CN105106028B - A kind of peptide composition for hair growth - Google Patents
A kind of peptide composition for hair growth Download PDFInfo
- Publication number
- CN105106028B CN105106028B CN201510543484.9A CN201510543484A CN105106028B CN 105106028 B CN105106028 B CN 105106028B CN 201510543484 A CN201510543484 A CN 201510543484A CN 105106028 B CN105106028 B CN 105106028B
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- hair
- composition
- polypeptide
- peptide
- growth
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- 230000008764 nerve damage Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000001702 nutmeg Substances 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 210000004918 root sheath Anatomy 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000003859 smegma Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000003797 telogen phase Effects 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940094879 tetrapeptide-21 Drugs 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical group SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
The present invention has published a kind of peptide composition for hair growth, the composition includes the polypeptide for promoting collagen generation and the polypeptide for promoting keratoprotein generation, for various alopecias or hair missing symptom, to promote new hair growth, and reinforce the root of generated hair, it is avoided to come off, so as to reach hair growth, increase, becomes denser purpose.The concentration of wherein each polypeptide is all at 0.01ppm~50000ppm (w/w).The composition of the present invention can be used for cosmetics, drug.
Description
Technical field
The invention belongs to medical cosmetic technical fields, provide one kind and suitably facilitate people and other mammalian hair growths
Peptide composition.
Various products are prepared into using the method for composite reactive polypeptide and include but not limited to Essence, lotion, is washed at shampoo
Liquid, creme, spray, gel, ointment and paste, for promoting hair growth, anti-alopecia-stopping makes the necks such as hair enrichment growth
Domain.
Background technology
It is described below comprising the background information to come in handy to understanding the present invention.But it is neither to recognize that any provided herein
Information is the present invention or the prior art in relation to applying for currently requiring that protection, nor recognizing any specific or implying what is be related to
The disclosed prior art.
1st, hair loss state introduction
Hair, eyebrow and eyelashes missing or Sparse Problems, not only influence the appearance of a people, can also cause the various psychology of patient
Disease.There is grinding for the research for being dedicated to solving hair, eyebrow and eyelashes missing or Sparse Problems, particularly hair missing in each state
Study carefully.Alopecia affects the male of 20% 20 years old age bracket, and is increased with the speed of every 10 years 10%, that is to say, that 50 years old left side
Right male, will have 50% to suffer from alopecia.
95% alopecia is caused by male sex hormone, with hair root sheath existing for 5 α-lidarutase enzymes it is related.5α-
Male sex hormone testosterone (testostearone) can be converted to 5 α-dihydrotestosterone (5 α-DHT) by lidarutase enzymes.5 α-DHT have
Inhibit the effect of hair matricyte, activate sebaceous glands and promote the secretion mobility of sebum fatty, hair luster is made to prevent drying.
If smegma increases, hair follicle development is influenced, hair follicle becomes smaller, and hair attenuates, so as to cause a large amount of hair fall in flakes.It is on the contrary
Hair is then thicker, is hardened, blackening.The reason of this explains male pattern baldness more than women, and women such as disease, weight or menopause
(estrogen secretion at this time plunges, it is impossible to offset the male sex hormone in body body-internal-circulation), is possible to alopecia.
2nd, the structure of hair and generation
Hair is a kind of keratoprotein, two part of the hair root composition being broadly divided under the hair shaft and skin on skin.Hair follicle
It is the bourse for being enclosed in root of hair, is the skin histology for enabling hair growth.Hair follicle is to promote the generation of hair keratoprotein
Key position.Normal great-hearted hair follicle, is connected by the papilla of basal part with the capillary in skin, and these
Nutrition is then shipped to hair by blood vessel by blood circulation.
Collagen in skin is then the supply station of trichotrophy, and the abundance of root of hair collagen can make hair
Send out tough securely.The micro- sem observation in hair cross section：Bosom is hair marrow, and centre is collagen, and outermost one layer is
Hair scale piece.Collagen mainly controls thick children, elasticity and the wettability of hair.
