CN108852615A - A kind of plant piece and corneal stroma pouch for corneal stroma implantation - Google Patents
A kind of plant piece and corneal stroma pouch for corneal stroma implantation Download PDFInfo
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- CN108852615A CN108852615A CN201810437950.9A CN201810437950A CN108852615A CN 108852615 A CN108852615 A CN 108852615A CN 201810437950 A CN201810437950 A CN 201810437950A CN 108852615 A CN108852615 A CN 108852615A
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- 210000003683 corneal stroma Anatomy 0.000 title claims abstract description 38
- 238000002513 implantation Methods 0.000 title claims abstract description 13
- 210000004087 cornea Anatomy 0.000 claims abstract description 72
- 201000002287 Keratoconus Diseases 0.000 abstract description 13
- 238000005516 engineering process Methods 0.000 abstract description 4
- 230000003902 lesion Effects 0.000 abstract description 4
- 238000009958 sewing Methods 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 description 14
- 210000002159 anterior chamber Anatomy 0.000 description 12
- 230000002980 postoperative effect Effects 0.000 description 10
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 102000008186 Collagen Human genes 0.000 description 8
- 108010035532 Collagen Proteins 0.000 description 8
- 229920001436 collagen Polymers 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 238000011084 recovery Methods 0.000 description 7
- 239000004677 Nylon Substances 0.000 description 5
- 229920001778 nylon Polymers 0.000 description 5
- 239000003855 balanced salt solution Substances 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 201000009310 astigmatism Diseases 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 208000029091 Refraction disease Diseases 0.000 description 2
- 230000004430 ametropia Effects 0.000 description 2
- 229910052798 chalcogen Inorganic materials 0.000 description 2
- 150000001787 chalcogens Chemical class 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 208000014733 refractive error Diseases 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 206010011033 Corneal oedema Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 201000004778 corneal edema Diseases 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Prostheses (AREA)
Abstract
The present invention relates to field of medical technology, provide a kind of plant piece for corneal stroma implantation, and the plant piece derives from donor's cornea, and the diameter for planting piece is 5.0~10.0mm, and with a thickness of 100~400 μm, angle is 30 °~150 °.The invention also includes the corneal stroma pouches to match with above-mentioned plant piece.The present invention is planted in piece implantation corneal stroma pouch, is sutured after paving or without sewing up the incision, cut closure increases the plant bed thickness of keratoconus, is suitable for carrying out at keratoconus lesion initial stage.For conventional operation on cornea, wound is small, restores fast, from the pain for largely reducing patient.
Description
Technical field
The present invention relates to field of medical article technology, and in particular to a kind of plant piece and cornea base for corneal stroma implantation
Matter pouch.
Background technique
Keratoconus or kerectasis disease are the common non-inflammatory of one kind, chronic, progressivity, cornea differentially expanding
Disease, with central cornea matrix, thinning, central summit is in that cone protrudes deformation, cornea loses normal arc, generates irregularly
The formation of astigmatism and scar is characterized, and is seriously reduced so as to cause the optical property of cornea.It often results in highly irregular myopia
Astigmatism, advanced stage will appear acute corneal edema, form scar, and eyesight is remarkably decreased.It is mainly in teenager, normal eyes successively carry out
Property morbidity, seriously affect quality of life, the study and work of patient.Since the cause of disease is still not clear, the treatment of this disease is relatively difficult.
Keratoconus or kerectasis disease early stage main be crosslinked by corneal collagen contact with hard air-permeable cornea
Mirror (Rigid Gas Permeable, RGP) treatment.Corneal collagen crosslinking art is the ultraviolet light,long wave activation core yellow with 370nm wavelength
Plain (a kind of photosensitizer), forms it into active chalcogen, and it is anti-that chemical crosslinking occurs between the amino of active chalcogen induction collagenous fibres
It answers, generates corneal collagen fibre diameter thickening, promote keratocyte apoptosis, improve cornea to resistance of a variety of degrading enzymes etc.
