CN105963237B - A kind of Novel mouthwash and its preparation method and application - Google Patents
A kind of Novel mouthwash and its preparation method and application Download PDFInfo
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- CN105963237B CN105963237B CN201610530007.3A CN201610530007A CN105963237B CN 105963237 B CN105963237 B CN 105963237B CN 201610530007 A CN201610530007 A CN 201610530007A CN 105963237 B CN105963237 B CN 105963237B
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- propolis extract
- mouthwash
- emulsifier
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 42
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 241000241413 Propolis Species 0.000 claims abstract description 35
- 229940069949 propolis Drugs 0.000 claims abstract description 35
- 239000000284 extract Substances 0.000 claims abstract description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 15
- 239000000341 volatile oil Substances 0.000 claims abstract description 14
- 241000196324 Embryophyta Species 0.000 claims abstract description 13
- 229940054190 hydroxypropyl chitosan Drugs 0.000 claims abstract description 13
- 235000019441 ethanol Nutrition 0.000 claims abstract description 12
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims abstract description 11
- 208000010266 Aggressive Periodontitis Diseases 0.000 claims abstract description 10
- 201000006727 periodontosis Diseases 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229930006000 Sucrose Natural products 0.000 claims abstract description 8
- 239000005720 sucrose Substances 0.000 claims abstract description 8
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims abstract description 7
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims abstract description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 6
- 235000019501 Lemon oil Nutrition 0.000 claims abstract description 5
- 239000010501 lemon oil Substances 0.000 claims abstract description 5
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 5
- 235000019477 peppermint oil Nutrition 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 20
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
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- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 238000004945 emulsification Methods 0.000 claims 2
- 208000007565 gingivitis Diseases 0.000 abstract description 10
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 8
- 229960003260 chlorhexidine Drugs 0.000 description 8
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- 208000024891 symptom Diseases 0.000 description 5
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical group O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 4
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 4
- 238000005352 clarification Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
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- 238000000265 homogenisation Methods 0.000 description 3
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
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- 208000015181 infectious disease Diseases 0.000 description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
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- 125000000185 sucrose group Chemical group 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- 206010000117 Abnormal behaviour Diseases 0.000 description 1
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- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
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- 229920000153 Povidone-iodine Polymers 0.000 description 1
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- 241000220317 Rosa Species 0.000 description 1
- 240000003705 Senecio vulgaris Species 0.000 description 1
- 235000000340 Solanum pseudocapsicum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 description 1
- 206010044016 Tooth abscess Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 240000004482 Withania somnifera Species 0.000 description 1
- 235000001978 Withania somnifera Nutrition 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
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- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
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- 238000002224 dissection Methods 0.000 description 1
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- 239000012153 distilled water Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
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- 150000002148 esters Chemical class 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- SFMJNHNUOVADRW-UHFFFAOYSA-N n-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamide Chemical compound C1=C(NC(=O)C=C)C(C)=CC=C1N1C(=O)C=CC2=C1C1=CC(C=3C=CC(NS(C)(=O)=O)=CC=3)=CC=C1N=C2 SFMJNHNUOVADRW-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 229960005053 tinidazole Drugs 0.000 description 1
- 230000036344 tooth staining Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of Novel mouthwashes and its preparation method and application.The Novel mouthwash is made of the raw material for preparing of following weight percent meter: hydroxypropyl chitosan 6~10%, plants essential oil 0.1~1%, propolis extract 1~3%, glycerol 4~8%, poly-D-lysine 0.2~1%, emulsifier 1~3% and ethyl alcohol 4~8%, surplus are water；Wherein plants essential oil is lemon oil and peppermint oil with (1.5~3): 1 weight ratio forms；Emulsifier is one of sucrose monoester, maltose monoesters, mannose monoesters.Novel mouthwash of the present invention has stronger inhibiting effect to plaque, can effectively anticaries and periodontosis generation, it is preferable to the therapeutic effect of gingivitis.In addition, Novel mouthwash of the present invention is safe and non-toxic, comfortable taste can eliminate oral peculiar smell, keep breath freshening.
Description
Technical field
The present invention relates to dental care products liquid, and in particular to a kind of Novel mouthwash and its preparation method and application.
Background technique
Past, people bias toward removing oral peculiar smell to the nursing in oral cavity more, but with the development of medicine, it has been found that,
Oral peculiar smell is not only related with eating habit, also related with mouth disease.Breath freshening is kept, prevents mouth disease, to become
The fresh target of oral care.
