CN106176215A - A kind of clamped bottle goods drying property and the keeping method of stability - Google Patents
A kind of clamped bottle goods drying property and the keeping method of stability Download PDFInfo
- Publication number
- CN106176215A CN106176215A CN201610488918.4A CN201610488918A CN106176215A CN 106176215 A CN106176215 A CN 106176215A CN 201610488918 A CN201610488918 A CN 201610488918A CN 106176215 A CN106176215 A CN 106176215A
- Authority
- CN
- China
- Prior art keywords
- clamped bottle
- packaging material
- dry
- stability
- bottle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001035 drying Methods 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000005022 packaging material Substances 0.000 claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 20
- 229910052756 noble gas Inorganic materials 0.000 claims abstract description 10
- 230000036512 infertility Effects 0.000 abstract description 2
- 238000011169 microbiological contamination Methods 0.000 abstract description 2
- 238000007789 sealing Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
Abstract
The invention discloses a kind of clamped bottle goods drying property and the keeping method of stability, there is following steps: S1, clamped bottle subpackage loads after medicine or clamped bottle lyophilizing complete；S2, the gas that filling is completely dried in the remaining space of clamped bottle；S3, plug is pressed in clamped bottle；S4, clamped bottle is made product after carry out outer package, be filled with dry gas outside in packaging material and seal, it is ensured that outer packaging material internal pressure be more than outer packaging material external pressure.The present invention can plug seal failure or bad in the case of ensure drying property and the stability of medicine；The noble gas being dried in clamped bottle or dry filtrated air, can do protection further to the medicine in clamped bottle；Can easily distinguish that quality there may be the product of change by naked eyes；The noble gas being dried or dry filtrated air within outer packaging material can carry out sterility protection to the plug side and the plug side being pressed in clamped bottle of installing syringe needle, prevent microbiological contamination, reduce security risk.
Description
Technical field
The present invention relates to a kind of clamped bottle goods drying property and the keeping method of stability, can be applicable to clamped bottle powder pin system
The drying property of product and other dried products keeps, including aseptic subpackaged goods and freeze-dried products.
Background technology
Clamped bottle does not has control antibiotic bottle with the end exactly, and bottleneck plug and aluminium lid seal, and bottom is with material same with plug
The piston seal of matter, loading after medicinal liquid is exactly a syringe not having syringe needle and push rod, make clamped bottle require internal diameter uniformly,
Cross section of inboard wall be standard round, inwall to justify, slide, without spots, the most just can ensure that good with piston seal.
At present for clamped bottle dried product, the drying property of its goods is all by clamped bottle piston and clamped bottle inwall
Sealing ensures.
Due to difference and the difference of production technology of clamped bottle and plug each material, different clamped bottle manufacturers
Repetition test is needed, it is ensured that clamped bottle and the sealing of plug when matching use with the product of plug manufacturer.But this still without
Method ensures that the sealing of clamped bottle and plug is 100% effective, and this also will directly affect the drying property of packaging medicine and stable
Property.
Meanwhile, clamped bottle goods implement injection time thrust size inappropriate and slide uneven also can affect its seal
Property, and then affect medicine.
Summary of the invention
According to clamped bottle goods set forth above in the technical problem of the aspects such as sealing, drying property and stability, and carry
For a kind of clamped bottle goods drying property and the keeping method of stability.
Present invention seek to address that when plug seals invalid or bad and injection use misoperation, it is to avoid in clamped bottle
Medicine contact with extraneous medium, thus protect medicine, prevent the drying property of medicine and stability not to be damaged.
Directly cannot be entered by naked eyes simultaneously for because of plug seal failure or the bad product causing medicine quality comparison
Row distinguishes, the drug safety risk existed, the present invention can effectively reduce.
The technological means that the present invention uses is as follows:
A kind of clamped bottle goods drying property and the keeping method of stability, it is characterised in that there are following steps:
S1, clamped bottle subpackage load medicine；
S2, the gas that filling is completely dried in the remaining space of described clamped bottle；
S3, plug is pressed in described clamped bottle；
After plug is pressed in described clamped bottle, the described dry gas in described clamped bottle is to described clamped bottle
Interior medicine plays the effect of protection.
S4, described clamped bottle is made product after carry out outer package, be filled with described dry gas close outside in packaging material
Envelope, it is ensured that outer packaging material internal pressure is more than outer packaging material external pressure.Both the internal pressure-fired of described outer packaging material after packaging had been ensured, it is to avoid
Due to described plug seal failure or bad time described clamped bottle in the contacting of medicine and external agency.
Described dry gas is dry noble gas or dry filtrated air.
The invention also discloses a kind of clamped bottle goods drying property and the keeping method of stability, it is characterised in that have as
Lower step:
After S1, clamped bottle lyophilizing complete, in the remaining space of described clamped bottle, fill the full gas being dried；
S2, plug is pressed in described clamped bottle；
After plug is pressed in described clamped bottle, the described dry gas in described clamped bottle is to described clamped bottle
Interior medicine plays the effect of protection.
