CN107593750A - Kill sustained-release granular formulation of the anti-root disease of nematode and preparation method thereof - Google Patents
Kill sustained-release granular formulation of the anti-root disease of nematode and preparation method thereof Download PDFInfo
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- CN107593750A CN107593750A CN201710835346.7A CN201710835346A CN107593750A CN 107593750 A CN107593750 A CN 107593750A CN 201710835346 A CN201710835346 A CN 201710835346A CN 107593750 A CN107593750 A CN 107593750A
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- sustained
- nematode
- killing
- granular formulation
- root disease
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- 201000010099 disease Diseases 0.000 title claims abstract description 70
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 70
- 241000244206 Nematoda Species 0.000 title claims abstract description 56
- 238000013268 sustained release Methods 0.000 title claims abstract description 51
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 51
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 238000009472 formulation Methods 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000005794 Hymexazol Substances 0.000 claims abstract description 33
- KGVPNLBXJKTABS-UHFFFAOYSA-N hymexazol Chemical compound CC1=CC(O)=NO1 KGVPNLBXJKTABS-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 239000011248 coating agent Substances 0.000 claims abstract description 11
- 238000000576 coating method Methods 0.000 claims abstract description 11
- 239000002270 dispersing agent Substances 0.000 claims abstract description 10
- 239000000945 filler Substances 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 10
- 239000000080 wetting agent Substances 0.000 claims abstract description 10
- 239000011230 binding agent Substances 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- 238000010521 absorption reaction Methods 0.000 claims abstract description 3
- 239000000853 adhesive Substances 0.000 claims abstract description 3
- 230000001070 adhesive effect Effects 0.000 claims abstract description 3
- 239000008187 granular material Substances 0.000 claims description 30
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 17
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 9
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 9
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 7
- 108010010803 Gelatin Proteins 0.000 claims description 6
- 229920000159 gelatin Polymers 0.000 claims description 6
- 239000008273 gelatin Substances 0.000 claims description 6
- 235000019322 gelatine Nutrition 0.000 claims description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 5
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 5
- OWYSSKOUATWAAO-UHFFFAOYSA-N C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)C=C)C1=CC=CC=C1)C1=CC=CC=C1 Chemical group C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)C=C)C1=CC=CC=C1)C1=CC=CC=C1 OWYSSKOUATWAAO-UHFFFAOYSA-N 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 4
- 239000004375 Dextrin Substances 0.000 claims description 4
- 241001272567 Hominoidea Species 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 4
- 235000019425 dextrin Nutrition 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 4
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 3
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 claims description 3
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 claims description 3
- 244000215068 Acacia senegal Species 0.000 claims description 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 229920000084 Gum arabic Polymers 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
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- 235000010489 acacia gum Nutrition 0.000 claims description 3
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- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 3
- 235000013871 bee wax Nutrition 0.000 claims description 3
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- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 3
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 3
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 3
- 229960005215 dichloroacetic acid Drugs 0.000 claims description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000010944 ethyl methyl cellulose Nutrition 0.000 claims description 3
- 239000001761 ethyl methyl cellulose Substances 0.000 claims description 3
- 239000004021 humic acid Substances 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 3
- 239000005011 phenolic resin Substances 0.000 claims description 3
- 229920001568 phenolic resin Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 3
- 239000004208 shellac Substances 0.000 claims description 3
- 235000013874 shellac Nutrition 0.000 claims description 3
- 229940113147 shellac Drugs 0.000 claims description 3
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 229940083466 soybean lecithin Drugs 0.000 claims description 3
- 235000019710 soybean protein Nutrition 0.000 claims description 3
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920002261 Corn starch Polymers 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
