CN105746564B - A kind of Pesticidal combination containing imidacloprid and dimehypo and its preparation method and application - Google Patents
A kind of Pesticidal combination containing imidacloprid and dimehypo and its preparation method and application Download PDFInfo
- Publication number
- CN105746564B CN105746564B CN201510989611.8A CN201510989611A CN105746564B CN 105746564 B CN105746564 B CN 105746564B CN 201510989611 A CN201510989611 A CN 201510989611A CN 105746564 B CN105746564 B CN 105746564B
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- CN
- China
- Prior art keywords
- dimehypo
- imidacloprid
- effervescent tablet
- pesticidal combination
- disintegrant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000005906 Imidacloprid Substances 0.000 title claims abstract description 106
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 229940056881 imidacloprid Drugs 0.000 title claims abstract description 106
- QSOHVSNIQHGFJU-UHFFFAOYSA-L thiosultap disodium Chemical compound [Na+].[Na+].[O-]S(=O)(=O)SCC(N(C)C)CSS([O-])(=O)=O QSOHVSNIQHGFJU-UHFFFAOYSA-L 0.000 title claims abstract description 106
- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- 230000000361 pesticidal effect Effects 0.000 title claims abstract description 38
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 117
- 239000004480 active ingredient Substances 0.000 claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 27
- 235000009566 rice Nutrition 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 240000007594 Oryza sativa Species 0.000 claims abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 66
- 239000007884 disintegrant Substances 0.000 claims description 52
- 239000000080 wetting agent Substances 0.000 claims description 52
- 239000002270 dispersing agent Substances 0.000 claims description 51
- 239000011734 sodium Substances 0.000 claims description 44
- 229910052708 sodium Inorganic materials 0.000 claims description 44
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 43
- -1 Succinate sodium sulfonate salt Chemical class 0.000 claims description 40
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- 239000000843 powder Substances 0.000 claims description 31
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- 239000008120 corn starch Substances 0.000 claims description 22
- 229940099112 cornstarch Drugs 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 22
- 229920005646 polycarboxylate Polymers 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 22
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 21
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 20
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- JSYPRLVDJYQMAI-ODZAUARKSA-N (z)-but-2-enedioic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.OC(=O)\C=C/C(O)=O JSYPRLVDJYQMAI-ODZAUARKSA-N 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 13
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 9
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 6
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical group [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
- 239000000047 product Substances 0.000 description 15
- 239000001257 hydrogen Substances 0.000 description 13
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 13
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 12
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 10
- 238000012360 testing method Methods 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 6
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
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- 159000000000 sodium salts Chemical class 0.000 description 4
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- 235000011152 sodium sulphate Nutrition 0.000 description 4
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- 239000005995 Aluminium silicate Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
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- 150000004665 fatty acids Chemical class 0.000 description 3
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- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical group O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229960000776 sodium tetradecyl sulfate Drugs 0.000 description 3
- KKDONKAYVYTWGY-UHFFFAOYSA-M sodium;2-(methylamino)ethanesulfonate Chemical compound [Na+].CNCCS([O-])(=O)=O KKDONKAYVYTWGY-UHFFFAOYSA-M 0.000 description 3
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 3
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- 239000004562 water dispersible granule Substances 0.000 description 3
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- 241001124076 Aphididae Species 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
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- 229920006243 acrylic copolymer Polymers 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 229960000892 attapulgite Drugs 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 235000018927 edible plant Nutrition 0.000 description 2
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- DSOOGBGKEWZRIH-UHFFFAOYSA-N nereistoxin Chemical compound CN(C)C1CSSC1 DSOOGBGKEWZRIH-UHFFFAOYSA-N 0.000 description 2
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- AULWPXHFRBLPAE-UHFFFAOYSA-N 6-chloropyridine Chemical compound ClC1=C=CC=C[N]1 AULWPXHFRBLPAE-UHFFFAOYSA-N 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
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- NTJUIYXKZYSHGC-UHFFFAOYSA-N [Na].S(=S)(=S)O Chemical compound [Na].S(=S)(=S)O NTJUIYXKZYSHGC-UHFFFAOYSA-N 0.000 description 1
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- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
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- CASPZMCSNJZQMV-UHFFFAOYSA-N ethane;2-methyloxirane Chemical compound CC.CC1CO1 CASPZMCSNJZQMV-UHFFFAOYSA-N 0.000 description 1
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- RRDQTXGFURAKDI-UHFFFAOYSA-N formaldehyde;naphthalene-2-sulfonic acid Chemical compound O=C.C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 RRDQTXGFURAKDI-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
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Abstract
The invention discloses a kind of Pesticidal combination containing imidacloprid and dimehypo and its preparation method and application, the composition is 1~40: 1~40 imidacloprid and dimehypo for active ingredient using mass ratio.The Pesticidal combination of the present invention is prepared simply, and effervescent tablet is made, prevents getting rid of insects available for rice terrace, preventive effect is apparently higher than the preventive effect that imidacloprid is applied alone or dimehypo is applied alone.In addition, micro mist is flown upward when the effervescent tablet also can effectively avoid distribution, make high-toxic pesticide low toxicity, can directly be spread fertilizer over the fields with hand, while reduce operating personnel's sucking micro mist during dispenser, avoid intoxication accident；Effervescent tablet generates a large amount of bubbles after meeting water, by the motive force for generating gas inside tablet, makes disintegration of tablet rapid, active ingredient is spread faster, is distributed evenly, active ingredient range of scatter is big, can give full play to drug effect；Effervescent tablet is directly thrown into paddy field, is saved labor, while reduces the injury to insect pollinators such as natural enemy and honeybees, there is good application prospect.
Description
Technical field
The present invention relates to a kind of Pesticidal combination containing imidacloprid and dimehypo, this is further related to containing imidacloprid and dimehypo
Effervescent tablet of Pesticidal combination and its preparation method and application belongs to technical field of pesticide.
