphlogistic.
The injecting fluid gel rubber material and the antiphlogistic can be carried out mixing tune in advance by the present embodiment by a certain percentage
With gelinite 3, the antiphlogistic is using liquid form or the drug of powder morphology, the ratio of the two and specific dosage, according to tool
Body situation appropriate can be adjusted, and can also add other auxiliary materials, to meet different treatment needs and expanding needs.
As shown in Figures 2 and 3, the side of the mesh bag 2 of the present embodiment is formed with several micropores 5, and the inside of mesh bag 2 is formed
It is useful for the accommodating cavity of accommodating gelinite 3.
The present embodiment in a state of use, the inside of holder 1 is in medicine delayed release device mesh bag 2 as shown in Figure 1, described solidifying
Glue material absorbs moisture expansion in the accommodating cavity and struts mesh bag 2 as shown in Figure 2, and the drug is right through micropore 5 and through-hole 4
Outer release.
It should be noted that the band medicine delayed release device of the present embodiment is under unused state, holder 1, mesh bag 2 and gel
Body 3 can be respectively prefabricated respectively, not be combined.It is likely to be the introduction according to the present embodiment by different manufacturers,
Holder 1, mesh bag 2, gel rubber material and drug are made respectively, then form one group of complete band medicine sustained release by the progress of another producer is mating
Device, supply third party use.
Illustratively, the mesh bag 2 of the present embodiment is specifically composed of two lateral plates 6 as shown in Figure 4, and the four of two lateral plates 6
Mutually bonding is connected and fixed circumferential edges as shown in Figure 3, and inside forms the accommodating cavity for housing gelinite 3, and in mesh bag 2
The internal accommodating cavity is preset with sponge material layer (not shown), while offering respectively on two lateral plates 6 multiple micro-
Hole 5.
Wherein, the pore size of micropore 5 and quantity are adjusted according to actual conditions, the present embodiment select suitable aperture and
The micropore of quantity makes gelinite 3 be unlikely to be extruded out of mesh bag 2 under the inner wall pressure of uterus, while drug therein can also
Effectively disengaged by micropore 5.
In different specific embodiments, the specific form of mesh bag is also that can be configured according to actual conditions, is such as adopted
The mesh bag etc. to form cuboid or square is combined with six lateral plates, thus the mesh bag can also be combined by other more lateral plates and
At or it is integrally formed, be interconnected and fixed by the edge of the lateral plate, inside formed for housing the gelinite
Accommodating cavity, and offer multiple micropores respectively on each lateral plate, details are not described herein again.
Illustratively, the mesh bag 2 of the present embodiment is made of degradable high polymer material, the degradable high polymer material packet
It includes one or more in following material：Polycaprolactone (PCL), polyglycolide (PGA), poly(hydrobutyl ester) (PHB), plasticity are formed sediment
Powder material, polyether-ether-ketone (PEEK), zein, polylactic acid (PLA), polydioxanone (PDO), lactic acid/hydroxyacetic acid
Copolymer (PLGA), collagen and methylcellulose.
Illustratively, the present embodiment can according to make need select as follows by biological degradability or biocompatible material
In it is one or more, make fluid-absorbing (such as moisture, body fluid or blood) and expand and form the gel rubber material of gel state：
Polycaprolactone (PCL), polyglycolide (PGA), poly(hydrobutyl ester) (PHB), plastic starch material, animal derived cellular matrix,
Gelatin, chitosan, platelet rich plasma, polyether-ether-ketone (PEEK), poly- methyl acid methyl esters, alginates, zein, de- cell are soft
Bone material, polylactic acid (PLA), polydioxanone (PDO) and lactic acid/co-glycolic acid (PLGA), collagen and/
Or methylcellulose.
The gel rubber material of the present embodiment can shift to an earlier date mixing preparation with the drug and semigel shape is made, and pass through pressure
Device injects in mesh bag, then further absorbs moisture by gel rubber material and become complete gel realization expansion completely.
