CN108066807A - The preparation method of the absorption styptic dressing of high imbibition ability - Google Patents
The preparation method of the absorption styptic dressing of high imbibition ability Download PDFInfo
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- CN108066807A CN108066807A CN201810120314.3A CN201810120314A CN108066807A CN 108066807 A CN108066807 A CN 108066807A CN 201810120314 A CN201810120314 A CN 201810120314A CN 108066807 A CN108066807 A CN 108066807A
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- 238000005213 imbibition Methods 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 23
- 230000004941 influx Effects 0.000 claims abstract description 26
- 230000005945 translocation Effects 0.000 claims abstract description 26
- 150000001875 compounds Chemical class 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000010413 sodium alginate Nutrition 0.000 claims description 12
- 239000000017 hydrogel Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- RBNPOMFGQQGHHO-UHFFFAOYSA-N -2,3-Dihydroxypropanoic acid Natural products OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 claims description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 claims description 8
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000005266 casting Methods 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000009987 spinning Methods 0.000 claims description 4
- 229920005615 natural polymer Polymers 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 230000000025 haemostatic effect Effects 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 13
- 208000027418 Wounds and injury Diseases 0.000 description 13
- 230000029663 wound healing Effects 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 4
- 239000012901 Milli-Q water Substances 0.000 description 3
- 238000002788 crimping Methods 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of preparation method of the absorption styptic dressing of high imbibition ability, including amounting to five steps：The preparation of bio-absorbable film, the preparation of influx and translocation layer, the engagement of bio-absorbable film and the influx and translocation layer, the preparation of bioresorbable porous mass layer, bioresorbable porous mass layer and influx and translocation layer, bio-absorbable film it is compound.The absorption styptic dressing of the high imbibition ability of the present invention, influx and translocation layer have excellent imbibition ability, greatly improve the imbibition ability of bleeding-stopping dressing, have good haemostatic effect.
Description
Technical field
The present invention relates to medicine and hygiene fields, and in particular to a kind of preparation side of the absorption styptic dressing of high imbibition ability
Method.
Background technology
In the treatment and nursing of skin trauma, hemostasis articles for use are one of indispensabilities, and in general, a ulcer wound is per balance
Secrete about 50 milliliters or so of liquid.And the absorbability for the dressing that general textile makes is below 200%, far from full
The demand of footcare erosive ulcers wound.
" bandage " for generally being used in daily etc., it is easy to use, easy to carry because having many advantages, such as, it is cheap, it obtains
Obtained extensive accreditation.But these hemostasis articles for use it is often long there are bleeding stopping period, wound by tissue fluid for a long time impregnate and
Swelling, undesirable to large area, high depth wound hemostasis effect, part, is unfavorable for wound and is cured the deficiencies of antibacterial bacteriostatic energy force difference
It closes.
When handling patient's wound, it is necessary to cover dressing on wound, prevent bacterium from invading and preventing moisture loss.Tradition
Though dressing such as gauze, bandage etc. have protective effect to the surface of a wound, moisturizing imbibition ability is poor, can only absorb the 4-5 of own wt
Times, and for some wounds when removing traditional dressing, the easy adhesion wound tissue of dressing causes secondary wound to destroy；Cause
This, in surgical operation, also usually needs some degradable, good biocompatibility dressing that organ is prevented to be adhered.
In consideration of it, it urgently proposes a kind of to prepare excellent, degradable, good biocompatibility the bleeding-stopping dressing of imbibition ability at present
Method.
The content of the invention
The technical problems to be solved by the invention be that the method for preparing bleeding-stopping dressing in the prior art is prepared only
Blood dressing imbibition ability is not ideal enough, is unfavorable for wound healing, and then provides that a kind of to prepare imbibition ability excellent, degradable, raw
The method of good, the absorbable bleeding-stopping dressing of object compatibility.
For this purpose, the present invention provides a kind of preparation method of the absorption styptic dressing of high imbibition ability, including walking as follows
Suddenly：
(1) preparation of bio-absorbable film：Natural macromolecular material particles is taken to be ground to powdered, be dissolved in water, stirred
Mix uniformly after be poured in plane, casting film-forming to get film-form bio-absorbable film；
(2) preparation of influx and translocation layer：By the polymer of the polymer of glyceric acid or lactide or both, heating polymerize,
Spinning is to get to influx and translocation layer；
(3) engagement of bio-absorbable film and the influx and translocation layer：The bio-absorbable film obtained in step (1) is used
The method of crimping is engaged with the influx and translocation layer obtained in step (2)；
(4) preparation of bioresorbable porous mass layer：Natural macromolecular material particles is taken to be ground to powdered, by itself plus
Enter into water, stirring is to being completely dissolved；Sodium alginate is taken, is mixed together with the natural polymer of dissolving, after mixing, is added
Heat generates the hydrogel of physical crosslinking；
(5) bioresorbable porous mass layer and influx and translocation layer, bio-absorbable film it is compound：It will be obtained in step (4)
Hydrogel milli-Q water, then the bio-absorbable film of gained in step (3) is put into mould with the influx and translocation layer
In tool, and the hydrogel is poured into mold, be then freeze-dried by mold convection drying or by mold to get three-layered node
The absorption styptic dressing of the high imbibition ability of structure.
