CN107510864A - A kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof - Google Patents
A kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof Download PDFInfo
- Publication number
- CN107510864A CN107510864A CN201710229242.1A CN201710229242A CN107510864A CN 107510864 A CN107510864 A CN 107510864A CN 201710229242 A CN201710229242 A CN 201710229242A CN 107510864 A CN107510864 A CN 107510864A
- Authority
- CN
- China
- Prior art keywords
- seal wire
- hydrophilic
- inner core
- tungstenic
- external diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 229910001000 nickel titanium Inorganic materials 0.000 claims abstract description 52
- 229920002635 polyurethane Polymers 0.000 claims abstract description 38
- 239000004814 polyurethane Substances 0.000 claims abstract description 38
- 230000008676 import Effects 0.000 claims abstract description 11
- 230000008859 change Effects 0.000 claims abstract description 6
- 238000000576 coating method Methods 0.000 claims description 29
- 239000011248 coating agent Substances 0.000 claims description 28
- 238000000227 grinding Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 12
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 11
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 11
- 239000011976 maleic acid Substances 0.000 claims description 11
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 11
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 claims description 8
- 210000004204 blood vessel Anatomy 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 230000007423 decrease Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000010422 painting Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 230000002485 urinary effect Effects 0.000 claims description 3
- 239000011247 coating layer Substances 0.000 claims 1
- 239000010936 titanium Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 5
- 230000002792 vascular Effects 0.000 description 5
- 229940030225 antihemorrhagics Drugs 0.000 description 4
- 238000005253 cladding Methods 0.000 description 4
- 230000000025 haemostatic effect Effects 0.000 description 4
- 210000005000 reproductive tract Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000013152 interventional procedure Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 2
- 210000001635 urinary tract Anatomy 0.000 description 2
- 229910000521 B alloy Inorganic materials 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 208000009443 Vascular Malformations Diseases 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007334 memory performance Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09108—Methods for making a guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09133—Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09175—Guide wires having specific characteristics at the distal tip
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof, the hydrophilic seal wire includes NiTi inner core, tungstenic polyurethane clad, hydrophilic coat, and tungstenic polyurethane clad is coated on core outer surface in NiTi；Hydrophilic seal wire includes three sections of functional areas, is sequentially connected connects respectively：Introduction segment, input section, hold section；NiTi inner core, the external diameter of tungstenic polyurethane clad of imports end change into taper, and its end is cambered surface, without corner angle；Input section is consistent with the NiTi inner core, the tungstenic polyurethane clad external diameter that hold section, and it is connected with the maximum diameter of imports end；Hydrophilic coat is applied to the tungstenic polyurethane clad outer surface of imports end, input section.Present invention introduces one kind can both improve seal wire performance boost clinical manipulation stability, and can eliminate because seal wire integrally hydrophilic superslide and be difficult to control causes maloperation, avoid hydrophilic superslide from falling the situation generation of operating table in operation.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly relates to a kind of hydrophilic seal wire of anti-slip interventional medicine
And preparation method thereof.
Background technology
Seal wire is in minimally invasive tube chamber（Lumen of vessels, uropoiesis tube chamber, alimentary canal enteric cavity or biliary tract, genital tract fallopian tube lumen）It is situated between
Enter played in treatment technology seek, by and the intervention device such as guiding catheter cross the position of narrow variation, it is tortuous by wriggling
Tube chamber, be finally directed to the important interventional medicine apparatus up to target site.It is narrow to become XOR pathology for bifurcated especially in tube chamber
When, it is small in the tiny cerebral artery of coronary artery, encephalic, vascular malformation and the tumour knurl that guiding super-selective enters coronary heart disease
During supply vesselses etc., irreplaceable guiding function is played.
Preferably minimally invasive intervention superslide seal wire is from its each section performance, it is desirable to which the outer front end without leave of its introduction segment is most
Carefully, it is consistent with the input section of guidewire body to progressively increase to the end end for external diameter, in favor of its sought in tube chamber vascular bifurcation,
Pipeline tapping, or break through the narrow zone of tube chamber.Thrust is forwarded with after when the input section of external diameter stable and consistent is beneficial to push
Continuous guidewire body enters.Seal wire end is about the holding position of 10 centimetres of the seal wire end person that is interventional procedure, and the position requires
Retention property is good, in favor of accurately manipulating seal wire, strictly avoid and prevent because hold performance it is bad and in tube chamber
The situation for being strayed into and falling from operating table.