Show that China's mouth disease illness rate is up to 97.6%, almost according to Chinese oral health association authority's statistical data
Everybody has different degrees of mouth disease, such as toothache, gingivitis, bleeding gums, saprodontia and periodontosis disease.Wherein, dental caries
Disease and periodontosis are to endanger the principal disease of Human Oral Cavity health.Plaque be dental caries and periodontosis it is critical it is pathogenic because
Element, effectively inhibiting plaque is to prevent and treat dental caries, the important means of periodontosis.Plaque controlling party relatively common at present
Method mainly includes that chemical gargle is gargled, Chinese medical extract gargle is gargled and physical method, such as brushes teeth and is carried out using dental floss
Cleaning of teeth.Especially gargle is welcomed by the people because using simply and can reach certain bacterial plaque inhibitory effect.
Currently used chemistry gargle contains the ingredients such as povidone iodine, acetic acid chlorhexidine, Cetylpyridinium Chloride, Tinidazole more,
Bactericidal effect with strong effect wide-spectrum, but its poor taste, it is big to irritation on mucous membrane, it is easy to produce sense of discomfort, and being used for a long time can
Oral normal flora can be caused to lack of proper care.Chinese medical extract gargle contains cloves, Radix Astragali, honeysuckle, climbing groundsel, radix bupleuri, sweet more
The ingredients such as grass, to oral cleaning is kept, prevention mouth infection tool has certain effect, but the gargle color containing Chinese medical extract
Relatively deep, commonly using can cause tooth staining, and the ingredient of Chinese medical extract is complex, holds that gargle during storage
Easily there is the problems such as muddy, deposited phenomenon and drug effect reduction.
Chinese patent application 201310648219.8 disclose it is a kind of with antibacterial anti-inflammatory deodorization gargle and its preparation
Method and purposes.The gargle is using pomegranate rind extract, rose, wintercherry fruit or calyx as primary raw material, with moisturizer, sweet taste
Agent, preservative and distilled water are formulated, which can reduce Plaque bacteria, and there is prevention and treatment gingivitis, periodontitis, oral cavity to burst
The effects of ulcer and oral cavity and laryngopharyngitis, and halitosis can be eliminated, keep oral cavity fresh and cool.
Summary of the invention
In order to solve the problems existing in the prior art, the present invention provides a kind of Novel mouthwash and its preparation method and application.
Novel mouthwash of the present invention has stronger inhibiting effect to plaque, can effectively anticaries and periodontosis hair
It is raw, it is preferable to the therapeutic effect of gingivitis.In addition, the Novel mouthwash is safe and non-toxic, it is different can to eliminate oral cavity for comfortable taste
Taste keeps breath freshening.
The present invention is by following technical solution to be attained in that
A kind of Novel mouthwash is made of the raw material for preparing of following weight percent meter: hydroxypropyl chitosan 6~10% is planted
Object essential oil 0.1~1%, propolis extract 1~3%, glycerol 4~8%, poly-D-lysine 0.2~1%, 1~3% and of emulsifier
Ethyl alcohol 4~8%, surplus are water；
The plants essential oil is lemon oil and peppermint oil with (1.5~3): 1 weight ratio forms；
The emulsifier is one of sucrose monoester, maltose monoesters, mannose monoesters.
Preferably, the Novel mouthwash is made of the raw material for preparing of following weight percent meter: hydroxypropyl chitosan
8%, plants essential oil 0.35%, propolis extract 2%, glycerol 6%, poly-D-lysine 0.65%, emulsifier 2% and ethyl alcohol 6%,
Surplus is water；
The plants essential oil is that lemon oil and peppermint oil are formed with the weight ratio of 2.5:1；
The emulsifier is one of sucrose monoester, maltose monoesters, mannose monoesters.
Further, the propolis extract preparation method the following steps are included:
(1) propolis paraffin removal is placed on 2~4h of pre-freeze in -10 DEG C of refrigerator, crushed, crossed 30 meshes, obtain propolis powder；
(2) ethanol solution that volume fraction is 95% is added into propolis powder for the ratio for being 1:12 in solid-liquid ratio, stirring
Sealing after uniformly impregnates 8~12min at 25 DEG C under conditions of 150~250MPa, after release, under room temperature, standing 2~
4h obtains propolis extract；
(3) propolis extract is placed in -50 DEG C of pre-freeze 3h, is then 50~60Pa in vacuum degree, is lyophilized 6 under the conditions of -5 DEG C
~8h keeps vacuum degree, continues 1~2h of freeze-drying at 20 DEG C to get propolis extract.
