CN105434919A - Medicine composition treating deep-rooted boils, ice sores and carbuncle sores and preparation method and application thereof - Google Patents

Abstract

The invention provides an external preparation for treating fire boils, ice sores and carbuncle sores, the active ingredient of which is prepared from medicinal materials in the following weight proportions: 10-20 parts of bezoar, 5-10 parts of silkworm, and Fangfeng 5-10 parts, 10-15 parts of cicada slough, 5-10 parts of Tianzhuhuang, 0-10 parts of saltpeter, 10-20 parts of mint, 5-10 parts of borneol, 10-20 parts of licorice, 10-20 parts of skullcap, scorpion 10-20 parts, realgar 15-20 parts. The present invention also provides a preparation method of the above-mentioned external preparation. The present invention has been used in clinical experiments to prove that it has remarkable curative effect and few side effects.

Description

A pharmaceutical composition for treating fire furuncle, ice sore and carbuncle sore, its preparation method and application

technical field

The invention specifically relates to an external preparation for treating fire furuncle, ice sore and carbuncle sore, its preparation method and application.

Background technique

At the beginning, furuncle is a conical inflammatory induration raised by follicular abscess, shaped like milia, yellow or purple in color, red, swollen, hot, and painful. The induration increases within a few days and the pain intensifies; then abscess forms and induration It becomes soft, the pain is relieved, and the abscess cavity collapses after the ulceration, and gradually heals. If it occurs in the extremities, there are red threads running up the affected area, which is called "red thread boil". If you see chills, high fever, coma, delirium, headache, and vomiting, it is a systemic purulent infection, which is called "fever and yellowing" in traditional Chinese medicine. Modern medicine generally adopts acupuncture and moxibustion and picking, but this method is easy to leave scars, and most people who are more concerned about appearance are unwilling to try and accept it.

Typical skin lesions of ice sores are localized finger caps, fava bean-sized, dark purple raised edematous plaques or indurations, unclear boundary, bright red edges, blue-purple center, tense and bright surface, cold to the touch, faded when pressed, Recovery after compression is slow. In severe cases, the swelling is intensified, and blisters may be formed on the surface, containing light yellow or bloody serum, and erosions or ulcers may be formed after the blisters break. Multiple symmetry occurs in the distal extremities, such as fingers, back of hands, feet, heels, cheeks, auricles, etc., and can also occur unilaterally. It mostly occurs in children and young women, and is more common in those with poor blood supply to the extremities and hyperhidrosis of the hands and feet. Consciously feel itching, burning, swelling. The itching is aggravated by heat, and those with erosions or ulcers feel pain. Falling ill every winter, self-healing after warm weather, protracted course of disease.

Carbuncle sores This disease is mostly formed by the accumulation of stagnant heat. When heat takes advantage of it, heat is better than cold, and the flesh and blood will rot and turn into pus. After the pus ulcers, the sores will not heal, so they are called carbuncle sores. It was a slightly raised purple-red infiltrated area with tough texture and unclear boundaries. There were multiple pus plugs on the surface of the central part, which were honeycomb-like after ulceration. Later, the central part gradually necrotic, dissolved, and collapsed, like a "crater", which contained pus and a large amount of necrotic tissue. It is easy to develop around and deep, with infiltrative edema around, and local lymph nodes are swollen and painful. In addition to local severe pain, most patients have obvious systemic symptoms, such as chills, fever, loss of appetite, and increased white blood cell count. Carbuncle sores are prone to systemic suppurative infection. The present disease is mainly external therapy, but the medicinal materials are single and the efficacy is not good.

Contents of the invention

The above-mentioned boils, ice sores and carbuncles are all different, but have similarities. The present invention mainly obtains the external preparation of the present invention through the research on the direction of clearing away heat and detoxification, which can not only treat the three kinds of sores , and the cure rate is as high as 95%.

