CN108853161A - Application of the Moringa in the drug that preparation improves brood health by maternal effect - Google Patents
Application of the Moringa in the drug that preparation improves brood health by maternal effect Download PDFInfo
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- CN108853161A CN108853161A CN201810777532.4A CN201810777532A CN108853161A CN 108853161 A CN108853161 A CN 108853161A CN 201810777532 A CN201810777532 A CN 201810777532A CN 108853161 A CN108853161 A CN 108853161A
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- 241000220215 Moringa Species 0.000 title claims abstract description 56
- 235000011347 Moringa oleifera Nutrition 0.000 title claims abstract description 56
- 230000036541 health Effects 0.000 title claims abstract description 29
- 230000008774 maternal effect Effects 0.000 title claims abstract description 27
- 244000144987 brood Species 0.000 title claims abstract description 21
- 239000003814 drug Substances 0.000 title claims abstract description 8
- 229940079593 drug Drugs 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims description 7
- 241001465754 Metazoa Species 0.000 claims abstract description 24
- 230000000474 nursing effect Effects 0.000 claims abstract description 4
- 210000002966 serum Anatomy 0.000 claims description 33
- 235000019687 Lamb Nutrition 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 7
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- 102000006395 Globulins Human genes 0.000 claims description 3
- 108010044091 Globulins Proteins 0.000 claims description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 3
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- 210000000952 spleen Anatomy 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract description 20
- 238000011161 development Methods 0.000 abstract description 10
- 238000009360 aquaculture Methods 0.000 abstract description 3
- 244000144974 aquaculture Species 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 description 9
- 230000035764 nutrition Effects 0.000 description 9
- 241000009328 Perro Species 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 5
- 230000035935 pregnancy Effects 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- 210000003754 fetus Anatomy 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 235000021195 test diet Nutrition 0.000 description 2
- 241001260012 Bursa Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 231100000678 Mycotoxin Toxicity 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000009027 insemination Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000009120 phenotypic response Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Feed For Specific Animals (AREA)
Abstract
The invention belongs to animal health fields, specifically disclose a kind of new application of Moringa, it is used to prepare through maternal effect and improves the drug of brood health, the maternal animal of the gestational period or nursing period is enabled to take in a certain amount of moringa powder, there is active influence to the physiochemical indice of filial generation brood, animal later period healthy growth and development can be effectively ensured, and promote aquaculture sustainable development and human health.
Description
Technical field
The invention belongs to animal health fields, and in particular, to Moringa improves brood by maternal effect in preparation
Application in the drug of health.
Background technique
Cause pathogeny imcrobe infection, abuse of antibiotics, mycotoxin contamination feed, vaccine are frequently inoculated with, seek in animal-breeding
It supports bad and factors stress be waited single or superposition can cause the deterioration of animal body health status.Animal body health shape
An important factor for state is restriction aquaculture sustainable development and human health, and the health of immature livestock and poultry animal is that the animal later period is strong
The guarantee of health growth and development.Maternal effect is to influence a big key factor of immature livestock and poultry animal health.Maternal effect refers to son
For a kind of physiological phenomenon that certain macroscopic features, physiological character and the production performance of livestock and poultry are directly affected by its female parent, it is son
Generation is a kind of power of Evolution of Population, it is also possible to a kind of mechanism of Regulation to population to a kind of phenotypic response of environmental heterogeneity.
Size, nutrient and the oxygen that maternal nutrition can influence placenta are transported to process and the fetus of fetus from parent
Nutrition and endocrine.Role during embryo growth and development of different nutriments is not identical.Fetus it is interior
Dirty equal allelotaxis are not only influenced by maternal nutrition state before birth, nevertheless suffer from maternal nutrition shape after birth during lactation
The influence of state.Nutrition is material base existing for life, and the balance of nutrient is necessary to animal physical efficiency normal growth and development.
Therefore, maternal nutrition effect very early just by domestic animal scholars recognize the young before birth and birth after by its mother
Influence of the body in terms of nutrition.When external nourishment situation changes, maternal nutrition can influence the growth and development of embryo, from
And influence offspring.It can be seen that maternal nutrition effect has long-term influence to the growth and development of offspring.
Moringa is a kind of tropical deciduous tree for having extraordinary economic value, have yield height, wide adaptability, simple cultivation,
The strong advantage of resistance, and Moringa nutritive value is high, and gross protein value is up to 27% in dry matter weight of leaf, amino acid composition
Rationally, vitamin rich in, mineral element and unsaturated fatty acid.In addition, Moringa active material master also rich in
If flavones, polysaccharide, polyphenols.Currently, Moringa alleviate vegetable protein in field of fodder instead of clover and herd by Preliminary Applications
The shortage of grass, has active influence to the production performance and Slaughter of animal.
Summary of the invention
The purpose of the present invention is to provide a kind of new application of Moringa, it is used to prepare through maternal effect and improves immature move
The drug of object health has significant impact to the physiochemical indice of filial generation brood after parent intake.
