CN107811890A - A kind of oral cavity caring toothpaste composition - Google Patents
A kind of oral cavity caring toothpaste composition Download PDFInfo
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- CN107811890A CN107811890A CN201711043873.0A CN201711043873A CN107811890A CN 107811890 A CN107811890 A CN 107811890A CN 201711043873 A CN201711043873 A CN 201711043873A CN 107811890 A CN107811890 A CN 107811890A
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- parts
- oil
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- tank
- powder
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 239000003589 local anesthetic agent Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical class COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 239000005368 silicate glass Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 210000004894 snout Anatomy 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- RRLOOYQHUHGIRJ-UHFFFAOYSA-M sodium;ethyl sulfate Chemical compound [Na+].CCOS([O-])(=O)=O RRLOOYQHUHGIRJ-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
A kind of oral cavity caring toothpaste composition of the present invention, by deionization 20-29, sodium azulenesulfonate 0.07-0.15, calgon 0.2-0.3, saccharin 0.2-0.3, sorbierite 19-25, caryophyllus oil 0.4-0.7, wintergreen 0.03-0.06, menthol 0.3-0.5, eucalyptus oil 0.04-0.07, Thymol 0.04-0.08, calcite 43-46, silica 1 .8-2.5, sodium carboxymethylcellulose 1.0-1.3, bioactivity glass 0.5-1.5, SM gels 0.7-1.0, lauryl sodium sulfate 2.0-2.5, it is made by weight.Effectively to solve oral hygiene and shield tooth health care problem, protection, alleviation and maintenance action are played to canker sore, hemodia, oral inflammation, carious tooth.
Description
Technical field
The invention belongs to field of household chemical, refers to the dentifrice composition that there is oral care to act on.
Background technology
Oral problem is mainly four kinds of situations：
One kind is canker sore, is that superficial ulcer on oral mucosa occurs also known as " aphtha ", big I from the grain of rice to
Soya bean size, into circular or oval, ulcer surface for it is recessed, around it is congested.It is apt to occur in lip, cheek, lingual margin etc..
Second is hemodia, is that enamel comes off and causes the exposure of tooth this aperture matter extraneous, tooth is caused after stimulation
Liquid stimulates nerve endings after quickly flowing inside tubules, causes the symptoms such as dental pain discomfort.Whether canker sore
Or hemodia can all bring strong impulse sense, discomfort is brought to people's life.
The third is the oral inflammations such as periodontitis, gingivitis, bleeding gums.
4th kind is carious tooth, and under the multifactor impact based on bacterium, dental hard tissue occurs what chronic progressive destroyed
A kind of disease.
Now, toothpaste on the market is mostly that effect type raw material is incorporated in toothpaste individually for a kind of its symptom.Such as：Cream
Middle addition traditional Chinese medicine ingredients or the chemicals for adding bacteriostasis, wherein, traditional Chinese medicine ingredients
It is that assisting in preventing and treating is only played to oral inflammation in tooth for canker sore, and adds the toothpaste of antibacterials, chemicals
Long-term use can make oral cavity flora lack of proper care.
All it is often the Chinese medicine extract that some clearing heat and removing internal heats are added in toothpaste for oral inflammation, to slow down inflammation,
But DeGrain.
It is that the chemical compositions such as strontium salt, fluoride are added in toothpaste for hemodia, slows down excitant pain, not
Complete repairing dental enamel.
It is that fluoride is added in toothpaste for carious tooth problem, promotes incipient enamel caries remineralization, but its tool also has necessarily
Limitation, it is only used for even surface easy to clean and needs repeatedly to embrocate.In addition the antibacterials such as chlorohexidene, triclosan are added with mostly
Agent, to suppress the formation of bacterial plaque, slow down and carious tooth face is corroded.Fluorine can make human body have slow poisoning, and chemicals causes oral cavity
Flora imbalance.
CN200710057417.1 discloses a kind of medicated toothpaste with sodium azulenesulfonate, adds in every 100 grams of toothpaste matrixes
Enter 0.01-1 grams of sodium azulenesulfonate.0.12-20% traditional Chinese medicine ingredients are added, its traditional Chinese medicine ingredients is honeysuckle, the capsule of weeping forsythia, Radix Isatidis, Pu
One kind in public English, Chinese violet, chrysanthemum, Herba portulacae, dittany bark, Chinese olive, lophatherum gracile, green tea, peppermint, mulberry leaf or it is a kind of with
On.The Chinese medicine extract of its publicity simply has the effect of clearing heat and detoxicating, faint to the inhibitory action of bacterium, and traditional Chinese medicine extraction
Liquid itself is with regard to easy microbiological contamination.In addition, only referred in its disclosed overall formulation with sodium azulenesulfonate biocidal property, but the antibacterial model of sodium azulenesulfonate
It is with limit.Therefore, problem be present in terms of its own anti-corrosion, its efficacy effect is under suspicion.
