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CN108096359A - A kind of itching analgesic ointment and preparation method thereof - Google Patents

A kind of itching analgesic ointment and preparation method thereof Download PDF

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Publication number
CN108096359A
CN108096359A CN201711483807.5A CN201711483807A CN108096359A CN 108096359 A CN108096359 A CN 108096359A CN 201711483807 A CN201711483807 A CN 201711483807A CN 108096359 A CN108096359 A CN 108096359A
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parts
extracting solution
ointment
water
capsaicine
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Inventor
汪娇
耿菲菲
李彪
韦勇
李章凤
林蓉
周艳梅
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YUNNAN HONGLV CAPSAICIN CO Ltd
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YUNNAN HONGLV CAPSAICIN CO Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/30—Extraction of the material
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a kind of itching analgesic ointment, including following components in parts by weight：10 15 parts of stearic acid, 7 13 parts of castor oil, 10 15 parts of atoleine are oil phase；0.5 3 parts of triethanolamine is emulsifier；38 parts of glycerine, 45 55 parts of deionized water, 0.5 2 parts of borneol, 0.1 1 parts of frutus cnidii extracting solution, 0.1 1 parts of Purslane extract, 0.1 1 parts of pericarpium zanthoxyli extracting solution, 0.1 1 parts of Radix Notoginseng extracting solution, 0.1 1 parts of root bark of shaggy-fruited dittany extracting solution, 0.1 1 parts of Folium Artemisiae Argyi extractive liquid, 0.1 1 parts of cotton rose extracting solution, 0.1 1 parts of fruit of summer cypress extracting solution, 0.01 1 parts of capsaicine are water phase and its both effectiveness ingredient；Outstanding 0.1 1 parts of horse antiseptic is preservative, the beneficial effects of the invention are as follows：The ointment has merged the effect of a variety of traditional Chinese medicine extracts ingredient, is also added into the fabulous capsaicine of itching analgesic effect, and irritation is small during use, and effect is rapid, and therapeutic effect is notable.

Description

A kind of itching analgesic ointment and preparation method thereof
Technical field
The present invention relates to a kind of itching analgesic ointment, are specifically a kind of itching analgesic ointment and preparation method thereof.
Background technology
Cutaneous pruritus refers to the clinically skin disease based on itch without the damage of apparent primary cutaneous.Itch is often Many systemic property diseases occur together or onset symptoms, disease Fa Shiqi itch unbearably, traditional antipruritic method is usually palliative, Slowly effect, repeatability is strong, obstinate.
Pain can be divided into Acute Pain, chronic ache, intractable pain, cancer pain and special pain.Common analgesia Class pharmaceutical dosage form has oral tablet, patch and spraying etc., and the drug medication amount of the type is big, takes effect slowly, there are other poison are secondary Effect.
The content of the invention
It is an object of the invention to provide a kind of itching analgesic ointment and preparation method thereof, to solve in above-mentioned background technology The problem of proposition.
To achieve the above object, the present invention provides following technical solution：
A kind of itching analgesic ointment, including following components in parts by weight：10-15 parts of stearic acid, 7-13 parts of castor oil, 10-15 parts of atoleine is oil phase；0.5-3 parts of triethanolamine is emulsifier；3-8 parts of glycerine, 45-55 parts of deionized water, borneol 0.5-2 parts, 0.1-1 parts of frutus cnidii extracting solution, 0.1-1 parts of Purslane extract, 0.1-1 parts of pericarpium zanthoxyli extracting solution, Radix Notoginseng extracting solution 0.1-1 parts, 0.1-1 parts of root bark of shaggy-fruited dittany extracting solution, 0.1-1 parts of Folium Artemisiae Argyi extractive liquid, 0.1-1 parts of cotton rose extracting solution, the fruit of summer cypress extraction 0.1-1 parts of liquid, 0.01-1 parts of capsaicine are water phase and its both effectiveness ingredient；Outstanding 0.1-1 parts of horse antiseptic is preservative.
