CN108030954A - One kind includes nanometer polysaccharide medical wound dressing - Google Patents

Abstract

A medical wound dressing containing nano polysaccharides belongs to the technical field of medical wound dressings. It includes a wet dressing, and the wet dressing is a hydrocolloid dressing or a hydrogel dressing or a silicone gel dressing or a seaweed dressing, and is characterized in that: the wet dressing is also added with nano-polysaccharide compounds or derivatives, and the added Nano polysaccharide compounds or derivatives are one or more of cellulose, starch, chitin, chitosan or derivatives; the particle size of sugar compounds or derivatives is nano-scale 200 nm ~ 1000 nm; sugar The mass parts of the compound or the derivative and the moist dressing are 0.1-20 parts and 70-115 parts respectively. The invention mixes the nano-sized polysaccharide with the wet dressing, so that the wound dressing can quickly absorb wound exudate and has good moisturizing performance; meanwhile, it can assist in enhancing the mechanical properties of the dressing.

Description

A kind of medical wound dressing containing nano polysaccharide

technical field

The invention belongs to the technical field of medical wound dressings, in particular to a medical wound dressing containing nano polysaccharides.

Background technique

Medical wound dressings are widely used in healing people's wounds, so people have proposed many "wound dressings" technical solutions, such as the announcement number: CN 102088937 A "wound dressing", announcement number: CN102784411A "wound dressing", announcement number: CN 103861144A "medical dressing and its preparation method", announcement number: CN 102625686B "antimicrobial medical dressing and protection of wound and catheter site", etc. The existing technical solutions for "wound dressings" have their own advantages, but according to the "gold standard" of chronic wound treatment, that is, the theory of "wound healing in a moist environment", using the characteristics of strong water absorption of nano-polysaccharide materials, the development "Wound dressings" that allow medical wound dressings to have a moist environment for the wound are rare.

Contents of the invention

Aiming at the deficiencies in the prior art, the present invention provides a medical wound dressing containing nano-polysaccharides, which mixes nano-polysaccharides with a wet dressing, so that the wound dressing can quickly absorb wound exudate and has good moisturizing properties; at the same time, it can Auxiliary enhancement of dressing mechanical properties.

Above-mentioned purpose of the invention is realized by following technical scheme, a kind of medical wound dressing that comprises nano polysaccharide class, comprises moist dressing, and described wet dressing is hydrocolloid dressing or hydrogel dressing or silicone gel dressing or seaweed salt dressing , the key points are: the wet dressing also adds nano-polysaccharide compounds or derivatives. The added nano-polysaccharide compounds or derivatives are one or more of cellulose, starch, chitin, chitosan or derivatives Various; the particle size of the sugar compound or derivative is nano-scale 200 nm to 1000 nm; the mass parts of the sugar compound or derivative and the wet dressing are 0.5 to 20 parts and 100 to 80 parts respectively.

Preferably, the moist dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 10-20 parts by mass of linear SIS (styrene-isoprene) block copolymer, 10-14 parts of olefin copolymer 18-22 parts of C5 petroleum resin, 8-12 parts of naphthenic oil 4010, 23-30 parts of sodium carboxymethyl cellulose, and 2-7 parts of pectin; The number of parts is 0.1-8 parts of nanocellulose, and the average particle size of nano-cellulose is 200-700 nm; 1-3 parts of antioxidant 1010 are also added.

Preferably, the wet dressing is a silicone gel dressing, and the silicone gel dressing includes 55-65 parts by mass of polydimethylsiloxane, 17-19 parts of multi-carbon alkyl polysiloxane , 19-21 parts of polydimethylsiloxane cross-linked polymer; the nano-polysaccharide compound or derivative added is 0.1-3 parts by mass of nano-amylose, and the average particle size of nano-amylose is 250~700nm.

Preferably, the moist dressing is an alginate dressing, and the alginate dressing includes 80-90 parts by mass of water, 4-8 parts of sodium alginate, and 2-4 parts of calcium chloride; The nano-polysaccharide compound or derivative is 0.1-3 parts by mass of nano-carboxymethylcellulose sodium, and the average particle diameter of nano-carboxymethylcellulose sodium is 200-700 nm.