The external preparation for treating boils, ice sores and carbuncles provided by the present invention, its active ingredients are prepared from medicinal materials comprising the following weight proportions: 10-20 parts of bezoar, 5-10 parts of silkworm, 5-10 parts of Fangfeng , 10-15 parts of cicada slough, 5-10 parts of Tianzhuhuang, 0-10 parts of saltpeter, 10-20 parts of mint, 5-10 parts of borneol, 10-20 parts of licorice, 10-20 parts of skullcap, 10-20 parts of scorpion ;

The external preparation of the present invention, wherein the weight ratio of the medicinal materials is preferably as follows: 11-20 parts of Calculus bezoar, 5-9 parts of silkworm, 7-10 parts of Fangfeng, 10-13 parts of cicada slough, 5-8 parts of Tianzhuhuang, saltpeter 5-7 parts, 16-20 parts of mint, 7-10 parts of borneol, 11-20 parts of licorice, 13-17 parts of skullcap, 11-15 parts of scorpion.

The external preparation of the present invention, wherein the weight ratio of the medicinal materials is more preferably as follows: 20 parts of bezoar, 5 parts of silkworm, 10 parts of Fangfeng, 10 parts of cicada slough, 5 parts of Tianzhuhuang, 5 parts of saltpeter, 20 parts of peppermint, 10 parts of borneol 15 parts of licorice, 15 parts of scutellaria baicalensis, and 15 parts of scorpion.

The external preparation of the present invention can be used for the treatment of fire boils, ice sores and carbuncle sores. When treating carbuncle sores, the medicinal materials for preparing the external preparation of the present invention preferably further include 15-20 parts of realgar.

Preferably, when treating carbuncle sores, the external preparation according to the present invention, wherein the weight ratio of the medicinal materials is as follows: 20 parts of bezoar, 5 parts of silkworm, 10 parts of Fangfeng, 10 parts of cicada slough, 5 parts of Tianzhuhuang, saltpeter 5 parts, 20 parts of mint, 10 parts of borneol, 15 parts of licorice, 15 parts of skullcap, 15 parts of scorpion, and 15 parts of realgar.

The external preparation of the present invention can be made into any external dosage form, including but not limited to ointment, gel, spray, oil, film coating, powder, tincture, preferably honey.

According to different dosage forms, the external preparation of the present invention can not only add physiological saline, but also include appropriate amounts of various other auxiliary materials. The selection of auxiliary materials matches the dosage form, preferably honey;

The amount of the above-mentioned excipients added is for the purpose of being able to prepare a dosage form with good performance, and those skilled in the art can determine the amount of the above-mentioned excipients according to the prior art without creative work. For example, if the dosage form is oil or honey, the amount of the auxiliary materials can be adjusted to form a paste.

The present invention also provides a preparation method of the above-mentioned pharmaceutical composition, comprising the following steps:

(1) Process the medicinal material into powder in proportion;

(2) Add the powder in step (1) and mix it with an appropriate amount of physiological saline until there are thick filaments;

(3) Mix the thick filament obtained in the step (2) with an appropriate amount of honey to prepare a paste.

The external preparation of the present invention controls the pathogenesis and uses the pharmacological effects of traditional Chinese medicines in a targeted manner. The composition of the present invention is composed of medicines for clearing away heat and detoxification/enhancing immunity and auxiliary materials. It can reduce the damage to the skin and reduce the drug resistance formed by single drug treatment. The pharmaceutical composition of the present invention has simple prescription, does not require special treatment, and reduces cumbersome work procedures.

The external preparation of the present invention has special effects in treating fire boils, ice sores and carbuncle sores, has remarkable curative effect, has few side effects, and can significantly improve the current effectiveness of treating sores and the treatment of sores suppurating and rupturing.

detailed description

The present invention is further illustrated below through specific embodiments and test examples. The following examples are used to illustrate the present invention rather than to limit the present invention, and the simple improvements carried out to the present invention according to the essence of the present invention all belong to the protection scope of the present invention.

The acquisition methods of various materials and reagents described in the examples are only to provide an experimental acquisition method to achieve the purpose of specific disclosure, and should not be a limitation on the sources of the materials and reagents of the present invention. In fact, the sources of the materials and reagents used are extensive, and any materials that can be obtained without violating laws and ethics can be replaced and used according to the tips in the examples.