CN201310546261.9 discloses a kind of Chinese herbal toothpaste containing pseudo-ginseng total saponins and Kessazulen sodium sulfonate, bag
Include functional additive, rubbing agent, NMF, adhesive, surfactant, sweetener, essence, preservative, water.Its is both effectiveness
Additive includes pseudo-ginseng total saponins and Kessazulen sodium sulfonate, and rubbing agent includes calcium carbonate and silica one of which or two
Kind, NMF includes sorbierite, polyethylene glycol 400 (or propane diols) two of which, and adhesive includes cellulose gum, OK a karaoke club
Glue or guar gum one of which or two kinds, surfactant is laruyl alcohol sodium sulfovinate, and sweetener is saccharin sodium, and preservative is
Outstanding horse B or sodium benzoate, surplus are essence, water.It is formulated in preservative select outstanding horse B, outstanding horse B be containing double imidazolidines
The mixture of base urea and nipagin esters, wherein being Form aldehyde release body with outstanding horse B, belong to carcinogenicity raw material.Therefore, this formula is present
Unsafe problems.
The content of the invention
It is an object of the invention to provide a kind of oral cavity caring toothpaste composition, effectively to solve oral hygiene and shield tooth health care
Problem.Protection, alleviation and maintenance action are played to canker sore, hemodia, oral inflammation, carious tooth.
Oral cavity caring toothpaste composition white lotion preparation method of the present invention, raw material is by weight ratio：
(1) prepared by water material：20.0-29.0 parts of deionization is put into aqueous phase tank, sodium azulenesulfonate is added in the state of stirring
0.07-0.15 part, 0.2-0.3 part of 0.2-0.3 part of calgon, saccharin stirring and dissolving it is uniform, then add sorbierite
19-25 parts stir, stand-by；
(2) preparation of oil plant：0.4-0.7 part of caryophyllus oil, 0.03-0.06 part of wintergreen, menthol are added in oil phase tank
0.3-0.5 part, 0.04-0.07 part of eucalyptus oil, 0.04-0.08 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 43-46 parts of calcite, silica 1 .8-2.5 part, carboxymethyl cellulose in powder material tank
Plain 1.0-1.3 parts of sodium, 0.5-1.5 parts of bioactivity glass, SM gels（Magnesiumaluminumsilicate）0.7-1.0 parts, dodecyl sulphate
2.0-2.5 parts of sodium is stirred even liquid, stand-by；
(4) production technology operates：
Water material in aqueous phase tank is pumped into three-in-one Manufacturing medicine extract machine by (4-1), then the powder suction in powder material tank is three-in-one
In Manufacturing medicine extract machine, stir, while vacuumize the gas in discharge lotion；
(4-2) then, the oil plant in oil phase tank is pumped into three-in-one Manufacturing medicine extract machine, stirred, while vacuumize discharge lotion
Interior gas, blowing obtain product.
The transparent lotion preparation method of oral cavity caring toothpaste composition of the present invention, raw material is by weight ratio：
(1) prepared by water material：Deionized water 7-9 parts are put into aqueous phase tank, stirring state add sodium azulenesulfonate 0.07-
0.15 part, 0.2-0.3 part of 0.2-0.3 part of calgon, saccharin stirring and dissolving it is uniform, then add sorbierite 50-62
Part, 5-15 parts of propane diols stir liquid, it is stand-by；
(2) preparation of oil plant：0.4-0.7 part of caryophyllus oil, 0.03-0.06 part of wintergreen, menthol are added in oil phase tank
0.4-0.6 part, 0.04-0.07 part of eucalyptus oil, 0.04-0.08 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 9-21 parts of silica 1,0.8-1.0 parts of sodium carboxymethylcellulose, life in powder material tank
0.5-1.5 parts of thing activity glass, 2.0-2.5 parts of lauryl sodium sulfate, be stirred it is even, it is stand-by；
(4) production technology operates：
Water material in aqueous phase tank is pumped into three-in-one Manufacturing medicine extract machine by (4-1), then the powder suction in powder material tank is three-in-one
In Manufacturing medicine extract machine, stir, while vacuumize the gas in discharge lotion；
(4-2) then, the oil plant in oil phase tank is pumped into three-in-one Manufacturing medicine extract machine, stirred, while vacuumize discharge lotion
Interior gas, blowing obtain product.
