CN105770978A - Biodegradable medical abdominal surgical suture material - Google Patents
Biodegradable medical abdominal surgical suture material Download PDFInfo
- Publication number
- CN105770978A CN105770978A CN201610156552.0A CN201610156552A CN105770978A CN 105770978 A CN105770978 A CN 105770978A CN 201610156552 A CN201610156552 A CN 201610156552A CN 105770978 A CN105770978 A CN 105770978A
- Authority
- CN
- China
- Prior art keywords
- layer
- suture material
- biodegradable
- surgical suture
- medical abdominal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003356 suture material Substances 0.000 title claims abstract description 19
- 230000003187 abdominal effect Effects 0.000 title claims abstract description 14
- 239000010410 layer Substances 0.000 claims abstract description 40
- 239000000463 material Substances 0.000 claims abstract description 30
- 239000000835 fiber Substances 0.000 claims abstract description 11
- 229920000954 Polyglycolide Polymers 0.000 claims abstract description 8
- 239000012792 core layer Substances 0.000 claims abstract description 8
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 8
- 239000004633 polyglycolic acid Substances 0.000 claims abstract description 8
- 239000004626 polylactic acid Substances 0.000 claims abstract description 8
- 229920001577 copolymer Polymers 0.000 claims abstract description 6
- 229920001661 Chitosan Polymers 0.000 claims abstract description 5
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 4
- 150000002596 lactones Chemical class 0.000 claims description 6
- 230000015556 catabolic process Effects 0.000 claims description 5
- 238000006731 degradation reaction Methods 0.000 claims description 5
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 229920001436 collagen Polymers 0.000 claims description 4
- 229920002101 Chitin Polymers 0.000 claims description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 3
- 239000001569 carbon dioxide Substances 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 abstract description 2
- 239000002131 composite material Substances 0.000 abstract 1
- 239000007857 degradation product Substances 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 239000012620 biological material Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- LKAPTZKZHMOIRE-KVTDHHQDSA-N (2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbaldehyde Chemical compound OC[C@H]1O[C@H](C=O)[C@@H](O)[C@@H]1O LKAPTZKZHMOIRE-KVTDHHQDSA-N 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- LKAPTZKZHMOIRE-UHFFFAOYSA-N chitose Natural products OCC1OC(C=O)C(O)C1O LKAPTZKZHMOIRE-UHFFFAOYSA-N 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- -1 hair Polymers 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005297 material degradation process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a biodegradable medical abdominal surgical suture material. The biodegradable medical abdominal surgical suture material, a composite biodegradable material, consists of a cylindrical core layer, a middle layer wrapping the core layer and a cover layer wrapping the middle layer, wherein the core layer is selected from polyglycolic acid, polylactic acid, polycrylactone or a copolymer thereof, the middle layer is selected from carboxymethyl chitosan, chitosan fibers or collagenous fibers, and the cover layer is selected from polyglycolic acid, polylactic acid, polycrylactone or a copolymer thereof. The biodegradable medical abdominal surgical suture material has the advantages of no toxicity, no irritation, biocompatibility and capability of avoiding causing inflammatory reaction since a degradation product of a surgical suture is finally decomposed into carbon dioxide and water which are free of toxicity.
Description
Technical field
The present invention relates to a kind of medical abdominal operation suture material of biodegradable, belong to bio-medical material production technical field.
Background technology
Biodegradable material medically refers to that a class has property, for surgical repair, physiotherapy and rehabilitation, diagnosis, treatment sufferer, it is possible to degradable and absorption in vivo, and tissue will not be produced dysgenic biomaterial.Development along with tissue engineering technique, Biodegradable material is developed rapidly, its range of application relates to nearly all volatile implanting device, including medicine controlled release carrier, sutures, operation nursing device, hemostat device, operation antiblocking film and tissue and cell engineering etc..