(1) Specific examples

The preparation of embodiment 1 pharmaceutical composition of the present invention

(1) Weigh the following medicinal materials in proportion: 20 parts of bezoar, 5 parts of silkworm, 10 parts of windproof, 10 parts of cicada slough, 5 parts of Tianzhuhuang, 5 parts of saltpeter, 20 parts of mint, 10 parts of borneol, 15 parts of licorice, 15 parts of skullcap 15 servings of whole scorpion. Pick and weigh and mix in the same container;

(2) Grind the ingredients in step (1) into powder and set aside; add the powder to the corresponding amount of physiological saline to prepare until there are thick filaments;

(3) Dissolve the thick filaments prepared in step (2) in honey and adjust until it becomes a paste.

The preparation of embodiment 2 pharmaceutical compositions of the present invention

The formula is: 20 parts of bezoar, 5 parts of silkworm, 10 parts of Fangfeng, 10 parts of cicada slough, 5 parts of Tianzhuhuang, 5 parts of saltpeter, 20 parts of mint, 10 parts of borneol, 15 parts of licorice, 15 parts of skullcap, 15 parts of scorpion, 15 parts realgar;

The preparation method is the same as in Example 1.

The preparation of embodiment 3 pharmaceutical composition of the present invention

The formula is: 20g bezoar, 5g silkworm, 10g windproof, 10g cicada slough, 5g geranium, 5g saltpeter, 20g mint, 10g borneol, 15g licorice, 15g skullcap, 15g scorpion, and 15g realgar.

The preparation method is the same as in Example 1.

The preparation of embodiment 4 pharmaceutical composition of the present invention

The formula is: 15g bezoar, 8g silkworm, 10g windproof, 5g cicada slough, 10g geranium, 5g saltpetre, 25g mint, 5g borneol, 18g licorice, 16g skullcap, 10g scorpion, 35g realgar.

The preparation method is the same as in Example 1.

Embodiment 5 Preparation of the pharmaceutical composition of the present invention

The formula is: 150g bezoar, 40g silkworm, 100g windproof, 50g cicada slough, 100g geranium, 50g saltpeter, 200g mint, 50g borneol, 180g licorice, 160g skullcap, 100g scorpion, 100g realgar.

The preparation method is the same as in Example 1.

Embodiment 6 Preparation of the pharmaceutical composition of the present invention

The formula is: grind 500g of Pediatric Qilisan finished product.

The preparation method is the same as in Example 1.

Embodiment 7 Preparation of the pharmaceutical composition of the present invention

The formula is: 500g of Pediatric Qilisan finished product and 150g of realgar.

The preparation method is the same as in Example 1.

Test example:

Next, test examples of the present invention will be described for further understanding of the present invention.

clinical experiments

(1) Fire boil test:

Select 20 patients who meet the inclusion criteria as subjects, and divide the subjects into 2 groups at random: A, the treatment group of the present invention, and B, the general treatment ointment roxithromycin control group on the market, with 10 people in each group. Before and after treatment, record and analyze the recovery degree of fire boils, analyze infection cases and follow-up for scar recovery.

When the diameter of the sore > 1cm, first cut the bubbly protrusion of the sore, squeeze out the pus, if the sore is <1cm, it is not necessary to cut the sore, and apply the pharmaceutical composition prepared by the method of Example 1 evenly on the sore Around, leave the middle part of the sore without ointment, and wrap it with gauze to prevent infection. Take off the gauze and change the medicine every 24 hours until the wound scabs.

1.1 Statistics on the number of people who healed fire boils before and after treatment: see Table 1

Table 1 Statistics of the number of people with fire boils healed before and after treatment

Note: compared with before treatment in each group, compared with after treatment of fire furuncle;

1.2 Statistical analysis of the number of patients with fire boils co-infected: see Table 2./

Table 2 Statistics on the number of people with fire boils co-infected before and after treatment

1.3 Comparison of clinical curative effect grading and number of scars healed: see Table 3

Table 3 The classification of curative effects of TCM syndromes and the statistics of the number of scars healed

Comparison between groups: P<0.05.