Various biological effect controls the state of an illness of lesion initial stage patient, avoids so that the mechanical strength of corneal stroma be made to increase
Continue to deteriorate.But corneal collagen crosslinking cannot be such that thinning cornea thickens, and nearest the study found that utilizing ophthalmic reaction instrument (one
Kind biological mechanics detector) it checks, fail to show that biological mechanics includes the (survey of viscous damping of corneal hysteresis amount
Amount) and cornea resistance factor (related to the viscoplasticity of cornea and deformation) dramatically increase for a long time.Therefore therapeutic effect at a specified future date is still
It is to be assessed.RGP cannot also prevent disease progression, and have some patientss working environment perhaps uncomfortable wearing RGP or the trouble having
Person's compliance is bad, is late for further consultation, is easy to appear the relevant complication of contact lense.When RGP cannot wear or correct defects of vision difference
When just need to do corneal graft.Corneal graft can increase the thickness of keratoconus plant bed, but 360 degree of cuttings are refreshing
Through normal level is not achieved in postoperative corneal sensitivity and nerve recovery forever.
Summary of the invention
In view of the above-mentioned problems, being matched the present invention provides a kind of plant piece for corneal stroma implantation and with the plant piece
Corneal stroma pouch, which is implanted into corneal stroma pouch, increases the plant bed thickness of keratoconus, increases cornea
Elasticity and resistance, wound is small, restores fast.
Technical scheme is as follows：
The present invention provides a kind of plant piece for corneal stroma implantation, the plant piece derives from donor's cornea, the plant
The diameter of piece is 5.0~10.0mm, and with a thickness of 100~400 μm, angle is 30 °~150 °.
Preferably, the plant piece has diopter.
It is furthermore preferred that the sphere power for planting piece is -12.00D~+6.00D.
It is furthermore preferred that the cylindrical mirror diopter for planting piece is -6.0D~+6.0D.
It is described the present invention also provides the corneal stroma pouch for planting piece described in a kind of matching above-mentioned technical proposal any one
The internal diameter of pouch is 5.0~10.0mm, and depth is 100~400 μm, 1~15mm of pouch mouth arc length.
The prior art is compared, and the present invention has the following advantages that：
The present invention provides a kind of plant piece for corneal stroma implantation and with the plants piece matched corneal stroma capsule
Bag.When the plant piece is implanted into, corneal stroma pouch is made in patient's corneal stroma upper cut, the present invention is planted into piece and is implanted into cornea base
It is sutured in matter pouch, after paving or without sewing up the incision, increases the plant bed thickness of keratoconus, increase weak cornea
Elasticity and resistance, biomethanics obviously become strong and develop to have the function that control disease, be suitable for keratoconus (or its
His kerectasis disease) lesion initial stage carries out.For operation on cornea compared with the existing technology, wound is small, restores fast, generally
Wound healing within 3 days, corneal diopter, elasticity and resistance stability are good, from the pain for largely reducing patient.
Detailed description of the invention
Fig. 1 is that corneal graft is implanted into corneal stroma schematic diagram, wherein 1 is plant piece, 2 be pouch, and 3 be corneal stroma.
Specific embodiment
The present invention provides a kind of plant piece for corneal stroma implantation, the plant piece derives from donor's cornea, the plant
The diameter of piece is 5.0~10.0mm, preferably 6.0~8.0mm；It is described plant piece with a thickness of 100~400 μm, preferably 200~
300μm；The angle for planting piece is 30 °~150 °, more preferably 50 °~120 °.
Plant piece of the present invention preferably has diopter.The sphere power for planting piece preferably -12.00D~+
6.00D, more preferably -8.00D~+4.00D, for improving because of myopia or long sight caused by ametropia problem.The plant
The cylindrical mirror diopter of piece is preferably -6.0D~+6.0D, more preferably -4.00D~+4.00D, caused by improving because of astigmatism
Ametropia problem.Plant piece with certain diopter can improve patient because bending while increasing cornea plant bed thickness
Light not just caused by eye-blurred.
The present invention is not particularly limited the production method for planting piece, using the conventional cornea making machine in this field
It is prepared, such as the laser machine of commercialization.