S3, described clamped bottle is made product after carry out outer package, be filled with described dry gas close outside in packaging material
Envelope, it is ensured that outer packaging material internal pressure is more than outer packaging material external pressure.Both the internal pressure-fired of described outer packaging material after packaging had been ensured, it is to avoid
Due to described plug seal failure or bad time described clamped bottle in the contacting of medicine and external agency.
Described dry gas is dry noble gas or dry filtrated air.
Find during use that outer packaging material leaks gas, then its internal product there may be the possibility of medicine quality comparison, then forbid
Use；On the contrary, if outer packaging material does not leaks gas, then there is not this risk in this product.
The invention have the advantages that
1, the sealing of clamped bottle plug cannot ensure that 100% is effective, and the present invention can be in plug seal failure or bad feelings
Drying property and the stability of medicine is ensured under condition；
2, the noble gas being dried in clamped bottle or dry filtrated air, can be guarantor further to the medicine in clamped bottle
Protect；
3, can easily distinguish that quality there may be the product of change by naked eyes；
4, the noble gas being dried or dry filtrated air within outer packaging material can be to plug side and the pressures installing syringe needle
The plug side entered in clamped bottle carries out sterility protection, prevents microbiological contamination, reduces security risk.
The present invention can be widely popularized in fields such as clamped bottle goods sealings for the foregoing reasons.
Accompanying drawing explanation
The present invention is further detailed explanation with detailed description of the invention below in conjunction with the accompanying drawings.
Fig. 1 is a kind of clamped bottle goods drying property and the keeping method intermediate champing of stability in the specific embodiment of the invention
The schematic flow sheet before product made by bottle.
Fig. 2 is a kind of clamped bottle goods drying property and the keeping method intermediate champing of stability in the specific embodiment of the invention
The schematic flow sheet after product made by bottle.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below in conjunction with the embodiment of the present invention
In accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is
The a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art
The every other embodiment obtained under not making creative work premise, broadly falls into the scope of protection of the invention.
Embodiment 1
As depicted in figs. 1 and 2, a kind of clamped bottle goods drying property and the keeping method of stability, there are following steps:
S1, clamped bottle 1 subpackage load medicine 2；
S2, the gas 3 that filling is completely dried in the remaining space of described clamped bottle 1；
S3, plug 4 is pressed in described clamped bottle 1；
S4, described clamped bottle 1 is made product 5 after carry out outer package, be filled with described dry gas 3 outside in packaging material 6
And seal, it is ensured that outer packaging material 6 internal pressure is more than outer packaging material external pressure.
Described dry gas 3 is the noble gas or dry filtrated air being dried.
Embodiment 2
As depicted in figs. 1 and 2, a kind of clamped bottle goods drying property and the keeping method of stability, there are following steps:
After S1, clamped bottle 1 lyophilizing complete, in the remaining space of described clamped bottle 1, fill the full gas 3 being dried；
S2, plug 4 is pressed in described clamped bottle 1；
S3, described clamped bottle 1 is made product 5 after carry out outer package, be filled with described dry gas 3 outside in packaging material 6
And seal, it is ensured that outer packaging material 6 internal pressure is more than outer packaging material external pressure.
Described dry gas 3 is the noble gas or dry filtrated air being dried.
Last it is noted that various embodiments above is only in order to illustrate technical scheme, it is not intended to limit；To the greatest extent
The present invention has been described in detail by pipe with reference to foregoing embodiments, it will be understood by those within the art that: it depends on
So the technical scheme described in foregoing embodiments can be modified, or the most some or all of technical characteristic is entered
Row equivalent；And these amendments or replacement, do not make the essence of appropriate technical solution depart from various embodiments of the present invention technology
The scope of scheme.
Claims (4)
1. a clamped bottle goods drying property and the keeping method of stability, it is characterised in that there are following steps:
S1, clamped bottle subpackage load medicine；
S2, the gas that filling is completely dried in the remaining space of described clamped bottle；
S3, plug is pressed in described clamped bottle；
S4, described clamped bottle is made product after carry out outer package, be filled with described dry gas outside in packaging material and seal, protect
Demonstrate,prove outer packaging material internal pressure more than outer packaging material external pressure.
A kind of clamped bottle goods drying property the most according to claim 1 and the keeping method of stability, it is characterised in that: institute
Stating dry gas is dry noble gas or dry filtrated air.
3. a clamped bottle goods drying property and the keeping method of stability, it is characterised in that there are following steps:
After S1, clamped bottle lyophilizing complete, in the remaining space of described clamped bottle, fill the full gas being dried；
S2, plug is pressed in described clamped bottle；
S3, described clamped bottle is made product after carry out outer package, be filled with described dry gas outside in packaging material and seal, protect
Demonstrate,prove outer packaging material internal pressure more than outer packaging material external pressure.