Each hair all originates in the hair breast at dermis of skin, it forms a ball top, then, thin by angling
The cell division of born of the same parents, piece hair of promotion grow up to.The growth cycle of hair, eyebrow and eyelashes is similar, is divided into growth
Phase-amortization period-stand-down, difference are growth cycle time differences.The early growth period service life of hair is about 2-6, later
Into stand-down and come off, daily growth length about 0.3mm.Eyelashes average growth rate is (0.12 ± 0.05) mm/ days, significantly
The speed of growth of 0.3mm/ days less than hair, eyelashes growth cycle are estimated as about 5-6 months, and the wherein duration in growth period puts down
It is (34 ± 9) day.Eyebrow growth cycle is about 2 months, grows about 0.2mm daily
3rd, hair therapy situation
For hair, eyebrow and eyelashes missing or Sparse Problems, according to severity, the therapeutic scheme used is different.Hand
Art therapy has skin flap transplantation expander method, but operation wound is big, locally stays scar, and convalescence is long, and patient is generally unwilling to receive；
Hair loss transplants healthy hair follicle to alopecia position, growth is allowed to go out new hair, this surgical procedure is improper, can easily lead
Cause hair follicle necrosis.
Prevention alopecia such as Bimatoprost in terms of drug, also known as Bimatoprost, dew secrete root etc., which is U.S.'s eyesight
The ingredient included in the prescription medicine Lumigan (Lu Meigen) for the treatment of glaucoma that strong company will produce in the end of the year 2006, can promote eyelash
Hair growth then produces eyelash growing liquid by many cosmetics companies as raw material.But Bimatoprost can excessively cause optic nerve
Damage may cause visual impairment even to be blinded, may also result in the symptoms such as retina swelling and inflammatory eye in addition.
Minoxidil (Minoxidil) is the drug for being clinically usually used in hair therapy at present, is found in the U.S., and FDA is criticized
Standard can locally use 2% minoxidil in male and female, can take off most of male and female androgenetic
Hair patient grows macroscopic hair/fine, however, it was found that the side effect of administration includes scalp irritation and facial hair increases
Add.Whether in addition, it is effective that year is at least spent to assess this drug.
Chinese herbal medicine is used in recent years with nourishing qi and blood, promoting circulation of blood dissolving stasis, the turbid functional treatment alopecia through dredging collateral, to pass through office
Portion stimulates scalp, and the Chinese herbal medicine extract to promote blood circulation is primary raw material, then is equipped with auxiliary material and forms.But the work of Chinese herbal medicine
Indefinite with mechanism, research also needs to further deeply, and the extraction process of Chinese medicine is complicated, of high cost.
4th, polypeptide is used for trichogenous situation
With biotech development, emerge in an endless stream for hair growth and trichogenous Biochemical Drugs.In recent years, it is living
Property polypeptide be applied to solve alopecia and promote hair regeneration by the attention of dept. of dermatology of various countries and cosmetology expert.
The 80s and 90s in last century, the U.S. find therapeutic effect of the copper victory peptide in hair hyperplasia, it mainly stimulates root of hair
Hair follicle generates hair, is applied in hair-growing and hair care product as raw material.The generating and nourishing hair product of cupric peptide components is U.S. doctor
Under medicine company ProCyte brand Tricomin series, and possess multiple patents (USA Pat No 5538945,
5177061,5120831).The patent of Japanese Laid-Open invention：Hair promotes the oligopeptides (publication number of activity：CN1445236A), it is
A kind of length is about the separation oligopeptides of 5-104 amino acid residue, preferably comprise one or more above-mentioned oligopeptides as activity into
One or more pharmaceutically acceptable medicine preparations point are added again into creme, spray, and the form application of coating liquid and patch etc. can promote
Into the activity of epithelisin hair follicle, so as to promote hair growth.United States Patent (USP) (domestic 102596170 A of publication No. CN) is open to be used
In the composition and method of enhancing eyelashes, predominantly N- biotinyl-gly-his-lys and creatine, the two compound action in
Eyelash follicle position, can cooperate with increases eyelashes number, and the generation of creatine stimulation keratin 5.United States Patent (USP) (domestic publication number
CN1622797A) a kind of trichogenous composition of Actin-Binding Peptide is disclosed, which contains β thymosin fragments, energy
Promote hair follicle increased activity, number increases, so as to stimulate hair growth.South Korea discloses the patent (application number of invention
200680039713.2)：Cosmetic composition for the peptide for promoting hair growth and improvement wrinkle and comprising the peptide, is also wrapped
Containing with human thymus's β -4 active peptides, but C- ends hydroxyl or amido modified, N- ends are with selected from having acetyl group, palm
Protecting group protection in the groups such as acyl is, myristyl.Domestic patent publication No. CN1634568A, hair growth liquor basis are days
Right biomaterial keratin is chemically treated by some row into albumen containing medicinal function, function peptide matters and 19 kinds of amino acid,
To adjust cellular keratinization speed, effectively inhibit the secretion of sebaceous glands, improve hair follicle physiological function and reach prevention alopecia and promote hair
Long effect occurs, after listed with 31 polypeptide hair-care essences.