Further, the emulsifier is sucrose lauric acid monoester, monolauroyl maltose, mannose lauric acid list
One of ester.
Preferably, the emulsifier is sucrose lauric acid monoester.
In addition, the present invention also provides the preparation methods of the Novel mouthwash described in one kind, comprising the following steps:
(1) plants essential oil, propolis extract, glycerol and ethyl alcohol is taken to mix, at 4 DEG C, homogeneous 10 under conditions of 25~30MPa
~15min is to get solution A；
(2) hydroxypropyl chitosan, poly-D-lysine, emulsifier and water is taken to mix, stirring is completely dissolved to material, obtains solution
B；
(3) solution A is added in solution B under stiring, at 4 DEG C, homogeneous 5min under conditions of 25~30MPa, filtering,
Up to Novel mouthwash.
Correspondingly, the invention also discloses the purposes of the Novel mouthwash, prepared by the specially described Novel mouthwash
Prevent and treat the purposes in the drug of dental caries or periodontosis.
Compared with prior art, present invention has an advantage that each component in Novel mouthwash provided by the invention is mutual
Coordinate, mutual gain, makes gargle that there is extremely strong killing effect to bacterium, plaque can be effectively inhibited and formed, pre- preventing decayed tooth
The generation of disease and periodontosis, especially preferable to the therapeutic effect of gingivitis and safe and non-toxic, comfortable taste, faint scent overflows, and can disappear
Removing abnormal flavor in oral cavity keeps breath freshening.Furthermore Novel mouthwash provided by the invention is simple, at low cost with preparation process, holds
The features such as easy to produce, easy to use.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the present invention is not limited only to following embodiment.
The preparation of 1 propolis extract of embodiment
Preparation method:
(1) propolis paraffin removal is placed on pre-freeze 3h in -10 DEG C of refrigerator, crushed, crossed 30 meshes, obtain propolis powder；
(2) ethanol solution that volume fraction is 95% is added into propolis powder for the ratio for being 1:12 in solid-liquid ratio, stirring
Sealing, at 25 DEG C, impregnates 10min after uniformly under conditions of 200MPa, after release, under room temperature, stands 3h, obtains propolis extraction
Liquid；
(3) propolis extract is placed in -50 DEG C of pre-freeze 3h, is then 50Pa in vacuum degree, 8h is lyophilized under the conditions of -5 DEG C, protects
Vacuum degree is held, continues to be lyophilized 2h at 20 DEG C to get propolis extract.
The preparation of 2 propolis extract of embodiment
It is essentially identical that the preparation method is the same as that of Example 1, and difference is that the pressure impregnated in step (2) is 250MPa.
The preparation of 3 propolis extract of embodiment
It is essentially identical that the preparation method is the same as that of Example 1, and difference is that the pressure impregnated in step (2) is 150MPa.
The rate of extract (%) and general flavone content (%) of propolis extract made from embodiment 1-3 see the table below.
| Testing index | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| The rate of extract (%) | 49.84 | 48.25 | 46.12 |
| General flavone content (%) | 57.35 | 55.86 | 54.37 |
As seen from the above table, propolis extract general flavone content highest made from embodiment 1, therefore with bee made from embodiment 1
The conduct of glue extract prepares raw material and prepares gargle of the present invention.
The preparation of embodiment 4-8 Novel mouthwash
The raw material for preparing of 4-8 Novel mouthwash of the embodiment of the present invention see the table below (by weight percentage)
Preparation method:
(1) plants essential oil, propolis extract, glycerol and ethyl alcohol is taken to mix, at 4 DEG C, homogeneous 10min under conditions of 30MPa,
Up to solution A；
(2) hydroxypropyl chitosan, poly-D-lysine, emulsifier and water is taken to mix, stirring is completely dissolved to material, obtains solution
B；
(3) solution A is added in solution B under stiring, at 4 DEG C, homogeneous 5min under conditions of 25MPa, filtering to get
Novel mouthwash.
The preparation of 1 Novel mouthwash of comparative example
1 Novel mouthwash of comparative example of the present invention prepares that raw material is same as Example 4, and difference is, in preparation method
Step (1) and step (3) without cryogenic high pressure homogenization, specifically:
(1) it takes plants essential oil, propolis extract, glycerol and ethyl alcohol to mix, is stirred evenly under room temperature to get solution A；
(2) hydroxypropyl chitosan, poly-D-lysine, emulsifier and water is taken to mix, stirring is completely dissolved to material, obtains solution
B；
(3) solution A is added in solution B under stiring, is stirred evenly under room temperature, filtered to get novel mouth wash
Liquid.