A kind of clamped bottle goods drying property the most according to claim 4 and the keeping method of stability, it is characterised in that: institute
Stating dry gas is dry noble gas or dry filtrated air.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610488918.4A CN106176215A (en) | 2016-06-28 | 2016-06-28 | A kind of clamped bottle goods drying property and the keeping method of stability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610488918.4A CN106176215A (en) | 2016-06-28 | 2016-06-28 | A kind of clamped bottle goods drying property and the keeping method of stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106176215A true CN106176215A (en) | 2016-12-07 |
Family
ID=57461136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610488918.4A Pending CN106176215A (en) | 2016-06-28 | 2016-06-28 | A kind of clamped bottle goods drying property and the keeping method of stability |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106176215A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997044068A1 (en) * | 1996-05-23 | 1997-11-27 | Schering Ag | Method of terminally sterilizing filled syringes |
| CN1607968A (en) * | 2001-11-02 | 2005-04-20 | 梅里迪安医学技术公司 | Medicament container, a medicament dispensing kit for administering medication and a method for packaging the same |
| JP2006271781A (en) * | 2005-03-30 | 2006-10-12 | Toppan Printing Co Ltd | Manufacturing method of sterilization packaging bag for medical products |
| CN101565105A (en) * | 2009-06-03 | 2009-10-28 | 海口市制药厂有限公司 | Method for preparing ceftizoxime powder injection for injection and use thereof |
| CN101766812A (en) * | 2008-12-31 | 2010-07-07 | 上海医药工业研究院 | Liquid drug combination containing exenatide or analogues thereof |
| CN103961311A (en) * | 2014-05-26 | 2014-08-06 | 成都市海通药业有限公司 | Heparin sodium injection and preparation method thereof |
| CN104771367A (en) * | 2015-04-27 | 2015-07-15 | 四川制药制剂有限公司 | Preparation process of azlocillin sodium for injection |
-
2016
- 2016-06-28 CN CN201610488918.4A patent/CN106176215A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997044068A1 (en) * | 1996-05-23 | 1997-11-27 | Schering Ag | Method of terminally sterilizing filled syringes |
| CN1607968A (en) * | 2001-11-02 | 2005-04-20 | 梅里迪安医学技术公司 | Medicament container, a medicament dispensing kit for administering medication and a method for packaging the same |
| JP2006271781A (en) * | 2005-03-30 | 2006-10-12 | Toppan Printing Co Ltd | Manufacturing method of sterilization packaging bag for medical products |
| CN101766812A (en) * | 2008-12-31 | 2010-07-07 | 上海医药工业研究院 | Liquid drug combination containing exenatide or analogues thereof |
| CN101565105A (en) * | 2009-06-03 | 2009-10-28 | 海口市制药厂有限公司 | Method for preparing ceftizoxime powder injection for injection and use thereof |
| CN103961311A (en) * | 2014-05-26 | 2014-08-06 | 成都市海通药业有限公司 | Heparin sodium injection and preparation method thereof |
| CN104771367A (en) * | 2015-04-27 | 2015-07-15 | 四川制药制剂有限公司 | Preparation process of azlocillin sodium for injection |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2707523C2 (en) | Preparation of two-chamber container | |
| KR100775152B1 (en) | Process for preparing sterile compressible packages for pharmaceutical products | |
| CA2617967C (en) | Container | |
| US2816690A (en) | Pressure packaging system for liquids | |
| WO2007035746A2 (en) | Specimen enclosure apparatus and containers and closure devices for the same | |
| TWI592345B (en) | A packaging method and device for packaging parts made of elastomer | |
| CN104312021A (en) | Halogenated butyl rubber pad capable of replacing medical synthesized isoprene pad | |
| CN106176215A (en) | A kind of clamped bottle goods drying property and the keeping method of stability | |
| US6626311B2 (en) | Selectively venting and load-sealing closure | |
| CN105092159A (en) | Packaging seal air tightness detection method | |
| US20190135507A1 (en) | Closure And Package That Vents At High Pressure | |
| CN105651455A (en) | Method for detecting vacuum degree of double-layer infusion bag | |
| WO2019038612A1 (en) | Plant for the production of containers, particularly containers for medical, pharmaceutical, cosmetic, food products or the like | |
| CN208872485U (en) | A kind of medication containment detection device | |
| CN203958732U (en) | A kind of powder and liquid double-chamber bag production system | |
| CN208932934U (en) | A kind of yellow rice wine envelope bottle | |
| CN104786237B (en) | Gloves apparatus on a kind of isolator and gloves replacing method | |
| CN204606521U (en) | Presser for liquid reagent bottle cap fall prevention | |
| JP2013001450A (en) | Method of manufacturing capsule product | |
| AU2019100522A4 (en) | Vial stopper | |
| CN210213317U (en) | Bottle cap with good sealing performance | |
| CN218145831U (en) | High sealed equipment of installing of liquid skin care products | |
| US20020066716A1 (en) | Selectively venting and load-sealing closure | |
| CN113636519A (en) | Aseptic production method of aerosol | |
| BR112021019317A2 (en) | Method for filling containers with a liquid filling material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161207 |