As further embodiment of the present invention：Including following components in parts by weight：11-14 parts of stearic acid, castor oil 8-12 parts, 11-14 parts of atoleine be oil phase；1.5-2 parts of triethanolamine is emulsifier；4-7 parts of glycerine, deionized water 47-53 Part, 1-1.5 parts of borneol, 0.4-0.7 parts of frutus cnidii extracting solution, 0.4-0.7 parts of Purslane extract, pericarpium zanthoxyli extracting solution 0.4-0.7 Part, 0.4-0.7 parts of Radix Notoginseng extracting solution, 0.4-0.7 parts of root bark of shaggy-fruited dittany extracting solution, 0.4-0.7 parts of Folium Artemisiae Argyi extractive liquid, cotton rose extracting solution 0.4-0.7 parts, 0.4-0.7 parts of fruit of summer cypress extracting solution, 0.1-0.91 parts of capsaicine be water phase and its both effectiveness ingredient；Outstanding horse antibacterial 0.4-0.7 parts of agent is preservative.
As further scheme of the invention：Including following components in parts by weight：12 parts of stearic acid, castor oil 10 Part, 12 parts of atoleine are oil phase；1.7 parts of triethanolamine is emulsifier；5 parts of glycerine, 50 parts of deionized water, 1.3 parts of borneol, snake 0.5 part of machine tool extracting solution, 0.5 part of Purslane extract, 0.5 part of pericarpium zanthoxyli extracting solution, 0.5 part of Radix Notoginseng extracting solution, root bark of shaggy-fruited dittany extraction 0.5 part of liquid, 0.5 part of Folium Artemisiae Argyi extractive liquid, 0.5 part of cotton rose extracting solution, 0.5 part of fruit of summer cypress extracting solution, 0.5 part of capsaicine are water phase And its both effectiveness ingredient；Outstanding 0.5 part of horse antiseptic is preservative.
A kind of preparation method of itching analgesic ointment, comprises the following steps：
S1, the preparation of Chinese medicine extract
(1) preparation of fruit of summer cypress extracting solution：It is 1 by solid-liquid ratio by the fruit of summer cypress and 95% ethanol solution:10 proportioning into Row addition, the heating water bath 1.5h at 80 DEG C recycle fraction, in triplicate, finally merge extracting solution three times, utilize rotary evaporation Instrument concentrated to get；
(2) preparation of pericarpium zanthoxyli extracting solution：It is 1 by solid-liquid ratio by pericarpium zanthoxyli and 70% ethanol solution:20 proportioning is added Add, the heating water bath 1h at 60 DEG C, recycle fraction, in triplicate, finally merge extracting solution three times, using Rotary Evaporators by its Concentration to get；
(4) preparation of cottonrose hibiscus flower extracting solution：It is 1 by solid-liquid ratio by cottonrose hibiscus flower and 50% ethanol solution:10 match somebody with somebody Than being added, the heating water bath 1.5h at 70 DEG C recycles fraction, in triplicate, finally merges extracting solution three times, utilize rotation Evaporimeter concentrated to get；
Remaining extracting solution is the finished product directly bought；
S2, the preparation of ointment bases
The stearic acid, castor oil and atoleine of above-mentioned parts by weight are weighed as oil phase, then weighs above-mentioned parts by weight As water phase, triethanolamine is emulsifier for several glycerine and deionized water, by water phase and oil phase be respectively placed in 80 DEG C of water-baths into Row heating, after it is completely dissolved, slowly mutually pours into water in oil phase, adds in emulsifier afterwards and is constantly stirred straight To complete emulsification to get ointment bases；
It is prepared by S3, finished product
By borneol, capsaicine, fruit of summer cypress extracting solution, pericarpium zanthoxyli extracting solution, cottonrose hibiscus flower extracting solution, frutus cnidii extracting solution, horse Bitterroot extracting solution, Radix Notoginseng extracting solution, root bark of shaggy-fruited dittany extracting solution and Folium Artemisiae Argyi extractive liquid, are placed in beaker according to above-mentioned parts by weight, stir It mixes and is mixed into extraction liquid mixture, when the ointment bases in step S2 is cooled to 40 DEG C, extraction liquid mixture is slowly added to Being stirred continuously in ointment bases makes it uniformly, added in during stirring outstanding horse antiseptic to get；
S4 is packed and stored after the finished product that S3 is obtained is dispensed.
