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CN106215262B - Oxygenation device and oxygen close method in a kind of venous lumen - Google Patents

Oxygenation device and oxygen close method in a kind of venous lumen Download PDF

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Publication number
CN106215262B
CN106215262B CN201610766047.8A CN201610766047A CN106215262B CN 106215262 B CN106215262 B CN 106215262B CN 201610766047 A CN201610766047 A CN 201610766047A CN 106215262 B CN106215262 B CN 106215262B
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Prior art keywords
oxygen
vein
pipe
blood
closes
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CN106215262A (en
Inventor
解启莲
徐晓嵘
张晓明
余洪龙
马祖长
韩迎春
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Anhui Tongling Bionic Technology Co Ltd
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Anhui Tongling Bionic Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1678Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/02Gases
    • A61M2202/0208Oxygen

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Oxygenation device and oxygen close method in a kind of venous lumen,Oxygenation device includes that the vein oxygen being inserted into vein blood vessel closes pipe in the venous lumen,Pipe, which is closed, with the vein oxygen stretches out the control device that venous blood pipe end is connect,The control device is for accurately controlling the oxygen flow being passed through in the vein oxygen conjunction pipe,The vein oxygen closes pipe longitudinal section and is classified as oxygen transferring in vein pipe by a side wall and semi-permeable membrane with nano through holes,Oxygen closes channel,Efferent duct,Oxygen is transported to vein blood vessel by oxygen transferring in vein pipe,Oxygen is allowed to be directly entered blood and close with hemoglobin oxygen around this pass of the alveolar of diffusing capacity,Lung can be preferably replaced when cannot in lung failure or temporarily play oxygenation,With membrane oxygenator,Oxygen carrying substitute or liquid oxygen charging method are compared,The apparatus structure is simple,It is easy to use,It is not required to blood drainage to external,To avoid various possible infection,Blood oxygen carrying content is high,Stability is preferable.