Preferably, in step (2), the glyceric acid and the lactide are that mass ratio is 1：(1~5).
Preferably, glyceric acid described in step (2) is 200 DEG C -300 DEG C with the temperature that lactide heating polymerize.
Preferably, in step (1), the natural macromolecular material mass fraction soluble in water that is made into is 0.5%~10%
Colloidal liquid.
Preferably, the step of step (1) is further included after natural macromolecular material dissolving, sodium alginate is added in.
Preferably, in step (1), the natural macromolecular material obtains mass ratio as 2 with the sodium alginate:(1~
3)。
Preferably, in step (2), the mass ratio of the natural macromolecular material and the sodium alginate is (1~5):1.
Preferably, step (1), the natural macromolecular material described in step (2) include one kind in ossein, gelatin.
Technical solution provided by the invention, has the following advantages that：
The absorption styptic dressing of high imbibition ability of the present invention, is made of the macromolecule of Bioabsorbable,
It, can be by biological decomposition and absorption after wound healing with good biocompatibility；What is more important, it is of the present invention
High imbibition ability absorption styptic dressing, have three-decker, the bio-absorbable film, the bioresorbable porosity
Matter layer, the influx and translocation layer.Bioresorbable porous mass layer is bonded with wound surface, has good water imbibition, and institute
Bio-absorbable film is stated with preferable hydrophily, is not contacted with cell, tissue, prevents the bioresorbable porous mass layer
Moisture is by having preferable haemostatic effect, being conducive to wound healing.And influx and translocation layer has the quick work for absorbing liquid
With greatly strengthening the imbibition ability of bleeding-stopping dressing.
Specific embodiment
Embodiment 1
The absorption styptic dressing of the high imbibition ability of the present embodiment has three-decker, successively by bio-absorbable film, suction
Receive enhancement layer, bioresorbable porous mass layer is formed.
Its preparation method is as follows：
(1) preparation of the bio-absorbable film：It weighs 20g gelatin particles and is ground to powdered, be dissolved in water, be made into
Mass fraction is 0.5%~10% colloidal liquid, adds in 5g sodium alginates, glass or stainless steel plate are poured over after stirring evenly
On, casting film-forming, room temperature dries the bio-absorbable film up to film-form；
(2) preparation of the influx and translocation layer：By glyceric acid, lactide according to 1:1 mass ratio is incorporated in water, and stirring is equal
It is even, then high temperature polymerization is carried out using 300 DEG C of high temperature, then natural cooling obtains mixing material, the mixing material that will be obtained
It is put into the spinneret of special-shaped spinneret orifice and carries out spinning, be absorbed enhancement layer；
(3) engagement of the bio-absorbable film and the influx and translocation layer：The bio-absorbable that will be obtained in step (1)
Film is engaged with the methods of crimping with the influx and translocation layer obtained in step (2)；
(4) preparation of the bioresorbable porous mass layer：Weigh 20g gelatin particles be ground to it is powdered, by itself plus
Enter into the water of 20ml, stir to gelatin and be completely dissolved；Weigh 10g sodium alginates, be mixed together with the gelatin of dissolving, first with
200r/min is quickly stirred 1-2 minutes, is then stirred 10 minutes with 100r/min, after mixing, mixed solution is heated again
To 50 DEG C -60 DEG C, that is, generate the hydrogel of the physical crosslinking；The hydrogel milli-Q water that will be obtained, then by step
(3) the bio-absorbable film of gained is put into the influx and translocation layer in mold in, and the hydrogel is poured into mold,
Then by mold convection drying or by mold in -20 DEG C freeze 2~5h after freeze-drying to get three-decker the absorption
Property bleeding-stopping dressing.
Embodiment 2
The absorption styptic dressing of the high imbibition ability of the present embodiment has three-decker, successively by bio-absorbable film, suction
Receive enhancement layer, bioresorbable porous mass layer is formed.
Its preparation method is as follows：
(1) preparation of the bio-absorbable film：20g osseins particulate abrasive is weighed to powdered, is dissolved in water, matches somebody with somebody
Into the colloidal liquid that mass fraction is 0.5%~10%, 5g sodium alginates are added in, glass or stainless steel are poured over after stirring evenly
On plate, casting film-forming, room temperature dries the bio-absorbable film up to film-form；
(2) preparation of the influx and translocation layer：By glyceric acid, lactide according to 1:3 mass ratio is incorporated in water, and stirring is equal
It is even, then high temperature polymerization is carried out using 300 DEG C of high temperature, then natural cooling obtains mixing material, the mixing material that will be obtained
It is put into the spinneret of special-shaped spinneret orifice and carries out spinning, be absorbed enhancement layer；
(3) engagement of the bio-absorbable film and the influx and translocation layer：The bio-absorbable that will be obtained in step (1)
Film is engaged with the methods of crimping with the influx and translocation layer obtained in step (2)；
(4) preparation of the bioresorbable porous mass layer：20g osseins particulate abrasive is weighed to powdered, by it
It is added in the water of 20ml, stirs to gelatin and be completely dissolved；Weigh 10g sodium alginates, be mixed together with the gelatin of dissolving, first with
200r/min is quickly stirred 1-2 minutes, is then stirred 10 minutes with 100r/min, after mixing, mixed solution is heated again
To 50 DEG C -60 DEG C, that is, generate the hydrogel of the physical crosslinking；The hydrogel milli-Q water that will be obtained, then by step
(3) the bio-absorbable film of gained is put into the influx and translocation layer in mold in, and the hydrogel is poured into mold,
Then by mold convection drying or by mold in -20 DEG C freeze 2~5h after freeze-drying to get three-decker the absorption
Property bleeding-stopping dressing.