Background technology
Imidacloprid, English common name：Imidacloprid, chemical name：1- (6- chloropyridine -3- pyridylmethyls)-N-
Nitroimidazoline -2- base amine, sterling is clear crystal, there is faint odor.Imidacloprid belongs to nitro-methylene-type absorbability and kills
Worm agent has stomach toxicity and action of contace poison, high with it by inhibiting nicotinic acetylcholine esterase receptor in insect nerve system
Competitive binding is allowed to death after neural paralysis so as to destroy the normal conduction of the nervous centralis of insect.Imidacloprid has fabulous
Systemic activity, have special efficacy, such as aphid, plant hopper, aleyrodid, leafhopper, thrips to sucking pest, to coleoptera, dipteron
Mesh and lepidoptera pest are also effective, such as Lissorhoptrus oryzophilus Kuschel, rice leaf beetles, rice borer, leaf miner, but invalid to nematode and red spider,
Available for crops such as rice, wheat, corn, cotton, potato, vegetables, beet, fruit trees.
Dimehypo, English name：Bisultap, chemical name：The bis- thiosulfonic acid sodium base propane of 2- dimethylamino -1,3-,
Sterling is white crystal, there is off-odor, and the easy moisture absorption is soluble easily in water, is stablized under the conditions of neutral and meta-alkali, in acid condition
It decomposes, stablizes at normal temperatures.Dimehypo category nereistoxin insecticides are a kind of never poisons, after insect contact and feeding medicament
Ability that is blunt, slow in action, losing infringement crop is shown, stops development, polypide softening, paralyse, until dead.Dimehypo
There is very strong systemic action, can be absorbed and conducted by the leaf of crop, root etc., be mainly used for preventing striped rice borer, yellow rice borer, leaf roll snout moth's larva
Unbearable punching etc., suitable for crops such as vegetables, paddy and wheat, fruit trees.
The single dose of imidacloprid and dimehypo belongs to broad spectrum insecticide, prevents getting rid of insects available for rice terrace, but with
The increase of the medicine time limit, there is pest resistance to insecticide, insecticidal spectrum is narrow, dosage is big the shortcomings of, not only increase cost, environmental pressure
Increase.The two compounding can solve the above problems, and will be of great significance to practical application.
In addition, the dosage form of imidacloprid and dimehypo now be mostly wettable powder, water dispersible granules, these dosage forms need with
The form of spraying carries out dispenser, and this insecticide-applying way is time-consuming, and labor intensity is big, and the utilization rate of active ingredient is relatively low,
The chance that medicament is in direct contact with people is increased, increases the danger to dispenser personnel.Effervescent tablet（effervescent
Tablet, EB）It is that can generate bubble rapidly in input water and be disintegrated the Formulation of dispersion, can directly spreads fertilizer over the fields use.It for
Pulvis（Directly dust）Have significant supplementary function with the spray formulation being diluted with water, the effervescent tablet can direct labor spread fertilizer over the fields or
Unmanned aerial vehicle is spread fertilizer over the fields in rice terrace, time saving and energy saving.
Invention content
The object of the present invention is to provide a kind of Pesticidal combination containing imidacloprid and dimehypo, the composition by imidacloprid with
Dimehypo is compounded, and improves insecticidal effect.
It is a further object of the present invention to provide a kind of effervescent tablet dosage form of the Pesticidal combination, which does not need to spray
Dispenser, can direct labor spread fertilizer over the fields or aircraft is spread fertilizer over the fields, it is time saving and energy saving.
It is a further object of the present invention to provide application of the Pesticidal combination in pest control, are mainly used for rice terrace
Prevent plant hopper and rice borer.
The present invention obtains composition of good performance using imidacloprid and dimehypo as active ingredient, by compounding.Imidacloprid
There is higher control effect to rice terrace plant hopper and rice borer with the compounding of dimehypo, there are apparent synergy works between two components
With, and mixed rear active ingredient dosage is reduced, and is effectively reduced ecology and environmental pollution, can also be delayed pest to single medicine
The resistance of agent has good application prospect.
Technical scheme is as follows：
A kind of Pesticidal combination, active ingredient are imidacloprid and dimehypo, and the mass ratio of imidacloprid and dimehypo is 1~40
: 1~40.In this proportional region, gained Pesticidal combination has good insecticidal effect, and dosage significantly reduces.Further
, the mass ratio of imidacloprid and dimehypo is preferably 0.05~15:1, more preferably 0.5~2:1, most preferably 1:1.According to excellent
Select the composition drug effect that ratio is used with more preferable.
Pesticidal combination of the present invention in order to preferably use, can be added on disclosed pesticide in the prior art and be subjected to
Auxiliary material dosage form of good performance, such as wettable powder, water dispersible granules, effervescent tablet etc. is made.When dosage form is made, desinsection
The content of active ingredient is 5~40wt%, preferably 5~30wt%, most preferably more preferable 15~25wt%, 15-20wt% in composition.
At present, water dispersible granules and wettable powder need to carry out dispenser, time-consuming, labor intensity in the form of spraying
Greatly, and the chance that medicament is in direct contact with people is increased, increases the danger to dispenser personnel.And effervescent tablet can effectively avoid
Micro mist flies upward pollution ambient enviroment during distribution, while reduces operating personnel's sucking micro mist during dispenser, can avoid intoxication accident；
High-toxic pesticide low toxicity can also be made, can directly be spread fertilizer over the fields with hand, and will not be poisoned.In addition, effervescent tablet generates a large amount of gas after meeting water
Bubble by the motive force for generating gas inside tablet, makes disintegration of tablet rapid, and active ingredient is spread faster, is distributed more equal
Even, active ingredient range of scatter is big, can give full play to drug effect, and effervescent tablet is directly thrown into paddy field, saves labor, reduces simultaneously
Injury to insect pollinators such as honeybees.Therefore Pesticidal combination of the present invention is preferably effervescent tablet.