Biodegradable material includes: 1) natural degradable macromolecular material: mainly have collagen, gelatin, chitose, hair, alginic acid, blood vessel, serum fibrin, polyamino acid etc..Great advantage is that catabolite is prone to be absorbed without generation inflammatory reaction, but there is the weakness of poor mechanical property.At nature, by carbon dioxide, water, microorganism and sunlight synthesis of natural material again and again, the good characteristic of material is handed on by genetic technique that biosphere is marvellous from generation to generation.2) synthesis of degradable macromolecular material: be the main study subject of current used in tissue engineering biomaterial, wherein based on polyactide series material；This kind of material degradation speed and intensity are adjustable, it is easy to plastotype and structure high porosity three-dimensional rack；This kind of material essence has the disadvantage that the concentration release of its catabolite easily produces inflammatory reaction, and culture environment acidity can be made too high.Such material is weak to cellular affinity, generally requires physical method or adds some factor ability adherent cell.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art part, it is provided that a kind of medical abdominal operation suture material of biodegradable.
The medical abdominal operation suture material of biodegradable of the present invention, described suture material is complex biological degradation material, it is made up of cylinder core layer, the intermediate layer being wrapped on inner sandwich layer and parcel exodermis on the intermediate layer, the material of described inner sandwich layer is selected from polyglycolic acid, polylactic acid, poly-second lactone or its copolymer, the material in described intermediate layer is selected from carboxymethyl chitosan fiber, chitin fiber or collagen fiber, and the material of described exodermis is selected from polyglycolic acid, polylactic acid, poly-second lactone or copolymer.
Preferably,
The thickness of described inner sandwich layer, intermediate layer and exodermis is than for (2-4): 2:(1-3).
The medical abdominal operation suture material of biodegradable of the present invention, has the following technical effect that avirulence, nonirritant biocompatibility, and the catabolite of operation suture thread is ultimately breaks down into nontoxic carbon dioxide and water, is not result in inflammatory reaction.
Detailed description of the invention
Embodiment 1
The medical abdominal operation suture material of biodegradable of the present invention, described suture material is complex biological degradation material, it is made up of cylinder core layer, the intermediate layer being wrapped on inner sandwich layer and parcel exodermis on the intermediate layer, the material of described inner sandwich layer is selected from polyglycolic acid, the material in described intermediate layer is selected from carboxymethyl chitosan fiber, and the material of described exodermis is selected from polyglycolic acid.The thickness of described inner sandwich layer, intermediate layer and exodermis is than for 4:2:3.
Embodiment 2
The medical abdominal operation suture material of biodegradable of the present invention, described suture material is complex biological degradation material, it is made up of cylinder core layer, the intermediate layer being wrapped on inner sandwich layer and parcel exodermis on the intermediate layer, the material of described inner sandwich layer is selected from polylactic acid, the material in described intermediate layer is selected from chitin fiber, and the material of described exodermis is selected from polylactic acid.The thickness of described inner sandwich layer, intermediate layer and exodermis is than for 2:2:1.
Embodiment 3
The medical abdominal operation suture material of biodegradable of the present invention, described suture material is complex biological degradation material, it is made up of cylinder core layer, the intermediate layer being wrapped on inner sandwich layer and parcel exodermis on the intermediate layer, the material of described inner sandwich layer is selected from poly-second lactone, the material in described intermediate layer is selected from carboxylic collagen fiber, and the material of described exodermis is selected from poly-second lactone.The thickness of described inner sandwich layer, intermediate layer and exodermis is than for 3:2:2.
Claims (2)
1. the medical abdominal operation suture material of biodegradable, it is characterized in that, described suture material is complex biological degradation material, it is made up of cylinder core layer, the intermediate layer being wrapped on inner sandwich layer and parcel exodermis on the intermediate layer, the material of described inner sandwich layer is selected from polyglycolic acid, polylactic acid, poly-second lactone or its copolymer, the material in described intermediate layer is selected from carboxymethyl chitosan fiber, chitin fiber or collagen fiber, and the material of described exodermis is selected from polyglycolic acid, polylactic acid, poly-second lactone or copolymer.