The present invention also provides the corneal stroma pouches for matching above-mentioned plant piece, containing for planting piece.Cornea base of the invention
Matter pouch is the corneal pocket being opened on cornea, for containing the plant piece.In the present invention, the internal diameter of the pouch is 5.0
~10.0mm, preferably 6.0~8.0mm；The depth of the pouch is 100~400 μm, preferably 200~300 μm.The present invention
Thickness of the depth of the pouch containing corneal epithelium.The mouth arc length of pouch of the present invention is 1~15mm, preferably 5~10mm.
Corneal stroma pouch of the present invention preferably uses the conventional cornea machine in this field to make, and such as commercialization swashs
Optic angle film machine.After setting machine parameter, operation production is directly carried out on patient's cornea.
The present invention plants the donor's cornea made in piece implantation corneal stroma pouch, paves, sews up the incision.This hair
Donor's cornea plant piece is preferably passed through pouch using iris repositor or injector by the bright implantation for planting piece
Notch is sent into recipient cornea stromal pocket, and paves.Suture of the present invention is preferably sutured with ophthalmology suture, such as 10-0
Nylon wire.
The present invention plants donor's cornea in piece implantation recipient cornea pouch, and the plant bed that can increase keratoconus is thick
Degree, increases the elasticity and resistance of weak cornea, and biomethanics obviously becomes strong to have the function that control disease development, is suitble to
It is carried out at keratoconus lesion initial stage.For operation on cornea compared with the existing technology, wound is small, restores fast, general 3 days it
Interior wound healing, corneal diopter stability is good, from the pain for largely reducing patient.
To make the objectives, technical solutions, and advantages of the present invention clearer, below with reference to embodiment to the present invention into
Row detailed description, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
1, donor's cornea plants the production of piece：
1) corneal graft parameter is arranged in FS200 femtosecond laser machine：Diameter 7.8mm, 200 μm of thickness, 150 ° of angle；
2) corneal graft is put on artificial anterior chamber, injecting balanced salt solution using syringe makes the artificial anterior chamber pressure be about
40-50mmHg, and keep pressure steady；
3) artificial anterior chamber is put on station, starting FS200 femtosecond laser machine is planted according to step 1) parameter production cornea
Piece；
4) blunt separation corneal graft, and it is spare to remove corneal graft；
2, the production of recipient cornea stromal pocket：
1) corneal stroma pouch parameter is arranged in the full femtosecond laser machine of Zeiss visumax：Diameter 8.3mm, depth is (containing on cornea
Skin thickness) 150 μm, pouch mouth arc length 2.3mm；
2) after the completion of parameter setting, negative pressure ring attracts cornea, and negative pressure is formed well, starts full femtosecond laser machine transmitting and swashs
Light makes corneal stroma pouch；
3) blunt separation corneal stroma pouch；
3, piece is planted using the donor's cornea that iris repositor makes step 1 and step 2 receptor angle is sent by pouch notch
Membrane matrix pouch, and pave；
4,10-0 nylon line suture recipient cornea stromal pocket notch.
1 embodiment of table, 1 preoperative and postoperative cornea recovery situation
Embodiment 2
1, donor's cornea plants the production of piece：
1) corneal graft parameter is arranged in FS200 femtosecond laser machine：Diameter 5.8mm, 150 μm of thickness, 55 ° of angle；
2) corneal graft is put on artificial anterior chamber, injecting balanced salt solution using syringe makes the artificial anterior chamber pressure be about
40~50mmHg, and keep pressure steady；
3) artificial anterior chamber is put on station, starting FS200 femtosecond laser machine is planted according to step 1) parameter production cornea
Piece；
4) blunt separation corneal graft, and it is spare to remove corneal graft；
2, the production of recipient cornea stromal pocket：
1) corneal stroma pouch parameter is arranged in the full femtosecond laser machine of Zeiss visumax：Diameter 6.3mm, depth is (containing on cornea
Skin thickness) 100 μm, pouch mouth arc length 2.0mm；
2) after the completion of parameter setting, negative pressure ring attracts cornea, and negative pressure is formed well, starts full femtosecond laser machine transmitting and swashs
Light makes corneal stroma pouch；
3) blunt separation corneal stroma pouch；
3, piece is planted using the donor's cornea that injector makes step 1 and step 2 recipient cornea base is sent by pouch notch
Matter pouch, and pave；
4,10-0 nylon line suture recipient cornea stromal pocket notch.