Effervescent tablet preparation formulation of the present invention can directly spread fertilizer over the fields use, time saving and energy saving, safety higher.In active ingredient mu dosage
Under conditions of determining, if preparation of traditional Chinese medicine active constituent content is too high, it can make between spreading fertilizer over the fields rear tablet that spacing is excessive, tablet collapses
Active ingredient needs the long period to spread after solution（And there are signs of degradation in water for active ingredient）, it is unfavorable for drug effect performance, because
This effervescent tablet active constituent content is not higher than 40wt%, is typically chosen 5~40wt%.Meanwhile product is reduced with content, required original
The costs such as material, production, packaging, transport can be increased accordingly, comprehensive cost and preventive effect, active constituent content preferably 5~30wt%, more
It is preferred that 15~25wt%, most preferably 15-20wt%.
Further, the auxiliary material of effervesce tablet preparation of the present invention can select dispersant, wetting agent, disintegrant and filler, collapse
Solution agent is divided into as disintegrant acid source（Abbreviation acid source）With disintegrant alkali source（Abbreviation alkali source）.Active ingredient and each auxiliary material weight percent
It is than content：Active ingredient 5~40%（Preferably 5~30wt%, further preferably 10~30wt%, further preferably for 15~
25wt%, most preferably 15-20wt%）, dispersant 3~6%, wetting agent 1~4%, disintegrant 15~50%, filler surplus.Work as use
During following weight percent content, the performance and drug effect of effervescent tablet are more preferably：Active ingredient 5~40%（Preferably 5~30wt%,
Further preferably 10~30wt% is further preferably 15~25wt%, most preferably 15-20wt%）, dispersant 5wt%, wetting agent
1.5wt%, disintegrant 30wt%, filler surplus.When using following weight percent content, the performance and drug effect of effervescent tablet are most
It is good：Active ingredient 15-20wt%, dispersant 5wt%, wetting agent 1.5wt%, disintegrant 30wt%, filler surplus.
In addition, under conditions of active ingredient mu dosage and active constituent content determine, every weight of effervescent tablet（Monolithic matter
Amount）Also have an impact to drug effect.Monolithic quality is too low, elegant phenomenon is had when spreading fertilizer over the fields, monolithic quality is excessively high, and effervescent tablet is in field
Spacing is excessive, can there is prevention dead angle.Empirical tests, when the monolithic quality of effervescent tablet is 1.0~6.0g, such as 1.0g, 2.0g,
When 3.0g, 4g, 5g, 6g, effect is preferable.When monolithic quality is 1.0g and 2.0g, still there is a small amount of drift phenomenon when spreading fertilizer over the fields use；
When monolithic quality is 4g, 5g and 6g, after spreading fertilizer over the fields use, tablet is excessive in the spacing of rice terrace, and active ingredient needs after disintegration
Long period spreads（And there are signs of degradation in water for active ingredient）, it is unfavorable for the performance of drug effect, therefore monolithic quality is preferred
For 1.0-5.0g, when monolithic quality is 3.0g, effervescent tablet performance and drug effect are best.
In above-mentioned effervescent tablet, the dispersant is di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, 2- naphthalene sulfonic acid formaldehyde polymers sodium salt, horse
Come sour-acrylic copolymer salt, polyox-yethylene-polyoxypropylene block copolymer, naphtholsulfonic acid formaldehyde condensation products sodium salt, epoxy second
Alkane-propylene oxide block copolymer, aryl phenol polyethenoxy ether, double naphthalenesulfonate formaldehyde condensation compound sodium salts, polycarboxylate sodium, alkane
Base sodium phenolsulfonate, alkyl naphthalene sulfonic acid formaldehyde condensation products sodium salt, calcium lignosulfonate and alkyl phenol polyoxyethylene ether formaldehyde condensation
It is one or more in object sulfate.
In above-mentioned effervescent tablet, the wetting agent is lauryl sodium sulfate, neopelex, lignin sulfonic acid
Sodium, pull open powder, a- sulfo methyl esters, sodium tetradecyl sulfate, Negel, a- alkene sulfonic acid sodiums, fatty acid amide
N methyl taurine sodium salt, dialkyl group Succinate sodium sulfonate salt, sodium sulfate of polyethenoxy ether of fatty alcohol, alkylphenol-polyethenoxy
One in ether sodium sulfate, alkyl phenol polyoxyethylene ether succinic acid half ester sodium sulfonate, fatty acid sulfates and aliphatic ester sulfate
Kind is a variety of.
In above-mentioned effervescent tablet, the disintegrant is made of acid source and alkali source, acid source for citric acid, tartaric acid, succinic acid,
One or more in hexanedioic acid, niter cake, phosphoric acid, succinic acid, fumaric acid and malic acid, alkali source is sodium bicarbonate, carbonic acid
It is one or more in sodium, potassium carbonate, saleratus and calcium carbonate.
In above-mentioned effervescent tablet, the filler is kaolin, attapulgite, diatomite, bentonite, white carbon, lightweight carbon
It is one or more in sour calcium, cornstarch, urea, talcum powder and anhydrous sodium sulfate.
When auxiliary material select following components when effervescent tablet performance and drug effect more preferably：The dispersant is by polycarboxylate sodium and Ma
Take sour-acrylic copolymer salt in mass ratio 1:9 mix；The wetting agent is by dialkyl group Succinate sodium sulfonate salt and ten
Sodium dialkyl sulfate in mass ratio 1:2 mix；The disintegrant acid source is preferably citric acid, and alkali source is preferably bicarbonate
The mass ratio of sodium, citric acid and sodium bicarbonate is 14:16；The filler is cornstarch.