Experimental example
To verify the technique effect of absorbable hemostasia dressing of the present invention, following wound healing assay is carried out：
Healthy adult rabbit 10 is taken, is divided into 2 groups, each 5, is denoted as 1 group of embodiment, 2 groups of embodiment, Intravenous Anesthesia, Gu
Determine onto operating table, unhairing at back and femur ditch, scratch in body surface, thin vessels, apply the embodiment of the present invention 1, reality respectively
2 quick-acting haemostatic powder wound dressing of example is applied, manually presses 15-60s.The situation of 7 days after observing bleeding stopping period and performing the operation.
It is understood through experimental result, since bleeding part is different, bleeding stopping period has differences tested animal.But 7 days after performing the operation,
Using absorbable hemostasia dressing of the present invention, tested animal wound healing is good, and limbs can be freely movable.
Obviously, the above embodiments are merely examples for clarifying the description, and is not intended to limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And the obvious variation thus extended out or
Among changing still in the protection domain of the invention.
Claims (8)
1. the preparation method of the absorption styptic dressing of high imbibition ability, which is characterized in that include the following steps：
(1) preparation of bio-absorbable film：Natural macromolecular material particles is taken to be ground to powdered, be dissolved in water, stirring is equal
Be poured over after even in plane, casting film-forming to get film-form bio-absorbable film；
(2) preparation of influx and translocation layer：By the polymer of the polymer of glyceric acid or lactide or both, heating polymerize, spinning,
Obtain influx and translocation layer；
(3) engagement of bio-absorbable film and the influx and translocation layer：The bio-absorbable film obtained in step (1) is crimped
Method engaged with the influx and translocation layer obtained in step (2)；
(4) preparation of bioresorbable porous mass layer：Natural macromolecular material particles is taken to be ground to powdered, added it to
In water, stirring is to being completely dissolved；Sodium alginate is taken, is mixed together with the natural polymer of dissolving, after mixing, heating, i.e.,
Generate the hydrogel of physical crosslinking；
(5) bioresorbable porous mass layer and influx and translocation layer, bio-absorbable film it is compound：The water that will be obtained in step (4)
Gel is washed with water, then the bio-absorbable film of gained in step (3) is put into the influx and translocation layer in mold, and will
The hydrogel is poured into mold, is then freeze-dried by mold convection drying or by mold to get described in three-decker
The absorption styptic dressing of high imbibition ability.
2. according to the preparation method of the absorption styptic dressing of the high imbibition ability described in claim 1, which is characterized in that step
Suddenly in (2), the glyceric acid and the lactide are that mass ratio is 1：(1~5).
3. according to the preparation method of the absorption styptic dressing of the high imbibition ability described in claim 2, which is characterized in that step
Suddenly glyceric acid described in (2) is 200 DEG C -300 DEG C with the temperature that lactide heating polymerize.
4. the preparation method of the absorption styptic dressing of the high imbibition ability according to any one in claim 1-3,
It is characterized in that, in step (1), the natural macromolecular material is soluble in water to be made into the glue that mass fraction is 0.5%~10%
Liquid.
5. according to the preparation method of the absorption styptic dressing of the high imbibition ability described in claim 4, which is characterized in that step
Suddenly the step of (1) is further included after natural macromolecular material dissolving, sodium alginate is added in.
6. the preparation method of the absorption styptic dressing of the high imbibition ability according to any one in claim 5, special
Sign is, in step (1), the natural macromolecular material obtains mass ratio as 2 with the sodium alginate:(1~3).
7. the absorption styptic dressing of the high imbibition ability according to any one in claim 1-6, which is characterized in that step
Suddenly in (2), the mass ratio of the natural macromolecular material and the sodium alginate is (1~5):1.
8. the absorption styptic dressing of the high imbibition ability according to any one in claim 1-7, which is characterized in that step
Suddenly (1), the natural macromolecular material described in step (2) include one kind in ossein, gelatin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120314.3A CN108066807A (en) | 2018-02-07 | 2018-02-07 | The preparation method of the absorption styptic dressing of high imbibition ability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120314.3A CN108066807A (en) | 2018-02-07 | 2018-02-07 | The preparation method of the absorption styptic dressing of high imbibition ability |
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