Described in above-mentioned raw materials：
Caryophyllus oil：Amount containing phenol >=90%, optional Shanghai Wanxiang Flavors ＆ Fragrances Co., Ltd.'s product；
Silica：It is comprehensive, toothpaste level, the golden three river silicon materials Co., Ltd products of optional Zhaoqing；
SM gels（Magnesiumaluminumsilicate）：Toothpaste level.
The present invention plays collaboration and made using extracted form natural plant composition is combined with bioactivity glass and sodium azulenesulfonate
With to canker sore, the prevention and maintenance of stomatitis, hemodia, carious tooth problem.
Sodium azulenesulfonate is the abbreviation of Kessazulen sodium sulfonate, is extracted from composite family yellow chamomile, chamomile.Chemical name
For:Isosorbide-5-Nitrae-dimethyl-7-isopropyl Azulene-3-sodium sulfonate.With anti-inflammatory, such as gingivitis, periodontitis, bleeding gums mouth
Chamber problem.There is repair to mucosal tissue simultaneously, the regeneration of the energy tachyauxesis factor, repair oral wounds and pain of alleviation.
Therefore, effect is notable in terms of the treatment of mouth disease, will not cause flora imbalance problem.The present invention makes as functional raw material
With.
Bioactivity glass：The silicate glass being made up of bases such as SiO2, Na2O, CaO and P2O5, it is that there is life
The novel biomaterial of thing activity.Dental hypersensitiveness and remineralization incipient dental caries can be effectively treated, there is resistance acid producing ability
And to early stage Streptococcus sanguis bacterial plaque and the antibacterial action of mixing supragingival plaque.Meanwhile bioactivity glass is that one kind can be to machine
Body tissue is repaired, substituted and regenerated, has the material that can make that bonding action is formed between tissue and material.Bioactivity glass
The catabolite of glass can promote the generation of growth factor, the procreation for promoting cell, the gene expression for strengthening Gegenbaur's cell and bone
The growth of tissue.Its active ingredient forms hydroxyapatite crystal and is deposited on dental surface after being reacted with saliva, closing is sudden and violent
The dentinal tubule of dew, available for treating dental hypersensitiveness.The present invention does functional raw material use.
Caryophyllus oil：For volatile oil of the dry flower of plant clove of myrtaceae through distillation gained, there is high osmosis.Fourth
The analgesia bacteria resistance function of fragrant phenol is very strong, has inhibitory action to 12 kinds of bacteriums such as Staphylococcus aureus, Escherichia coli.Conduct of the present invention
Bacteriostatic agent uses.
Eucalyptus oil：The essential oil extracted in leaf, branch from blue gum, folium eucalypti tree, cinnamomum camphora tree and camphor tree etc..Eucalyptus oil is also known as white
Thousand layers of brain, cineole, it is a kind of colourless oil liquid.To staphylococcus aureus, pneumococcus, Pseudomonas aeruginosa, Escherichia coli,
Shigella dysenteriae etc. has stronger bacteriostasis.The present invention uses as bacteriostatic agent.
Wintergreen：It is essential oil obtained by one kind from aithullium wintergreen leaf extraction.The blood of oral cavity gum can be promoted to follow
Ring, pain of alleviation.The present invention uses as synergist.
Thymol（Thymol）：It is the amphyl of cymene (to spreading colored hydrocarbon).Its molecular formula is
C10H14O, it is isomer with carvacrol, is gained the name due to being found in thyme.Generally separated and extracted by thyme linaloe oil
Obtain white crystalline solid.The bactericidal action of Thymol is stronger than phenol, particularly to hemolytic relative gene, golden yellow Portugal
Grape bacterium, Salmonella choleraesuls have inhibitory or killing effect, and toxicity is low, have sterilization, fungicidal action to oral cavity mucosa, to carious tooth
Chamber has anti-corrosion, local anesthetic action, for oral cavity, the disinfection of throat.The present invention uses as bacteriostatic agent.