It of courses, in other specific embodiments, the gel rubber material of the invention with selected by medicine delayed release device can be with
Be gel sponge material etc. other meet medical water swellability gel rubber material, can also be gel sponge material and injection
The mixture of body gel rubber material.The drug can also use the other drugs such as anodyne or biological agent according to actual conditions,
It can also use two or three in a variety of drugs such as anodyne, antiphlogistic and biological agent and be used in mixed way, herein not
It repeats again.
As the further embodiment of the present embodiment, the holder 1 of the present embodiment includes connecting rod 7 and under external force
The variable elastic support ring 8 of ring diameter size.
As shown in Figure 1, for axial alignment at tubular, connecting rod 7 is connected to two adjacent bullets to multiple elastic support rings 8 successively
Property support ring 8 on, elastic support ring 8 and connecting rod 7 constitute the holder of the variable sleeve-shaped of inner space size.
Illustratively, the elastic support ring 8 of the present embodiment is formed by connecting by one in sinuous elastic strip head and the tail, this reality
It applies example and the variable purpose of inside and outside diameter is realized by V-structure therein and elastic material performance jointly.
Fig. 5 shows the planar development form for the holder 1 being made of multiple elastic support rings 8 and connecting rod 7, such as Fig. 5 institutes
The a plurality of sinuous elastic strip (i.e. the unfoldable shape of elastic support ring 8) shown is set up in parallel, and is attached by connecting rod,
The mesh sides with multiple special-shaped through-holes are formed, side wall rolls and same sinuous elastic strip joins end to end
The holder for forming sleeve-shaped, passes through the variation combination elastic material properties of each V shapes body angle in elastic support ring, Ke Yiyou
The ring diameter variation of each elastic support ring of realization of effect, then realizes the adaptive change in internal stent space.
The length of the present embodiment connecting rod can adjust according to actual needs, it might even be possible to be the coating for meeting connection and needing
, can also be to select telescopic rod or elastic rod with expansion performance, further increase axial stretching ability.
Illustratively, the elastic support ring of the present embodiment and the following biological degradability of connecting rod or biocompatible material
At least one of material material is constituted：Polycaprolactone (PCL), polyglycolide (PGA), poly(hydrobutyl ester) (PHB), plastic starch
Material, polyether-ether-ketone (PEEK), zein, polylactic acid (PLA), polydioxanone (PDO) and lactic acid/hydroxyacetic acid are total
Polymers (PLGA), collagen and/or methylcellulose etc..
It of courses, for the present invention in other specific embodiments, the specific composition of holder and the form of presentation are also can have
Different variations, as shown in fig. 7, the present invention elastic support ring can also by multiple elastic circular rings connect and head and the tail connect and
At forming side wall as shown in Figure 7 and roll to form holder again.Elastic support ring can also directly select vertical bar shape, corrugated etc.
The elastic ring of form, elastic ring are arranged along same central axes, and the branch that adjacent spring circle forms straight cylindrical is connected by connecting rod
Frame etc., details are not described herein again.
The present embodiment is particularly applicable in medicine delayed release device in the treatment of inflammation of uterus, and specific method for implantation is not yet
Be same as conventional whole method for implantation, the method for implantation with medicine delayed release device of the present embodiment using seperated implantation,
Implantation process includes the following steps：
Holder 1 is sent into intrauterine by step 1；
Step 2, the inside that mesh bag 2 is sent into holder 1；
Step 3 injects gelinite 3 inside mesh bag 2；
Step 4,2 internal injection liquid (such as physiological saline) of past mesh bag so that gelinite 3 quickly absorbs the injecting fluid
Realize self-expanding.
Holder 1 is first implanted by the present embodiment by the step 1, then is implanted into mesh bag 2 by the step 2, due to net
There is no the support substances such as gelinite 3 for 2 inside of bag, so small volume, facilitates implantation；It is injected suitably by the step 3 again
The gelinite 3 of amount completes the assembling with medicine delayed release device in intrauterine, neither influences using effect, while can also realize minimally invasive
Implantation reduces the loss that implantation process brings patient, and further increases the success rate of implantation；Step 4 gives gel material
Material provides sufficient liquid, and gel state is quickly formed for its absorption expansion.