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- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
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- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- RZXLPPRPEOUENN-UHFFFAOYSA-N Chlorfenson Chemical compound C1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=C(Cl)C=C1 RZXLPPRPEOUENN-UHFFFAOYSA-N 0.000 claims 1
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims 1
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 claims 1
- 229940083982 sodium phytate Drugs 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
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- LUPNKHXLFSSUGS-UHFFFAOYSA-M sodium;2,2-dichloroacetate Chemical compound [Na+].[O-]C(=O)C(Cl)Cl LUPNKHXLFSSUGS-UHFFFAOYSA-M 0.000 description 2
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of sustained-release granular formulation for killing the anti-root disease of nematode and preparation method thereof.The sustained-release granular formulation for killing the anti-root disease of nematode contains active component and auxiliary element, and active component contains MTI-446 and hymexazol；Auxiliary element contains binding agent, dispersant, wetting agent, sustained release agent, filler and coating.Killing the preparation method of the sustained-release granular formulation of the anti-root disease of nematode includes following key step：Female powder will be obtained after hymexazol and filling carrier absorption；Female powder, MTI-446 active compound, wetting agent, dispersant, sustained release agent, filler are well mixed, crushed by airslide disintegrating mill；Crushed material is added into adhesive, extruder grain is carried out by Squeezinggranulator, is then coated with coating material, obtains the sustained-release granular formulation for killing the anti-root disease of nematode of steady quality.Prevention effect of the present invention is notable, and application process is easy and effective, flexibly easy to operate, and the lasting period is long, does not produce poisoning, to soil, crop nonhazardous, to production and user's safety.
Description
Technical field
The present invention relates to technical field of pesticide combination, and in particular to a kind of sustained-release granular formulation for killing the anti-root disease of nematode and
Its preparation method.
Background technology
Due to the irrational utilization such as continuous cropping and long-time chemical fertilizer, agricultural chemicals, cause the soil issues such as soil hardening, acidifying tight
Weight, causes nematode and root soil-borne disease to occur and be on the rise year after year.Main two class of nematode is root-knot nematode and born of the same parents
Capsule nematode, the general underproduction 10%~40% of nematode, the energy underproduction more than 80% when part continuous cropping is planted, or even total crop failure.
Root disease contaminates crop root or neck based on fungi when condition is suitable, be divided into obligatory parasitism and non-obligate
Parasitic two classes, obligatory parasitism is plant vasular beam disease fungus, as sharp spore sickle and Huang wither wilting caused by wheel branch spore, withered.It is non-
Obligatory parasitism be it is external infect fungi, the seedling as caused by pythium spp is rotten, root-rot and dampings off, seedling blight caused by rhizoctonia
Deng.After the harm of root nematode, wound is more, and the intrusion of favourable germ is so as to aggravating the generation of root disease and propagation.Morbidity
Initial stage does not show manifest symptom, can cause crop Large Scale Death with aggravation is infected, serious loss is caused to agricultural production.
Nematode and root disease early stage are not easy to observe, once in external presentation, come into the disease later stage, now treat not
It is only time-consuming, and be difficult to eradicate.
Preventing and treating underground pest and disease damage can be by selecting resistance to disease or disease-resistant variety or non-host crop crop rotation or floods and droughts crop at present
Crop rotation, or the medicament used are high poison processing soil treatment agent, or carry out high temperature close plastic shed, mainly using foliage-spray, leaching root, pouring root as
It is main.But because land resource is limited, resistance to sick disease-resistant variety can only reduce the harm of nematode and root disease, and it is big to develop kind difficulty
Cost is high；Some germs can survive 5~10 years in soil, and crop rotation realizes that difficulty is big；High poison processing soil treatment agent residual is big, expense
Height, beneficial bacterium harmful bacteria is logical to kill, and destroys rhizosphere soil ecological environment, and there is carcinogenic, teratogenesis part；High temperature close plastic shed is only applicable
When facility cultivation, operating cost, and beneficial bacterium and harmful bacteria are logical kills, and destroy soil ecology balance；Foliage-spray slowly effect, radical cure
Not thoroughly, and find that symptom has been the later stage, treatment difficulty is big, and preventive effect does not protrude, and leaching root is time-consuming, inconvenient for operation.