Description

Oxygenation device and oxygen close method in a kind of venous lumen
Technical field
The present invention relates to oxygenation fields, and in particular to oxygenation device and oxygen close method in a kind of venous lumen.
Background technique
It is well known that the deposit of oxygen is little in human body, it is necessary to continuously feeding oxygen in a steady stream just from the external world can sustain life, Therefore all from clinically initial mask oxygen inhalation to nose conduit, hyperbaric oxygen chamber and the Ventilators occurred in succession later etc. It is conceived to through respiratory tract oxygen supply, and has become the important means of various anoxic treatments.However, for some particular patients 's, often Rule oxygen supply method can seem helpless.Such as in face of the acute lung injury, traumatic due to caused by Serious respiratory tract burn etc. Hypertonicity pulmonary edema, SARS etc. caused by hydropneumothorax, seawater cause the patient of pulmonary diffusion function serious hindrance, and main problem is simultaneously Dysfunction of ventilation is not lain in, therefore usually can not effectively save the life of patient through conventional respiratory tract oxygen supply;Meanwhile some special In the case of, the limitation of conventional oxygen supply method also brings many obstacles to the rescue of patient.So, oxygen supply approach can be changed, It attempts to be used as supplemental oxygen new method by vein even oral wait, makes oxygen straight around this pass of the alveolar of diffusing capacity It taps into blood?
In fact recent domestic never stops in relation to the research in terms of oxygen carrying substitute, such as without matrix blood egg White, genetic engineering artificial blood, the circulating protein solution of liposome package, perfluor carbon solution etc., but due to these product process Complicated, expensive, from technology maturation, there are also relatively large distances so far, are still difficult to use in clinic.And it was once answered in China used Liquid oxygen charging method then includes light quantum blood therapy (UIB), blood-magent therapy, magnesium arginyl amine hydroperoxide Carbamide Peroxide method, light quantum Liquid treatment etc., but be also respectively present blood drawing oxygenation and feed back some defects such as operation is loaded down with trivial details, blood oxygen carrying content is few, stability is poor.
Summary of the invention
The present invention closes method to solve the above problems, providing oxygenation device and oxygen in a kind of venous lumen.
The following technical solution is employed for the technical problems to be solved by the invention to realize:
Oxygenation device in a kind of venous lumen, oxygenation device includes the vein oxygen being inserted into vein blood vessel in the venous lumen Pipe is closed, pipe is closed with the vein oxygen and stretches out the control device that venous blood pipe end is connect, which is passed through for accurately controlling The vein oxygen closes the oxygen flow in pipe, and the vein oxygen closes pipe insertion vein blood vessel partial longitudinal section will by semi-permeable membrane, side wall It is divided into oxygen transferring in vein pipe, oxygen closes channel, efferent duct, and nano through holes are evenly distributed on the side wall, and the semi-permeable membrane is permitted Perhaps gas passes through, and blood cannot pass through.
The control device includes oxygen cathete, flowmeter, pressure gauge, controller, control panel;The oxygen transferring in vein pipe end End is connect by a hose with the oxygen cathete front end, is located at vein blood vessel outer end in oxygen transferring in vein pipe and is equipped with pressure gauge, institute Pressure gauge to be stated to connect with the controller, the controller is connect with the control panel, flowmeter is installed on oxygen cathete, The flowmeter is connect with controller, and oxygen cathete front end is provided with bypass branch, and control valve, control are housed in the bypass branch Valve is connect with controller.
Oxygen transferring in vein pipe, efferent duct insertion vein blood vessel front end portion sealing, oxygen close Channel front end opening, and blood is opened from this Mouth enters oxygen and closes channel, and nano through holes are evenly distributed on side wall, and semi-permeable membrane allows gas to pass through, and blood cannot pass through, quiet The hemoglobin oxygen that oxygen in arteries and veins oxygen cathete passes through in through-hole and oxygen conjunction channel on side wall in blood closes, and oxygen produces during closing Raw carbon dioxide and extra oxygen pass through semi-permeable membrane and enter efferent duct and be discharged from output pipe end, in output pipe end Check valve is installed, is closed in oxygen and is provided with open-work below channel on corresponding tube wall, the blood that oxygen closes is completed and is flowed from the open-work It returns in vein blood vessel, barrier layer is provided with below open-work, barrier layer closes pipe along vein oxygen for anti-Hemostatic Oral Liquid and flows out venous blood Pipe.