Any of the above patent and research all show that polypeptide has activation hair follicle or activation keratoprotein gene, promotes angle
Matter albumen generates, so as to make hair growth.But the polypeptide in publication, molecular mass is big, is unfavorable for the absorption of skin,
Reduce the utilization rate of polypeptide.More than patent stresses to be that hair is promoted to grow, and ignores and the solid and hair of taking aim at for newly growing hair is not easy
The research to come off.Also it is only the use of single polypeptide in the product use listed, which has limited the performances of polypeptide effect.
Invention content
The present invention according to the structure and physiological activity of hair, using with promote the polypeptide of hair keratoprotein generation with
Polypeptide with stimulation collagen generation combines, and not only can promote hair growth, but also enhance with the growth of hair follicle stimulating
The generation of the collagen of perifollicolar skin supplements the nutrition of new long hair, reinforces root of hair, makes hair more sturdy,
Toughness is stronger.This promotes single effect polypeptide of hair keratoprotein generation to have more significant effect, reaction than being only used only
Go out apparent synergistic effect, and can aid in hair health growth, to achieve the purpose that hair increases enrichment.
The present invention, which discloses, proposes a kind of peptide composition for hair growth, makees comprising being generated with stimulation collagen
Polypeptide and the polypeptides in combination for promoting keratoprotein generation：
A, selected from the following polypeptides of one or more with promotion keratoprotein generation, including but not limited to nutmeg
Acyl pentapeptide -17, myristoyl hexapeptide -16；
B, selected from the following polypeptide of one or more generated with stimulation collagen, including but not limited to biotin
Tripeptides -1 (Biotinyl-GHK), acetyl group tetrapeptide -3, copper peptide (GHK-Cu), palmityl tripeptides -1, tripeptides -1, palmityl five
Peptide -3, tetrapeptide -21, palmityl hexapeptide -6, palmityl tripeptides -5, acetyl group tetrapeptide -11, myristoyl pentapeptide -11, myristoyl six
Peptide -4, myristoyl octapeptide -1, hexapeptide -3, pentapeptide -31, wherein a concentration of 0.01ppm~5% (w/w) of each polypeptide fractions, solvent
For water.
The mechanism of action in the present invention with the polypeptide for promoting keratoprotein generation is as follows：Myristoyl pentapeptide -17, Pork and beans
The mechanism of action of cool acyl hexapeptide -16 is identical, is all the expression for stimulating keratin gene, so as to reach trichogenous mesh
, it is the SymPeptide that the fragrant company of German moral producesTMSeries of products.
In the present invention, peptide composition can add other bioactive substance, and adding ingredient is helped including some
In educating the active constituent sent out, preferably biotin, (5,7,4 ')-trihydroxyflavone, oleanolic acid, biochanin a
(Biochanin a).(5,7,4 ')-trihydroxyflavone is a kind of flavonoids extracted from citrus, has diastole blood
The effect of pipe.Oleanolic acid is the substance extracted in a kind of leaf from olive, can inhibit 5α-reductase and is reduced into cortisol
DHT；The effect of biochanin a is similar with its.
The polypeptide that the present invention has collagen generation is able to maintain that the complete of perifollicolar skin, provides hair growth institute
Nutrition is needed, hair is enabled to take aim at solid.It is preferred that biotin tripeptides -1, copper peptide, acetyl group tetrapeptide -3.Biotin tripeptides -1 is that one kind belongs to
The polypeptide of Matrikines series, it stimulates the collagen generated that can anchor at hair in dermic hair follice.Copper peptide mainly pierces
Swash hair follicle, promote hair growth.Acetyl group tetrapeptide -3 more research confirm promote collagen growths, contribute to hair,
The growth of eyelashes.
The present invention combines the mechanism of action of the above components, according to hair growth rule and the structure of hair, polypeptides in combination
Object can be following combination：
Polypeptide compound of the present invention can be that myristoyl pentapeptide -17 and biotin tripeptides -1 combine.
Polypeptide compound of the present invention can be myristoyl pentapeptide -17, biotin tripeptides -1 and the combination of copper peptide.