The effervescent tablet of above-mentioned imidacloprid and dimehypo is by active ingredient, dispersant, wetting agent, disintegrant（Disintegrant acid
Source and disintegrant alkali source）It is made with filler, preparation method includes the following steps：
（1）It takes the half of active ingredient, dispersant, wetting agent and filler respectively by quality, by the half of active ingredient, divides
The half of the half of powder, the half of wetting agent and filler is uniformly mixed with disintegrant acid source, is ground into fine powder, and fine powder adds water to pinch
It is granulated, dries after conjunction, obtain particle A, it is spare；
（2）Disintegrant alkali source with remaining component is uniformly mixed, is ground into fine powder, fine powder adds water to be granulated after mediating, dries
It is dry, particle B is obtained, it is spare；
（3）Particle A and B are uniformly mixed, tabletting is carried out, obtains Pesticidal combination effervescent tablet.
Above-mentioned steps（1）With（2）In, each material is crushed using ultra micro airflow pulverization, and gained fine powder is 550-
750 mesh or so.
Above-mentioned steps（1）With（2）In, it is granulated with comminutor is waved, grain size is selected to be carried out in the particle of 20 mesh or so
Drying uses.
Above-mentioned steps（1）With（2）In, it dries and is carried out at 60-65 DEG C, be dried to moisture to less than 0.5wt%.
Above-mentioned steps（3）In, tabletting is carried out using tablet press machine, and the monolithic weight of obtained effervescent tablet is 1.0-6.0g.
Pesticidal combination good disinsection effect of the present invention, drug effect is high, reduces drug usage amount, has delayed pest resistance to insecticide
It generates, effervescent tablet preparation method is simple and convenient to operate, and energy direct labor or unmanned aerial vehicle are spread fertilizer over the fields, time saving and energy saving, convenient for promoting
Using.Therefore, the present invention also protects the application of the Pesticidal combination and its effervescent tablet in rice terrace pest is prevented.
In above application, rice terrace pest is mainly rice terrace plant hopper and rice borer.When Pesticidal combination is effervescent tablet
When, directly effervesce is carried out to spread fertilizer over the fields use, it is easy to operate.
The present invention compounds imidacloprid and dimehypo, the advantages of effectively having played the two, and products obtained therefrom is quality
Different, good drug efficacy, available for rice terrace pest control, preventive effect is apparently higher than the preventive effect that imidacloprid is applied alone or dimehypo is applied alone.This
Inventive composition can significantly save financial cost, while can also reduce residual quantity of the medicament in agricultural product and environment, delay
Pest resistance to insecticide generates, and extends the service life of medicament, has important economic implications, environment protection significance and ecological significance.
Imidacloprid and dimehypo Pesticidal combination are made effervescent tablet by the present invention, and preparation method is simple and convenient to operate, energy
Consumption is few, and environmental protection can realize continuous production, product quality is excellent.Effervescent tablet has the following advantages：1st, medicine can be effectively reduced
Agent usage amount is not easy to cause chemical injury of crops；2nd, do not need to be added to the water dissolved dilution spray pesticide again, can direct labor spread fertilizer over the fields or
Aircraft, which is spread fertilizer over the fields, has directionality in rice terrace, dispenser, and the effervescent tablet of spreading can reach the place of needs, time saving province really
Power, it is convenient and efficient；3rd, it is not attached on the cauline leaf of crop, drift small, environmental pollution is small, avoids direct contact with kill day
Enemy, to dispenser personnel safety.
Specific embodiment
Further, with specific examples below, the present invention is described in detail, but the present invention is limited to absolutely not these examples
Son.Unless otherwise instructed, following each component contents are weight percentage.
1 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 10%, dimehypo 10%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
Preparation method is：By half and the disintegrant acid of imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass
After source is sufficiently mixed uniformly, ultra micro air-flow crushing is carried out, obtains 750 mesh fine powders, then gained fine powder in kneader is added in and is fitted
The water of amount（The water of quality of material 3-5wt%）It mediates, is granulated through waving comminutor, obtain the particle of 20 mesh or so, particle is in 60 DEG C of bakings
It is dry, it is spare；By alkali source and remaining component（Imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass half）Fully
After mixing, ultra micro air-flow crushing is carried out, obtains 750 mesh fine powders, then gained fine powder is added in into suitable water in kneader
（The water of quality of material 3-5wt%）Mediate, through wave comminutor be granulated 20 mesh or so particle, particle is standby in 60 DEG C of drying
With；Two kinds of particles are sufficiently mixed uniformly, through tabletting machine, obtain the effervescent tablet of piece weight 3.0g, as 20% imidacloprid
Dimehypo effervescent tablet.
2 20% imidacloprid dimehypo effervescent tablet of embodiment
Effervescent tablet formula and the preparation method is the same as that of Example 1, unlike：Effervescent tablet piece weight is 1.0g.
3 20% imidacloprid dimehypo effervescent tablet of embodiment
Effervescent tablet formula and the preparation method is the same as that of Example 1, unlike：Effervescent tablet piece weight is 2.0g.
4 20% imidacloprid dimehypo effervescent tablet of embodiment
Effervescent tablet formula and the preparation method is the same as that of Example 1, unlike：Effervescent tablet piece weight is 4.0g.
5 20% imidacloprid dimehypo effervescent tablet of embodiment
Effervescent tablet formula and the preparation method is the same as that of Example 1, unlike：Effervescent tablet piece weight is 5.0g.
6 20% imidacloprid dimehypo effervescent tablet of embodiment
Effervescent tablet formula and the preparation method is the same as that of Example 1, unlike：Effervescent tablet piece weight is 6.0g.