It should be noted that in other specific embodiments, above-mentioned steps 4 are also dispensed, can be by uterus
Internal body fluid provides liquid needed for expansion for gel rubber material, and gel rubber material can also realize that water swelling forms gel state.
Illustratively, in specific practical operation, the method for implantation with medicine delayed release device for uterus of the present embodiment
Specific implantation process is as follows：
Specific steps 1：
A, under the auxiliary of hysteroscope, use seal wire from uterus vaginal approach first so that seal wire reaches uterus position, edge
It seal wire and the stent-expansion device for being preinstalled with holder 1 is implanted into intrauterine；
B, the interior bar of the stent-expansion device is extracted out, the outer tube of the stent-expansion device and is set in the outer tube
On 1 indwelling of holder in intrauterine；
C, under the monitoring of hysteroscope, by the slow expandable stent 1 of the stent-expansion device, until reaching scheduled size
After stop.Illustratively, the expansion of holder 1 is that upper bottom edge is longer than bottom for cross section as shown in FIG. 6 by the stent-expansion device
The trapezoidal sleeve-shaped on side.
Specific steps 2：It is sent to intrauterine under the auxiliary of hysteroscope through conduit after mesh bag 2 is folded, then removes
Go out the conduit, the expansion of the mesh bag 2 restores its unfolded preceding state.
Specific steps 3：Gelinite 3 is modulated in advance, gelinite 3 is injected into 2 inside of mesh bag in advance by external pressure devices
If the sponge material layer in, gelinite 3 corpus uteri pendular ring within the border gradually water suction (can be internal moisture, can also
It is injecting fluid) expansion struts mesh bag to form preferable support force, and the drug in gelinite 3 is outside by micropore 5 on mesh bag 2
Portion continues slow dispersal events.Whether further implement above-mentioned steps 4, is selected according to actual conditions.
It pressurizes to stent-expansion device in the implantation process of specific steps 1, to realize the slow expansion of holder 1
(can not also pressurize, adaptively pressurizeed by mesh bag self-expanding).Stent-expansion device is the auxiliary with expansible effect
Tool, such as foley's tube (commercial type medical, select appropriate size), filling in sacculus has contrast agent.This
Stenter to implant mode under kind contraction and compressive state, may be implemented the minimum to patient trauma.
In entire specific implantation process, medical staff is using the present embodiment with medicine delayed release device and according to the present embodiment
Method for implantation is operated, and minimally invasive implantation may be implemented in band medicine delayed release device, outer support is formed by holder, in intrauterine through body
The lower gradually expansion of pendular ring border certain time effect, struts mesh bag and forms the inner support with good biological adaptability, the two is common
Form reliable and suitable inside support (mesh bag and holder can form various shapes under the limitation of external intrauterine wall).Gel
Body and sponge material layer are mixed with realization inside uterus, and gel rubber material is effectively limited in mesh bag, and the medicine that gelinite includes
Object then penetrates to be realized at intrauterine wall in mesh bag micropore and continues slowly to release the drug around, as well as gel rubber material and mesh bag
Effect, drug will not directly be fallen from holder two-port or through hole.
With it is above-mentioned be only the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications should also regard
For protection scope of the present invention.
Claims (10)
1. a kind of band medicine delayed release device for uterus, which is characterized in that including：Holder, mesh bag and gelinite；
The holder is in integrally sleeve-shaped, and surrounding side wall is formed with several through-holes；
The gelinite is mainly made of the drug of the gel rubber material of fluid-absorbing expansion and treatment uterine disease；
The side of the mesh bag is formed with several micropores, and the inside of the mesh bag is formed with for housing the accommodating of the gelinite
Chamber；
In a state of use, the mesh bag is in the inside of the holder, and the gel rubber material absorbs water in the accommodating cavity
Expansion is divided to strut the mesh bag, the drug is externally discharged through the micropore and the through-hole.
2. being used for the band medicine delayed release device in uterus as described in claim 1, it is characterised in that：The gel rubber material is gel sea
One or both of continuous material and injecting fluid gel rubber material.