The preparation of 2 Novel mouthwash of comparative example
2 Novel mouthwash of comparative example of the present invention prepares that raw material is substantially the same manner as Example 4, and difference is, with carboxymethyl
Chitosan replaces hydroxypropyl chitosan.
Preparation method is the same as embodiment 4.
Test example one, Novel mouthwash quality evaluation of the present invention
Color, clarity, pH are carried out to Novel mouthwash made from the embodiment of the present invention 4,7,8 and comparative example 1,2 respectively
Value, limit test of microbe, as a result see the table below.
The gargle quality measurements produced by the present invention of table 1
| Group | Color | Clarity | PH value | Microbial limit |
| Embodiment 4 | It is almost colourless | Clarification | 6.58 | Golden staphylococci, Pseudomonas aeruginosa are not detected |
| Embodiment 7 | It is almost colourless | Clarification | 6.56 | Golden staphylococci, Pseudomonas aeruginosa are not detected |
| Embodiment 8 | It is almost colourless | Clarification | 6.60 | Golden staphylococci, Pseudomonas aeruginosa are not detected |
| Comparative example 1 | Light brown | There is suspended particulate | 6.57 | Golden staphylococci, Pseudomonas aeruginosa are not detected |
| Comparative example 2 | It is almost colourless | Clarification | 6.55 | Golden staphylococci, Pseudomonas aeruginosa are not detected |
As seen from the above table, the hydroxypropyl chitosan in Novel mouthwash is made to give full play to its suction through cryogenic high pressure homogenization
Attached property, the beeswax and the pigment in gargle for being effectively removed propolis extract remaining improve clarity；And carboxymethyl chitosan
Sugar replacement hydroxypropyl chitosan does not influence the color of gargle, clarity, pH value and limit test of microbe.
Test example two, Novel mouthwash safety evaluatio of the present invention
Determination of acute toxicity is carried out to Novel mouthwash provided by the invention.Take 50 mouse, 18~22g of weight, male and female
It is fifty-fifty, it is divided into embodiment 4,7,8 and 1,2 group of comparative example, every group 10, gives each embodiment and comparative example system to intragastric administration on mice respectively
The Novel mouthwash obtained, given low 20g/kg, are observed continuously 14 days by 3 times/day, record poisoning manifestations and death condition.Knot
Fruit shows that mouse does not occur any abnormal behaviour after stomach-filling, and there are no dead number of cases, and the devices such as the heart, liver, spleen, lung, kidney are observed after dissection
Official is no abnormal, shows that Novel mouthwash provided by the invention is safe and non-toxic.
Test example three, Novel mouthwash of the present invention evaluate plaque inhibitory effect
1. subjects
80 youth volunteers are screened, men and women is fifty-fifty, and be included in standard: whole body health is in order；Full mouth must not be less than 20
Function tooth；Women is not at the gestational period and nursing period；Test does not take antibiotic and uses gargle in first 3 months；No
Other similar experimental study is participated in simultaneously.Exclusion criteria: the drug of test result may be influenced by taking other；It is ground in participation
Antibiotic was used before studying carefully in 1 month.
2. test method
Volunteer is randomly divided into 8 groups, every group of 10 people, respectively blank control group, positive controls, embodiment 4-8 group,
Comparative example 1-2 group.Blank control group uses physiological saline, and positive controls use compound chlorhexidine gargle (Shenzhen south Guangdong medicine
Industry Co., Ltd), embodiment 4-8 group and comparative example 1-2 group respectively using gargle made from corresponding embodiment and comparative example,
Respectively contained using the gargle of 20mL after volunteer is early daily, evening brushes teeth and gargles 30s.Using Quigley-Hein improvement after 2 months
Turesky plaque index evaluates gum bacterial plaque, and is compared with the plaque index detected before test, and standards of grading are as follows: 0:
Without bacterial plaque；1: there is the bacterial plaque being dispersed in tooth neck edge；2: the visible continuous thin bacterial plaque band (about lmm wide) in neck edge；3: tooth
Neck bacterial plaque band is greater than lmm, but is less than the 1/3 of facing；4: bacterial plaque covers the 1/3~2/3 of facing；5: bacterial plaque covers facing 2/3
More than, as a result it see the table below.