7 15% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 7.5%, dimehypo 7.5%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
8 18% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 9%, dimehypo 9%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
9 22% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 11%, dimehypo 11%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
10 25% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 12.5%, dimehypo 12.5%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer
Salt 4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbon
Sour hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
11 10% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 5%, dimehypo 5%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
12 12% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 6%, dimehypo 6%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
13 28% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 14%, dimehypo 14%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
14 30% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 15%, dimehypo 15%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
15 5% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 2.5%, dimehypo 2.5%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
16 8% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 4%, dimehypo 4%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
17 35% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 17.5%, dimehypo 17.5%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer
Salt 4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbon
Sour hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
18 40% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 20%, dimehypo 20%, dispersant polycarboxylate sodium 0.5%, maleic acid-acrylic acid copolymer salt
4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%, carbonic acid
Hydrogen sodium 16%, cornstarch supplies 100%.
The preparation method is the same as that of Example 1.
19 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 10%, dimehypo 10%, dispersant polycarboxylate sodium 3%, naphtholsulfonic acid formaldehyde condensation products sodium salt 2%,
Wetting agent a- sulfo methyl esters 1.0%, fatty acid amide N methyl taurine sodium salt 1.0%, disintegrant hexanedioic acid 7%, calcium carbonate
8%, kaolin supplies 100%.
The preparation method is the same as that of Example 1.
20 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 13.33%, dimehypo 6.67%, dispersant polycarboxylate sodium 3%, epoxy ethane-epoxy propane are embedding
Section copolymer 3%, wetting agent sodium sulfate of polyethenoxy ether of fatty alcohol 1.0%, lauryl sodium sulfate 3%, disintegrant adipic acid 12%,
Sodium bicarbonate 18%, cornstarch supplies 100%.
Preparation method is：By half and the disintegrant acid of imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass
After source is sufficiently mixed uniformly, ultra micro air-flow crushing is carried out, obtains 700 mesh fine powders, then gained fine powder in kneader is added in and is fitted
The water of amount（The water of quality of material 3-5wt%）It mediates, is granulated through waving comminutor, obtain the particle of 20 mesh or so, particle is in 65 DEG C of bakings
It is dry, it is spare；By alkali source and remaining component（Imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass half）Fully
After mixing, ultra micro air-flow crushing is carried out, obtains 700 mesh fine powders, then gained fine powder is added in into suitable water in kneader
（The water of quality of material 3-5wt%）Mediate, through wave comminutor be granulated 20 mesh or so particle, particle is standby in 65 DEG C of drying
With；Two kinds of particles are sufficiently mixed uniformly, through tabletting machine, obtain the effervescent tablet of piece weight 3.0g, as 20% imidacloprid
Dimehypo effervescent tablet.
21 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 6.67%, dimehypo 13.33%, dispersant ethylene oxide-propylene oxide block copolymer 2%, virtue
Base phenol polyethenoxy ether 1%, wetting agent lauryl sodium sulfate 1%, disintegrant fumaric acid 7%, sodium bicarbonate 8%, talcum powder is supplied
100%。
Preparation method is：By half and the disintegrant acid of imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass
After source is sufficiently mixed uniformly, ultra micro air-flow crushing is carried out, obtains 700 mesh fine powders, then gained fine powder in kneader is added in and is fitted
The water of amount（The water of quality of material 3-5wt%）It mediates, is granulated through waving comminutor, obtain the particle of 20 mesh or so, particle is in 60 DEG C of bakings
It is dry, it is spare；By alkali source and remaining component（Imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass half）Fully
After mixing, ultra micro air-flow crushing is carried out, obtains 700 mesh fine powders, then gained fine powder is added in into suitable water in kneader
（The water of quality of material 3-5wt%）Mediate, through wave comminutor be granulated 20 mesh or so particle, particle is standby in 60 DEG C of drying
With；Two kinds of particles are sufficiently mixed uniformly, through tabletting machine, obtain the effervescent tablet of piece weight 3.0g, as 20% imidacloprid
Dimehypo effervescent tablet.
22 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 18.75%, dimehypo 1.25%, dispersant maleic acid-acrylic acid copolymer salt 2.5%, alkyl phenol
Polyoxyethylene ether formaldehyde condensation products sulfate 2.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 1.0%, fatty alcohol polyoxy second
Alkene ether sodium sulfate 1.0%, disintegrant niter cake 30%, sodium bicarbonate 20%, diatomite supplies 100%.
Preparation method is：By half and the disintegrant acid of imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass
After source is sufficiently mixed uniformly, ultra micro air-flow crushing is carried out, obtains 600 mesh fine powders, then gained fine powder in kneader is added in and is fitted
The water of amount（The water of quality of material 3-5wt%）It mediates, is granulated through waving comminutor, obtain the particle of 20 mesh or so, particle is in 60 DEG C of bakings
It is dry, it is spare；By alkali source and remaining component（Imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass half）Fully
After mixing, ultra micro air-flow crushing is carried out, obtains 600 mesh fine powders, then gained fine powder is added in into suitable water in kneader
（The water of quality of material 3-5wt%）Mediate, through wave comminutor be granulated 20 mesh or so particle, particle is standby in 60 DEG C of drying
With；Two kinds of particles are sufficiently mixed uniformly, through tabletting machine, obtain the effervescent tablet of piece weight 3.0g, as 20% imidacloprid
Dimehypo effervescent tablet.
23 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 0.95%, dimehypo 19.05%, the double naphthalenesulfonate formaldehyde condensation compound sodium salts 3.5% of dispersant, alkyl
Sodium phenolsulfonate 2.5%, wetting agent alkyl phenol polyoxyethylene ether succinic acid half ester sodium sulfonate 0.8%, fatty acid sulfates 1.4% collapse
Agent succinic acid 12%, sodium carbonate 9% are solved, cornstarch supplies 100%.