2 embodiment of table, 2 preoperative and postoperative cornea recovery situation
Embodiment 3
1, donor's cornea plants the production of piece：
1) corneal graft parameter is arranged in FS200 femtosecond laser machine：Diameter 9.8mm, 380 μm of thickness, 110 ° of angle；Plant piece band
There is diopter, sphere power is -1.75D, and cylindrical mirror diopter is -0.50D；
2) corneal graft is put on artificial anterior chamber, injecting balanced salt solution using syringe makes the artificial anterior chamber pressure be about
40-50mmHg, and keep pressure steady；
3) artificial anterior chamber is put on station, starting FS200 femtosecond laser machine is planted according to step 1) parameter production cornea
Piece；
4) blunt separation corneal graft, and it is spare to remove corneal graft；
2, the production of recipient cornea stromal pocket：
1) corneal stroma pouch parameter is arranged in the full femtosecond laser machine of Zeiss visumax：Diameter 10.0mm, depth (contain cornea
Epithelial thickness) 200 μm, pouch mouth arc length 4.5mm；
2) after the completion of parameter setting, negative pressure ring attracts cornea, and negative pressure is formed well, starts full femtosecond laser machine transmitting and swashs
Light makes corneal stroma pouch；
3) blunt separation corneal stroma pouch；
3, donor's cornea described in step 1 is planted by piece using injector and step 2 recipient cornea matrix is sent by pouch notch
Pouch, and pave；
4,10-0 nylon line suture recipient cornea stromal pocket notch.
3 embodiment of table, 3 preoperative and postoperative cornea recovery situation
Embodiment 4
1, donor's cornea plants the production of piece：
1) corneal graft parameter is arranged in FS200 femtosecond laser machine：Diameter 7.8mm, 250 μm of thickness, 80 ° of angle；Plant piece band
There are diopter, sphere power 3.5D, cylindrical mirror diopter is 5.0D；
2) corneal graft is put on artificial anterior chamber, injecting balanced salt solution using syringe makes the artificial anterior chamber pressure be about
40-50mmHg, and keep pressure steady；
3) artificial anterior chamber is put on station, starting FS200 femtosecond laser machine is planted according to step 1) parameter production cornea
Piece；
4) blunt separation corneal graft, and it is spare to remove corneal graft；
2, the production of recipient cornea stromal pocket：
1) corneal stroma pouch parameter is arranged in the full femtosecond laser machine of Zeiss visumax：Diameter 8.3mm, depth is (containing on cornea
Skin thickness) 200 μm, pouch mouth arc length 3.5mm；
2) after the completion of parameter setting, negative pressure ring attracts cornea, and negative pressure is formed well, starts full femtosecond laser machine transmitting and swashs
Light makes corneal stroma pouch；
3) blunt separation corneal stroma pouch；
3, donor's cornea described in step 1 is planted by piece using iris repositor and step 2 recipient cornea is sent by pouch notch
Stromal pocket, and pave；
4,10-0 nylon line suture recipient cornea stromal pocket notch.
4 embodiment of table, 4 preoperative and postoperative cornea recovery situation
Comparative example 1
Keratoconus, in the preoperative with the recovery situation of 3 months after operation, is being shown in Table 5 through collagen cross-linking post-operative cornea.
5 keratoconus of table is in collagen cross-linking post-operative cornea recovery situation
| It is preoperative | Postoperative March | |
| Uncorrected visual acuity | 0.15 | 0.1 |
| It corrects defects of vision | 0.3 | 0.1 |
| Curvature | 50.0/56.7 | 55.2/57.2 |
| Corneal thickness | 430 | 444 |
| Biomethanics (DA) | 1.28 | 1.22 |
| Biomethanics (SP-A1) | 45.1 | 35.7 |
Wherein, in table 1~5, biomethanics (DA) represents Central corneal deformability/periphery 2mm deformability ratio, number
Value is higher, and the cornea that represents is softer, and biomethanics is poorer；Biomethanics (SP-A1) represents cornea stiffness, the higher representative of numerical value
Biological mechanics is better.