Therefore, by the research and development and innovation of technical staff, it have developed a kind of anti-slip interventional medicine and taken with hydrophilic seal wire
For traditional seal wire.
The content of the invention
For deficiency of the prior art, the technical problem to be solved in the present invention is the provision of a kind of anti-slip intervention doctor
Learn with hydrophilic seal wire and preparation method thereof.
In order to solve the above technical problems, the present invention is realized by following scheme：A kind of anti-slip interventional medicine is with hydrophilic
Seal wire, the hydrophilic seal wire include NiTi inner core, tungstenic polyurethane clad, hydrophilic coat, the tungstenic polyurethane clad
It is coated on core outer surface in NiTi；
The hydrophilic seal wire includes three sections of functional areas, is sequentially connected connects respectively：Introduction segment, input section, hold section；
NiTi inner core, the external diameter of tungstenic polyurethane clad of the imports end change into taper, and its end is cambered surface, without corner angle；
The input section is consistent with the NiTi inner core, the tungstenic polyurethane clad external diameter that hold section, its maximum diameter with imports end
Connection；
The hydrophilic coat is applied to the tungstenic polyurethane clad outer surface of imports end, input section.
Further, the external diameter of the hydrophilic seal wire is 0.035 inch of seal wire.
Further, the hydrophilic seal wire is in the blood vessels in use, its NiTi inner core uses NiTi of the external diameter for 0.5mm
Silk；
When the hydrophilic seal wire is used to make the seal wire of urinary system, its NiTi inner core uses titanium-nickel wire of the external diameter for 0.55mm；
When the hydrophilic seal wire is used for alimentary canal, its NiTi inner core uses titanium-nickel wire of the external diameter for 0.6mm.
Further, the introduction segment from end to the length between input section between 10-15cm, bore by its NiTi inner core
The external diameter of shape portion front end is 0.2mm, and the 10-15 centimetre length scope internal-and external diameters since front end gradually increase, until with
The NiTi inner core external diameter of input section is consistent.
Further, the hydrophilic coat is cross-linked pvp coat or maleic acid coat.
Further, the length for holding section is between 8-15cm.
A kind of preparation method of hydrophilic seal wire, it is characterised in that following steps：
Step 1, the making of NiTi inner core：
One section of interception meets seal wire external diameter and the Ultimum Ti wire rod of guidewire length requirement, first, by Ultimum Ti
For wire rod through being ground to tapered section of the tapers of front end 10-15 centimeter lengths, the front end external diameter of tapered section of the taper is 0.18-
0.22mm；
Step 2, the external coating of NiTi inner core make, and the clad is tungstenic polyurethane clad：
Core of the NiTi inner core through tube extruding machine is sent into, treats that NiTi inner core is sent out with tungstenic polyurethane clad head end from mouth mold
When, length has at the uniform velocity been pulled first equal to the holding section of tungstenic polyurethane clad and the length of input section, has then slowly been increased
Draw rate, the introduction segment of tungstenic polyurethane clad is slowly attenuated, be split into taper；
Step 3, the seal wire in step 3 is coated into cross-linked pvp or maleic acid, using with the falling type coating machine for holding folder,
The tail end for clamping seal wire in step 3 to be coated is held, adjusts and the fixed folder that holds drops to from the coating centimeters of liquid level 10,
I.e. when seal wire is with folder decline is held in step 3, drop to last 10 centimetres of seal wire and still rest on liquid level, without entering
Enter in coating liquid, after adjusting this setting, start coating machine and be coated, the coating liquid is cross-linked pvp or maleic acid；
According to above painting method, the hydrophilic coating carried out is only carried out in the introduction segment and input section of seal wire, the holding of seal wire
Duan Wei does hydrophilic superslide coating processing, so that product seal wire remains the manipulation and torsion when being easy to clinical manipulation, also avoids
Seal wire may fall the situation of operating table because of slip.