Polypeptide compound of the present invention can be myristoyl pentapeptide -17, myristoyl hexapeptide -16, biotin tripeptides -
1 and copper peptide combination.
Polypeptide compound of the present invention can be myristoyl pentapeptide -17, myristoyl hexapeptide -16, biotin tripeptides -
1st, acetyl group tetrapeptide -3 and the combination of copper peptide.
Polypeptide compound of the present invention can be myristoyl pentapeptide -17, biotin tripeptides -1, oleanolic acid and (5,
7,4 ')-trihydroxyflavone combination.
Polypeptide compound of the present invention can be that myristoyl pentapeptide -17 and acetyl group tetrapeptide -3 combine.
Polypeptide compound of the present invention can be -3 group of myristoyl pentapeptide -17, biochanin a and acetyl group tetrapeptide
It closes.
The composition of the present invention, can be applied to may generate hair reduction and/or the patient there are hair reduction.
Head, eyelashes and eyebrow position including patient.
It can be extraction lipid and/or synthesis lipid, water or fat-soluble active ingredient the invention also includes adding ingredient, plant
Object extract, tissue extract, marine extracts, antioxidant, moisturizer, stabilizer or preservative etc., specific each component
A concentration of 0.01ppm~5% (w/w).
The present invention includes addition moisturizer, preferably such as glycerine, Aloe Vera Gel, Sodium Hyaluronate；Polyol class preservative, preferably
Pungent glycol；The comprehensive reagent of stable components, preferably 1,2- hexylene glycols are maintained including anti-microbial type；The above components it is a concentration of
0.01ppm~5% (w/w) etc..
The present invention includes pH adjusting agent, and the pH adjusting agent is selected from：Triethanolamine, sodium bicarbonate, saleratus, preferably three
Ethanol amine；PH value range is 3.0~8.0, preferably 5.0-7.0.
In the embodiment of the present invention, peptide composition can be made various products and include but is not limited to hair-care essence liquid,
Lotion, shampoo, washing lotion, creme, spray, gel, ointment and paste, mascara, informer's agent, eyebrow pencil.Dosage form can be various
Preparation includes but is not limited to solution, lotion, gel, solid and liposome.
The present invention relative to the prior art advantageous effect, including：
During the present invention in embodiment in vitro culture hair follicle tissue by testing, compared with 2% minoxidil, polypeptides in combination
Object is on hair growth is promoted, hence it is evident that better than minoxidil, this provides new drug foundation for clinical treatment alopecia.Numerous
Data is it has been shown that single polypeptide such as biotin tripeptides -1, acetyl group tetrapeptide -3, myristoyl pentapeptide -17 has confirmed and hair
Growth has indirect/direct function and effect, and have a large amount of clinical data, therefore in this experiment, peptide composition group is promoting
In hair growth, compared with above single peptide, there is the effect for being substantially better than single peptide, show significantly to act synergistically.
The clinical test of the embodiment of the present invention is found, 1, embodiment 3 is preferably implemented and is used as eyelashes growth-promoting media, embodiment 5
As natural on-off cycles of hair growth liquid, implement 6 and be used as eyebrow growth-promoting media, these peptide compositions can be obviously promoted head in clinical trial
The quantity increase of hair, eyebrow, eyelashes, increase in density.
Description of the drawings
Fig. 1 is the averag density schematic diagram for promoting natural on-off cycles of hair growth clinical test anagen；
Fig. 2 is the averag density schematic diagram for promoting natural on-off cycles of hair growth clinical test telogen；
Fig. 3 is to increase schematic diagram for eyelashes to be promoted to grow clinical test eyelashes density；
Fig. 4 is to increase schematic diagram for eyelashes to be promoted to grow clinical test eyelash length；
Fig. 5 is to increase schematic diagram for eyelashes to be promoted to grow clinical test eyebrow.
Specific embodiment
With reference to embodiment and attached drawing, the present invention is described in further detail, but the embodiment invented is not limited to
This.
Embodiment 1 promotes the Essence of eyelashes growth
Prescription (1 kilogram of Essence)：
Preparation method：
The Sodium Hyaluronate of formula ratio is added to the water, stirring makes to be uniformly mixed, and is then heated to 80~85 DEG C, heat preservation
Stirring makes it be uniformly dispersed.Temperature drops to 40 DEG C hereinafter, addition myristoyl pentapeptide -17, biotin tripeptides -1, biotin are pungent
Glycol and 1,2- hexylene glycol, stir evenly.With the pH value of 15% triethanolamine tune solution to 5.5 or so.