Preparation method is：By half and the disintegrant acid of imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass
After source is sufficiently mixed uniformly, ultra micro air-flow crushing is carried out, obtains 550 mesh fine powders, then gained fine powder in kneader is added in and is fitted
The water of amount（The water of quality of material 3-5wt%）It mediates, is granulated through waving comminutor, obtain the particle of 20 mesh or so, particle is in 60 DEG C of bakings
It is dry, it is spare；By alkali source and remaining component（Imidacloprid, dimehypo, dispersant, wetting agent and filler gross mass half）Fully
After mixing, ultra micro air-flow crushing is carried out, obtains 550 mesh fine powders, then gained fine powder is added in into suitable water in kneader
（The water of quality of material 3-5wt%）Mediate, through wave comminutor be granulated 20 mesh or so particle, particle is standby in 60 DEG C of drying
With；Two kinds of particles are sufficiently mixed uniformly, through tabletting machine, obtain the effervescent tablet of piece weight 3.0g, as 20% imidacloprid
Dimehypo effervescent tablet.
24 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 0.49%, dimehypo 19.51%, the double naphthalenesulfonate formaldehyde condensation compound sodium salts 3% of dispersant, polycarboxylic acids
Sodium salt 0.5%, wetting agent sodium tetradecyl sulfate 1.5%, Negel 1.5%, disintegrant tartaric acid 28%, sodium carbonate 16%,
Diatomite supplies 100%.
Preparation method is the same as embodiment 23.
25 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 19.51%, dimehypo 0.49%, dispersant polyox-yethylene-polyoxypropylene block copolymer 1%, virtue
Base phenol polyethenoxy ether 2%, wetting agent fatty acid sulfates 1.5%, fatty acid amide N methyl taurine sodium salt 1.0%, disintegrant
DL-malic acid 17%, saleratus 23%, attapulgite supplies 100%.
Preparation method is the same as embodiment 23.
26 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 0.65%, dimehypo 19.35%, dispersant aryl phenol polyethenoxy ether 2%, maleic-acrylic acid
Copolymer salt 2%, wetting agent sodium tetradecyl sulfate 1.5%, alkyl phenol polyoxyethylene ether succinic acid half ester sodium sulfonate 0.5%, disintegration
Agent phosphatase 11 2%, calcium carbonate 8%, kaolin supplies 100%.
Preparation method is the same as embodiment 23.
27 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 19.05%, dimehypo 0.95%, dispersant di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 4.5%, ethylene oxide-ring
Ethylene Oxide block copolymer 1%, wetting agent Negel 2%, dialkyl group Succinate sodium sulfonate salt 0.5%, disintegrant fourth two
Acid 20%, potassium carbonate 30%, urea supplies 100%.
Preparation method is the same as embodiment 23.
28 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 13.33%, dimehypo 6.67%, dispersant polycarboxylate sodium 0.5%, maleic-acrylic acid copolymerization
Object salt 4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%,
Sodium bicarbonate 16%, cornstarch supplies 100%.Preparation method is the same as embodiment 21.
29 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 6.67%, dimehypo 13.33%, dispersant polycarboxylate sodium 0.5%, maleic-acrylic acid copolymerization
Object salt 4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%,
Sodium bicarbonate 16%, cornstarch supplies 100%.Preparation method is the same as embodiment 22.
30 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 18.75%, dimehypo 1.25%, dispersant polycarboxylate sodium 0.5%, maleic-acrylic acid copolymerization
Object salt 4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%,
Sodium bicarbonate 16%, cornstarch supplies 100%.Preparation method is the same as embodiment 23.
31 20% imidacloprid dimehypo effervescent tablet of embodiment
Formula：Imidacloprid 0.95%, dimehypo 19.05%, dispersant polycarboxylate sodium 0.5%, maleic-acrylic acid copolymerization
Object salt 4.5%, wetting agent dialkyl group Succinate sodium sulfonate salt 0.5%, lauryl sodium sulfate 1.0%, disintegrant citric acid 14%,
Sodium bicarbonate 16%, cornstarch supplies 100%.Preparation method is the same as embodiment 24.
Properties of product are tested
The advantages of portioned product performance data and the test of pesticide effectiveness are to prove effervescent tablet of the present invention is set forth below.
First, effervescent tablet performance test
Swollen bag, the performance test results are not as shown in table 1 below for effervescent tablet obtained by various embodiments of the present invention：
1 properties of product test result of table
Note：Floatability refers to that product enters and swims in water surface up or down after water and sink to the bottom.For this product, product drift
It floats on the surface, active ingredient is contributed to spread in water.
It is up-to-standard that effervescent tablet of the present invention is can be seen that by above-mentioned data, and passes through embodiment 1 and 19, embodiment
20 and 28, embodiment 21 and 29 comparison as can be seen that auxiliary agent most preferably with combining, the property of effervescent tablet product can be improved
Energy.
2nd, rice terrace pest controling effect is studied
1st, medicament used
Experimental pharmacy：The made preparation of the embodiment of the present invention；
Comparison medicament：Imidacloprid 70%WG（It is purchased in market）, dimehypo 20%SL（It is purchased in market）.
2nd, test method：
It is tested May summer in rice terrace, rice terrace pest has aphid, thrips, leafhopper, aleyrodid, plant hopper, Echinocnemussquameus
First, rice borer, rice leaf beetles etc..During experiment, select 32 plots of rice terraces as trial zone, every plot of trial zone rice terrace respectively according to
The following table 2 and table 3 carry out dispenser.Application method is：Embodiment effervesce needed for every piece of trial zone is calculated according to active ingredient dosage
The dosage of tablet, and trial zone is spread in uniform in using artificial broadcast's mode and carries out dispenser prevention, comparison medicament imidacloprid 70%WG
Dispenser prevention is carried out using cauline leaf spray pattern with comparison medicament dimehypo 20%SL（With 450 kg/ha of water during herbal sprinkling
It is diluted）, weather is fine on the day of dispenser, the dispenser during morning 9~11,25 DEG C of the highest temperature, 15 DEG C of the lowest temperature.Simultaneous selection one
Block rice terrace does not spray any medicament as check plot, check plot.