In step 1：Grinding step is completed using the coreless grinding machine for adjusting grinding angle, and its specific method is：By nickel
10-15 centimetres of the front end of titanium memory alloy wire is inserted between the Grinding wheel and guide wheel of coreless grinding machine, is ground to 10-15 lis of front end
Tapered section of the taper of rice, the front end external diameter of tapered section of the taper is 0.18-0.22mm, such as need front end into it is curved when, by 3 lis of front end
Meter Chang Du Ultimum Ti wire rod is under mould fixation using heat treatment bend fixing.
Further, the cross-linked pvp is pharmaceutical grade cross-linked pvp.
Relative to prior art, the beneficial effects of the invention are as follows：Present invention introduces one kind to be applied to clinical intravascular, uropoiesis
Road, alimentary canal, genital tract tube chamber are interior to implement intervention diagnosis and the hydrophilic seal wire with multibank capability area for the treatment of.The seal wire bag
Include the submissive introduction segment in front end, middle smooth input section and the holding section for being easy to grip at rear.The seal wire is characterized in：Parent
The introduction segment of water superslide it is submissive and with thinner front end and gradually slowly external diameter thickening until being transitioned into and intermediate region
Smooth section external diameter it is consistent, such slowly external diameter taper change is advantageous to the seal wire and enters into and through narrow curved position；
The smooth input section in centre of guidewire body part, then change according to the difference of application site, required rigidity inner core makes this
Partial super-elasticity and hardness reaches used tube chamber（Such as different blood vessels, the urinary tract, alimentary canal, genital tract tube chamber）Using when
Requirement, such as：Alimentary canal is generally harder, secondary but Endovascular and the urinary tract, and is required in genital tract most soft；Seal wire is last
Hold Duan Ze and be fabricated to non-hydrophilic coated segment, be advantageous to hold seal wire during interventional procedure, avoid the occurrence of clinic at present and easily occur
Seal wire excessively slide unmanageable and be strayed into tube chamber or situation about falling from operating table.
Guidewire body has three-decker, the Nitinol inner core of total length and the tungstenic polyurethane bag of wrapping inner core outward from interior
Coating, most surface are only coating covering front end introduction segment and the hydrophilic coat of middle smooth input section.Present invention introduces one
Kind can both improve seal wire performance boost clinical manipulation stability, and can eliminate because seal wire integrally hydrophilic superslide and being difficult to control causes
Maloperation, avoid hydrophilic superslide from falling the situation of operating table in operation and occur.
Brief description of the drawings
Fig. 1 is the hydrophilic guide wire schematic diagram of the present invention.
Embodiment
The preferred embodiments of the present invention are described in detail below in conjunction with the accompanying drawings, so that advantages and features of the invention energy
It is easier to be readily appreciated by one skilled in the art, apparent is clearly defined so as to be made to protection scope of the present invention.
Accompanying drawing 1, a kind of hydrophilic seal wire of anti-slip interventional medicine of the invention are refer to, the hydrophilic seal wire is included in NiTi
Core 4, tungstenic polyurethane clad 5, hydrophilic coat 6, the tungstenic polyurethane clad 5 are coated on the outer surface of NiTi inner core 4；
The hydrophilic seal wire includes three sections of functional areas, is sequentially connected connects respectively：Introduction segment 1, input section 2, hold section 3；
NiTi inner core 4, the external diameter of tungstenic polyurethane clad 5 of the imports end 1 change into taper, and its end is cambered surface, without rib
Angle；
The input section 2 with hold section 3 NiTi inner core 4, tungstenic polyurethane 5 external diameters of clad it is consistent, its with imports end 1 most
Big footpath connection；
The hydrophilic coat 6 is applied to the outer surface of tungstenic polyurethane clad 5 of imports end 1, input section 2.
The external diameter of the hydrophilic seal wire is 0.035 inch of seal wire.
The hydrophilic seal wire is in the blood vessels in use, its NiTi inner core 4 uses titanium-nickel wire of the external diameter for 0.5mm；
When the hydrophilic seal wire is used to make the seal wire of urinary system, its NiTi inner core 4 uses titanium-nickel wire of the external diameter for 0.55mm；
When the hydrophilic seal wire is used for alimentary canal, its NiTi inner core 4 uses titanium-nickel wire of the external diameter for 0.6mm.