It is as follows the effect of fractions in the present invention：
Borneol：Antibacterial, anti-inflammatory effect, higher concentration (0.5%) is to staphylococcus, streptococcus, the double ball mattresses of pneumonia, large intestine bar Pathogenic dermatophyte of bacterium and part etc. has inhibitory action；
Frutus cnidii：Energy removing dampness and destroying parasites, treats eczema, allergic dermatitis；
Purslane：Clearing heat and detoxicating, Li Shui dries, and dissipates blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, blood-stanching and blood-cooling.Cure mainly dysentery Disease, enteritis, ephritis, postpartum uterine hemorrhage are had blood in stool, the illnesss such as mastitis；
Pericarpium zanthoxyli：Except the stink smell of various meats；Promote salivary secretion, increase appetite；It distends the blood vessels, so as to play reduction blood The effect of pressure；Parasite can be removed by taking pepper water；There are fragrant stomach invigorating, warming spleen and stomach for dispelling cold, damp dispelling and pain relieving, desinsection removing toxic substances, antipruritic solution raw meat The effect of；
Radix Notoginseng：Hemoptysis spits blood, has blood in stool, uterine bleeding, traumatic hemorrhage；Treating swelling and pain by traumatic injury and Blood stasis；
The root bark of shaggy-fruited dittany：Antibacterial, antitumaous effect have certain influence to cardiovascular system and blood；
Folium artemisiae argyi：Folium artemisiae argyi is in vitro to bacillus anthracis, Alpha-hemolytic streptococcus, B- Streptococcus hemolyticus, corynebacterium diphtheriae, false diphtheria bar 10 kinds of gram sun such as bacterium, Diplococcus pneumopniae, gold-coloured staphylococci, Staphylococcus citreus, staphylococcus aureus, hay bacillus Property aerophil all has antibacterial action.Also there is hemostasis, it is antimycotic, it relievings asthma, cholagogic, antiallergy and other effects；
Cottonrose hibiscus flower：Cotton rose can be clearing heat and detoxicating, can be used in treating cough with lung heat, Nv Xingbai with cooling blood and hemostasis Band and menorrhalgia etc. can also carry out external application, have to treatment traumatic injury, burn and scald, mastitis, lymph inflammation etc. certain Effect also has effects that detumescence and apocenosis.Containing certain effective ingredient such as brass glucoside, anthocyanin etc. in cotton rose, use It spends the ointment that 20% is made into plus vaseline, can treat local infection；
The fruit of summer cypress：Diuresis, clearing away damp-heat.Control difficult urination, gonorrhoea, under band, hernia, rubella, sore, mange；
Capsaicine：Capsaicine is mainly to synthesize and store to play analgesia and block by influencing the release of neuropeptide substance p Effect.Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 is a kind of 11 peptides, is a kind of important nerve conduction medium, pain and itch can be passed to by peripheral nerve Spinal nerve and high-level center nerve.Capsaicine mainly acts on the Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 in c-type sensory neuron, and the conductive skin pain sensation With some in the exactly c-type nerve fibre of ill itch without the slow Conductive fiber of marrow.Local topical capsaicine acts on periphery god Through aixs cylinder, cause the reduction from all neurons (periphery and maincenter) Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, so as to fulfill analgesia and it is antipruritic the effect of.It is suitable For short-term relief muscle as caused by rheumatism and the mild pain and back pain and strain in joint, pull caused pain Bitterly.
Compared with prior art, the beneficial effects of the invention are as follows：The present invention has dispelling wind and arresting itching, promoting blood circulation to remove blood stasis, and detumescence stops The effect of pain, available for treating the symptoms such as common neurodermatitis, pruitus, herpes zoster, traumatic injury.The ointment melts The effect of having closed a variety of traditional Chinese medicine extracts ingredient, is also added into the fabulous capsaicine of itching analgesic effect, and when use stimulates Property it is small, effect is rapid, and therapeutic effect is notable.
Specific embodiment
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
10 parts of stearic acid, 7 parts of castor oil, 10 parts of atoleine are weighed as oil phase；45 parts of 3 parts of glycerine, deionized water works For water phase, 0.5 part of triethanolamine is emulsifier, and above-mentioned oil phase is mutually placed in 80 DEG C of water-baths with water and is heated, and treats it completely After dissolving, slowly water is mutually poured into oil phase, afterwards add in emulsifier and be constantly stirred until completely emulsify to get Ointment bases；By 0.5 part of borneol, 0.1 part of frutus cnidii extracting solution, 0.1 part of Purslane extract, 0.1 part of pericarpium zanthoxyli extracting solution, Radix Notoginseng 0.1 part of extracting solution, 0.1 part of root bark of shaggy-fruited dittany extracting solution, 0.1 part of Folium Artemisiae Argyi extractive liquid, 0.1 part of cotton rose extracting solution, fruit of summer cypress extracting solution 0.1 part, 0.01 part of capsaicine be placed in beaker, be stirred into extraction liquid mixture, when ointment bases is cooled to 40 DEG C, will Extraction liquid mixture, which is slowly added to be stirred continuously in ointment bases, makes it uniformly, and outstanding horse antiseptic is added in during stirring It 0.1 part, is packed and is stored after then finished product is dispensed.