Embodiment 2 promotes the Essence of eyelashes growth
Prescription (1 kilogram of Essence)：
Preparation method：
The Sodium Hyaluronate of formula ratio is added to the water, stirring makes to be uniformly mixed, and is then heated to 80~85 DEG C, heat preservation
Stirring makes it be uniformly dispersed.Temperature drops to 40 DEG C hereinafter, addition myristoyl pentapeptide -17, biotin tripeptides -1, copper peptide, biology
Element, pungent glycol and 1,2- hexylene glycol, stir evenly.With the pH value of 15% triethanolamine tune solution to 5.5 or so.
Embodiment 3 promotes the Essence of eyelashes growth
Prescription (1 kilogram of Essence)：
Preparation method：
The Sodium Hyaluronate of formula ratio is added to the water, stirring makes to be uniformly mixed, and is then heated to 80~85 DEG C, heat preservation
Stirring makes it be uniformly dispersed.Temperature drops to 40 DEG C hereinafter, adding in myristoyl pentapeptide -17, myristoyl hexapeptide -16, biotin
Tripeptides -1, copper peptide, biotin, pungent glycol and 1,2- hexylene glycol, stir evenly.With the pH value of 15% triethanolamine tune solution extremely
5.5 left and right.
Embodiment 4 promotes the Essence of natural on-off cycles of hair growth
Prescription (1 kilogram of Essence)：
Preparation method：
The Sodium Hyaluronate of formula ratio is added to the water, stirring makes to be uniformly mixed, and is then heated to 80~85 DEG C, heat preservation
Stirring makes it be uniformly dispersed.Temperature drops to 40 DEG C hereinafter, adding in myristoyl pentapeptide -17, myristoyl hexapeptide -16, biotin
Tripeptides -1, copper peptide, acetyl group tetrapeptide -3, biotin, pungent glycol and 1,2- hexylene glycol, stir evenly.With 15% triethanolamine tune
The pH value of solution is to 6.5 or so.
Embodiment 5 promotes the Essence of natural on-off cycles of hair growth
Prescription (1 kilogram of Essence)：
Preparation method：
The Sodium Hyaluronate of formula ratio is added to the water, stirring makes to be uniformly mixed, and is then heated to 80~85 DEG C, heat preservation
Stirring makes it be uniformly dispersed.Temperature drop to 40 DEG C hereinafter, add in dissolve 5,7,4 '-trihydroxyflavone, oleanolic acid, N- give birth to
Object element base-gly-his-lys, copper victory peptide, butanediol, pungent glycol and 1,2- hexylene glycol, stir evenly.With 15% triethanolamine tune
The pH value of solution is to 6.5 or so.
6 eyebrow growth-promoting media of embodiment
Prescription (1 kilogram of Essence)：
Preparation method：
The Sodium Hyaluronate of formula ratio is added to the water, stirring makes to be uniformly mixed, and is then heated to 80~85 DEG C, heat preservation
Stirring makes it be uniformly dispersed.Temperature drops to 40 DEG C hereinafter, addition myristoyl pentapeptide -17, acetyl group tetrapeptide -3, biotin are pungent
Glycol and 1,2- hexylene glycol, stir evenly.With the pH value of 15% triethanolamine tune solution to 5.5 or so.
7 eyebrow growth-promoting media of embodiment
Prescription (1 kilogram of Essence)：
Preparation method：
The Sodium Hyaluronate of formula ratio is added to the water, stirring makes to be uniformly mixed, and is then heated to 80~85 DEG C, heat preservation
Stirring makes it be uniformly dispersed.Temperature drops to 40 DEG C hereinafter, adding in myristoyl pentapeptide -17, acetyl group tetrapeptide -3, biochanin
A, biotin, pungent glycol and 1,2- hexylene glycol, stir evenly.With the pH value of 15% triethanolamine tune solution to 5.5 or so.
The experiment that embodiment 8 influences hair growth in culture model in vitro
Sample source：Take healthy volunteer's scalp tissue, the problems such as volunteer is without hair dyeing, head dermatose, age 20-40
Between year.Scalp tissue is detached under the microscope, collects the hair follicle tissue of early growth period.