The present invention plays the synergistic function of each function raw material, and sodium azulenesulfonate is weak at antibacterial aspect and suppresses flora species
Few, the present invention utilizes its another characteristic, and sodium azulenesulfonate can accelerate plants essential oil（Caryophyllus oil, eucalyptus oil）Penetrate into ulcer
The cell membrane in face, eugenol, eucalyptus oil, Thymol is set more easily to act on ulcer surface.The wintergreen of supplying plays rush again
Enter the sanguimotor effect of gum, you can to accelerate repair process of the sodium azulenesulfonate to mucomembranous cell, while Azulene sulphur can be helped
Sour sodium promotes the power of regeneration of growth factor, reduces plants essential oil（Caryophyllus oil, eucalyptus oil）To the excitant of ulcer surface, lifting is repaiied
The effect of multiple canker sore, pain of alleviation.
Bioactivity glass is as a kind of bioactive materials of silicate property, in the sodium ion and solution in molecule
Hydrogen ion is replaced, and raises pH values;And it is deposited on after the calcium, phosphate ion release in molecule with the calcium and phosphorus ionses in saliva
Tooth surface, the holey mineralising apatite layer rich in calcium phosphorus is formed, enhance the absorption and desorption effect of growth factor, influence
The same period propagation of macrophage action time, Gegenbaur's cell absorption and Gegenbaur's cell and differentiation.Hereafter, dentin layer is made very
It is mineralized soon, i.e. repairing dental enamel layer.The class hydroxy-apatite of generation blocks exposed dentine aperture and promotes enamel ore deposit again
Change, improve tooth antiallergic ability.But this patent also utilizes another feature in addition to using above-mentioned effect：Bioactivity glass
Solution can make the bacterium inside bacterium class the environment of an anoxic gas be present, and metabolism is slow, the susceptibility of antibacterials be reduced, together
When produce higher osmotic pressure, make the cell membrane of full bacterium become shrinkage and immature holes, bacterium becomes short by a large amount of reunions
A small amount of aggregation of chain.This patent coordinates it and plant extracts（Eugenol, eucalyptus oil, Thymol）Use, it is so fast
Speed penetrates into eugenol, eucalyptus oil, Thymol in snout cavity bacterial cell, i.e., in the relatively low situation of concentration, is acting synergistically
Under suppression to Streptococcus sanguis, cariogenic bacteria, streptococcus mutans, actinomyces viscosus kill effect, improve the present invention to cariogenic bacteria,
Effect is alleviated in the suppression of heel dental caries and gingivitis.
There is protective effect to enamel, the capacity antacid in enamel face, promote incipient enamel caries in mineralising.I.e. to tooth carious tooth
There are early prevention and protective action.
The present invention does not add artificial preservative, and it is good as formula preservative, safe effect to extract composition by the use of pure plant.
It is safe and non-stimulating to oral cavity, it can effectively press down and kill oral cavity pathogen, ensure the oral environment of health.
The present invention makes oral cavity pathogen obtain effectively for oral problems such as canker sore, hemodia, oral inflammations
After suppression is killed or suppressed, while oral cavity ulcerated mucosa and enamel are repaired, comprehensive maintenance is carried out to oral cavity, at the same it is right
Oral cavity does not produce stimulation.
Embodiment
Oral cavity caring toothpaste composition white lotion prepares embodiment 1：
(1) prepared by water material：29 parts of deionization is put into aqueous phase tank, 0.07 part of sodium azulenesulfonate, six inclined is added in the state of stirring
0.2 part of 0.24 part of sodium phosphate, saccharin stirring and dissolving are uniform, then add 19 parts of liquid that stir of sorbierite, stand-by；
(2) preparation of oil plant：0.6 part of caryophyllus oil, 0.05 part of wintergreen, 0.3 part of menthol, eucalyptus oil are added in oil phase tank
0.04 part, 0.04 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：In powder material tank successively by 44 parts of calcite, 2.2 parts of silica, 1.0 parts of sodium carboxymethylcellulose,
0.9 part of bioactivity glass, SM gels（Magnesiumaluminumsilicate）0.8 part, 2.0 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：
Water material in aqueous phase tank is pumped into three-in-one Manufacturing medicine extract machine by (4-1), then the powder suction in powder material tank is three-in-one
In Manufacturing medicine extract machine, stir, while vacuumize the gas in discharge lotion；
(4-2) then, the oil plant in oil phase tank is pumped into three-in-one Manufacturing medicine extract machine, stirred, while vacuumize discharge lotion
Interior gas, blowing obtain product.