Results prompt: Tables 1-2 show that the two groups of medicines have recorded and analyzed the recovery degree of patients with fire boils. All have significant improvement. Wherein improving patient's fire furuncle aspect, treatment group is better than matched group (P＜0.05=, shows that the present invention improves the effect of cardinal symptom and is better than market general treatment ointment roxithromycin, prompting treatment group is mainly by treating fire furuncle. Clear away heat and detoxify, improve the body's immunity, prevent infection, improve the patient's condition, and significantly increase the cure rate to improve the condition.

Table 3 shows, this compatibility is significantly better than roxithromycin (P＜0.05) between the group comparison of two groups of curative effect grades; Wherein this compatibility is better than roxithromycin (P＜0.05) in two levels of clinical cure and marked effect.

(2) ice sore test: select 40 routine patients who meet the inclusion criteria as the experimenter, and the experimenter is completely divided into 2 groups at random: A group of the present invention, B market pure code brand snake oil chilblain ointment 15g control group, each Group of 20 people. Before and after treatment, record and analyze the recovery degree of ice sore, and analyze the recovery degree of ice sore combined with rupture.

Apply the pharmaceutical composition prepared by the method of Example 1 evenly around the sore, leave the middle part of the sore without ointment, wrap it with gauze to prevent the sore from breaking, take off the gauze and change the medicine every 24 hours, until the wound is scabbed That's it.

2.1 Statistical comparison of the number of scabies healed before and after treatment: see Table 1

Table 1 Statistics on the number of people with scabies healed before and after treatment

Note: compared with before treatment in each group; compared with after ice sore treatment;

2.2 Analysis of data on the number of people recovering from ice sore combined with rupture: see Table 4

Table 4 Statistics on the number of people recovering from ice sore combined with rupture before and after treatment

The results suggest that: Table 1 shows that the two groups of drugs have recorded and analyzed the degree of ice sore recovery of the patients. All have a certain improvement effect, but the effect is not particularly significant. Among them, in terms of improving ice sores, the treatment group is better than the control group (P<0.05). It can be seen that the effect of this combination on improving the main symptoms is better than chilblain ointment, suggesting that the treatment group mainly improves the body’s immunity and prevents sores by treating ice sore patients. rupture and improve the patient's condition.

Table 2 shows that the curative effect of both groups is poor for ruptured ice sores and the recovery is slow. But the overall healing rate of the treatment group was significantly higher than that of the control group. It shows that the control of ulcer rupture is one of the main means of clinical prognosis.

(3) carbuncle sore test: select 30 patients who meet the inclusion criteria as subjects, and the subjects are completely randomly divided into 2 groups: A treatment group of the present invention, B market general western medicine combination: sulfametronidazole plus formazan Oxypyrimidine was used as the control group, 15 people in each group. Before and after treatment, record and analyze the recovery degree of carbuncle sores, analyze infection cases and follow-up for scar recovery.

When the diameter of the sore > 1cm, first cut the bubbly protrusion of the sore, squeeze out the pus, if the sore is <1cm, it is not necessary to cut the sore, and apply the pharmaceutical composition prepared by the method of Example 2 evenly on the sore Around, leave the middle part of the sore without ointment, and wrap it with gauze to prevent infection. Take off the gauze and change the medicine every 24 hours until the wound scabs.

3.1 Statistical comparison of the number of healed carbuncle sores before and after treatment: see Table 1

Table 1 Statistics of the number of carbuncle sores healed before and after treatment

Note: compared with before treatment in each group, compared with after treatment of carbuncle sore;

3.2 Statistical analysis of the number of co-infected people treated with carbuncle sores: see Table 4

Table 4 Statistics on the number of co-infected carbuncle sores before and after treatment

3.3 Classification of clinical curative effect and statistical comparison of the number of scars healed: see Table 3

Table 3 The classification of curative effects of TCM syndromes and the statistics of the number of scars healed

Comparison between groups: P<0.05.