2. the medical abdominal operation suture material of biodegradable according to claim 1, it is characterised in that the thickness of described inner sandwich layer, intermediate layer and exodermis is than for (2-4): 2:(1-3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610156552.0A CN105770978A (en) | 2016-03-21 | 2016-03-21 | Biodegradable medical abdominal surgical suture material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610156552.0A CN105770978A (en) | 2016-03-21 | 2016-03-21 | Biodegradable medical abdominal surgical suture material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105770978A true CN105770978A (en) | 2016-07-20 |
Family
ID=56393053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610156552.0A Pending CN105770978A (en) | 2016-03-21 | 2016-03-21 | Biodegradable medical abdominal surgical suture material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105770978A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106725677A (en) * | 2017-01-03 | 2017-05-31 | 万越 | What a kind of x-ray developed is long placed in absorbable suture |
| CN107970487A (en) * | 2017-12-26 | 2018-05-01 | 徐州仁和医疗科技有限公司 | A kind of novel medical operation suture |
| CN108607115A (en) * | 2018-06-13 | 2018-10-02 | 李华刚 | A kind of M lips shaping suture |
| CN110665045A (en) * | 2019-10-17 | 2020-01-10 | 王时灿 | Absorbable suture for obstetrics and gynecology department and preparation method thereof |
| CN112402686A (en) * | 2020-12-09 | 2021-02-26 | 单县华宇缝合制品有限公司 | Easily degradable collagen line and preparation method thereof |
| CN113304304A (en) * | 2021-06-21 | 2021-08-27 | 青岛理工大学 | Drug-loaded degradable absorbable medical suture and preparation method thereof |
| CN114177343A (en) * | 2021-11-12 | 2022-03-15 | 长春圣博玛生物材料有限公司 | Suture, preparation method and medical braided fabric |
| CN114753022A (en) * | 2022-03-23 | 2022-07-15 | 合肥工业大学 | Self-repairing waterproof polylactic acid fiber fabric with core-shell structure |
| CN120514905A (en) * | 2025-07-25 | 2025-08-22 | 上海经海纬象生物材料有限公司 | Composite medical suture and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537020A (en) * | 2001-07-30 | 2004-10-13 | 株式会社日本组织工程 | Base material for tissue regeneration, material for transplantation, and method for producing same |
| CN101033563A (en) * | 2007-03-30 | 2007-09-12 | 东南大学 | High-strength composite nano fiber long yarn and manufacturing method thereof |
| CN101406710A (en) * | 2008-11-25 | 2009-04-15 | 同济大学 | Suture thread containing bioactive components and preparation method thereof |
| CN101703794A (en) * | 2009-11-18 | 2010-05-12 | 中国人民解放军第二炮兵总医院 | Controlled degradable surgical suture thread and fabricating method thereof |
| CN102008751A (en) * | 2010-11-24 | 2011-04-13 | 北京道淼浩博科技发展有限公司 | Biodegradable stent composite material and preparation method thereof |
| CN104667340A (en) * | 2013-11-26 | 2015-06-03 | 沈攀攀 | A biodegradable suture with bioactivity |
-
2016
- 2016-03-21 CN CN201610156552.0A patent/CN105770978A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537020A (en) * | 2001-07-30 | 2004-10-13 | 株式会社日本组织工程 | Base material for tissue regeneration, material for transplantation, and method for producing same |
| CN101033563A (en) * | 2007-03-30 | 2007-09-12 | 东南大学 | High-strength composite nano fiber long yarn and manufacturing method thereof |
| CN101406710A (en) * | 2008-11-25 | 2009-04-15 | 同济大学 | Suture thread containing bioactive components and preparation method thereof |
| CN101703794A (en) * | 2009-11-18 | 2010-05-12 | 中国人民解放军第二炮兵总医院 | Controlled degradable surgical suture thread and fabricating method thereof |
| CN102008751A (en) * | 2010-11-24 | 2011-04-13 | 北京道淼浩博科技发展有限公司 | Biodegradable stent composite material and preparation method thereof |
| CN104667340A (en) * | 2013-11-26 | 2015-06-03 | 沈攀攀 | A biodegradable suture with bioactivity |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106725677A (en) * | 2017-01-03 | 2017-05-31 | 万越 | What a kind of x-ray developed is long placed in absorbable suture |
| CN107970487A (en) * | 2017-12-26 | 2018-05-01 | 徐州仁和医疗科技有限公司 | A kind of novel medical operation suture |