Preferably, the moist dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 36-40 parts by mass of linear SIS (styrene-isoprene) block copolymer, 10-14 parts of polyacrylic acid Ester copolymer, 13 to 17 parts of C5 petroleum resin, 13 to 17 parts of naphthenic oil 4010, 12 to 16 parts of sodium carboxymethyl cellulose, 1 to 3 parts of gelatin; the added nano polysaccharide compounds or derivatives are 5-17 parts by mass of nano carboxymethyl cellulose sodium, the average particle diameter of nano carboxymethyl cellulose sodium is 700-900 nm; 1-3 parts by mass of antioxidant 1010 is also added.

Preferably, the moist dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 13-17 parts by mass of linear SIS (styrene-isoprene) block copolymer, 12-17 parts of olefin copolymer 12-17 parts of C5 petroleum resin, 11-15 parts of naphthenic oil 4010, 28-32 parts of sodium carboxymethyl cellulose, 3-7 parts of cross-linked sodium carboxymethyl cellulose; also added nano-polysaccharides The compound or derivative is 0.1-7 parts by mass of nanocellulose, and the average particle size of nanocellulose is 250-350 nm; 1-3 parts by mass of antioxidant 1010 is also added.

Preferably, the wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 6-7 parts by mass of polyvinyl alcohol, 70-80 parts of water, 13-17 parts of vinylpyrrolidone, 1-3 parts of As the joint agent polyacrylamide, the nano-polysaccharide compound or derivative added is 0.1-1.5 parts by mass of nano-chitosan, and the average particle diameter of the nano-chitosan is 200-550 nm.

Preferably, the wet dressing is a silicone gel dressing, and the silicone gel dressing includes 55 to 65 parts by mass of dimethylsiloxane, 16 to 20 parts of multi-carbon alkyl polysiloxane, 18-22 parts of polydimethylsiloxane cross-linked polymer; the nano-polysaccharide compound or derivative added is 0.1-2.5 parts by mass of nano-amylose, and the average particle size of nano-amylose is 200 ~700nm.

Preferably, the wet dressing is a hydrogel dressing, and the hydrogel dressing includes 10-14 parts by mass of polyvinyl alcohol, 65-75 parts of water, 10-20 parts of polyvinylpyrrolidone, 1.5- 2.5 Acrylic ester copolymer; the nano-polysaccharide compound or derivative added is 0.5-2 parts by mass of nano-chitosan, and the average particle size of nano-chitosan is 450-550nm.

Preferably, the wet dressing is a hydrogel dressing, and the hydrogel dressing includes 30-40 parts by mass of glycerin, 35-45 parts of water, 6-10 parts of partially neutralized sodium polyacrylate, 3-7 parts of polyacrylic acid, 3-7 parts of boehm, 0.5-1.5 parts of disodium ethylenediamine tetraacetate; the nano-polysaccharide compound or derivative added is 3-7 parts by mass of nano-dialdehyde The average particle diameter of the cellulose and nano-dialdehyde cellulose is 800-1000 nm; 0.05-0.15 parts by mass of pH regulator tartaric acid is also added.

Beneficial effects of the present invention: it can quickly absorb wound exudate, and has good moisturizing properties; at the same time, it can assist in enhancing the mechanical properties of the dressing; the moist dressing can not only provide an environment for wound healing, but also has less replacement frequency, and can relieve wounds during replacement. pain. Because the wet dressing of the present invention includes hydrocolloid dressing, hydrogel dressing, silicone gel dressing, seaweed salt dressing, described wet dressing also adds nano polysaccharide compound or derivative, forms gel after it absorbs water, keeps wound Healing environment, and the viscosity is greatly weakened after the gel is formed, not only can quickly absorb a large amount of wound exudate, maintain the wound healing environment, but also can assist in enhancing the tensile strength of the water-absorbing dressing to prevent the second damage to the wound; nano-polysaccharides Because the compounds or derivatives are nanomaterials, because nanomaterials have size effects, quantum effects, surface effects, etc., they can exhibit different physical and chemical properties, that is, not only retain the original chemical reactivity, but also have a highly ordered structure , Larger specific surface area, large specific surface area and abundant hydroxyl groups exposed on the surface enable nano-sized polysaccharides to have a certain degree of hydrophilicity and water retention; in addition, according to the announcement number: CN 101974172B, patent number: 201010522109.3 "a nanocrystalline The conclusion of "Preparation Method of Cellulose and Its Carbon Black/Rubber Composite Material": A small amount of nano-cellulose (NCC) combined with silica can greatly enhance the molecular interaction with natural rubber and improve the mechanical strength of rubber products. This is the scientific basis for the above-mentioned "can assist in enhancing the mechanical properties of dressings".