Oral cavity caring toothpaste composition white lotion prepares embodiment 2：
(1) prepared by water material：25 parts of deionization is put into aqueous phase tank, 0.15 part of sodium azulenesulfonate, six inclined is added in the state of stirring
0.25 part of 0.20 part of sodium phosphate, saccharin stirring and dissolving are uniform, then add 22 parts of liquid that stir of sorbierite, stand-by；
(2) preparation of oil plant：0.5 part of caryophyllus oil, 0.06 part of wintergreen, 0.4 part of menthol, eucalyptus oil are added in oil phase tank
0.05 part, 0.06 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：In powder material tank successively by 43 parts of calcite, 2.3 parts of silica, 1.3 parts of sodium carboxymethylcellulose,
1.5 parts of bioactivity glass, SM gels（Magnesiumaluminumsilicate）0.7 part, 2.2 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：With embodiment 1.
Oral cavity caring toothpaste composition white lotion prepares embodiment 3：
(1) prepared by water material：20 parts of deionization is put into aqueous phase tank, 0.09 part of sodium azulenesulfonate, six inclined is added in the state of stirring
0.26 part of 0.23 part of sodium phosphate, saccharin stirring and dissolving are uniform, then add 25 parts of liquid that stir of sorbierite, stand-by；
(2) preparation of oil plant：0.4 part of caryophyllus oil, 0.03 part of wintergreen, 0.5 part of menthol, eucalyptus oil are added in oil phase tank
0.07 part, 0.05 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：In powder material tank successively by 46 parts of calcite, silica 1 .8 parts, 1.1 parts of sodium carboxymethylcellulose,
1.0 parts of bioactivity glass, SM gels（Magnesiumaluminumsilicate）0.9 part, 2.5 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：With embodiment 1.
Oral cavity caring toothpaste composition white lotion prepares embodiment 4：
(1) prepared by water material：26 parts of deionization is put into aqueous phase tank, 0.12 part of sodium azulenesulfonate, six inclined is added in the state of stirring
0.3 part of 0.3 part of sodium phosphate, saccharin stirring and dissolving are uniform, then add 20 parts of liquid that stir of sorbierite, stand-by；
(2) preparation of oil plant：0.7 part of caryophyllus oil, 0.04 part of wintergreen, 0.35 part of menthol, eucalyptus oil are added in oil phase tank
0.06 part, 0.07 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：In powder material tank successively by 45 parts of calcite, 2.2 parts of silica, 1.2 parts of sodium carboxymethylcellulose,
0.8 part of bioactivity glass, SM gels（Magnesiumaluminumsilicate）0.75 part, 2.3 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：With embodiment 1.
Oral cavity caring toothpaste composition white lotion prepares embodiment 5：
(1) prepared by water material：23 parts of deionization is put into aqueous phase tank, 0.13 part of sodium azulenesulfonate, six inclined is added in the state of stirring
0.27 part of 0.25 part of sodium phosphate, saccharin stirring and dissolving are uniform, then add 24 parts of liquid that stir of sorbierite, stand-by；
(2) preparation of oil plant：0.45 part of caryophyllus oil, 0.058 part of wintergreen, 0.45 part of menthol, folium eucalypti are added in oil phase tank
0.058 part of oil, 0.08 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 44 parts of calcite, 2.5 parts of silica, sodium carboxymethylcellulose 1.08 in powder material tank
Part, 0.5 part of bioactivity glass, SM gels（Magnesiumaluminumsilicate）1.0 parts, 2.4 parts of lauryl sodium sulfate be stirred even, treat
With；
(4) production technology operates：With embodiment 1.
The transparent lotion of oral cavity caring toothpaste composition prepares embodiment 1：
(1) prepared by water material：9 parts of deionization is put into aqueous phase tank, 0.08 part of sodium azulenesulfonate, six inclined phosphorus are added in the state of stirring
0.25 part of sour 0.2 part of sodium, saccharin stirring and dissolving are uniform, then add 15 parts of 50 parts of sorbierite, propane diols liquid that stir, treat
With；
(2) preparation of oil plant：0.6 part of caryophyllus oil, 0.04 part of wintergreen, 0.4 part of menthol, eucalyptus oil are added in oil phase tank
0.06 part, 0.05 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 21 parts of silica, 0.8 part of sodium carboxymethylcellulose, bioactivity glass in powder material tank
0.5 part, 2.0 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：
Water material in aqueous phase tank is pumped into three-in-one Manufacturing medicine extract machine by (4-1), then the powder suction in powder material tank is three-in-one
In Manufacturing medicine extract machine, stir, while vacuumize the gas in discharge lotion；
(4-2) then, the oil plant in oil phase tank is pumped into three-in-one Manufacturing medicine extract machine, stirred, while vacuumize discharge lotion
Interior gas, blowing obtain product.