In order to solve the above technical problems, the present invention is achieved by the following technical programs：
It is found by numerous studies, application of the Moringa in the drug that preparation improves brood health by maternal effect is led to
Cross maternal effect improve brood health mode be：The Moringa is taken in into maternal animal, preferably by the Moringa and often
Rule feed takes in maternal animal together.
Further, the Moringa is leaf of Moringa or Moringa cauline leaf mixture.
Further, the preparation method of the Moringa is：Fresh leaf of Moringa or Moringa cauline leaf mixture are acquired, it is dry
To moisture content 10wt% hereinafter, being smashed again to 30 mesh of granularity.
Further, the maternal animal is the jenny of the gestational period or nursing period.
Further, the weight ratio of the Moringa and conventional feed is 1：9-49.
Further, the animal is pig, sheep, dog, cat or chicken.
Further, the brood health that improves includes urea content, the raising piglet blood reduced in piglet serum
The vigor of CAT and SOD in total cholesterol level, raising piglet serum in clear.
Further, the raising brood health includes improving chick index and spleen index and bursal index, improving son
Chicken serum total protein and globulin content.
Further, the raising brood health includes improving total antioxidant capacity and superoxides in lamb serum
The activity of mutase reduces the content of malonaldehyde in lamb serum and improves the content of IgG and IgM in lamb serum.
Further, the raising brood health includes improving total antioxidant capacity and superoxides in puppy serum
The activity of mutase reduces the content of malonaldehyde in puppy serum and improves the content of IgG and IgM in puppy serum.
A kind of drug improving brood health by maternal effect, including Moringa.
The present invention has following positive beneficial effect：
The present invention passes through the study found that the maternal animal of the gestational period or nursing period is enabled to take in a certain amount of moringa powder, immature to filial generation
The physiochemical indice of animal has active influence, and animal later period healthy growth and development can be effectively ensured, and promotes aquaculture sustainable
Development and human health.
Specific embodiment
It is further specifically described below by specific embodiment to of the invention.If experimental method used in following is without special
Illustrate, is the existing conventional method of the art, used ingredient or material are unless otherwise specified to pass through quotient
The available ingredient of industry approach or material.
Embodiment 1
S1. fresh leaf of Moringa is acquired, by fresh leaf of Moringa natural drying, until being ground into granularity after moisture content 10wt% or less
The leaf of Moringa powder of 30 mesh or so；
S2. leaf of Moringa powder is pressed into Tables 1 and 2 formula feed.
1 sow gestation step-by-step test diet of table composition
2 insemination of sows of table excellent feeding stage and nursery phase test diet composition
Almost the same healthy female Landrace 45 of parity, weight, feed intake are chosen, three processing groups is randomly divided into, passes through system
Then adjustment guarantees that group difference is not significant for meter analysis, 3 repetitions of each processing, 5 sows of each repetition.Feeding experiment is from matching
Kind the last fortnight starts to weaned piglet to terminate（24-28 days after birth）, acquire each piglet serum and carry out biochemical indicator respectively and resist
Oxidation index detection, the results are shown in Table 3, table 4.
Through analyzing, 4% and 8% leaf of Moringa powder group significantly reduces the urea content in piglet serum（P<0.05）；4% is peppery
The wooden leaf powder group significantly improves piglet glucose in serum and total protein content（P<0.05）；8% leaf of Moringa powder group significantly mentions
The vigor of CAT and SOD in high piglet serum（P<0.05）.
The decline of serum urea nitrogen shows that the synthesis of protein in brood body increases, and the increase of total serum protein
It illustrates this point, shows that brood is in a good state of health, premunition is strong.CAT and SOD is oxidation resistant enzyme, Neng Gouqing
Except free radical, the health of animal is protected.
Influence of the 3 leaf of Moringa powder of table to Serum Biochemical Index in Piglets
Influence of the 4 leaf of Moringa powder of table to piglet Serum antioxidant indices
Embodiment 2
S1. fresh leaf of Moringa is acquired, by fresh leaf of Moringa natural drying, until after moisture content 10wt% or less；It is ground into granularity
The leaf of Moringa powder of 30 mesh or so；
S2. 0%, 5% and 10% leaf of Moringa powder is added respectively in laying hens essential ration.
Choose weight it is close, with a batch of healthy triple-yolked egg chicken 150, be randomly divided into three processing groups, pass through statistics
Then adjustment guarantees that group difference is not significant for analysis, 5 repetitions of each processing, 10 hens of each repetition.
Related test results are shown in Table 5, table 6, through analyzing, 10% leaf of Moringa powder group, 21 age in days chick index and spleen index and the bursa of farbricius
Index significantly improves；Chick serum total protein and globulin content also significantly improve.