When vein oxygen closes the 0.6-0.8 that tube section area is vein blood vessel area of section, neither influence blood is in blood vessel In flowing, and have preferable oxygenation efficiency.
A kind of vein oxygen conjunction method, includes the following steps:
1), vein oxygen conjunction pipe is inserted into vein blood vessel, and carries out the back works such as hemostasis disinfection;
2) oxygen pressure being passed through in oxygen transferring in vein pipe, is set on the control panel as a setting value;
3), the control panel transfers signals to controller, and controller controls flowmeter and opens and to oxygen transferring in vein pipe Interior conveying oxygen, the oxygen in oxygen transferring in vein pipe, which passes through the through-hole on side wall and enters oxygen, to be closed channel and closes the blood in channel with oxygen Oxygen closes, and generated carbon dioxide and extra oxygen pass through semi-permeable membrane and enters efferent duct and be discharged from output pipe end, complete The blood closed at oxygen closes the side wall open-work below channel from oxygen and flows back to vein blood vessel, while in pressure gauge monitoring oxygen transferring in vein pipe Oxygen pressure keeps flow to be calculated as an opening angle when reaching setting value, during oxygen closes, if there is the oxygen that pressure gauge measures Pressure is higher than setting value, and pressure gauge first feeds back signal to controller, and controller, which issues, opens control valve order, and control valve is opened One angle simultaneously gradually reduces the oxygen pressure in oxygen transferring in vein pipe, and when being reduced to setting value, controller, which issues, closes control valve Order, if the oxygen pressure that pressure gauge measures occur is lower than setting value, pressure gauge feeds back signal to controller, and controller, which issues, to be increased Large capacity meter opening angle order, until the oxygen pressure in oxygen transferring in vein pipe is equal to setting value;
4), during oxygen closes, vein oxygen closes the blood inlet end blood oxygen concentration measuring instrument of pipe insertion vein blood vessel front and back end, goes out The oxygen measured is closed the feedback of the oxygen content in forward and backward blood to controller respectively for blood end blood oxygen concentration measuring instrument and display is controlling Panel, medical staff correct the setting value of oxygen pressure in oxygen transferring in vein pipe accordingly.
Beneficial effects of the present invention are:Pipe is closed by being inserted into vein oxygen in vein blood vessel, which closes pipe longitudinal section By a side wall and semi-permeable membrane with nano through holes is classified as oxygen transferring in vein pipe, oxygen closes channel, efferent duct, oxygen passes through quiet Arteries and veins oxygen cathete is transported to vein blood vessel, allowed around this pass of the alveolar of diffusing capacity oxygen be directly entered blood and with it is blood red Albumen oxygen closes, and generated carbon dioxide and extra oxygen pass through semi-permeable membrane and enters efferent duct and be discharged from output pipe end, Lung can be preferably replaced when cannot in lung failure or temporarily play oxygenation, with membrane oxygenator, oxygen carrying generation Articles or liquid oxygen charging method are compared, and the apparatus structure is simple, easy to use, be not required to blood drainage to external, to keep away Exempt from various possible infection, blood oxygen carrying content is high, stability is preferable.
Detailed description of the invention
Fig. 1 is schematic diagram of the present invention;
Fig. 2 is the profilograph that vein oxygen closes that pipe is inserted into vein blood vessel part.
Specific embodiment
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below Embodiment is closed, the present invention is further explained.
As shown in Figure 1, oxygenation device in a kind of venous lumen, including vein oxygen close pipe 2, flowmeter 8, pressure gauge 3, controller 6, control panel 7;Vein oxygen close pipe 2 be inserted into 1 partial longitudinal section of vein blood vessel by semi-permeable membrane 2C, that side wall 2E is classified as vein is defeated Oxygen pipe 2A, oxygen close channel 2D, efferent duct 2B, as shown in Fig. 2, the oxygen transferring in vein end pipe 2A passes through hose 12 and 9 front end of oxygen cathete Connection, oxygen transferring in vein pipe 2A are located at 1 outer end of vein blood vessel and are equipped with pressure gauge 3, and pressure gauge 3 is connect with controller 6, controller 6 It is connect with control panel 7, pressure gauge 3 is for monitoring in oxygen transferring in vein pipe 2A oxygen pressure in real time and by the data feedback measured to controlling Device processed is equipped with flowmeter 8 on oxygen cathete 9, and flowmeter 8 is for controlling the oxygen flow being passed through in oxygen transferring in vein pipe 2A, flowmeter 8 It is connect with controller 6,9 front end of oxygen cathete is provided with bypass branch 11, control valve 10, control valve 10 are housed in bypass branch 11 It is connect with controller 6, when the oxygen pressure in oxygen transferring in vein pipe is higher than setting value, vein is made by the opening angle of control valve 10 Oxygen pressure reduction in oxygen cathete 2A turns off control valve 10 to setting value.