Preventive effect computational methods：
Wherein CK0-- number of pest before clear water control treatment；
CK1-- 7d number of pest after clear water control treatment；
a0-- number of pest before dispenser；
a1-- 7d number of pest after dispenser；
3rd, result
The effervescent tablet performance and efficacy testing result of 3.1 embodiment 1-18 see the table below 2.
2 properties of product of table and efficacy testing result (preventive effect %, 7 days after dispenser)
| Product index | Drift value, % | Preventive effect (active ingredient dosage：25 grams/ha) |
| Embodiment 1 | 0.86% | 98.7% |
| Embodiment 2 | 8.53% | 98.2% |
| Embodiment 3 | 6.73% | 98.1% |
| Embodiment 4 | 0.94% | 93.1% |
| Embodiment 5 | 0.91% | 87.3% |
| Embodiment 6 | 0.79% | 82.6% |
| Embodiment 7 | 0.80% | 98.2% |
| Embodiment 8 | 0.84% | 98.0% |
| Embodiment 9 | 0.79% | 93.3% |
| Embodiment 10 | 0.75% | 92.3% |
| Embodiment 11 | 0.86% | 98.1% |
| Embodiment 12 | 0.88% | 98.2% |
| Embodiment 13 | 0.83% | 88.1% |
| Embodiment 14 | 0.87% | 87.3% |
| Embodiment 15 | 0.70% | 98.1% |
| Embodiment 16 | 0.84% | 98.2% |
| Embodiment 17 | 0.88% | 83.1% |
| Embodiment 18 | 0.83% | 82.1% |
Note：It is influenced when drift value refers to spread fertilizer over the fields by wind speed, fails to reach the quantity of target area.
As can be seen from the above table, embodiment 1,2,3,4,5 and 6 active constituent contents are 20%, tablet weight is respectively 3.0,
1.0th, 2.0,4.0,5.0 and 6.0g, when can be seen that effervescent tablet tablet weight >=3.0g by above-mentioned data, drift value is most
Small, during tablet weight ＜ 3.0g, drift value can reach more than 5%, and it is small to be primarily due to tablet weight, easily with wind drift；Effervesce
During tablet tablet weight≤3.0g, preventive effect is up to more than 98%, and during tablet weight ＞ 3.0g, as piece increases again, preventive effect gradually drops
Low, especially embodiment 6 and 7 prevents effect from reducing apparent, this is primarily due to active ingredient is identical, unit area medication
Measure it is identical in the case of, with becoming larger for piece weight, it is also increasing to spread fertilizer over the fields rear tablet spacing, and active ingredient needs longer after disintegration
Time spreads（And there are signs of degradation in water for active ingredient）, it is unfavorable for the performance of drug effect.In conclusion effervescent tablet tablet
When piece weight is 3.0g, product drift value, preventive effect are up to optimal effectiveness.
In addition, embodiment 1,7,8,9,10,11,12,13,14,15,16,17 and 18 tablet weights are 3.0g, by upper
When stating data and can be seen that active constituent content as 15-20%, resultant effect that cost and preventive effect are optimal, active ingredient contains
It measures when being 15~25%, cost and preventive effect resultant effect take second place, when active constituent content is 5~30%, cost and preventive effect synthesis effect
Third, when active constituent content is 35~40%, cost and preventive effect resultant effect are minimum, this is primarily due to active ingredient for fruit
After content raising, in effective ingredient consumption under the same conditions, the usage amount of medicament can relative drop, between corresponding tablet between
Away from can also become larger, active ingredient needs the long period to spread after disintegration（And there are signs of degradation in water for active ingredient）, it is unfavorable
In the performance of drug effect.But since product is reduced with content, the costs such as required raw material, production, packaging, transport can be increased accordingly.It is comprehensive
Upper described, which is 5~40wt%, preferably 5~30wt%, more preferable 15~25wt%, most preferably
15-20wt%。
3.2 other embodiment effervescent tablet efficacy testing results are as shown in table 3 below.
3 other embodiment effervescent tablet of table prevention rice terrace pest effect (preventive effect %, 7 days after dispenser)
| Rice terrace | Medicament | Active ingredient dosage (gram/ha) | Preventive effect |
| 1 | The effervescent tablet of embodiment 1 | 25 | 98.7% |
| 2 | The effervescent tablet of embodiment 19 | 25 | 93.2% |
| 3 | The effervescent tablet of embodiment 20 | 25 | 90.5% |
| 4 | The effervescent tablet of embodiment 21 | 25 | 90.1% |
| 5 | The effervescent tablet of embodiment 22 | 25 | 87.2% |
| 6 | The effervescent tablet of embodiment 23 | 25 | 87.3% |
| 7 | The effervescent tablet of embodiment 24 | 25 | 83.5% |
| 8 | The effervescent tablet of embodiment 25 | 25 | 84.1% |
| 9 | The effervescent tablet of embodiment 26 | 25 | 84.2% |
| 10 | The effervescent tablet of embodiment 27 | 25 | 85.8% |
| 11 | The effervescent tablet of embodiment 28 | 25 | 95.7% |
| 12 | The effervescent tablet of embodiment 29 | 25 | 95.5% |
| 13 | The effervescent tablet of embodiment 30 | 25 | 92.2% |
| 14 | Imidacloprid 70%WG | 30 | 79.5% |
| 15 | Dimehypo 20%SL | 700 | 80.1% |
From table 3 it can be seen that within the scope of the present invention, gained imidacloprid dimehypo Pesticidal combination dosage is than single
Medicament significantly reduces, and preventive effect is maintained at more than 83%, and the mass ratio of imidacloprid and dimehypo is 0.05~15:When in the range of 1,
Gained Pesticidal combination preventive effect is maintained at more than 85%, and mass ratio is 0.5~2:When in the range of 1, preventive effect is maintained at more than 90%, matter
Ratio is measured 1:When 1, gained Pesticidal combination best results, for preventive effect more than 98%, this illustrates the selection of drug ratios to drug effect
Promotion has a significant impact.In addition, pass through embodiment 1 and 19, embodiment 20 and 28, embodiment 21 and 29, embodiment 22 and 30, reality
Apply example 1,28,29 and 30 comparison more, it is apparent that the selection of active ingredient and auxiliary material also have to the promotion of drug effect it is larger
Influence.