5 21 age in days chick organ index of immunity (g/kg) of table
6 21 age in days chick serum protein content (mg/ml) of table
Embodiment 3
S1. fresh Moringa branches and leaves are acquired, by fresh Moringa branches and leaves natural drying, until after moisture content 10wt% or less；It is ground into
The Moringa cauline leaf powder of 30 mesh of granularity or so；
S2. the leaf of Moringa powder of 0wt%, 2wt% and 3wt% are added respectively in the basal feed of pregnancy boer goat.
It is close, pregnancy boer goat 75 healthy to choose weight, is randomly divided into three processing groups, by statisticalling analyze then
Adjustment guarantees that group difference is not significant, 5 repetitions of each processing, 5 goats of each repetition.
Related test results are shown in Table 7, table 8, through analyzing, always resist in 10 days old lamb serum of 2% and 3% Moringa cauline leaf powder group
Oxidability and the activity of superoxide dismutase significantly improve, while significantly reducing the content of malonaldehyde in serum；2% He
The content of IgG and IgM significantly improves in 10 days old lamb serum of 3% Moringa cauline leaf powder group.
7 10 days old lamb Serum antioxidant indices of table
8 10 days old lamb sero-immunity index of table
Embodiment 4
S1. fresh Moringa branches and leaves are acquired, by fresh Moringa branches and leaves natural drying, until after moisture content 10wt% or less；It is ground into
The Moringa cauline leaf powder of 30 mesh of granularity or so；
S2. the leaf of Moringa powder of 0wt%, 3wt% and 6wt% are added respectively in the basal feed of pregnancy beasle dog.
Related test results are shown in Table 9, table 10, through analyzing, always resist in 10 age in days dog serums of 3% and 6% Moringa cauline leaf powder group
Oxidability and the activity of superoxide dismutase significantly improve, while significantly reducing the content of malonaldehyde in serum；3% He
The content of IgG and IgM significantly improves in 10 age in days dog serums of 6% Moringa cauline leaf powder group.
9 10 age in days dog serum Antioxidant Indexes of table
10 10 age in days dog serum immune indexes of table
The above is only a preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, without departing from the principle of the present invention, can also make several improvements, these improvement also should be regarded as protection of the invention
Range.
Claims (10)
1. application of the Moringa in the drug that preparation improves brood health by maternal effect.
2. application according to claim 1, it is characterised in that：In such a way that maternal effect improves brood health
For：The Moringa is taken in into maternal animal.
3. application according to claim 2, it is characterised in that：The maternal animal is the female of the gestational period or nursing period
Animal.
4. application according to claim 2, it is characterised in that：In such a way that maternal effect improves brood health
For：The Moringa is taken in into maternal animal together with conventional feed.
5. application according to claim 4, it is characterised in that：The weight ratio of the Moringa and conventional feed is 1：9-49.
6. application according to claim 1, it is characterised in that：The Moringa is leaf of Moringa or Moringa cauline leaf mixture.
7. application according to claim 1, it is characterised in that：The preparation method of the Moringa is：Acquire fresh Moringa
Drying is to moisture content 10wt% hereinafter, smashing to obtain the final product.
8. application according to claim 1, it is characterised in that：The raising brood health includes reducing piglet serum
In urea content, improve piglet serum in total cholesterol level, improve piglet serum in CAT and SOD vigor.
9. application according to claim 1, it is characterised in that：The raising brood health includes improving chick spleen
Index and bursal index improve Chick serum total protein and globulin content.
10. application according to claim 1, it is characterised in that：The raising brood health include improve lamb or
Total antioxidant capacity and the activity of superoxide dismutase, the content for reducing malonaldehyde in lamb or puppy serum in puppy serum
With the content for improving IgG and IgM in lamb or puppy serum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810777532.4A CN108853161A (en) | 2018-07-16 | 2018-07-16 | Application of the Moringa in the drug that preparation improves brood health by maternal effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810777532.4A CN108853161A (en) | 2018-07-16 | 2018-07-16 | Application of the Moringa in the drug that preparation improves brood health by maternal effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108853161A true CN108853161A (en) | 2018-11-23 |
Family
ID=64302368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810777532.4A Withdrawn CN108853161A (en) | 2018-07-16 | 2018-07-16 | Application of the Moringa in the drug that preparation improves brood health by maternal effect |
Country Status (1)
| Country | Link |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688321A (en) * | 2012-06-16 | 2012-09-26 | 佛山科学技术学院 | Traditional Chinese medicine preparation improving health of nursing sows and piglets thereof by maternal therapy |
| CN107232399A (en) * | 2017-07-03 | 2017-10-10 | 隆安县荣胜养殖有限公司 | A kind of application process of Moringa in pork pig is raised |
-
2018
- 2018-07-16 CN CN201810777532.4A patent/CN108853161A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688321A (en) * | 2012-06-16 | 2012-09-26 | 佛山科学技术学院 | Traditional Chinese medicine preparation improving health of nursing sows and piglets thereof by maternal therapy |
| CN107232399A (en) * | 2017-07-03 | 2017-10-10 | 隆安县荣胜养殖有限公司 | A kind of application process of Moringa in pork pig is raised |
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