Blood inlet end blood oxygen concentration measuring instrument 5, bleeding are respectively arranged in oxygen transferring in vein pipe 2A insertion 1 front and back end of vein blood vessel Blood oxygen concentration measuring instrument 4 is held, blood inlet end blood oxygen concentration measuring instrument 5, bleeding end blood oxygen concentration measuring instrument 4 are connected respectively to controller 6。
Oxygen transferring in vein pipe 2A, efferent duct 2B are inserted into the sealing of vein blood vessel front end portion, and oxygen closes channel 2D front opening, blood Enter oxygen from the opening and close channel 2D, nano through holes are evenly distributed on side wall 2E, semi-permeable membrane 2C allows gas to pass through, blood It cannot pass through, the oxygen in oxygen transferring in vein pipe 2A passes through the hemoglobin in through-hole and oxygen conjunction channel 2D on side wall 2E in blood Oxygen closes, and the carbon dioxide and extra oxygen that oxygen generates during closing pass through semi-permeable membrane 2C and enter efferent duct 2B and from efferent duct The discharge of the end 2B, is equipped with check valve 13 in the end efferent duct 2B, closes in oxygen and is provided on corresponding tube wall below the 2D of channel Hole is completed the blood that oxygen closes and is flow back into vein blood vessel 1 from the open-work, is provided with barrier layer 2F, barrier layer 2F below open-work Pipe 2, which is closed, along vein oxygen for anti-Hemostatic Oral Liquid flows out vein blood vessel.
When vein oxygen closes the 0.6-0.8 that 2 area of section of pipe is 1 area of section of vein blood vessel, neither influence blood is in blood Flowing in pipe, and there is preferable oxygenation efficiency.
A kind of vein oxygen conjunction method, includes the following steps:
1), vein oxygen conjunction pipe 2 is inserted into vein blood vessel 1, and carries out the back works such as hemostasis disinfection;
2) oxygen pressure being passed through in oxygen transferring in vein pipe 2A, is set on control panel 7 as a setting value;
3), control panel 7 transfers signals to controller 6, and controller 6 controls flowmeter 8 and opens and to oxygen transferring in vein pipe Oxygen is conveyed in 2A, the oxygen in oxygen transferring in vein pipe 2A passes through the through-hole on side wall 2E and enters oxygen conjunction channel 2D and close channel with oxygen Interior blood oxygenation, generated carbon dioxide and extra oxygen pass through semi-permeable membrane 2C and enter efferent duct 2B and from efferent duct The discharge of the end 2B completes the side wall open-work that the blood that oxygen closes is closed from oxygen below the 2D of channel and flows back to vein blood vessel, while pressure gauge 3 is supervised The oxygen pressure in oxygen transferring in vein pipe is controlled, it is an opening angle that flowmeter 8 is kept when reaching setting value, during oxygen closes, if There is the oxygen pressure that pressure gauge 3 measures and be higher than setting value, pressure gauge 3 first by signal feedback to controller 6, beat by the sending of controller 6 The order of control valve 10 is opened, control valve 10, which opens an angle, simultaneously gradually reduces the oxygen pressure in oxygen transferring in vein pipe 2A, when being reduced to When setting value, controller 6, which issues, closes the order of control valve 10, if the oxygen pressure that pressure gauge 3 measures occur is lower than setting value, pressure Meter 3 feeds back signal to controller 6, and controller 6, which issues, increases 8 opening angle order of flowmeter, until in oxygen transferring in vein pipe 2A Oxygen pressure be equal to setting value;
4), during oxygen closes, the blood inlet end blood oxygen concentration measuring instrument 5 of the vein oxygen conjunction insertion of pipe 2 vein blood vessel front and back end, The oxygen measured is closed the feedback of the oxygen content in forward and backward blood to controller 6 respectively and shown by bleeding end blood oxygen concentration measuring instrument 4 Control panel 7, medical staff correct the setting value of oxygen pressure in oxygen transferring in vein pipe 2A accordingly.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry For personnel it should be appreciated that the present invention is not limited to the above embodiments, described in the above embodiment and specification is only the present invention Preference, be not intended to limit the invention, without departing from the spirit and scope of the present invention, the present invention also has various Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute Attached claims and its equivalent thereof.