Embodiment 2
Claim 15 parts of stearic acid, take 13 parts of castor oil, 15 parts of atoleine as oil phase；55 parts of 8 parts of glycerine, deionized water works For water phase, 3 parts of triethanolamine is emulsifier, and above-mentioned oil phase is mutually placed in 80 DEG C of water-baths with water and is heated, and treats that it is completely molten Xie Hou slowly mutually pours into water in oil phase, adds in emulsifier afterwards and is constantly stirred until emulsification is to get soft completely Cream base matter；By 2 parts of borneol, 1 part of frutus cnidii extracting solution, 1 part of Purslane extract, 1 part of pericarpium zanthoxyli extracting solution, 1 part of Radix Notoginseng extracting solution, 1 part of root bark of shaggy-fruited dittany extracting solution, 1 part of Folium Artemisiae Argyi extractive liquid, 1 part of cotton rose extracting solution, 1 part of fruit of summer cypress extracting solution, 1 part of capsaicine are placed in burning In cup, extraction liquid mixture is stirred into, when ointment bases is cooled to 40 DEG C, extraction liquid mixture is slowly added to ointment Being stirred continuously in matrix makes it uniformly, and outstanding 1 part of horse antiseptic is added in during stirring, is wrapped after then finished product is dispensed Dress and storage.
Embodiment 3
Claim 12 parts of stearic acid, take 10 parts of castor oil, 12 parts of atoleine as oil phase；50 parts of 5 parts of glycerine, deionized water works For water phase, 1.7 parts of triethanolamine is emulsifier, and above-mentioned oil phase is mutually placed in 80 DEG C of water-baths with water and is heated, and treats it completely After dissolving, slowly water is mutually poured into oil phase, afterwards add in emulsifier and be constantly stirred until completely emulsify to get Ointment bases；By 1.3 parts of borneol, 0.5 part of frutus cnidii extracting solution, 0.5 part of Purslane extract, 0.5 part of pericarpium zanthoxyli extracting solution, Radix Notoginseng 0.5 part of extracting solution, 0.5 part of root bark of shaggy-fruited dittany extracting solution, 0.5 part of Folium Artemisiae Argyi extractive liquid, 0.5 part of cotton rose extracting solution, fruit of summer cypress extracting solution 0.5 part, 0.5 part of capsaicine be placed in beaker, be stirred into extraction liquid mixture, when ointment bases is cooled to 40 DEG C, will Extraction liquid mixture, which is slowly added to be stirred continuously in ointment bases, makes it uniformly, and outstanding horse antiseptic 1 is added in during stirring Part, it is packed and is stored after then finished product is dispensed.
Through clinical test case 30, continuous medication is after 30 days, statistical result showed, wherein 16 are cured, effective 9, Effective 2, invalid or exacerbation 2.Wherein total effective rate is 93%.Using this product without any side effects such as toxic, harmful, and Therapeutic effect is notable.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned exemplary embodiment, Er Qie In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims Variation is included within the present invention.
Moreover, it will be appreciated that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should Using specification as an entirety, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art It is appreciated that other embodiment.

Claims (4)

1. a kind of itching analgesic ointment, which is characterized in that including following components in parts by weight：10-15 parts of stearic acid, castor-oil plant 7-13 parts oily, 10-15 parts of atoleine is oil phase；0.5-3 parts of triethanolamine is emulsifier；3-8 parts of glycerine, deionized water 45- 55 parts, 0.5-2 parts of borneol, 0.1-1 parts of frutus cnidii extracting solution, 0.1-1 parts of Purslane extract, 0.1-1 parts of pericarpium zanthoxyli extracting solution, three Seven 0.1-1 parts of extracting solutions, 0.1-1 parts of root bark of shaggy-fruited dittany extracting solution, 0.1-1 parts of Folium Artemisiae Argyi extractive liquid, 0.1-1 parts of cotton rose extracting solution, 0.1-1 parts of skin extracting solution, 0.01-1 parts of capsaicine are water phase and its both effectiveness ingredient；Outstanding 0.1-1 parts of horse antiseptic is anti-corrosion Agent.