Pesticidal combination of the present invention improves the control effect of rice terrace pest it can be seen from testing above, subtracts simultaneously
Lack the usage amount of drug, it is economical and practical, effectively reduce ecology and environmental pollution, significant effect.The composition makes simultaneously
Into effervescent tablet, do not need to carry out dispenser in the form of spraying, it is time saving and energy saving；Drug drifts about when can effectively avoid dispenser, pollution
Ambient enviroment；Operating personnel's Sucked medicine during reduction dispenser, can avoid intoxication accident；During dispenser there is directionality, make to spread
The effervescent tablet of cloth can reach the place of needs really；It is not attached on the cauline leaf of plant, avoids direct contact with kill natural enemy.
Claims (14)
1. a kind of Pesticidal combination, it is characterized in that：Dosage form is effervescent tablet, and component is active ingredient and auxiliary material, active ingredient and
Each auxiliary material weight percent content is：Active ingredient 5~40%, dispersant 3~6%, wetting agent 1~4%, disintegrant 15~50%,
Filler surplus；The active ingredient is imidacloprid and dimehypo, and the mass ratio of imidacloprid and dimehypo is 1~40: 1~40；
The dispersant is by polycarboxylate sodium and maleic acid-acrylic acid copolymer salt in mass ratio 1:9 mix；The wetting
Agent is by dialkyl group Succinate sodium sulfonate salt and lauryl sodium sulfate in mass ratio 1:2 mix；The disintegrant is by acid
Source and alkali source composition, acid source is citric acid, and alkali source is sodium bicarbonate, and the mass ratio of citric acid and sodium bicarbonate is 14:16；It is described
Filler is cornstarch.
2. according to Pesticidal combination described in claim 1, it is characterized in that：The mass ratio of imidacloprid and dimehypo is 0.05~15:
1。
3. according to the Pesticidal combination described in claim 2, it is characterized in that：The mass ratio of imidacloprid and dimehypo is 0.5~2:1.
4. according to the Pesticidal combination described in claim 3, it is characterized in that：The mass ratio of imidacloprid and dimehypo is 1:1.
5. Pesticidal combination according to claim 1, it is characterized in that：Active constituent content is 5~30wt%.
6. Pesticidal combination according to claim 5, it is characterized in that：Active constituent content is 15~25wt%.
7. Pesticidal combination according to claim 6, it is characterized in that：Active constituent content is 15-20wt%.
8. according to the Pesticidal combination described in any one of claim 1-6, it is characterized in that：Auxiliary material forms and each auxiliary material weight hundred
Divide than content and be：Dispersant 5%, wetting agent 1.5%, disintegrant 30%, filler surplus.
9. according to the Pesticidal combination described in any one of claim 1-4, it is characterized in that：Active ingredient and auxiliary material weight percent
It is than content：Active ingredient 15-20%, dispersant 5%, wetting agent 1.5%, disintegrant 30%, filler surplus.
10. according to the Pesticidal combination described in any one of claim 1-6, it is characterized in that：Every weight of effervescent tablet for 1.0~
6.0g。
11. Pesticidal combination according to claim 10, it is characterized in that：Every weight of effervescent tablet is 1.0-5.0g.
12. Pesticidal combination according to claim 11, it is characterized in that：Every weight of effervescent tablet is 3.0g.
13. a kind of preparation method of Pesticidal combination described in claim 1, it is characterized in that：The component of Pesticidal combination is has
Effect ingredient, dispersant, wetting agent, disintegrant and filler, disintegrant are divided into disintegrant acid source and disintegrant alkali source, preparation process packet
It includes：
（1）The half of active ingredient, dispersant, wetting agent and filler is taken respectively by quality, by the half of active ingredient, dispersant
Half, the half of the half of wetting agent and filler be uniformly mixed with disintegrant acid source, fine powder is ground into, after fine powder adds water to mediate
It is granulated, drying obtains particle A, spare；
（2）Disintegrant alkali source with remaining component is uniformly mixed, is ground into fine powder, fine powder adds water to be granulated after mediating, dries, obtain
Particle B, it is spare；
（3）Particle A and B are uniformly mixed, tabletting is carried out, obtains Pesticidal combination effervescent tablet.
14. application of the Pesticidal combination in rice terrace pest is prevented described in a kind of any one of claim 1~12.
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| CN107821426B (en) * | 2017-11-23 | 2020-06-16 | 江苏邦盛生物科技有限责任公司 | Insecticidal composition containing dazomet and imidacloprid and application thereof |
| CN111802402A (en) * | 2020-08-05 | 2020-10-23 | 山东京博石油化工有限公司 | Insecticidal effervescent tablet containing thiamethoxam and dimehypo for paddy field through broadcast application, and preparation method and application thereof |
| CN111802400A (en) * | 2020-08-05 | 2020-10-23 | 山东京博石油化工有限公司 | Acetamiprid and dimehypo-containing insecticidal effervescent tablet applied to paddy field by broadcasting and preparation method and application thereof |
| CN113841711A (en) * | 2021-11-03 | 2021-12-28 | 宜宾樟之美生物科技有限公司 | Method for using mixture of biological preparation containing eucalyptus globulus oil and biological insecticide |
| CN114651833B (en) * | 2022-03-10 | 2024-01-16 | 赤天化科技集团有限公司 | Insecticidal composition containing dimefon and application thereof |
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