Tissue cultures：Hair follicle tissue is added in comprising 10ng/mL cortisols (hydrocortisone), 10 μ g/mL pancreas islet
The culture medium of element, 2mM L-Glutamines, 100U/mL penicillin, is placed in 37 DEG C, 5%CO2Incubator in, it is continuous to cultivate
14 days.Add in each peptide composition and single polypeptide, another two groups be separately added into isometric physiological saline as a control group and
2% minoxidil.
Data determination：Respectively in culture 0 day, 7 days, 14 days growth rates for measuring hair lengths.
1 hair growth rate of table
| Grouping | 7 days | 14 days |
| Control group | 4.5% | 10.1% |
| Minoxidil | 7.5% | 12.9% |
| 1 peptide composition group of embodiment | 10.9% | 18.7% |
| 2 peptide composition group of embodiment | 10.1% | 18.9% |
| 3 peptide composition group of embodiment | 11.2% | 19.8% |
| 4 peptide composition group of embodiment | 10.8% | 18.5% |
| 5 peptide composition group of embodiment | 12.1% | 19.7% |
| 6 peptide composition group of embodiment | 11.7% | 18.6% |
| 7 peptide composition group of embodiment | 10.5% | 17.9% |
| Acetyl group tetrapeptide -1 | 7.9% | 12.5% |
| Myristoyl pentapeptide -17 | 8.4% | 14.9% |
| Biotin tripeptides -1 | 8.0% | 13.9% |
As a result as can be seen that the group hair growth for adding in 2% minoxidil is considerably longer than control group, illustrate that this is trained
Work(.
Data above is learnt, is individually added into the polypeptide group for promoting keratoprotein generation, and hair is also considerably longer than control group,
Display promotes the polypeptide of keratoprotein significantly to have trichogenous effect.
Data are shown, keratoprotein and the hair of the peptide composition group of collagen generation is promoted to be considerably longer than control
Group, while also longer than the polypeptide group for being individually added into promotion keratoprotein generation, illustrate comprising promotion collagen and keratoprotein
The peptide composition group of generation significantly play the role of it is trichogenous, and the combination on hair growth better than individually promote
The polypeptide group generated into keratoprotein.Result of the test side illustration, containing the polypeptide group for promoting collagen and keratoprotein generation
Closing object has good synergistic effect.
From subsequent clinical trial it is found that keratoprotein and the peptide composition group of collagen generation is promoted to promote hair
It is better than the group of 2% minoxidil in growth, this provides foundation for clinical treatment alopecia using novel drugs.
Embodiment 9 promotes natural on-off cycles of hair growth clinical test
Selection 60 is because of the volunteer of androgenetic alopecia, average age 46 years old, all volunteers without hypoferric anemia,
Thyroid gland and relevant pathology spy shape, head hair did not receive any treatment yet.In this Experimental Area, at least
There are 200 hairs, wherein 70% is in early growth period.
15 people use 5 peptide composition group of embodiment, and 15 people use minoxidil, and 15 people use placebo, and 15 people use
Biotin tripeptides -1, the concentration of each group drug are the same.In head zone haircut (the haircut region area about 1.8cm of detection2), even
Continuous 3 days acquisition haircut position pictures, assessment early growth period and final hair.Every night is primary using drug, continuous 4
Month.Using microscope and automaticdata image collecting analyzer device record D0 (the 0th day) and the data of 4 months.
It draws：Compare D0 (the 0th day) and 4 months, each group hair is at the averag density in growth period and each group hair
In the averag density of hair final period, hair initial stage and final averag density comparing result difference are as depicted in figs. 1 and 2.
Result of the test shows that peptide composition group can effectively facilitate hair growth, increases the hair in the anagen phase
It is more；Data are shown on table, and polypeptide is expected to substitute minoxidil, is used clinically for the treatment of bald head；Peptide composition group is apparent
Better than single polypeptide, significant synergistic effect is showed.
Result of the test shows that peptide composition group can effectively reduce the hair of growth medium, effectively prevents coming off for hair；
Data are shown on table, and peptide composition group is substantially better than single polypeptide, show significant synergistic effect.
Embodiment 10 promotes eyelashes growth clinical test
50 volunteers are selected, record the quantity and length of these volunteer's on the face eyelashes, lower eyelid eyelashes respectively
Quantity and length.
It is divided into five groups：3 peptide composition of 1 peptide composition of embodiment and embodiment, Bimatoprost, myristoyl five
Peptide -17, placebo.Continuous use smears once, and records the quantity and length of on the face/lower eyelid eyelashes for 4 weeks, 8 weeks sooner or later
Degree.