In addition, largely pouring liquid pesticidal easily causes soil pollution, medicament wastes and input cost is all of a relatively high, and penetrates into
The active component of roots deep is generally unattainable lethasl concentration requirement, therefore prevention effect is undesirable.Current solution
Not only preventing and treating opportunity is not easy to hold, and is difficult to eradicate, also generally existing heavy dose Pesticide use problem, causes environment and plant
The problems such as noxious material remains in object protrudes.The medicament of preventing and treating nematode and root disease is only controlled mostly based on single product in addition
Treatment nematode only prevents and treats root disease, single effect, and prevention effect is poor.
Granule is common dosage forms in solid pesticide, can spread fertilizer over the fields, spread manuer in holes, seed manure with broadcast, ditch spread, punching are applied, to crop root
Disease is more matched, focus of going directly, efficiently quick, and application method also can be flexibly grasped according to the state of an illness and Different Crop, and saving of labor saves
When, but effective time is short in soil, and it is volatile and ineffective, cause granule quickly to dissolve when especially rainwater is excessive and release
Put, be also easy to produce poisoning.
Therefore, develop it is a kind of can not only prevent and treat nematode and can prevent and treat root disease have for a long time prevent effect more ring
Protect more efficient pesticide control and formulation is extremely urgent.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of sustained-release granular formulation for killing the anti-root disease of nematode and its preparation
Method.The granule can spread fertilizer over the fields, bottom application, seed manure with broadcasting, ditch spread or spreading manuer in holes, be obviously improved the preventing and treating effect of nematode and root disease
Fruit, high-efficiency low-toxicity, while stimulate and take root, cost-effective, simplification can also extend the preventing and treating time while operation.
In order to solve the above technical problems, the present invention adopts the following technical scheme that：
A kind of sustained-release granular formulation for killing the anti-root disease of nematode is designed, containing active component and auxiliary element, the active component is
MTI-446 and hymexazol.
Preferably, MTI-446 and the part by weight of hymexazol are the 0.02%~40% of granule total amount.
Preferably, the weight of MTI-446 and hymexazol ratio is 0.01~20：20~0.01.
Killing the auxiliary element of the sustained-release granular formulation of the anti-root disease of nematode includes binding agent, dispersant, wetting agent, sustained release
Agent, filler and coating, the part by weight of binding agent are the 2%~5% of granule total amount；The part by weight of dispersant is that granule is total
The 2%~6% of amount；The part by weight of wetting agent is the 2%~6% of granule total amount；The part by weight of sustained release agent is granule total amount
2%~3%；The part by weight of filler is the 40.00%~91.98% of granule total amount.
Preferably, binding agent used is soybean lecithin, gelatin, polyvinyl alcohol, polyethylene glycol, soybean protein, dextrin, pine
At least one of fragrant, starch.
Preferably, dispersant used is triphenyl vinyl phenol polyoxyethylene ether phosphate, alkylphenol-polyethenoxy base ether sulphur
Hydrochlorate, naphthalene sulfonate, sodium lignin sulfonate or calcium lignosulfonate, sodium cellulose glycolate, polyoxyethylene polyoxypropylene base ether
One kind in block copolymer.
Preferably, wetting agent used is alkylaryl polyoxyethylene ether sulfate, APES, poly alkyl alcohol
One kind in oxyethylene group ether, alkylnaphthalene sulfonate.
Preferably, filler used is sodium humate, humic acid potassium, bentonite, diatomite, white carbon, precipitated calcium carbonate, jade
At least one of rice starch.
Preferably, coating material used be paraffin, ceresine, beeswax, collodion, Cellulose Acetate Phthalate, xanthans,
Gelatin, gum arabic, polyvinylpyrrolidone, aluminium-magnesium silicate, polyvinyl alcohol, phenolic resin, shellac, carboxymethyl cellulose,
At least one of ethyl cellulose, methylcellulose and sodium alginate.