As it can be seen that the present invention has a clear superiority compared with corneal collagen is crosslinked treatment keratoconus：1, operating time obviously contracts
It is short, operating time of the present invention 10 minutes and corneal collagen is crosslinked operating time 20 minutes；2, postoperative patient discomfort significant reaction subtracts
Gently；3, the present invention can increase the corneal thickness of patient in terms of postoperative effect, so that biomethanics (cornea hardness) is obvious
Become by force to have the function that control disease development.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (5)
1. a kind of plant piece for corneal stroma implantation, which is characterized in that the plant piece derives from donor's cornea, the plant piece
Diameter is 5.0~10.0mm, and with a thickness of 100~400 μm, angle is 30 °~150 °.
2. plant piece according to claim 1, which is characterized in that the plant piece has diopter.
3. plant piece according to claim 2, which is characterized in that it is described plant piece sphere power be -12.00D~+
6.00D。
4. plant piece according to claim 2, which is characterized in that the cylindrical mirror diopter for planting piece is -6.0D~+6.0D.
5. planting the corneal stroma pouch of piece described in a kind of matching Claims 1 to 4 any one, which is characterized in that the pouch
Internal diameter be 5.0~10.0mm, depth be 100~400 μm, 1~15mm of pouch mouth arc length.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810437950.9A CN108852615A (en) | 2018-05-09 | 2018-05-09 | A kind of plant piece and corneal stroma pouch for corneal stroma implantation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810437950.9A CN108852615A (en) | 2018-05-09 | 2018-05-09 | A kind of plant piece and corneal stroma pouch for corneal stroma implantation |
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| Publication Number | Publication Date |
|---|---|
| CN108852615A true CN108852615A (en) | 2018-11-23 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810437950.9A Pending CN108852615A (en) | 2018-05-09 | 2018-05-09 | A kind of plant piece and corneal stroma pouch for corneal stroma implantation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492505A (en) * | 2023-05-11 | 2023-07-28 | 山东第一医科大学附属眼科医院(山东省眼科医院) | Artificial cornea endothelial transplanting sheet and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020138070A1 (en) * | 2001-03-23 | 2002-09-26 | Peyman Gholam A. | Adjustable ablatable inlay |
| CN101066471A (en) * | 2007-04-25 | 2007-11-07 | 中山大学中山眼科中心 | Cell-eliminating coanea matrix and its prepn process |
| CN101400321A (en) * | 2006-03-16 | 2009-04-01 | 阿尔贝特·达克瑟尔 | corneal implant |
| RU2565485C1 (en) * | 2014-06-25 | 2015-10-20 | Учреждение Российской академии медицинских наук Научно-исследовательский институт глазных болезней РАМН (НИИГБ РАМН) | Method for surgical management of keratoconus |
| CN105664254A (en) * | 2015-12-09 | 2016-06-15 | 北京大学第三医院 | Application and use method of acellular dermal matrix |
-
2018
- 2018-05-09 CN CN201810437950.9A patent/CN108852615A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020138070A1 (en) * | 2001-03-23 | 2002-09-26 | Peyman Gholam A. | Adjustable ablatable inlay |
| CN101400321A (en) * | 2006-03-16 | 2009-04-01 | 阿尔贝特·达克瑟尔 | corneal implant |
| CN101066471A (en) * | 2007-04-25 | 2007-11-07 | 中山大学中山眼科中心 | Cell-eliminating coanea matrix and its prepn process |
| RU2565485C1 (en) * | 2014-06-25 | 2015-10-20 | Учреждение Российской академии медицинских наук Научно-исследовательский институт глазных болезней РАМН (НИИГБ РАМН) | Method for surgical management of keratoconus |
| CN105664254A (en) * | 2015-12-09 | 2016-06-15 | 北京大学第三医院 | Application and use method of acellular dermal matrix |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492505A (en) * | 2023-05-11 | 2023-07-28 | 山东第一医科大学附属眼科医院(山东省眼科医院) | Artificial cornea endothelial transplanting sheet and application thereof |
| CN116492505B (en) * | 2023-05-11 | 2023-12-08 | 山东第一医科大学附属眼科医院(山东省眼科医院) | Artificial cornea endothelial transplanting sheet and application thereof |
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