The introduction segment 1 is from end to the length between input section 2 between 10-15cm, and its tapered portion of NiTi inner core 4 is most
The external diameter of front end is 0.2mm, and the 10-15 centimetre length scope internal-and external diameters since front end gradually increase, until and input section
The external diameter of NiTi inner core 4 it is consistent.
The hydrophilic coat 6 is cross-linked pvp coat or maleic acid coat.
The length for holding section 3 is between 8-15cm.
Tungstenic polyurethane clad 5 is formed for 4 complete polymer of NiTi inner core using tungstenic polyurethane extrusion cladding
Cladding, to contact of the isolating metal wire rod with vascular wall, avoids metal wire rod from directly being contacted with vascular wall, and then reduces possible
The vascular stimulation of appearance and infringement.The hydrophilic coat 6 of seal wire, introduction segment and input section to seal wire carry out hydrophilic superslide coating
Disposal, the hydrophilic coatings of holding Duan Buzuo of 10 centimetres of seal wire end, is easy to clinical manipulation.
A kind of preparation method of hydrophilic seal wire, the preparation method comprise the following steps：
Step 1, the making of NiTi inner core 4：
One section of interception meets seal wire external diameter and the Ultimum Ti wire rod of guidewire length requirement, first, by Ultimum Ti
For wire rod through being ground to tapered section of the tapers of front end 10-15 centimeter lengths, the front end external diameter of tapered section of the taper is 0.18-
0.22mm；Grinding step is completed using the coreless grinding machine for adjusting grinding angle, and its specific method is：By Ultimum Ti line
10-15 centimetres of the front end of material is inserted between the Grinding wheel and guide wheel of coreless grinding machine, and the taper for being ground to 10-15 centimetres of front end is tapered
Section, the front end external diameter of tapered section of the taper is 0.18-0.22mm, such as need front end into it is curved when, by the NiTi of the centimetre length of front end 3
Memory alloy wire is under mould fixation using heat treatment bend fixing.
Step 2, the external coating of NiTi inner core 4 make, and the clad is tungstenic polyurethane clad 5：
Core of the NiTi inner core 4 through tube extruding machine is sent into, treats that NiTi inner core 4 is sent with the head end of tungstenic polyurethane clad 5 from mouth mold
When going out, length has at the uniform velocity been pulled first equal to the holding section of tungstenic polyurethane clad 5 and the length of input section, has then slowly been increased
Add draw rate, the introduction segment of tungstenic polyurethane clad 5 is slowly attenuated, be split into taper；
Step 3, the seal wire in step 3 is coated into cross-linked pvp or maleic acid, using with the falling type coating machine for holding folder,
The tail end for clamping seal wire in step 3 to be coated is held, adjusts and the fixed folder that holds drops to from the coating centimeters of liquid level 10,
I.e. when seal wire is with folder decline is held in step 3, drop to last 10 centimetres of seal wire and still rest on liquid level, without entering
Enter in coating liquid, after adjusting this setting, start coating machine and be coated, the coating liquid is cross-linked pvp or maleic acid；
According to above painting method, the hydrophilic coating carried out is only carried out in the introduction segment and input section of seal wire, the holding of seal wire
Duan Wei does hydrophilic superslide coating processing, so that product seal wire remains the manipulation and torsion when being easy to clinical manipulation, also avoids
Seal wire may fall the situation of operating table because of slip.
The cross-linked pvp is pharmaceutical grade cross-linked pvp.
Embodiment：
Experiment in vitro：Transparent, internal diameter is 2 millimeters, and the pvc pipe flexing for being about 3 meters entirely simulates pipe full into S vascular patterns
Pressure is 40-50mmHg water, and the flowing of water maintains the pressure by force (forcing) pump supplement water.
The hydrophilic seal wire of the present invention is sent into via the short sheath with haemostatic valve, the holding section of hydrophilic 10 centimetres of seal wire end is retained in
Outside pipeline, push and rotate seal wire, observation and feel know from experience push forward, post-tensioning and the situation in crooked pipeline part.