The preparation method of the above-mentioned sustained-release granular formulation for killing the anti-root disease of nematode, comprises the following steps：
（1）Female powder will be obtained after hymexazol and filling carrier absorption；
（2）By gained female powder and MTI-446 active compound and auxiliary element（Wetting agent, dispersant, sustained release agent, filler etc.）It is well mixed,
Crushed by airslide disintegrating mill；
（3）Adhesive is added into gained crushed material, extruder grain is carried out by Squeezinggranulator, then with coating material bag
Clothing, obtain the sustained-release granular formulation for killing the anti-root disease of nematode of steady quality.
Compared with prior art, advantageous effects of the invention are：
1. prevention effect of the present invention is notable, medicament contains desinsection and sterilization component（MTI-446 is different with hymexazol poisoning mechanism, makees
It is different with object, synergy, no antagonism, no interactions resistance can be coordinated）Proper Match, applied once double effectses, to making
Thing root nematode and disease have defences effect jointly well, is not easy repeatedly, eradicates thoroughly, cost-effective.
2. application process of the present invention is easy and effective, flexibly easy to operate, can spread fertilizer over the fields, bottom application, seed manure with broadcasting, spreading manuer in holes, use
Convenient, flexible, easy to operate, saving of work and time, disease of going directly, utilization rate is high, and preventing and treating protrudes.
3. lasting period of the invention is long, is not likely to produce poisoning, using released granular, the handling characteristics of granule are taken into account,
Applied once around crop rhizosphere, release is slow, all has prevention effect, and being not likely to produce for a long time to crop whole growth period
Poisoning.
4. the present invention is low in the pollution of the environment, the raw material that medicament is chosen belongs to environmentally friendly, is easy to get, and environment will not be caused dirty
Dye, and raw material is hypotoxicity, to soil, crop nonhazardous, to production and user's safety.
Embodiment
Illustrate the embodiment of the present invention with reference to embodiment, but following examples are used only to describe in detail
The present invention, and be not in any way limit the scope of the present invention.
Involved instrument and equipment is routine instrument device unless otherwise instructed in the examples below；Involved
Raw material and reagent are commercially available conventional products unless otherwise instructed；Involved experiment or the method for inspection, unless otherwise instructed,
It is conventional method.
Embodiment 1：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 0.02% MTI-446 hymexazol granule,
Raw material containing following quality proportioning：MTI-446 0.01%, hymexazol 0.01%, polyvinyl alcohol 2%, alkylphenol-polyethenoxy base ether sulphur
Hydrochlorate 2%, APES 4%, precipitated calcium carbonate 91.98%.
The sustained-release granular formulation preparation method for killing the anti-root disease of nematode is：By hymexazol female powder, MTI-446 active compound, wetting
Agent, dispersant, sustained release agent, filler are well mixed by formula dosage, are crushed, are added thereto a certain amount of by airslide disintegrating mill
Binding agent, by extruder grain, then with coating material paraffin, ceresine, beeswax, collodion, Cellulose Acetate Phthalate, Huang
Virgin rubber, gelatin, gum arabic, polyvinylpyrrolidone, aluminium-magnesium silicate, polyvinyl alcohol, phenolic resin, shellac, carboxymethyl are fine
The coating of at least one of element, ethyl cellulose, methylcellulose and sodium alginate is tieed up, the MTI-446 for obtaining steady quality is disliked
Mould clever granule.