Description of drawings

Figure 1: The result table of 24-hour water absorption test of dressings prepared with different proportions of nanocellulose (average particle size: 200 nm) in Example 1.

Fig. 2: The moist dressing of embodiment case 11 and embodiment case 1 is the composition of hydrocolloid dressing, the mass fraction is the same, adding 2 parts of anti-oxidant 1010 is the same, only does not add the implementation of prior art of nano polysaccharide compound or derivative Table 24 h water absorption test results of dressings prepared in the example.

It can be seen from the results in Figure 1 and Figure 2 that adding a small amount of nanocellulose can greatly improve the water absorption of hydrocolloid dressings.

Detailed ways

The present invention will be further described below by 1-11 specific examples.

Example 1 - Hydrocolloid Dressing Containing Nanocellulose

In order to prove the effect of nanocellulose on the water absorption of hydrocolloid dressings, the composition of the wet dressings is the same, the number of antioxidants added is the same, only the polysaccharide compounds or derivatives added are changed according to the number of parts by mass. The following three components:

Component one: the wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 18 parts of linear SIS (styrene-isoprene) block copolymer, 13 parts of olefin copolymer, 22 parts by mass Parts of C5 petroleum resin, 10 parts of naphthenic oil 4010, 28.2 parts of hydrophilic material sodium carboxymethyl cellulose, 6.6 parts of pectin, and 2 parts of antioxidant 1010; The number of parts is 0.4 parts of nanocellulose, and the average particle diameter of nanocellulose is 200 nm. Its water absorption is shown in Figure 1.

Component 2: the wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 18 parts by mass of linear SIS (styrene-isoprene) block copolymer, 13 parts of olefin copolymer, 22 parts Parts of C5 petroleum resin, 10 parts of naphthenic oil 4010, 28.2 parts of hydrophilic material sodium carboxymethyl cellulose, 6.6 parts of pectin, and 2 parts of antioxidant 1010; The number of parts is 0.6 parts of nanocellulose, and the average particle diameter of nanocellulose is 200 nm. Its water absorption is shown in Figure 1.

Component three: the wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 18 parts of linear SIS (styrene-isoprene) block copolymers, 13 parts of olefin copolymers, 22 parts by mass Parts of C5 petroleum resin, 10 parts of naphthenic oil 4010, 28.2 parts of hydrophilic material sodium carboxymethyl cellulose, 6.6 parts of pectin, and 2 parts of antioxidant 1010; The number of parts is 0.8 parts of nanocellulose, and the average particle diameter of nanocellulose is 200 nm. Its water absorption is shown in Figure 1.

Implementation Case 2—Silicone Gel Dressing Containing Nano-Amylose

The wet dressing is a silicone gel dressing, and the silicone gel dressing includes 60 parts of polydimethylsiloxane, 18 parts of multi-carbon alkyl polysiloxane, 20 parts of polydimethylsiloxane in parts by mass. Siloxane cross-linked polymer; the nano-polysaccharide compound or derivative added is 2 parts by mass of nano-amylose, and the average particle size of nano-amylose is 300nm.

Implementation Case 3 — Alginate Dressing Containing Nano-Carboxymethyl Cellulose Sodium

The wet dressing is an alginate dressing, and the alginate dressing includes 85 parts of water, 6 parts of sodium alginate, and 3 parts of calcium chloride in parts by mass; also added nano-polysaccharide compounds or derivatives It is 2 parts by mass parts of nano carboxymethyl cellulose sodium, and the average particle diameter of nano carboxymethyl cellulose sodium is 350 nm.

Implementation Case 4—Hydrocolloid Dressing Containing Nanostarch

The wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 38 parts by mass of linear SIS (styrene-isoprene) block copolymer, 12 parts of polyacrylate copolymer, 15 parts of C5 Petroleum resin, 15 parts of naphthenic oil 4010, 14 parts of sodium carboxymethyl cellulose, 2 parts of gelatin; the nano polysaccharide compounds or derivatives that are also added are 16 parts by mass parts of nano carboxymethyl cellulose sodium, nano The average particle diameter of sodium carboxymethylcellulose is 800 nm; 3 parts by mass of antioxidant 1010 are also added.