Animal experiment in vivo：Through femoral arteriography, it will be seated in the short sheath of haemostatic valve in femoral artery, through the band short sheath of haemostatic valve
The hydrophilic seal wire of the present invention is sent into, the holding section of hydrophilic 10 centimetres of seal wire end is retained in outside the band short sheath of haemostatic valve, checks and know from experience
Push, post-tensioning and the situation for importing curved blood vessel in the blood vessels.
In above experiment in vitro and animal vivo test, while the hydrophilic seal wire of external similar external diameter is contrasted in this model
In operational circumstances.Pay special attention to this seal wire and external similar seal wire is substantially better than on performance, torsion control and push performance is imported.
The selection of NiTi inner core 4：NiTi inner core 4 uses Ultimum Ti wire rod, and the wire rod has super-elasticity and memory
Performance, by being not susceptible to flexural deformation during very little angle of bend, Ultimum Ti wire rod is silk thread shape, is remembered using NiTi
The material of NiTi inner core 4 for recalling B alloy wire as seal wire has great superiority than the stainless steel wire that tradition uses, and making is led
Silk is by beneficial to passing through tortuous thin vessels in vivo.
The selection of tungstenic polyurethane clad 5, tungstenic polyurethane clad 5 is from excellent x-ray tracking display performance
Polyurethane, realized by extruding cladding wires technology to the cladding of NiTi inner core.
Hydrophilic coat 6 is using the good and the most frequently used hydrophilic high molecular material of Biocompatibility, material selection medicine
With level cross-linked pvp, other also may be selected as surface hydrophilic coating material such as maleic acid, and cross-linked pvp will get well than maleic acid.
The preferred embodiment of the present invention is the foregoing is only, is not intended to limit the scope of the invention, every profit
The equivalent structure or equivalent flow conversion made with description of the invention and accompanying drawing content, or directly or indirectly it is used in other phases
The technical field of pass, is included within the scope of the present invention.
Claims (9)
- A kind of 1. hydrophilic seal wire of anti-slip interventional medicine, it is characterised in that：The hydrophilic seal wire includes NiTi inner core（4）, tungstenic Polyurethane clad（5）, hydrophilic coat（6）, the tungstenic polyurethane clad（5）It is coated on NiTi inner core（4）Outer surface；The hydrophilic seal wire includes three sections of functional areas, is sequentially connected connects respectively：Introduction segment（1）, input section（2）, hold section （3）；The imports end（1）NiTi inner core（4）, tungstenic polyurethane clad（5）External diameter change into taper, its end is arc Face, without corner angle；The input section（2）With holding section（3）NiTi inner core（4）, tungstenic polyurethane clad（5）External diameter is consistent, and it is with leading Enter end（1）Maximum diameter connection；The hydrophilic coat（6）It is applied to imports end（1）, input section（2）Tungstenic polyurethane clad（5）Outer surface.
- A kind of 2. hydrophilic seal wire of anti-slip interventional medicine according to claim 1, it is characterised in that：The hydrophilic seal wire External diameter be 0.035 inch of seal wire.
- A kind of 3. hydrophilic seal wire of anti-slip interventional medicine according to claim 2, it is characterised in that：The hydrophilic seal wire is in the blood vessels in use, its NiTi inner core（4）Use titanium-nickel wire of the external diameter for 0.5mm；When the hydrophilic seal wire is used to make the seal wire of urinary system, its NiTi inner core（4）Use titanium-nickel wire of the external diameter for 0.55mm；When the hydrophilic seal wire is used for alimentary canal, its NiTi inner core（4）Use titanium-nickel wire of the external diameter for 0.6mm.
- A kind of 4. hydrophilic seal wire of anti-slip interventional medicine according to claim 1, it is characterised in that：The introduction segment （1）From end to input section（2）Between length between 10-15cm, its NiTi inner core（4）The external diameter of tapered portion front end is 0.2mm, the 10-15 centimetre length scope internal-and external diameters since front end gradually increase, until the NiTi inner core with input section（4） External diameter is consistent.