Embodiment 2：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 0.1% MTI-446 hymexazol granule, contain
The raw material of following quality proportioning：MTI-446 0.05%, hymexazol 0.05%, polyvinyl alcohol 2%, alkylphenol-polyethenoxy base ether sulfonic acid
Salt 2%, APES 4%, precipitated calcium carbonate 91.9%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 3：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 1% MTI-446 hymexazol granule, containing with
The raw material of lower quality proportioning：MTI-446 0.5%, hymexazol 0.5%, polyethylene glycol 3%, calcium lignosulfonate 3%, fatty alcohol polyoxy second
Alkene ether 5%, white carbon 88%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 4：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 5.5% MTI-446 hymexazol granule, contain
The raw material of following quality proportioning：MTI-446 5%, hymexazol 0.5%, dextrin 4%, triphenyl vinyl phenol polyoxyethylene ether phosphate 2%,
Alkylaryl polyoxyethylene ether sulfate 4%, precipitated calcium carbonate 84.5%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 5：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 20.1% MTI-446 hymexazol granule,
Raw material containing following quality proportioning：MTI-446 0.1%, hymexazol 20%, rosin 5%, sodium cellulose glycolate 5%, fatty alcohol polyoxy
Vinyl ethers 5%, white carbon 64.9%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 6：
A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 10.1% MTI-446 hymexazol granule, match somebody with somebody containing following quality
The raw material of ratio：MTI-446 0.1%, hymexazol 10%, soybean lecithin 5%, triphenyl vinyl phenol polyoxyethylene ether phosphate 3%, alkane
Base aryl polyoxyethylene ether sulfate 4%, cornstarch 77.9%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 7：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 15% MTI-446 hymexazol granule, contain
The raw material of following quality proportioning：MTI-446 1%, hymexazol 14%, soybean protein 2%, sodium lignin sulfonate 6%, alkylnaphthalene sulfonate
6%th, diatomite 71%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 8：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 30% MTI-446 hymexazol granule, contain
The raw material of following quality proportioning：MTI-446 12%, hymexazol 18%, gelatin 4%, polyoxyethylene polyoxypropylene base ether block copolymers
2%th, alkylaryl polyoxyethylene ether sulfate 6%, sodium humate 58%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 9：A kind of sustained-release granular formulation for killing the anti-root disease of nematode, i.e. 40% MTI-446 hymexazol granule, contain
The raw material of following quality proportioning：MTI-446 20%, hymexazol 20%, dextrin 5%, sodium cellulose glycolate 6%, alkylnaphthalene sulfonate
6%th, humic acid potassium 43%.
This kills the sustained-release granular formulation preparation method of the anti-root disease of nematode with embodiment 1.
Embodiment 10：Influence of the sustained-release granular formulation of the anti-root disease of nematode to cucumber Phytophthora root rot is respectively killed, is tested
Take pot-culture method indoor measurement, specific experiment step is as follows：
（1）By after cucumber seeds Steeping and budding through Phytophthora bacterium（Concentration 107CFU/mL）After processing, it is seeded into granule
In soil, so that the processing of granule is not applied in soil as blank control.
（2）After planting move on in illumination box and cultivated, temperature is 25 DEG C, and humidity is 70%~80%, daily observation
Emergence situation, diseased plant number was investigated after 7 days, 14 days.
（3）Diseased plant rate（%）Total seedling number × 100 of=diseased plant number/investigation
Prevention effect（%）=（Blank control diseased plant number-processing diseased plant number）/ blank control diseased plant number × 100
As a result：
It is as shown in table 1 that embodiment correspondingly kills influence of the sustained-release granular formulation of the anti-root disease of nematode to cucumber Phytophthora root rot,
Wherein, MTI-446 and hymexazol single dose are 0.5% granule.
The MTI-446 hymexazol compound drug indoor measurement result of table 1
。
As can be seen from the table, MTI-446 and hymexazol compounding released granular agent have substantially to cucumber Phytophthora root rot
Effect, while compound released granular agent and can significantly extend the lasting period.Compounding particle is taken in addition, in the premise of equal preventive effect
Under, reagent dosage is reduced, reduces the pollution to environment and the residual to soil, has saved cost.