3. being used for the band medicine delayed release device in uterus as described in claim 1, it is characterised in that：The drug is anodyne, disappears
One or both of scorching medicine and biological agent or three kinds.
4. being used for the band medicine delayed release device in uterus as described in claim 1, it is characterised in that：The mesh bag internal preset has sea
Continuous material layer.
5. being used for the band medicine delayed release device in uterus as described in claim 1, it is characterised in that：The mesh bag is by two lateral plates or more
Lateral plate is composed or integrally formed, is interconnected and fixed by the edge of the lateral plate, and inside is formed for housing
The accommodating cavity of gelinite is stated, offers multiple micropores on the lateral plate respectively.
6. the band medicine delayed release device as described in any one in claim 1-5 for uterus, it is characterised in that：The mesh bag is by can
Degraded macromolecular material is made.
7. being used for the band medicine delayed release device in uterus as claimed in claim 6, it is characterised in that：The degradable high polymer material
Including one or more in following material：Polycaprolactone, polyglycolide, poly(hydrobutyl ester), plastic starch material, polyethers ether
Ketone, zein, polylactic acid, polydioxanone, lactic acid/co-glycolic acid, collagen and methylcellulose.
8. being used for the band medicine delayed release device in uterus as described in claim 1, it is characterised in that：The holder include connecting rod and
The variable elastic support ring of ring diameter size under external force；Multiple elastic support rings successively axial alignment at tubular, institute
It states connecting rod to be connected on two adjacent elastic support rings, the elastic support ring and the connecting rod constitute inside
The holder of the variable sleeve-shaped of space size.
9. being used for the band medicine delayed release device in uterus as claimed in claim 8, it is characterised in that：The elastic support ring is in by one
Sinuous elastic strip head and the tail are formed by connecting.
10. being used for the band medicine delayed release device in uterus as claimed in claim 8, it is characterised in that：The elastic support ring is by more
A elastic circular ring connects and is formed by connecting from beginning to end.
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| CN201510443480.3A CN105013072B (en) | 2015-07-24 | 2015-07-24 | Band medicine delayed release device for uterus |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510443480.3A CN105013072B (en) | 2015-07-24 | 2015-07-24 | Band medicine delayed release device for uterus |
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| CN105013072B true CN105013072B (en) | 2018-08-31 |
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| CN108498217B (en) * | 2018-03-22 | 2021-03-16 | 西安交通大学 | 3D printing degradable stent for correcting vaginal deformity and manufacturing method thereof |
| CN110192940A (en) * | 2019-06-14 | 2019-09-03 | 苏州晶俊新材料科技有限公司 | A kind of degradable fallopian tube stent |
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| CN101854886A (en) * | 2007-03-15 | 2010-10-06 | 矫正-空位有限公司 | Prosthetic devices and methods of use |
| CN102120059A (en) * | 2011-03-11 | 2011-07-13 | 东南大学 | Medicinal stent-graft for preventing and treating intrauterine adhesion |
| CN103417272A (en) * | 2013-09-12 | 2013-12-04 | 中山大学附属第一医院 | Medicine distribution type uterus support |
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| US20050171569A1 (en) * | 2000-04-25 | 2005-08-04 | Impres Medical, Inc. | Method and apparatus for creating intrauterine adhesions |
| US20100004733A1 (en) * | 2008-07-02 | 2010-01-07 | Boston Scientific Scimed, Inc. | Implants Including Fractal Structures |
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| CN2936292Y (en) * | 2006-08-03 | 2007-08-22 | 天津市医疗器械厂 | Disposable urethral medicine package administration device |
| CN101854886A (en) * | 2007-03-15 | 2010-10-06 | 矫正-空位有限公司 | Prosthetic devices and methods of use |
| CN102120059A (en) * | 2011-03-11 | 2011-07-13 | 东南大学 | Medicinal stent-graft for preventing and treating intrauterine adhesion |
| CN104000652A (en) * | 2013-02-21 | 2014-08-27 | 王世亮 | Absorbable drug release bag film capable of preventing adhesion |
| CN103417272A (en) * | 2013-09-12 | 2013-12-04 | 中山大学附属第一医院 | Medicine distribution type uterus support |
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