| CN107970487B (en) * | 2017-12-26 | 2021-01-26 | 杭州整形医院有限公司 | Novel medical operation suture line |
| CN108607115A (en) * | 2018-06-13 | 2018-10-02 | 李华刚 | A kind of M lips shaping suture |
| CN110665045A (en) * | 2019-10-17 | 2020-01-10 | 王时灿 | Absorbable suture for obstetrics and gynecology department and preparation method thereof |
| CN112402686A (en) * | 2020-12-09 | 2021-02-26 | 单县华宇缝合制品有限公司 | Easily degradable collagen line and preparation method thereof |
| CN113304304A (en) * | 2021-06-21 | 2021-08-27 | 青岛理工大学 | Drug-loaded degradable absorbable medical suture and preparation method thereof |
| CN114177343A (en) * | 2021-11-12 | 2022-03-15 | 长春圣博玛生物材料有限公司 | Suture, preparation method and medical braided fabric |
| CN114753022A (en) * | 2022-03-23 | 2022-07-15 | 合肥工业大学 | Self-repairing waterproof polylactic acid fiber fabric with core-shell structure |
| CN120514905A (en) * | 2025-07-25 | 2025-08-22 | 上海经海纬象生物材料有限公司 | Composite medical suture and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105770978A (en) | Biodegradable medical abdominal surgical suture material | |
| Xu et al. | Electrospun medical sutures for wound healing: A review | |
| Kurowiak et al. | Biodegradable polymers in biomedical applications: a review—developments, perspectives and future challenges | |
| Pinho et al. | Peripheral nerve regeneration: current status and new strategies using polymeric materials | |
| Tanase et al. | PLA/chitosan/keratin composites for biomedical applications | |
| CN105705172B (en) | Hydrophilic electrostatic spinning biological composite scaffold material for tissue regeneration and preparation method and application thereof | |
| Alizadeh et al. | PDGF and VEGF-releasing bi-layer wound dressing made of sodium tripolyphosphate crosslinked gelatin-sponge layer and a carrageenan nanofiber layer | |
| Inui et al. | Regeneration of rotator cuff tear using electrospun poly (d, l-Lactide-Co-Glycolide) scaffolds in a rabbit model | |
| Kim et al. | Biocompatible bacterial cellulose composites for biomedical application | |
| Bibire et al. | Biopolymers for surgical applications | |
| Vashisth et al. | Drug functionalized microbial polysaccharide based nanofibers as transdermal substitute | |
| Rodríguez-Soto et al. | Small diameter cell-free tissue-engineered vascular grafts: biomaterials and manufacture techniques to reach suitable mechanical properties | |
| Nematollahi et al. | Fabrication of chitosan silk-based tracheal scaffold using freeze-casting method | |
| CN104888273B (en) | A kind of double-layer composite endocranium and preparation method thereof | |
| Stang et al. | Biocompatibility of different nerve tubes | |
| Brebels et al. | Polymer-based constructs for flexor tendon repair: a review | |
| Klabukov et al. | Biomechanical behaviors and degradation properties of multilayered polymer scaffolds: The phase space method for bile duct design and bioengineering | |
| Varoni et al. | Hierarchic micro-patterned porous scaffolds via electrochemical replica-deposition enhance neo-vascularization | |
| Mensah et al. | The chicken eggshell membrane: a versatile, sustainable, biological material for translational biomedical applications | |
| Song et al. | A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics | |
| Mokhtari et al. | Blood compatibility and cell response improvement of poly glycerol sebacate/poly lactic acid scaffold for vascular graft applications | |
| Sun et al. | Curcumin functionalized electrospun fibers with efficient pH real-time monitoring and antibacterial and anti-inflammatory properties | |
| CN104606722A (en) | Degradable gasket with anti-bacterial anti-adhesion performance | |
| Zarei et al. | Template‐Assisted Electrospinning and 3D Printing of Multilayered Hierarchical Vascular Grafts | |
| Liu et al. | Enhanced hemocompatibility and rapid magnetic anastomosis of electrospun small-diameter artificial vascular grafts |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160720 |
|
| RJ01 | Rejection of invention patent application after publication |