2. a kind of itching analgesic ointment according to claim 1, which is characterized in that including in parts by weight with the following group Point：11-14 parts of stearic acid, 8-12 parts of castor oil, 11-14 parts of atoleine are oil phase；1.5-2 parts of triethanolamine is emulsifier； 4-7 parts of glycerine, 47-53 parts of deionized water, 1-1.5 parts of borneol, 0.4-0.7 parts of frutus cnidii extracting solution, Purslane extract 0.4- 0.7 part, 0.4-0.7 parts of pericarpium zanthoxyli extracting solution, 0.4-0.7 parts of Radix Notoginseng extracting solution, 0.4-0.7 parts of root bark of shaggy-fruited dittany extracting solution, folium artemisiae argyi extraction 0.4-0.7 parts of liquid, 0.4-0.7 parts of cotton rose extracting solution, 0.4-0.7 parts of fruit of summer cypress extracting solution, 0.1-0.91 parts of capsaicine are water Phase and its both effectiveness ingredient；Outstanding 0.4-0.7 parts of horse antiseptic is preservative.
3. a kind of itching analgesic ointment according to claim 1, which is characterized in that include following components in parts by weight： 12 parts of stearic acid, 10 parts of castor oil, 12 parts of atoleine are oil phase；1.7 parts of triethanolamine is emulsifier；5 parts of glycerine, deionization 50 parts of water, 1.3 parts of borneol, 0.5 part of frutus cnidii extracting solution, 0.5 part of Purslane extract, 0.5 part of pericarpium zanthoxyli extracting solution, Radix Notoginseng extraction 0.5 part of liquid, 0.5 part of root bark of shaggy-fruited dittany extracting solution, 0.5 part of Folium Artemisiae Argyi extractive liquid, 0.5 part of cotton rose extracting solution, fruit of summer cypress extracting solution 0.5 Part, 0.5 part of capsaicine are water phase and its both effectiveness ingredient；Outstanding 0.5 part of horse antiseptic is preservative.
4. a kind of a kind of preparation method of itching analgesic ointment as described in claim 1-3 is any, which is characterized in that including with Lower step：
S1, the preparation of Chinese medicine extract
（1）The preparation of fruit of summer cypress extracting solution：It is 1 by solid-liquid ratio by the fruit of summer cypress and 95% ethanol solution:10 proportioning is added Add, the heating water bath 1.5h at 80 DEG C, recycle fraction, in triplicate, finally merge extracting solution three times, it will using Rotary Evaporators Its concentrate to get；
（2）The preparation of pericarpium zanthoxyli extracting solution：It is 1 by solid-liquid ratio by pericarpium zanthoxyli and 70% ethanol solution:20 proportioning is added, Heating water bath 1h at 60 DEG C is recycled fraction, in triplicate, finally merges extracting solution three times, concentrated using Rotary Evaporators, To obtain the final product；
（4）The preparation of cottonrose hibiscus flower extracting solution：It is 1 by solid-liquid ratio by cottonrose hibiscus flower and 50% ethanol solution:10 proportioning into Row addition, the heating water bath 1.5h at 70 DEG C recycle fraction, in triplicate, finally merge extracting solution three times, utilize rotary evaporation Instrument concentrated to get；
S2, the preparation of ointment bases
The stearic acid, castor oil and atoleine of above-mentioned parts by weight are weighed as oil phase, then weighs above-mentioned parts by weight As water phase, triethanolamine is emulsifier for glycerine and deionized water, and water phase and oil phase are respectively placed in 80 DEG C of water-baths is added Heat after it is completely dissolved, is slowly mutually poured into water in oil phase, adds in emulsifier afterwards and is constantly stirred until complete Full milk is to get ointment bases；
It is prepared by S3, finished product
By borneol, capsaicine, fruit of summer cypress extracting solution, pericarpium zanthoxyli extracting solution, cottonrose hibiscus flower extracting solution, frutus cnidii extracting solution, purslane Extracting solution, Radix Notoginseng extracting solution, root bark of shaggy-fruited dittany extracting solution and Folium Artemisiae Argyi extractive liquid, are placed according to above-mentioned parts by weight in beaker, and stirring is mixed Extraction liquid mixture when the ointment bases in step S2 is cooled to 40 DEG C, is slowly added to ointment by synthesis extraction liquid mixture Being stirred continuously in matrix makes it uniformly, added in during stirring outstanding horse antiseptic to get；
S4 is packed and stored after the finished product that S3 is obtained is dispensed.
CN201711483807.5A 2017-12-29 2017-12-29 A kind of itching analgesic ointment and preparation method thereof Pending CN108096359A (en)

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Application publication date: 20180601