The transparent lotion of oral cavity caring toothpaste composition prepares embodiment 2：
(1) prepared by water material：8 parts of deionization is put into aqueous phase tank, 0.09 part of sodium azulenesulfonate, six inclined phosphorus are added in the state of stirring
0.2 part of sour 0.25 part of sodium, saccharin stirring and dissolving are uniform, then add 11 parts of 55 parts of sorbierite, propane diols liquid that stir, treat
With；
(2) preparation of oil plant：0.5 part of caryophyllus oil, 0.05 part of wintergreen, 0.5 part of menthol, eucalyptus oil are added in oil phase tank
0.04 part, 0.08 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 20 parts of silica, 0.85 part of sodium carboxymethylcellulose, bioactivity glass in powder material tank
0.8 part of glass, 2.2 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：Embodiment 1 is prepared with transparent lotion.
The transparent lotion of oral cavity caring toothpaste composition prepares embodiment 3：
(1) prepared by water material：7.0 parts of deionization is put into aqueous phase tank, 0.1 part of sodium azulenesulfonate, six inclined is added in the state of stirring
0.23 part of 0.3 part of sodium phosphate, saccharin stirring and dissolving are uniform, then add 14 parts of 52 parts of sorbierite, propane diols liquid that stir, treat
With；
(2) preparation of oil plant：0.4 part of caryophyllus oil, 0.06 part of wintergreen, 0.45 part of menthol, eucalyptus oil are added in oil phase tank
0.06 part, 0.04 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 20.5 parts of silica, 0.9 part of sodium carboxymethylcellulose, bioactivity glass in powder material tank
1.2 parts of glass, 2.5 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：Embodiment 1 is prepared with transparent lotion.
The transparent lotion of oral cavity caring toothpaste composition prepares embodiment 4：
(1) prepared by water material：8 parts of deionized water is put into aqueous phase tank, 0.15 part of sodium azulenesulfonate, six inclined is added in the state of stirring
0.3 part of 0.24 part of sodium phosphate, saccharin stirring and dissolving are uniform, then add 6 parts of 60 parts of sorbierite, propane diols liquid that stir, treat
With；
(2) preparation of oil plant：0.55 part of caryophyllus oil, 0.055 part of wintergreen, 0.55 part of menthol, folium eucalypti are added in oil phase tank
0.07 part of oil, 0.06 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 9 parts of silica 1,1.0 parts of sodium carboxymethylcellulose, bioactivity glass in powder material tank
1.5 parts, 2.3 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：Embodiment 1 is prepared with transparent lotion.
The transparent lotion of oral cavity caring toothpaste composition prepares embodiment 5：
(1) prepared by water material：7 parts of deionization is put into aqueous phase tank, 0.07 part of sodium azulenesulfonate, six inclined phosphorus are added in the state of stirring
0.27 part of sour 0.22 part of sodium, saccharin stirring and dissolving are uniform, then add 5 parts of 62 parts of sorbierite, propane diols liquid that stir, treat
With；
(2) preparation of oil plant：0.7 part of caryophyllus oil, 0.03 part of wintergreen, 0.6 part of menthol, eucalyptus oil are added in oil phase tank
0.045 part, 0.07 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 20 parts of silica, 0.85 part of sodium carboxymethylcellulose, bioactivity glass in powder material tank
1.0 parts of glass, 2.2 parts of lauryl sodium sulfate be stirred it is even, it is stand-by；
(4) production technology operates：Embodiment is prepared with transparent lotion.
Above example product is tested by every regulation in national GB8372-2008 toothpaste standard.Meet
Meet standard gauge provisioning request.
White lotion example 1-5 sense organs and physical and chemical index testing result：
Transparent lotion example 1-5 sense organs and physical and chemical index testing result：
Microbiological indicator is examined by national GB 15979-2002 Appendix B detection method
White lotion example 1-5 bacterium inspection result is as follows
Transparent lotion example 1-5 bacterium inspection result is as follows:
Product of the present invention plays the application examination of protection, alleviation and maintenance action to canker sore, hemodia, oral inflammation
Test.
White lotion implements 1-5 application test results：
Hemodia is tested, every group of 30 people
Tests prove that the white lotion of product of the present invention has mitigation to hemodia.
Canker sore, every group of each 30 people
Tests prove that the white lotion of the present invention has mitigation to canker sore.
Oral inflammation trial state, every group of 30 people
Tests prove that the white lotion of the present invention has mitigation to oral inflammation.