2 each group of table is compared using plaque index after gargle 2 months
| Group | Plaque index before testing | Plaque index after test | Bacterial plaque rate of descent (%) |
| Blank control group | 3.25±0.32 | 3.24±0.30 | 0.31 |
| Positive controls | 3.23±0.33 | 2.24±0.29* | 30.65 |
| Embodiment 4 | 3.22±0.28 | 2.15±0.25* | 33.23 |
| Embodiment 5 | 3.24±0.35 | 2.20±0.32* | 32.10 |
| Embodiment 6 | 3.23±0.27 | 2.18±0.28* | 32.51 |
| Embodiment 7 | 3.28±0.29 | 2.26±0.30* | 31.10 |
| Embodiment 8 | 3.22±0.30 | 2.21±0.25* | 31.37 |
| Comparative example 1 | 3.27±0.27 | 2.68±0.35 | 18.04 |
| Comparative example 2 | 3.26±0.26 | 2.43±0.32* | 25.46 |
Note: compared with testing preceding plaque index,*P < 0.05.
The main component of compound chlorhexidine gargle is gluconic acid chlorhexidine and metronidazole, and clinic is mainly used in gum
The adjuvant treatment of bleeding gums, periodontal abscess, stomatocace that inflammation, pericoronitis, portacaval mucositis etc. are led to etc..By upper table
It is found that Novel mouthwash made from 4-8 of the embodiment of the present invention can effectively inhibit plaque, prevent and treat mouth disease, effect with
Compound chlorhexidine gargle is suitable.Since gargle provided by the invention is free of metronidazole class antibiotic, therefore its safety is more multiple
Square chlorhexidine gargle is high, and long-time service not will lead to Oral normal flora imbalance.
The gargle that comparative example 1 provides makes its constituent without carrying out cryogenic high pressure homogenization during the preparation process
The effect of interaction weakens, and the dissolution of effective component reduces, inhibits plaque reduces.The gargle that comparative example 2 provides is with carboxylic
The effect of methyl chitosan replaces hydroxypropyl chitosan, and gargle is made to inhibit plaque decrease, this may with close to neutral
Under the conditions of, the carboxyl in carboxymethyl chitosan is easy dehydrogenation, keeps negatively charged carboxymethyl chitosan easy and positively charged
Poly-D-lysine generates electrostatic force, elecrtonegativity anion binding on poly-D-lysine and bacteria cell wall is reduced, to reduce suppression
The effect of bacterial plaque processed.
Test example four, Novel mouthwash of the present invention are to juvenile's gingivitis treatment effect assessment
1. subjects
Screening clinical symptoms meet juvenile volunteer patients 150 of gingivitis, wherein male 90, female 60.All patients
Without severe systemic infection and systemic disease, antibacterials were not taken in nearly 1 month, did not received tooth in nearly 3 months
All specific treatments.
2. test method
Volunteer patients are randomly divided into 5 groups, every group of 30 people, respectively blank control group, positive controls, example 1 group,
Comparative example 1-2 group.Blank control group uses physiological saline, and positive controls use compound chlorhexidine gargle (Shenzhen south Guangdong medicine
Industry Co., Ltd), 4 groups of embodiment and comparative example 1-2 group be respectively using gargle made from embodiment 4 and comparative example 1,2.Aspiration
Patient sucks 20mL gargle 3min early, middle and late daily respectively, repeats not using containing gargling once containing gargling in 30min after discharge
Other liquid are gargled, and also without drinking-water, observe clinical efficacy after 2 weeks.Evaluate criterion of therapeutical effect are as follows: effective: subjective symptoms disappears,
Gingival index reduces 1.0 or more, and gingival pocket shoals；Improve: subjective symptoms mitigate, gingival index reduce 0.5 or more, gingival pocket shoal or
It is unchanged；Invalid: symptom, Signs are not improved.As a result it see the table below.
3 each group of table is compared using gingival index after gargle 2 weeks
| Group | Gingival index before treating | Gingival index after treatment |
| Blank control group | 2.24±0.33 | 2.23±0.28 |
| Positive controls | 2.20±0.34 | 1.12±0.30* |
| Embodiment 4 | 2.18±0.37 | 1.10±0.32* |
| Comparative example 1 | 2.23±0.35 | 1.84±0.36 |
| Comparative example 2 | 2.17±0.36 | 1.60±0.28 |
Note: compared with treating preceding gingival index,*P < 0.05.