The result prompts: Tables 1-2 show that the two groups of medicines have recorded and analyzed the recovery degree of carbuncle sores in patients. All have significant improvement. Wherein in improving patient's carbuncle sores, the treatment group is better than the control group, it can be seen that the present invention improves the effect of the main symptoms better than the market general western medicine combination medicine sulfametronidazole plus metmethoxine treatment, suggesting that the treatment group is mainly through the treatment of carbuncle. Sores clear away heat and detoxify, improve the body's immunity, prevent infection, improve the patient's condition, and the cure rate is significantly improved to improve the condition.

Table 3 shows that this combination is significantly better than the western medicine combination (P < 0.05) in the group comparison of the curative effect classification of the two groups; wherein this compatibility is better than the western medicine combination (P < 0.05) in two levels of clinical cure and marked effect.

Case study:

(1) Case 1:

Zhang Moumou, female, 28 years old, went to see a doctor on June 22, 2014, and felt pain because of a red, swollen sore on her leg. Examine and see: inspect and see that there is a skin red and swollen area in the leg, about 2cm in diameter, and with burning pain, it is diagnosed as fire furuncle. Cut open the sore with a scalpel after disinfection, release the pus therein, and give heat-clearing treatment, apply the external preparation of Example 1 evenly around the sore, leave the middle part of the sore without ointment, and wrap it with gauze to prevent infection. Remove the gauze and change the medicine every 24 hours. See the second clinic: see a doctor again every seven days, the symptoms have improved, the sores have begun to heal, and the wounds have begun to scab. The usage of the medicine is the same as above, and the gauze can be changed every two days. Third diagnosis: the symptoms continue to improve, the gauze can be removed, and the medicine can be directly applied to the affected area. Fourth diagnosis: the symptoms of redness, swelling and pain basically disappeared, the scars fell off, and new skin grew. Did not prescribe medicine again, advise its light diet. Follow up a case by regular visits to after one month and be normal.

(2) Case study 2:

Wang Moumou, female, 21 years old, went to see a doctor on December 25, 2014. Due to the cold weather, her hands were covered with chilblain, and it was ineffective after being applied with chilblain ointment. First visit: the skin of the patient's hands was red and swollen to the knuckles, some of them were blue-purple, the size of broad beans, dark purple-red raised edematous plaques or induration, with unclear boundary, bright red edges, blue-purple center, tense and bright surface, Cold to the touch, discoloration after pressure, slow recovery after decompression, partial cracks between palms and fingers, diagnosed as ice sores. The external preparation of embodiment 1 is evenly applied to the sore on the palm and its surroundings to prevent infection at the breach, and change the medicine every 24 hours. See the second clinic: see a doctor again every ten days, the symptoms have improved, the laceration has begun to heal, the wound has begun to scab, and the usage of the medicine is the same as above. Third diagnosis: symptoms continue to improve, and medication should be continued. Fourth diagnosis: the symptoms of redness, swelling and pain basically disappeared, and the scars disappeared. Did not prescribe medicine again, advised it to keep warm from the cold. Follow up a case by regular visits to after one month and be normal.

(3) Case study 3:

Liu XX, male, 36 years old, went to see a doctor on May 12, 2014. Because of red and white pustules on the back, tenderness, he felt chills, fever, and loss of appetite. First examination: visual examination showed a slightly raised purple-red infiltration area on the back, with tough texture and unclear boundaries. There were multiple pus plugs on the surface of the central part, which were honeycomb after ulceration. Axillary lymph nodes are swollen and painful. Cut open the blister with a scalpel after disinfection, release the pus therein, give heat-clearing treatment, apply the external preparation of Example 2 evenly around the sore, leave the middle part of the sore without ointment, and wrap it with gauze to prevent infection. Remove the gauze and change the medicine every 24 hours. See the second clinic: see a doctor again every seven days, the symptoms have improved, the sores have begun to heal, and the wounds have begun to scab. The usage of the medicine is the same as above, and the gauze can be changed every two days. Third diagnosis: the symptoms continue to improve, the gauze can be removed, and the medicine can be directly applied to the affected area. Four examinations: the symptoms of carbuncle sore basically disappeared, the enlarged lymph nodes returned to normal, the scars healed, and new skin grew. No further prescriptions were prescribed, and he was instructed to eat a light diet, and he was not allowed to eat tobacco, alcohol, fish, shrimp, meat, herbs, crab roe, etc., nor to drink cold beverages such as nectar tea. Follow up a case by regular visits to after one month and be normal.