Implementation Case 5—Hydrocolloid Dressing Containing Nano-Pululan

The wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 15 parts of linear SIS (styrene-isoprene) block copolymer, 15 parts of olefin copolymer, 14 parts of C5 petroleum resin in parts by mass , 13 parts of naphthenic oil 4010, 30 parts of sodium carboxymethylcellulose, 5 parts of croscarmellose sodium; the nano-polysaccharide compound or derivatives added are 5 parts by mass of nano-pullulan , the average particle diameter of nano-pullulan is 220 nm; 1 part of antioxidant 1010 is also added in parts by mass.

Example 6—Hydrogel dressing containing nano-chitosan

The wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 7 parts of polyvinyl alcohol, 75 parts of water, 15 parts of vinylpyrrolidone, and 2 parts of cross-linking agent in parts by mass; the nano-polysaccharide compound added Or the derivative is 0.5 parts by mass of nano-chitosan, and the average particle diameter of nano-chitosan is 500 nm.

Implementation Case 7 — Silicone Gel Dressing Containing Nano-Chitin

The wet dressing is a silicone gel dressing, and the silicone gel dressing includes 60 parts by mass of dimethylsiloxane, 18 parts of multi-carbon alkyl polysiloxane, 20 parts of polydimethylsiloxane The oxane cross-linked polymer; the added nano-polysaccharide compound or derivative is 2 parts by mass of nano-chitin, and the average particle size of nano-chitin is 300nm.

Example 8—Hydrogel dressing containing nano-chitosan

The wet dressing is a hydrogel dressing, and the hydrocolloid dressing includes 12 parts of polyvinyl alcohol, 70 parts of water, 15 parts of polyvinylpyrrolidone, and 2 parts of acrylate copolymer in parts by mass; The sugar compound or derivative is 0.5 parts by mass of nano-chitosan, and the average particle diameter of nano-chitosan is 500nm; 1 part by mass of pH regulator tartaric acid is also added.

Implementation Case 9—Hydrogel Dressing Containing Nano Dialdehyde Cellulose

The wet dressing is a hydrogel dressing, and the hydrogel dressing includes 35 parts of glycerin, 40 parts of water, 8 parts of partially neutralized sodium polyacrylate, 5 parts of polyacrylic acid, and 5 parts of Boehm in parts by mass. , 1 part of disodium ethylenediamine tetraacetate; the nano polysaccharide compounds or derivatives added are 5 parts by mass of nano-dialdehyde cellulose, and the average particle diameter of nano-dialdehyde cellulose is 900 nm; 0.1 parts by mass of pH regulator tartaric acid is added.

Implementation Case 10 — Alginate Composite Dressing Containing Nano-Chitin

The wet dressing is a seaweed salt dressing, and the seaweed salt dressing includes 88 parts by mass of water, 5 parts of sodium alginate, and 3 parts of calcium chloride; The number of parts by mass is 5 parts of nano-chitin, and the average particle diameter of nano-chitin is 1000 nm.

Embodiment 11 and the wet dressing of Embodiment 1 are the same composition and mass parts of hydrocolloid dressing, adding 2 parts of antioxidant 1010 is the same, only the embodiment of the prior art without adding nano-polysaccharide compounds or derivatives

The wet dressing is a hydrocolloid dressing, and the hydrocolloid dressing includes 18 parts by mass of linear SIS (styrene-isoprene) block copolymer, 13 parts of olefin copolymer, 22 parts of C5 petroleum resin , 10 parts of naphthenic oil 4010, 28.2 parts of hydrophilic material sodium carboxymethyl cellulose, 6.6 parts of pectin, and 2 parts of antioxidant 1010. Its water absorption is shown in Figure 2.

Claims (10)

1. one kind includes nanometer polysaccharide medical wound dressing, including moist dressing, the moist dressing are bearing hydrocolloid dressings Or aerogel dressing or Silica hydrogel dressing or seaweed salt dressing, it is characterised in that：The moist dressing is additionally added a nanometer polysaccharide Class compound or derivative, the nanometer polysaccharide compound or derivative of addition be cellulose, starch, chitin, chitosan or One or more in derivative；Saccharide compound or derivative particle diameter are the nm of 200 nm of nanoscale~1000；Saccharide compound Or derivative and moist dressing mass fraction are respectively 0.1~20 part and 70~115 parts.

2. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 10~20 parts of linear SIS by mass fraction（Styrene-isoamyl two Alkene）Block copolymer, 10~14 parts of olefin copolymers, 18~22 parts of C5 Petropols, 8~12 parts of naphthenic oils 4010,23~30 Part sodium carboxymethylcellulose, 2~7 parts of pectin；The polysaccharide compound or derivative being additionally added are by 0.1~8 part of mass fraction Nano-cellulose, nano-cellulose average grain diameter are 200~700 nm；It is additionally added 1~3 part of antioxidant 1010.

3. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is Silica hydrogel dressing, and the Silica hydrogel dressing includes 55~65 parts of dimethyl silicone polymers, 17~19 by mass fraction The poly- silicon oxide compound of the more carbon alkyl of part, 19~21 parts of Dimethicone Crosspolymers；The nanometer polysaccharide being additionally added Compound or derivative be by 0.1~3 portion of nanometer amylose of mass fraction, nanometer amylose average grain diameter for 250~ 700nm。

4. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is alginate dressing, the alginate dressing by mass fraction include 80~90 parts of water, 4~8 parts of sodium alginates, 2~4 parts of calcium chloride；The nanometer polysaccharide compound or derivative being additionally added are fine by 0.1~3 part of nanometer carboxymethyl of mass fraction The plain sodium of dimension, nanometer sodium carboxymethylcellulose average grain diameter is 200~700nm.

5. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 36~40 parts of linear SIS by mass fraction（Styrene-isoamyl two Alkene）Block copolymer, 10~14 parts of acrylate copolymers, 13~17 parts of C5 Petropols, 13~17 parts of naphthenic oils 4010, 12~16 parts of sodium carboxymethylcelluloses, 1~3 part of gelatin；The nanometer polysaccharide compound or derivative being additionally added are by mass parts 5~17 parts of nanometer sodium carboxymethylcelluloses of number, nanometer sodium carboxymethylcellulose average grain diameter are 700~900 nm；It has been additionally added By 1~3 part of antioxidant 1010 of mass fraction.

6. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 13~17 parts of linear SIS by mass fraction（Styrene-isoamyl two Alkene）Block copolymer, 12~17 parts of olefin copolymers, 12~17 parts of C5 Petropols, 11~15 parts of naphthenic oils 4010,28~ 32 parts of sodium carboxymethylcelluloses, 3~7 parts of Ac-Di-Sols；The nanometer polysaccharide compound or derivative being additionally added It is that the average grain diameter of nano-cellulose is 250~350 nm by 0.1~7 part of nano-cellulose of mass fraction；It has been additionally added by matter Measure 1~3 part of antioxidant 1010 of number.

7. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is bearing hydrocolloid dressing, the bearing hydrocolloid dressing by mass fraction include 6~7 parts of polyvinyl alcohol, 70~80 parts of water, 13~ 17 parts of vinylpyrrolidones, 1~3 part of crosslinking agent polyacrylamide；The nanometer polysaccharide compound or derivative being additionally added be by 0.1~1.5 part of Nano chitosan of mass fraction, the average grain diameter of Nano chitosan is 200~550 nm.

8. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is Silica hydrogel dressing, the Silica hydrogel dressing by mass fraction include 55~65 parts of dimethyl siloxanes, 16~20 parts The poly- silicon oxide compound of more carbon alkyl, 18~22 parts of Dimethicone Crosspolymers；The nanometer polysaccharide chemical combination being additionally added Thing or derivative be by 0.1~2.5 portion of nanometer amylose of mass fraction, nanometer amylose average grain diameter for 200~ 700nm。

9. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist Dressing is aerogel dressing, and the aerogel dressing includes 10~14 parts of polyvinyl alcohol, 65~75 parts of water, 10 by mass fraction ~20 parts of polyvinylpyrrolidones, 1.5~2.5 parts of acrylate copolymers；The nanometer polysaccharide compound or derivative being additionally added Thing is by 0.5~2 part of Nano chitosan of mass fraction, and Nano chitosan average grain diameter is 450~550nm.

10. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is wet Property dressing be aerogel dressing, the aerogel dressing by mass fraction include 30~40 parts of glycerine, 35~45 parts of water, 6~ Sodium Polyacrylate, 3~7 parts of polyacrylic acid, 3~7 parts of ripple nurses, 0.5~1.5 part of ethylenediamine tetra-acetic acid two that 10 parts of parts neutralize Sodium；The nanometer polysaccharide compound or derivative being additionally added are by 3~7 parts of nano double aldocelluloses of mass fraction, nano double Aldocellulose average grain diameter is 800~1000 nm；It has been additionally added by 0.05~0.15 part of pH adjusting agent winestone of mass fraction Acid.