- A kind of 5. hydrophilic seal wire of anti-slip interventional medicine according to claim 1, it is characterised in that：The hydrophilic coating Layer（6）For cross-linked pvp coat or maleic acid coat.
- A kind of 6. hydrophilic seal wire of anti-slip interventional medicine according to claim 1, it is characterised in that：The holding section （3）Length between 8-15cm.
- A kind of 7. preparation method of hydrophilic seal wire with described in claim 1-6 any one, it is characterised in that following steps：Step 1, NiTi inner core（4）Making：One section of interception meets seal wire external diameter and the Ultimum Ti wire rod of guidewire length requirement, first, by Ultimum Ti For wire rod through being ground to tapered section of the tapers of front end 10-15 centimeter lengths, the front end external diameter of tapered section of the taper is 0.18- 0.22mm；Step 2, NiTi inner core（4）External coating make, the clad is tungstenic polyurethane clad（5）：By NiTi inner core（4）Core through tube extruding machine is sent into, and treats NiTi inner core（4）With tungstenic polyurethane clad（5）Head end is certainly When mouth mold is sent out, length has at the uniform velocity been pulled first and has been equal to tungstenic polyurethane clad（5）Holding section and input section length, after And slowly increase draw rate, make tungstenic polyurethane clad（5）Introduction segment slowly attenuate, be split into taper；Step 3, the seal wire in step 3 is coated into cross-linked pvp or maleic acid, using with the falling type coating machine for holding folder, The tail end for clamping seal wire in step 3 to be coated is held, adjusts and the fixed folder that holds drops to from the coating centimeters of liquid level 10, I.e. when seal wire is with folder decline is held in step 3, drop to last 10 centimetres of seal wire and still rest on liquid level, without entering Enter in coating liquid, after adjusting this setting, start coating machine and be coated, the coating liquid is cross-linked pvp or maleic acid；According to above painting method, the hydrophilic coating carried out is only carried out in the introduction segment and input section of seal wire, the holding of seal wire Duan Wei does hydrophilic superslide coating processing, so that product seal wire remains the manipulation and torsion when being easy to clinical manipulation, also avoids Seal wire may fall the situation of operating table because of slip.
- 8. preparation method according to claim 7, it is characterised in that step 1：Grinding step, which uses, adjusts grinding angle Coreless grinding machine complete, its specific method is：The mill of coreless grinding machine is inserted into 10-15 centimetres of the front end of Ultimum Ti wire rod Cut between wheel and guide wheel, be ground to tapered section of the taper of 10-15 centimetres of front end, the front end external diameter of tapered section of the taper is 0.18-0.22mm, such as need front end into it is curved when, by the Ultimum Ti wire rod of the centimetre length of front end 3 mould fixation under Using heat treatment bend fixing.
- 9. preparation method according to claim 7, it is characterised in that：The cross-linked pvp is pharmaceutical grade cross-linked pvp.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710229242.1A CN107510864A (en) | 2017-04-10 | 2017-04-10 | A kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710229242.1A CN107510864A (en) | 2017-04-10 | 2017-04-10 | A kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107510864A true CN107510864A (en) | 2017-12-26 |
Family
ID=60721728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710229242.1A Pending CN107510864A (en) | 2017-04-10 | 2017-04-10 | A kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107510864A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201288A (en) * | 2018-07-10 | 2019-09-06 | 李长岭 | A kind of seal wire and its preparation method and application for blood vessel intervention |
| CN110339460A (en) * | 2019-07-17 | 2019-10-18 | 深圳市凯思特医疗科技股份有限公司 | A kind of production method of loach seal wire |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07275366A (en) * | 1994-01-28 | 1995-10-24 | Terumo Corp | Guide wire |