Cream product of the invention white carry out total number of bacterial colonies, coli-group, pathogenic pyogenic baeceria, fungus colony sum,
Bacteriostatic test（Escherichia coli, staphylococcus aureus, Candida albicans）, stability test（Candida albicans）Detection：Report
Announcement numbering the Liao Dynasty, which disappears, picks up（2017）0083-2, No. 0083-5, particular content is as follows.
1st, it is as follows to the bacteriostasis property result of the test of staphylococcus aureus：
Staphylococcus aureus ATCC 6538（China Committee for Culture Collection of Microorganisms's common micro-organisms center）
4th generation.
Conclusion：According to National Standard of the People's Republic of China《Disposable Sanitary Accessory standard》GB15979-2002,
Experiment is repeated 3 times, and action time is 2 minutes, and the average bacteriostasis rate to staphylococcus aureus is 100.00%.Have relatively strong antibacterial
Effect.
2nd, it is as follows to Escherichia coli bacteriostasis property result of the test：
Note：The equal asepsis growth of negative control group.
(the biological inoculum preservation administration committee common micro-organisms center of Escherichia coli 8099）4th generation.
Conclusion：According to National Standard of the People's Republic of China《Disposable Sanitary Accessory standard》GB15979-2002,
Experiment is repeated 3 times, and action time is 2 minutes, and the average bacteriostasis rate to Escherichia coli is 100.00%.There is stronger bacteriostasis.
3rd, it is as follows to Candida albicans bacteriostasis property result of the test：
Note：The equal asepsis growth of negative control group.
Candida albicans ATCC 10231（China Committee for Culture Collection of Microorganisms's common micro-organisms center）4th
Generation.
Conclusion：According to National Standard of the People's Republic of China《Disposable Sanitary Accessory standard》GB15979-2002,
Experiment is repeated 3 times, and action time is 2 minutes, and the average bacteriostasis rate to candida albicans is 100.00%.There is stronger bacteriostasis.
4th, microorganism detection result：
| Testing index | Standard | Measured value |
| Total number of bacterial colonies（cfu/g） | ≤200 | 0 |
| Coliform | It must not detect | Do not detect |
| Staphylococcus aureus | It must not detect | Do not detect |
| Pseudomonas aeruginosa | It must not detect | Do not detect |
| Bacillus hemolyticus | It must not detect | Do not detect |
| Fungus colony sum（cfu/g） | ≤100 | 0 |
Note：The equal asepsis growth of negative control group
Conclusion：Experiment is repeated 3 times.Microorganism detection meets National Standard of the People's Republic of China's Disposable Sanitary Accessory
Standard》GB15979-2002 regulation.
5th, acute eye irritation test：Numbering the Liao Dynasty disappears inspection（2017）No. 0083-3.
As a result it is as follows：
Conclusion：Instill 1h after tested material, No. 1, No. 2 rabbit conjunctivas there is congested, oedema in various degree and extensive when 48h
Multiple, cornea, iris have no different change；Cornea, conjunctiva, iris no abnormality seen change during No. 3 rabbit experiments（Table 1）.Press
《Disinfection technology standard》Middle table 2-14 judges that it is nonirritant to Rabbits with Acute eye irritant test result that this is tested.
Stability test（To Candida albicans bacteriostatic test）As a result it is as follows：
Note：The equal asepsis growth of negative control group.
Candida albicans ATCC 10231（China Committee for Culture Collection of Microorganisms's common micro-organisms center）4th
Generation.
Conclusion：According to National Standard of the People's Republic of China《Disposable Sanitary Accessory standard》GB15979-2002,
Experiment is repeated 3 times, after storage（Accelerated test：Place 37 DEG C ± 1 DEG C of temperature, relative humidity 75% ± 1%, standing time 90
My god）, action time 2min.Average bacteriostasis rate to Candida albicans is 100.00%.There is stronger bacteriostasis.
The transparent lotion of the present invention carries out total number of bacterial colonies, coli-group, pathogenic bacteria, bacteriostatic test（Escherichia coli, gold
Staphylococcus aureus, Candida albicans）, stability test（Microbial method 37 DEG C 90 days）, acute eye irritation test detection.
Conclusion is shown in that the Liao Dynasty disappears inspection（2015）No. 0340-2, the Liao Dynasty disappears inspection（2015）No. 0340-5, the Liao Dynasty disappears inspection（2015）No. 0340-3 inspection
Test report.Meet National Standard of the People's Republic of China《Disposable Sanitary Accessory standard》GB15979-2002 rule
It is fixed.