Claims (4)

1. oxygenation device in a kind of venous lumen, it is characterised in that:Oxygenation device is inserted into vein blood vessel including one in the venous lumen In vein oxygen close pipe, close pipe with the vein oxygen and stretch out the control device that connect of venous blood pipe end, the control device is for smart Really control is passed through the oxygen flow in the vein oxygen conjunction pipe, and the vein oxygen closes pipe insertion vein blood vessel partial longitudinal section by semi-transparent Film, side wall are classified as oxygen transferring in vein pipe, oxygen closes channel, efferent duct, are evenly distributed with nano through holes on the side wall, described Semi-permeable membrane allows gas to pass through, and blood cannot pass through.
2. oxygenation device in a kind of venous lumen as described in claim 1, it is characterised in that:The control device includes oxygen therapy Pipe, flowmeter, pressure gauge, controller, control panel;The oxygen transferring in vein pipe end passes through a hose and the oxygen cathete front end Connection, is located at vein blood vessel outer end in oxygen transferring in vein pipe and is equipped with pressure gauge, and the pressure gauge is connect with the controller, control Device is connect with the control panel, flowmeter is equipped on oxygen cathete, the flowmeter is connect with controller, before oxygen cathete End is provided with bypass branch, and control valve is housed in the bypass branch, and control valve is connect with controller.
3. oxygenation device in a kind of venous lumen as claimed in claim 2, it is characterised in that:The oxygen transferring in vein pipe is inserted into vein Blood vessel front and back end is respectively arranged with blood inlet end blood oxygen concentration measuring instrument, bleeding end blood oxygen concentration measuring instrument, the blood inlet end blood oxygen Concentration measuring apparatus, bleeding end blood oxygen concentration measuring instrument are connect with the controller respectively.
4. oxygenation device in a kind of venous lumen as claimed in claim 1 or 2, it is characterised in that:The vein oxygen closes tube section Area is the 0.6-0.8 of vein blood vessel area of section.
CN201610766047.8A 2016-08-29 2016-08-29 Oxygenation device and oxygen close method in a kind of venous lumen Active CN106215262B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112237674A (en) * 2020-09-15 2021-01-19 安徽通灵仿生科技有限公司 Micro-nano venous oxygen therapy device

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114073794A (en) * 2020-08-14 2022-02-22 刘齐山 Oxygen Controllers and Automation Control Systems

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2100859A (en) * 1981-06-18 1983-01-06 Instrumentarium Oy Method of and apparatus for determining and controlling the gas content of the blood
US5058416A (en) * 1986-06-21 1991-10-22 Siemens Aktiengesellschaft Apparatus for the determination of the partial pressure of gases dissolved in a fluid
CN2732249Y (en) * 2004-10-21 2005-10-12 杜磊 Intravenous oxygenator
CN206652037U (en) * 2016-08-29 2017-11-21 安徽通灵仿生科技有限公司 Oxygenation device in a kind of venous lumen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576590A (en) * 1983-12-29 1986-03-18 Fiddian Green Richard G Intraluminal membrane oxygenator method for a tubular organ of the gastrointestinal tract
US9101711B2 (en) * 2007-10-07 2015-08-11 Chi-Wei Tao Intravascular nano-bubbling oxygenator

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2100859A (en) * 1981-06-18 1983-01-06 Instrumentarium Oy Method of and apparatus for determining and controlling the gas content of the blood
US5058416A (en) * 1986-06-21 1991-10-22 Siemens Aktiengesellschaft Apparatus for the determination of the partial pressure of gases dissolved in a fluid
CN2732249Y (en) * 2004-10-21 2005-10-12 杜磊 Intravenous oxygenator
CN206652037U (en) * 2016-08-29 2017-11-21 安徽通灵仿生科技有限公司 Oxygenation device in a kind of venous lumen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112237674A (en) * 2020-09-15 2021-01-19 安徽通灵仿生科技有限公司 Micro-nano venous oxygen therapy device

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