Claims (9)

1. treat an external preparation for fiery furuncle, ice skin ulcer, carbuncle disease skin ulcer, its active component is prepared from by the medical material comprising following weight proportion: Calculus Bovis 10 ~ 20 parts, Bombyx Batryticatus 5 ~ 10 parts, Radix Saposhnikoviae 5 ~ 10 parts, Periostracum Cicadae 10 ~ 15 parts, Concretio Silicea Bambusae 5 ~ 10 parts, 0 ~ 10 part, Sal Nitri, Herba Menthae 10 ~ 20 parts, Borneolum Syntheticum 5 ~ 10 parts, 10 ~ 20 parts, Radix Glycyrrhizae, Radix Scutellariae 10 ~ 20 parts, Scorpio 10 ~ 20 parts.

2. external system as claimed in claim 1, wherein said medical material weight proportion is as follows: Calculus Bovis 11 ~ 20 parts, Bombyx Batryticatus 5 ~ 9 parts, Radix Saposhnikoviae 7 ~ 10 parts, Periostracum Cicadae 10 ~ 13 parts, Concretio Silicea Bambusae 5 ~ 8 parts, 5 ~ 7 parts, Sal Nitri, Herba Menthae 16 ~ 20 parts, Borneolum Syntheticum 7 ~ 10 parts, 11 ~ 20 parts, Radix Glycyrrhizae, Radix Scutellariae 13 ~ 17 parts, Scorpio 11 ~ 15 parts.

3. external preparation as claimed in claim 2, wherein said medical material weight proportion is as follows: Calculus Bovis 20 parts, Bombyx Batryticatus 5 parts, Radix Saposhnikoviae 10 parts, Periostracum Cicadae 10 parts, Concretio Silicea Bambusae 5 parts, 5 parts, Sal Nitri, Herba Menthae 20 parts, Borneolum Syntheticum 10 parts, 15 parts, Radix Glycyrrhizae, Radix Scutellariae 15 parts, Scorpio 15 parts.

4. the arbitrary external preparation as described in claims 1 to 3, is characterized in that, described medical material also comprises Realgar 15 ~ 20 parts.

5. external preparation as claimed in claim 4, wherein said medical material weight proportion is as follows: Calculus Bovis 20 parts, Bombyx Batryticatus 5 parts, Radix Saposhnikoviae 10 parts, Periostracum Cicadae 10 parts, Concretio Silicea Bambusae 5 parts, 5 parts, Sal Nitri, Herba Menthae 20 parts, Borneolum Syntheticum 10 parts, 15 parts, Radix Glycyrrhizae, Radix Scutellariae 15 parts, Scorpio 15 parts, Realgar 15 parts.

6. the arbitrary external preparation as described in Claims 1 to 5, wherein also comprises appropriate normal saline and appropriate Mel as adjuvant.

7. the preparation method of the arbitrary external preparation described in right 1 ~ 6, comprises the steps:

(1) in proportion by processing of crude drugs powdered;

(2) powder of step (1) is added mix with appropriate normal saline, to there being dense thick filament;

(3) the dense thick filament of described step (2) gained is mixed with appropriate Mel, is modulated into pastel.

8. the application of the arbitrary external preparation described in Claims 1 to 5 in the medicine of the fiery furuncle of preparation treatment, ice skin ulcer, carbuncle disease skin ulcer.

9. the application of the arbitrary external preparation described in claim 4 or 5 in the medicine of preparation treatment carbuncle disease skin ulcer.