Claims (3)
1. oral cavity caring toothpaste composition white lotion preparation method, it is characterized in that：
Raw material is by weight ratio；
(1) prepared by water material：20.0-29.0 parts of deionization is put into aqueous phase tank, sodium azulenesulfonate is added in the state of stirring
0.07-0.15 part, 0.2-0.3 part of 0.2-0.3 part of calgon, saccharin stirring and dissolving it is uniform, then add sorbierite
19-25 parts stir, stand-by；
(2) preparation of oil plant：0.4-0.7 part of caryophyllus oil, 0.03-0.06 part of wintergreen, menthol are added in oil phase tank
0.3-0.5 part, 0.04-0.07 part of eucalyptus oil, 0.04-0.08 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 43-46 parts of calcite, silica 1 .8-2.5 part, carboxymethyl cellulose in powder material tank
Plain 1.0-1.3 parts of sodium, 0.5-1.5 parts of bioactivity glass, SM gel 0.7-1.0 parts, lauryl sodium sulfate 2.0-2.5
Part is stirred even liquid, stand-by；
(4) production technology operates：
Water material in aqueous phase tank is pumped into three-in-one Manufacturing medicine extract machine by (4-1), then the powder suction in powder material tank is three-in-one
In Manufacturing medicine extract machine, stir, while vacuumize the gas in discharge lotion；
(4-2) then, the oil plant in oil phase tank is pumped into three-in-one Manufacturing medicine extract machine, stirred, while vacuumize discharge lotion
Interior gas, blowing obtain product.
2. the transparent lotion preparation method of oral cavity caring toothpaste composition, it is characterized in that：
Raw material is by weight ratio；
(1) prepared by water material：Deionized water 7-9 parts are put into aqueous phase tank, stirring state add sodium azulenesulfonate 0.07-
0.15 part, 0.2-0.3 part of 0.2-0.3 part of calgon, saccharin stirring and dissolving it is uniform, then add sorbierite 50-62
Part, 5-15 parts of propane diols stir liquid, it is stand-by；
(2) preparation of oil plant：0.4-0.7 part of caryophyllus oil, 0.03-0.06 part of wintergreen, menthol are added in oil phase tank
0.4-0.6 part, 0.04-0.07 part of eucalyptus oil, 0.04-0.08 part of Thymol is stirred even liquid, stand-by；
(3) prepared by powder：Successively by 9-21 parts of silica 1,0.8-1.0 parts of sodium carboxymethylcellulose, life in powder material tank
0.5-1.5 parts of thing activity glass, 2.0-2.5 parts of lauryl sodium sulfate, be stirred it is even, it is stand-by；
(4) production technology operates：
Water material in aqueous phase tank is pumped into three-in-one Manufacturing medicine extract machine by (4-1), then the powder suction in powder material tank is three-in-one
In Manufacturing medicine extract machine, stir, while vacuumize the gas in discharge lotion；
(4-2) then, the oil plant in oil phase tank is pumped into three-in-one Manufacturing medicine extract machine, stirred, while vacuumize discharge lotion
Interior gas, blowing obtain product.
3. the oral cavity caring toothpaste composition that the preparation method of claim 1 or 2 obtains.
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| CN108743408A (en) * | 2018-09-01 | 2018-11-06 | 金旭环保制品（深圳）有限公司 | A kind of tooth whitening moistening cleaning tissue |
| CN109223663A (en) * | 2018-11-23 | 2019-01-18 | 丹东康齿灵牙膏有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis |
| CN111686021A (en) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | Toothpaste for relieving dentin sensitivity |
| CN113318020A (en) * | 2021-05-17 | 2021-08-31 | 上海凡越实业有限公司 | Multifunctional tooth powder |
| CN113975185A (en) * | 2021-09-27 | 2022-01-28 | 深圳芳新悦享品牌管理有限公司 | Toothpaste containing bioactive glass particles and preparation method thereof |
| CN114272191A (en) * | 2022-01-21 | 2022-04-05 | 福建省梦娇兰日用化学品有限公司 | Toothpaste for protecting gingiva and children and preparation method thereof |
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| CN113975185A (en) * | 2021-09-27 | 2022-01-28 | 深圳芳新悦享品牌管理有限公司 | Toothpaste containing bioactive glass particles and preparation method thereof |
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| CN114272191A (en) * | 2022-01-21 | 2022-04-05 | 福建省梦娇兰日用化学品有限公司 | Toothpaste for protecting gingiva and children and preparation method thereof |
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