Embodiment 11：
Influence of the sustained-release granular formulation of the anti-root disease of nematode to cucumber root-knot nematode is respectively killed, cell planting experiment method is taken in experiment
Outdoor measure, specific experiment step are as follows：
（1）4 groups of processing of Setup Experiments and 1 group of blank control, wherein each treatment group uses agricultural chemicals as shown in table 2：The institute for the treatment of group 4
The agricultural chemicals used is identical with granule component content and preparation method that embodiment 3 provides, and application process is the preceding cave of transplanting
Apply.Active component containing species same as Example 3 and dosage in agricultural chemicals Unit Weight used in treatment group 3, but at this
The hybrid particles for two kinds of single doses used of reason.Containing same as Example 3 in agricultural chemicals Unit Weight used in treatment group 2
The active component of species and dosage, but the application method of the processing is to drench root after transplanting, agricultural chemicals and dosage used in treatment group 1
It is identical with treatment group 2, but application process is to spray.Blank control group only applies the non-active ingredient that particle is prepared in embodiment 2
Carrier granular, without any active component.
2 each treatment group of table uses agricultural chemicals
。
（2）Selection first crop has the plot of serious root-knot nematode harm, takes 4 treatment groups to be used with 1 blank control group
Four repetitions, altogether 20 cells, the random district's groups arrangement of cell, each plot area 20m2, plant same breed and density
Cucumber seedling.Each treatment group is handled accordingly by the dosage of 1kg/ mus, and blank control group is also according to identical dosage and method
Handled.
（3）The underground part disease pest of cucumber seedling is mainly root-knot nematode, in this, as this Germicidal efficacy and measurement index.Yu Yi
30 days after cultivation, 60 days respectively gather cell in half cucumber root observation nematode Harm, and investigate and record morbidity level
Other and prevention effect.
（4）Root-knot nematode hazard rating standard and prevention effect calculation formula are as follows：
Root-knot nematode Harm level classification standard is：0 grade, no root knot, health of root；1 grade, only a small amount of root knot, account for full root system
Less than 1 ~ 25%；2 grades, root knot quantity is medium, accounts for full root system below 26 ~ 50%；3 grades, root knot quantity is more, accounts for the 51 of full root system
Less than ~ 75%；4 grades, root knot quantity is a lot, accounts for the 76 ~ 100% of full root system；
Disease index calculation formula：
Disease index=100 × ∑（Diseased plant numbers at different levels × typical value at different levels）/（Investigate total strain number × 4）
Prevention effect calculation formula：
Prevention effect（%）=（Check plot disease index-treatment region disease index）/ check plot disease index × 100%
As a result：
The 30th day after transplanting, the average statistics result of 60 days each experiment district's groups disease indexs and prevention effect it is as shown in table 3：
Table 3 respectively tests district's groups disease index and prevention effect
。
From table 3 it is observed that the disease index of processing 4 is significantly lower than treatment group 1, treatment group 2, treatment group 3 and blank
Control group, its 30 days, 60 days preventive effect effects be respectively 86.42%, 81.12%, hence it is evident that higher than other treatment groups.Two kinds of compounding in addition
The released granular agent service life of active component is longer, is better than other processing modes on the lasting period.
Therefore, the generation of root root-knot nematode can be prevented and treated well using released granular agent provided by the invention, used
Positive effect is better than other experimental groups and uses agricultural chemicals, that is to say, that the released granular agent of two kinds of active ingredients of compounding has bright
Aobvious collaboration and synergistic effect.Root, convenient spraying are separately also relatively drenched in method of application.
The present invention is described in detail above in conjunction with embodiment, still, person of ordinary skill in the field can
Understand, on the premise of present inventive concept is not departed from, each design parameter in above-described embodiment can also be changed, shape
Into multiple specific embodiments, it is common excursion of the invention, is no longer described in detail one by one herein.
Claims (10)
- A kind of 1. sustained-release granular formulation for killing the anti-root disease of nematode, it is characterised in that containing active component and auxiliary element, the work Property composition is MTI-446 and hymexazol.