4 each group of table is compared using comprehensive therapeutic effect after gargle 2 weeks
| Group | Effective (%) | It improves | In vain | Total effective rate (%) |
| Positive controls | 25(83.3) | 3 | 2 | 93.3 |
| Embodiment 4 | 26(86.7) | 3 | 1 | 96.7 |
| Comparative example 1 | 14(46.7) | 10 | 6 | 80.0 |
| Comparative example 2 | 19(63.3) | 7 | 4 | 86.7 |
As seen from the above table, the gum that gargle made from the embodiment of the present invention 4 can be effectively reduced juvenile volunteer patients refers to
Number has a better effect treatment gingivitis tool, better than gargle made from compound chlorhexidine gargle and comparative example 1,2.Table
Bright, gargle made from the embodiment of the present invention 4 can effectively improve alleviated gingivitis symptom, and gingivitis is prevented to be further development of periodontal
Disease plays a significant role prevention periodontosis.
The above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
Limitation of the invention, protection scope of the present invention should be defined by the scope defined by the claims..For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change
It also should be regarded as protection scope of the present invention into retouching.
Claims (5)
1. a kind of Novel mouthwash, which is characterized in that be made of the raw material for preparing of following weight percent meter: hydroxypropyl chitosan
6~10%, plants essential oil 0.1~1%, propolis extract 1~3%, glycerol 4~8%, poly-D-lysine 0.2~1%, emulsification
Agent 1~3% and ethyl alcohol 4~8%, surplus are water；
The plants essential oil is lemon oil and peppermint oil with (1.5~3): 1 weight ratio forms；
The emulsifier is one of sucrose monoester, maltose monoesters, mannose monoesters；
The preparation method of the propolis extract the following steps are included:
(1) propolis paraffin removal is placed on 2~4h of pre-freeze in -10 DEG C of refrigerator, crushed, crossed 30 meshes, obtain propolis powder；
(2) ethanol solution that volume fraction is 95% is added into propolis powder for the ratio for being 1:12 in solid-liquid ratio, stirs evenly
After seal, at 25 DEG C, under conditions of 150~250MPa impregnate 8~12min, after release, under room temperature, stand 2~4h, obtain
Propolis extract；
(3) propolis extract is placed in -50 DEG C of pre-freeze 3h, is then 50~60Pa in vacuum degree, freeze-drying 6 under the conditions of -5 DEG C~
8h keeps vacuum degree, continues 1~2h of freeze-drying at 20 DEG C to get propolis extract.
2. Novel mouthwash according to claim 1, which is characterized in that prepare raw material group by following weight percent meter
At: hydroxypropyl chitosan 8%, plants essential oil 0.35%, propolis extract 2%, glycerol 6%, poly-D-lysine 0.65%, emulsification
Agent 2% and ethyl alcohol 6%, surplus are water；
The plants essential oil is that lemon oil and peppermint oil are formed with the weight ratio of 2.5:1；
The emulsifier is one of sucrose monoester, maltose monoesters, mannose monoesters.
3. Novel mouthwash according to claim 1 or 2, which is characterized in that the emulsifier be sucrose lauric acid monoester,
One of monolauroyl maltose, mannose lauric acid monoester.
4. a kind of method for preparing Novel mouthwash a method according to any one of claims 1-3, which is characterized in that including following step
It is rapid:
(1) plants essential oil, propolis extract, glycerol and ethyl alcohol is taken to mix, at 4 DEG C, homogeneous 10 under conditions of 25~30MPa~
15min is to get solution A；
(2) hydroxypropyl chitosan, poly-D-lysine, emulsifier and water is taken to mix, stirring is completely dissolved to material, obtains solution B；
(3) solution A is added in solution B under stiring, at 4 DEG C, homogeneous 5min under conditions of 25~30MPa, filtering to get
Novel mouthwash.
5. use of the Novel mouthwash according to claim 1 to 4 in the drug of preparation prevention and treatment dental caries or periodontosis
On the way.
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| CN106726710B (en) * | 2016-12-22 | 2019-10-18 | 北京刷新活力健康科技有限公司 | A kind of effervescent tablet and the preparation method and application thereof containing polylysine and parahydroxyacet-ophenone |
| CN108042466A (en) * | 2017-12-12 | 2018-05-18 | 刘宝刚 | A kind of anti-inflammatory sterilization, the oral care composition of prevention and treatment dental caries |
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| JP4625625B2 (en) * | 2003-11-14 | 2011-02-02 | ライオン株式会社 | Disinfectant and composition for oral cavity containing the disinfectant |
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