As a result：The 4 weeks density with 8 weeks eyelashes is recorded, as shown in Figure 3；And the length increased, as shown in Figure 4.
Come as can be seen from Figure 3, peptide composition group can significantly increase eyelashes density, and the density of peptide composition group is bright
The aobvious effect more than single polypeptide, this illustrates that peptide composition is better than single polypeptide.
Fig. 3 is also shown, and peptide composition is better than Bimatoprost, is expected to substitute Bimatoprost.
Come as can be seen from Figure 4, peptide composition group can be obviously promoted eyelash length, and the length of peptide composition group increases
The long effect for being significantly greater than single polypeptide, this illustrates that peptide composition is better than single polypeptide.
Fig. 4 is also shown, and polypeptide is better than Bimatoprost, is expected to substitute Bimatoprost.
Embodiment 11 promotes eyebrow growth clinical test
60 volunteers with apparent eyebrow missing of selection, record the quantity of eyebrow, volunteer are divided into respectively
Four groups：6 peptide composition group of embodiment, acetyl group tetrapeptide -3, Bimatoprost, placebo.It smears sooner or later daily primary.Record
The percentage increased using eyebrow after 60 days.Such as Fig. 5.
As can be seen from the figure come, peptide composition group can be obviously promoted the quantity of eyebrow growth, peptide composition group
The effect of single polypeptide is significantly greater than to the growth rate of eyebrow, this illustrates that peptide composition is better than single polypeptide.
It is also shown in figure, peptide composition is better than Bimatoprost, is expected to substitute than horse forefront in the growth of eyebrow quantity
Amine.
The above content is the further details of explanation that the specific preferred embodiment of combination is the present invention, but not
Represent that the specific implementation of the present invention is limited to these explanations.For the those of ordinary skill that neck is restrained belonging to the present invention,
Without departing from the inventive concept of the premise, several simple deductions or replacement can also be made, is regarded as belonging to the present invention
Protection domain in.
Claims (9)
1. a kind of peptide composition for hair growth, which is characterized in that comprising with stimulation collagen nucleus formation
Polypeptide and the polypeptide for promoting keratoprotein generation：
The peptide composition is combined for myristoyl pentapeptide -17 and biotin tripeptides -1；Either myristoyl pentapeptide -17 and
Acetyl group tetrapeptide -3 combines；Either myristoyl pentapeptide -17 and biotin tripeptides -1, the combination of copper peptide；Either myristoyl
Pentapeptide -17, myristoyl hexapeptide -16 and biotin tripeptides -1, the combination of copper peptide；Either myristoyl pentapeptide -17, myristoyl
Hexapeptide -16 and biotin tripeptides -1, acetyl group tetrapeptide -3, the combination of copper peptide,
A concentration of 0.01ppm~50000ppm (w/w) of wherein each polypeptide fractions, solvent is water.
2. composition as described in claim 1, which is characterized in that can add some help to educate send out other into
Point, selected from one or more kinds of following substances：Biotin, 5,7,4 '-trihydroxyflavone, oleanolic acid, biochanin a, respectively
A concentration of 0.01ppm~50000ppm (w/w) of substance.
3. composition as described in claim 1, which is characterized in that moisturizer is further included, selected from one or more kinds of following objects
Matter：Glycerine, Aloe Vera Gel, Sodium Hyaluronate, each material concentration are 0.01ppm~50000ppm (w/w).
4. composition as described in claim 1, which is characterized in that further include polyol class preservative, a concentration of 0.01ppm~
50000ppm(w/w)。
5. composition as described in claim 1, which is characterized in that further include the comprehensive examination that anti-microbial type maintains stable components
Agent, a concentration of 0.01ppm~50000 (w/w).
6. composition as described in claim 1, which is characterized in that further include pH adjusting agent, the pH adjusting agent is selected from：Three second
Hydramine, sodium bicarbonate, saleratus, pH value range are 3.0~8.0.
7. composition as described in claim 1, which is characterized in that product made of the composition be selected from hair-care essence liquid,
Shampoo, washing lotion, mascara, informer's agent, eyebrow pencil.
8. composition as described in claim 1, which is characterized in that the dosage form of the composition is selected from lotion, creme, spraying
Agent, gel, paste, freeze-dried powder, liposome.
9. composition as described in claim 1, which is characterized in that the hair is selected from hair, eyebrow and eyelashes.
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