- 2. the sustained-release granular formulation according to claim 1 for killing the anti-root disease of nematode, it is characterised in that the MTI-446 and The weight sum of hymexazol accounts for the 0.02%~40% of granule gross weight.
- 3. the sustained-release granular formulation according to claim 1 for killing the anti-root disease of nematode, it is characterised in that the MTI-446 with The weight ratio of hymexazol is 0.01~20：20~0.01.
- 4. the sustained-release granular formulation according to claim 1 for killing the anti-root disease of nematode, it is characterised in that the auxiliary element Containing binding agent, dispersant, wetting agent, sustained release agent, filler and coating；The binding agent accounts for the 2%~5% of granule gross weight；Institute State dispersant accounts for granule gross weight 2%~6%；The wetting agent accounts for the 2%~6% of granule gross weight；The sustained release agent accounts for The 2%~3% of granule gross weight；The filler accounts for the 40.00%~91.98% of granule gross weight.
- 5. the sustained-release granular formulation according to claim 4 for killing the anti-root disease of nematode, it is characterised in that the binding agent is At least one of soybean lecithin, gelatin, polyvinyl alcohol, polyethylene glycol, soybean protein, dextrin, rosin, starch.
- 6. the sustained-release granular formulation according to claim 4 for killing the anti-root disease of nematode, it is characterised in that the dispersant is Triphenyl vinyl phenol polyoxyethylene ether phosphate, alkylphenol-polyethenoxy base ether sulfonate, naphthalene sulfonate, sodium lignin sulfonate or At least one of calcium lignosulfonate, sodium cellulose glycolate, polyoxyethylene polyoxypropylene base ether block copolymers.
- 7. the sustained-release granular formulation according to claim 4 for killing the anti-root disease of nematode, it is characterised in that the wetting agent is In alkylaryl polyoxyethylene ether sulfate, APES, aliphatic alcohol polyethenoxy base ether, alkylnaphthalene sulfonate It is at least one.
- 8. the sustained-release granular formulation according to claim 4 for killing the anti-root disease of nematode, it is characterised in that the filler is corruption At least one of sodium phytate, humic acid potassium, bentonite, diatomite, white carbon, precipitated calcium carbonate, cornstarch.
- 9. the sustained-release granular formulation according to claim 4 for killing the anti-root disease of nematode, it is characterised in that the coating material For paraffin, ceresine, beeswax, collodion, Cellulose Acetate Phthalate, xanthans, gelatin, gum arabic, polyvinyl pyrrole Alkanone, aluminium-magnesium silicate, polyvinyl alcohol, phenolic resin, shellac, carboxymethyl cellulose, ethyl cellulose, methylcellulose and marine alga At least one of sour sodium.
- 10. killing the preparation method of the sustained-release granular formulation of the anti-root disease of nematode described in claim 1, comprise the following steps：（1）Female powder first will be obtained after hymexazol and filling carrier absorption；（2）The female powder, MTI-446 active compound and auxiliary element are well mixed again, crushed by airslide disintegrating mill；（3）Then adhesive is added into gained crushed material, extruder grain is carried out by Squeezinggranulator, finally uses coating material Coating, is produced.
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| CN112400890A (en) * | 2020-11-13 | 2021-02-26 | 河北威远生物化工有限公司 | Nematicidal granules containing sodium dimethyldithiocarbamate and preparation method thereof |
| JPWO2020203963A1 (en) * | 2019-04-05 | 2021-11-04 | 三井化学アグロ株式会社 | Agricultural chemical composition with enhanced efficacy |
| CN118127061A (en) * | 2024-02-02 | 2024-06-04 | 河北上瑞生物科技有限公司 | Composite agent for preventing and controlling root-knot nematodes and preparation method thereof |
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| CN118127061A (en) * | 2024-02-02 | 2024-06-04 | 河北上瑞生物科技有限公司 | Composite agent for preventing and controlling root-knot nematodes and preparation method thereof |
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