| EP0714673A2 (en) * | 1994-11-29 | 1996-06-05 | Target Therapeutics, Inc. | Guidewire |
| EP0778042A2 (en) * | 1995-12-04 | 1997-06-11 | Target Therapeutics, Inc. | Nickel-titanium, lubricious medical catheter wire |
| US5749837A (en) * | 1993-05-11 | 1998-05-12 | Target Therapeutics, Inc. | Enhanced lubricity guidewire |
| JP2003250904A (en) * | 2002-02-28 | 2003-09-09 | Nippon Zeon Co Ltd | Medical guidewire |
| US20120109108A1 (en) * | 2010-10-28 | 2012-05-03 | Abbott Cardiovascular Systems Inc. | Nickel-titanium core guide wire |
| CN105268085A (en) * | 2015-11-10 | 2016-01-27 | 深圳麦普奇医疗科技有限公司 | Hydrophilic micro-guide wire for minimally-invasive intervention and manufacturing method of hydrophilic micro-guide wire |
-
2017
- 2017-04-10 CN CN201710229242.1A patent/CN107510864A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5749837A (en) * | 1993-05-11 | 1998-05-12 | Target Therapeutics, Inc. | Enhanced lubricity guidewire |
| JPH07275366A (en) * | 1994-01-28 | 1995-10-24 | Terumo Corp | Guide wire |
| EP0714673A2 (en) * | 1994-11-29 | 1996-06-05 | Target Therapeutics, Inc. | Guidewire |
| EP0778042A2 (en) * | 1995-12-04 | 1997-06-11 | Target Therapeutics, Inc. | Nickel-titanium, lubricious medical catheter wire |
| JP2003250904A (en) * | 2002-02-28 | 2003-09-09 | Nippon Zeon Co Ltd | Medical guidewire |
| US20120109108A1 (en) * | 2010-10-28 | 2012-05-03 | Abbott Cardiovascular Systems Inc. | Nickel-titanium core guide wire |
| CN105268085A (en) * | 2015-11-10 | 2016-01-27 | 深圳麦普奇医疗科技有限公司 | Hydrophilic micro-guide wire for minimally-invasive intervention and manufacturing method of hydrophilic micro-guide wire |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201288A (en) * | 2018-07-10 | 2019-09-06 | 李长岭 | A kind of seal wire and its preparation method and application for blood vessel intervention |
| CN110339460A (en) * | 2019-07-17 | 2019-10-18 | 深圳市凯思特医疗科技股份有限公司 | A kind of production method of loach seal wire |
| CN110339460B (en) * | 2019-07-17 | 2022-04-01 | 深圳市凯思特医疗科技股份有限公司 | Manufacturing method of loach guide wire |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3217806U (en) | Balloon catheter with flexible connection between tip and balloon | |
| WO2020124551A1 (en) | Novel microcatheter | |
| CN104398330B (en) | Stent delivery system | |
| CN105268085A (en) | Hydrophilic micro-guide wire for minimally-invasive intervention and manufacturing method of hydrophilic micro-guide wire | |
| CN205514708U (en) | Little pipe of external diameter and hardness gradual change | |
| CN106994204A (en) | Double sacculus medicine-coated balloon dilating catheters | |
| CN205198665U (en) | Sacculus expansion pipe of double -deck hypo pipe | |
| CN221787801U (en) | Middle catheter with adjustable head end | |
| CN214286250U (en) | Intervention catheter with direction-changeable head end | |
| CN204364182U (en) | stent delivery system | |
| CN107510864A (en) | A kind of anti-slip interventional medicine hydrophilic seal wire and preparation method thereof | |
| CN205964676U (en) | Adopt sacculus pipe of curved form head end | |
| CN208911235U (en) | More seal wire medicine balloon dilating catheters | |
| CN114796813A (en) | Guide wire guiding device for intravascular intervention | |
| CN211584832U (en) | Distal access catheter | |
| CN213789513U (en) | Drug balloon conveying system with protection device | |
| CN202459800U (en) | Oesophagus double-balloon catheter with adjustable diameter | |
| CN207429504U (en) | A kind of hydrophilic seal wire of anti-slip interventional medicine | |
| CN107669382A (en) | Foley's tube conveying device is used in a kind of entocranial artery shaping | |
| CN205108686U (en) | Wicresoft intervenes with hydrophilic little seal wire | |
| CN212016426U (en) | Serial drug eluting balloon | |
| JP3998918B2 (en) | Guide wire | |
| CN212395150U (en) | Bifurcated stent delivery device for blood vessels | |
| CN213911918U (en) | Balloon dilatation catheter | |
| CN104548317B (en) | A kind of guiding catheter with shaping inner core |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171226 |